Serum Chitotriosidase Activity in Pulmonary Tuberculosis: Response to Treatment and Correlations with Clinical Parameters

Gulhan Cakır,Seyfettin Gumus,Ergun Ucar,Hatice Kaya,Ergun Tozkoparan,Emin Ozgur Akgul,Bulent Karaman,Omer Deniz,Ismail Kurt,Metin Ozkan,Hayati Bilgic 대한진단검사의학회 2012 Annals of Laboratory Medicine Vol.32 No.3

Background: Chitotriosidase is an accepted marker of macrophage activation. In this study, we investigated serum chitotriosidase levels in pulmonary tuberculosis (PTB). Methods: Forth-two patients with PTB and 30 healthy subjects were enrolled in the study. The radiological extent of PTB, radiological sequela after treatment, and the degree of smear positivity were assessed. Chitotriosidase levels were measured by a fluorometric method. Results: The serum chitotriosidase levels of the PTB patients were significantly higher than those of the control subjects (39.73±24.97 vs. 9.63±4.55 nmol/mL/h, P<0.001). After completion of the standard 6-month antituberculous treatment, chitotriosidase levels in PTB patients significantly decreased (10.47±4.54 nmol/mL/h, P<0.001). Chitotriosidase levels correlated significantly with the radiological extent of PTB, degree of smear positivity, and post-treatment radiological sequela score (r=0.439, r=0.449, and r=0.337, respectively). Conclusions: This study demonstrated that serum chitotriosidase levels increase in PTB; therefore, chitotriosidase can be used as a marker of disease activity, severity, and response to treatment. Background: Chitotriosidase is an accepted marker of macrophage activation. In this study, we investigated serum chitotriosidase levels in pulmonary tuberculosis (PTB). Methods: Forth-two patients with PTB and 30 healthy subjects were enrolled in the study. The radiological extent of PTB, radiological sequela after treatment, and the degree of smear positivity were assessed. Chitotriosidase levels were measured by a fluorometric method. Results: The serum chitotriosidase levels of the PTB patients were significantly higher than those of the control subjects (39.73±24.97 vs. 9.63±4.55 nmol/mL/h, P<0.001). After completion of the standard 6-month antituberculous treatment, chitotriosidase levels in PTB patients significantly decreased (10.47±4.54 nmol/mL/h, P<0.001). Chitotriosidase levels correlated significantly with the radiological extent of PTB, degree of smear positivity, and post-treatment radiological sequela score (r=0.439, r=0.449, and r=0.337, respectively). Conclusions: This study demonstrated that serum chitotriosidase levels increase in PTB; therefore, chitotriosidase can be used as a marker of disease activity, severity, and response to treatment.

Neuroendocrine Tumor of Tailgut Cyst with Unexpected Metastases

Gulhan Ipek Deniz 대한핵의학회 2022 핵의학 분자영상 Vol.56 No.6

Neuroendocrine tumors (NETs) originate from the neuroendocrine cells, which are found in various organs. NETs occurfrequently in the gastrointestinal tract. NETs arising from tailgut cysts are uncommon. We herein report an interesting caseof metastatic tailgut cyst NET, which was firstly diagnosed as plasmacytoma.

Acoustic Analysis of Condenser Fan of Split Air Conditioner Using Numerical and Experimental Method

Nitin Gulhane,Sandip Patil,Kanwaljeet Singh 대한설비공학회 2015 International Journal Of Air-Conditioning and Refr Vol.23 No.2

The present work aims to investigate the accurate method of performing computational fluid dynamics (CFD) — Acoustic analysis for axial flow fans in split air conditioner system. A comprehensive simulation procedure is developed to predict flow-induced noise in a system. The three-dimensional domain using k–ε turbulence model and Ffowcs Williams and Hawkings (FW-H) acoustic model is considered to predict noise generated by the fan blade surface. The acoustic and flow performances of the fan are predicted simultaneously using a computational aero-acoustic technique (combining steady flow and noise propagation analysis). The different cases are simulated by varying the blade angle, blade depth, blade width and serrations at trailing edge of fan blade. An impact of each of these parameter on A-weighted sound pressure level (SPL) and mass flow rate at outlet is determined. The numeric value of obtained A-weighted SPL by CFD simulation is found to be in close agreement with the experimental result within 5.4%. Finally, above mentioned parameters are varied in simulation and optimized design is proposed based on A-weighted SPL and cubic feet per minute (CFM). All simulations are carried out in commercially available CFD solver; ANSYS FLUENT 13.

Photocatalytic degradation of textile dye CI Basic Yellow 28 wastewater by Degussa P25 based TiO₂

Konecoglu, Gulhan,Safak, Toygun,Kalpakli, Yasemen,Akgun, Mesut Techno-Press 2015 Advances in environmental research Vol.4 No.1

Wastewaters of textile industry cause high volume colour and harmful substance pollutions. Photocatalytic degradation is a method which gives opportunity of reduction of organic pollutants such as dye containing wastewaters. In this study, photocatalytic degradation of C.I. Basic Yellow 28 (BY28) as a model dye contaminant was carried out using Degussa P25 in a photocatalytic reactor. The experiments were followed out at three different azo dye concentrations in a reactor equipped UV-A lamp (365 nm) as a light source. Azo dye removal efficiencies were examined with total organic carbon and UV-vis measurements. As a result of experiments, maximum degradation efficiency was obtained as 100% at BY28 concentration of $50mgL^{-1}$ for the reaction time of 2.5 h. The photodegradation of BY28 was described by a pseudo-first-order kinetic model modified with the langmuir-Hinshelwood mechanism. The adsorption equilibrium constant and the rate constant of the surface reaction were calculated as $K_{dye}=6.689{\cdot}10^{-2}L\;mg^{-1}$ and $k_c=0.599mg\;L^{-1}min^{-1}$, respectively.

Knowledge, Attitudes and Behaviour of Women Working in Government Hospitals Regarding Breast Self Examination

Yurdakos, Kursat,Gulhan, Yildirim Beyazit,Unalan, Demet,Ozturk, Ahmet Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.8

Background: Breast self examination (BSE), performed regularly every month, is one of the most important methods in the early diagnosis of breast cancer. This study was performed with the aim of establishing the knowledge, attitudes, and behavior of women working in government hospitals within the province of Samsun regarding BSE. Materials and Methods: This cross-sectional study was conducted between January-March 2012, on a total of 550 women (500 health personnel, and 50 general administration services (GAS) workers) from 7 government hospitals and the Cancer Early Diagnosis, Screening, and Education Centre (CEDSEC). Percentages were used for the descriptive statistics, and the chi-square test for the evaluation of statistical importance. Values of p<0.05 were accepted as significant. Results: The mean age of the participants was $36.2{\pm}15.3$, and 42.5% were in the 30-39 year old age group, 78.0% being married. Seventy-eight point four percent (78.4%) of the health personnel and 76.0% of the GAS workers performed BSE. However, the rates of performing BSE regularly every month were only 25.6% and 5.0%. Within the health personnel, 1.4% stated that they did not perform BSE because they found it unnecessary as they had no history of breast cancer in their family, 3.6% did not do so due to fear and stress, 13.2% because they forgot, and 14.6% because they had no complaints. Some 22.2% of the health personnel and 52.0% of the GAS workers had undergone mammographic evaluation, the difference being significant (p<0.05), 84.1% of the health personnel and 61.9% of the GAS workers knowing symptoms of breast cancer. Conclusions: Women in society should be brought to a certain level of awareness and knowledge regarding BSE. It is of the utmost importance that health personnel, who carry the responsibility for counseling and enlightening society, should interiorize the necessary knowledge, attitudes and behavior.

Lack of Influence of Pregnancy on the Prognosis of Survivors of Thyroid Cancer

Budak, Adnan,Gulhan, Ibrahim,Aldemir, Onur Suleyman,Ileri, Alper,Tekin, Emine,Ozeren, Mehmet Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.11

Objective: The aim of this study is to investigate the influence of pregnancy on prognosis of thyroid cancer. Methods: A total of 72 patients aged between 15-45 years who underwent total or subtotal thyroidectomy and subsequently radioablation were followed up under suppression. Individuals who had term pregnancies after diagnosis of cancer (group 1, n: 36) and who were non-pregnant (group 2, n:36) were included in the study. Both groups were compared in terms of scintigraphic relapse and metastasis, ultrasonographic relapse, stage change of lympadenopathy at the beginning and at the end of the study. Results: Relapse was detected in 4 out of 36 pregnant patients (11.1%) and in 5 out of 36 non-pregnant patients (13.9%) with no significant difference between groups (p=1.00). Pathologic lymphadenopathy was detected in 2 out of 36 pregnant patients (5.6%) and in 2 out of 36 non-pregnant patients (5.6%) (p=1.00), and metastasis in 3 (8.3%) and in 1 (2.8%), respectively (p=0.61). While stage change was detected in only one pregnant patient (2.8%), and none of the non-pregnant again there was no significant difference (p=1.00). Conclusions: We conclude that pregnancy does not have an influence on prognosis of thyroid cancer.

Synthesis and Study of Antibacterial and Antifungal Activities of Novel 2-[[(Benzoxazole/benzimidazole-2-yl)sulfanyl]acetylamino]thiazoles

Kaplancikli, Zafer-Asim,Gulhan, Turan-Zitouni,Revial, Gilbert,Guven, Kiymet The Pharmaceutical Society of Korea 2004 Archives of Pharmacal Research Vol.27 No.11

Several 2-[[(benzoxazole/benzimidazole-2-yl)sulfanyl]acetylamino]thiazoles derivatives were synthesized by reacting 4-substituted-2-(chloroacetylamino)thiazoles with benzoxazole/benzimidazole-2-thioles in acetone and in the presence of $K_2CO_3$. The chemical structures of the compounds were elucidated by IR, $^1H-NMR$, and $FAB^{+}-MS$ spectral data. Their antimicrobial activities against Micrococcus luteus (NRLL B-4375), Bacillus cereus (NRRL B-3711), Proteus vulgaris (NRRL B-123), Salmonella typhimurium (NRRL B-4420), Staphylococcus aureus (NRRL B-767), Escherichia coli (NRRL B-3704), Candida albicans and Candida globrata (isolates obtained from Osmangazi Uni. Fac.of Medicine) were investigated and in this investigation, a significant level of activity was illustrated.

ON STRONGLY θ-e-CONTINUOUS FUNCTIONS

Ozkoc, Murad,Aslim, Gulhan Korean Mathematical Society 2010 대한수학회보 Vol.47 No.5

A new class of generalized open sets in a topological space, called e-open sets, is introduced and some properties are obtained by Ekici [6]. This class is contained in the class of $\delta$-semi-preopen (or $\delta-\beta$-open) sets and weaker than both $\delta$-semiopen sets and $\delta$-preopen sets. In order to investigate some different properties we introduce two strong form of e-open sets called e-regular sets and e-$\theta$-open sets. By means of e-$\theta$-open sets we also introduce a new class of functions called strongly $\theta$-e-continuous functions which is a generalization of $\theta$-precontinuous functions. Some characterizations concerning strongly $\theta$-e-continuous functions are obtained.

ON FIXED POINT THEOREMS FOR MULTIVALUED MAPPINGS OF FENG-LIU TYPE

ALTUN, ISHAK,MINAK, GULHAN Korean Mathematical Society 2015 대한수학회보 Vol.52 No.6

In the present paper, considering the Jleli and Samet's technique we give many fixed point results for multivalued mappings on complete metric spaces without using the Pompeiu-Hausdorff metric. Our results are real generalization of some related fixed point theorems including the famous Feng and Liu's result in the literature. We also give some examples to both illustrate and show that our results are proper generalizations of the mentioned theorems.

Poster Session : PS 0070 ; Cardiology : The Effect of Serum Hepcidin Level on Anemia in Heart Failure

( Betul Borku Uysal ),( Feray Akbas ),( Esma Altunoglu ),( Gulhan Ipek Deniz ),( Duygu Uysal ),( Harun Uysal ),( Hanife Usta Atmaca ),( Yasin Yuksel ),( Hale Aral ),( Guven Cetin ),( M Cem Ar ),( Must 대한내과학회 2014 대한내과학회 추계학술대회 Vol.2014 No.1

Background: Anemia is an accelerating problem among patients with heart failure. In this study, we investigated whether anemia in heart failure was related to hepcidin level. Methods: Totally 70 patients; 50 patients with heart failure and 20 otherwise healthy subjects with no history of a chronic illness including heart failure as control group, were included in the study. Heart failure was verifi ed by echocardiography in each subject and patients were defi ned as ones with reduced ejection fraction (HFrEF) if EF = 40% and with preserved ejection fraction (HFpEF) if EF 40-50%. Exclusion criteria included presence of kidney failure (serum creatinine level>1.4), history of hemorrhage (gastrointestinal or severe menstrual bleeding), chronic liver disease (ALT>2 folds), hematologic disease, iron replacement therapy or blood transfusion in the past six months, hypothyroidism, autoimmune disease and manifest infection. Results: There was no correlation between hepcidin concentration and age, weight, creatinine, iron, vitamin B12, folate, white blood cell (WBC), platetelet, mean corpuscular volume, ESR, ejection fraction (EF) (p > 0,05). There was a positive correlation between hepcidin level and urea, ferritin, hemoglobin, hematocrite, C-reactive protein (p < 0,05). Hepcidin levels of anemic heart failure patients were signifi cantly lower than the non-anemic heart failure patients (p < 0,05). Conclusions: We found that serum hepcidin level in anemic patients with heart failure was lower than in heart failure patients without anemia. Previously, progression of heart failure was found to be associated with decline in circulating hepcidin and the development of iron defi ciency and low hepcidin level was related to unfavorable out come. We believe that iron defi ency occurs as a result of infl ammatory process in heart failure and therefore hepcidin concentrations decrease as a response. However, long-term follow up studies are needed.