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- 저자 : MINAK, GULHAN (검색결과 4 건)
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Min, A-K,Jeong, J Y,Go, Y,Choi, Y-K,Kim, Y-D,Lee, I-K,Park, K-G Springer Verlag 2013 Diabetologia Vol.56 No.2
<P>Fenofibrate is a drug used to treat hyperlipidaemia that works by inhibiting hepatic triacylglycerol synthesis. Sterol regulatory element binding protein-1c (SREBP-1c) is a major regulator of the expression of genes involved in hepatic triacylglycerol synthesis. In addition, endoplasmic reticulum (ER)-bound transcription factor families are involved in the control of various metabolic pathways. Here, we show a novel function for an ER-bound transcription factor, cAMP response element binding protein H (CREBH), in fenofibrate-mediated inhibition of hepatic lipogenesis. The effects of fenofibrate and adenovirus-mediated Crebh (also known as Creb313) overexpression (Ad-Crebh) on hepatic SREBP-1c production and lipogenesis in vitro and in vivo were investigated. We also examined whether downregulation of endogenous hepatic Crebh by small interfering (si)RNA restores the fenofibrate effect on hepatic lipogenesis and SREBP-1c production. Finally, we examined the mechanism by which CREBH inhibits hepatic SREBP-1c production. Fasting and fenofibrate treatment induced CREBH production and decreased SREBP-1c levels. Indeed, Ad-Crebh inhibited insulin- and liver X receptor agonist TO901317-induced Srebp-1c (also known as Srebf1) mRNA expression in cultured hepatocytes. Moreover, increased production of CREBH in the liver of mice following tail-vein injection of Ad-Crebh inhibited high-fat diet-induced hepatic steatosis through inhibition of Srebp-1c expression. The inhibition of endogenous Crebh expression by siRNA restored fenofibrate-induced suppression of Srebp-1c expression and hepatic lipid accumulation both in vitro and in vivo. These results show that fenofibrate decreases hepatic lipid synthesis through induction of CREBH. This study suggests CREBH as a novel negative regulator of SREBP-1c production and hepatic lipogenesis.</P>
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ON FIXED POINT THEOREMS FOR MULTIVALUED MAPPINGS OF FENG-LIU TYPE
ALTUN, ISHAK,MINAK, GULHAN Korean Mathematical Society 2015 대한수학회보 Vol.52 No.6
In the present paper, considering the Jleli and Samet's technique we give many fixed point results for multivalued mappings on complete metric spaces without using the Pompeiu-Hausdorff metric. Our results are real generalization of some related fixed point theorems including the famous Feng and Liu's result in the literature. We also give some examples to both illustrate and show that our results are proper generalizations of the mentioned theorems.
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ON FIXED POINT THEOREMS FOR MULTIVALUED MAPPINGS OF FENG-LIU TYPE
Ishak Altun,Gülhan Minak 대한수학회 2015 대한수학회보 Vol.52 No.6
In the present paper, considering the Jleli and Samet’s technique we give many fixed point results for multivalued mappings on complete metric spaces without using the Pompeiu-Hausdorff metric. Our results are real generalization of some related fixed point theorems including the famous Feng and Liu’s result in the literature. We also give some examples to both illustrate and show that our results are proper generalizations of the mentioned theorems.
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Critical thrust force and feed rate determination in drilling of GFRP laminate with backup plate
Hossein Heidary,Mohammad A. Mehrpouya,Hamed Saghafi,Giangiacomo Minak 국제구조공학회 2020 Structural Engineering and Mechanics, An Int'l Jou Vol.73 No.6
Using backup plate is one of the most commonly used methods to decrease drilling-induced delamination of composite laminates. It has been shown that, the size of the delamination zone is related to the vertical element of cutting force named as thrust force. Also, direct control of thrust force is not a routine task, because, it depends on both drilling parameters and mechanical properties of the composite laminate. In this research, critical feed rate and thrust force are predicted analytically for delamination initiation in drilling of composite laminates with backup plate. Three common theories, linear elastic fracture mechanics, classical laminated plate and mechanics of oblique cutting, are used to model the problem. Based on the proposed analytical model, the effect of drill radius, chisel edge size, and backup plate size on the critical thrust force and feed rate are investigated. Experimental tests were carried out to prove analytical model.
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