http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
Structural and Elastic Properties of the Magnetic Shape Memory Ni2MnGa1−xInx Alloy
Fumiya Kitanishi,Kohji Nakamura,Toru Akiyama,Tomonori Ito 한국물리학회 2013 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.63 No.3
The structural and the elastic properties of the magnetic shape memory Ni2MnGa1−xInx (x 0.25) alloy were investigated from first principles calculations within the generalized gradient approximationby using the full-potential linearized augmented plane-wave method and the Connolly-Williams cluster expansion method. The calculated lattice constant and bulk modulus have analmost linear dependence on the In composition x, where the former increases and the latter decreaseswhen x increases. In contrast, the calculated shear modulus, C0 = (C11 − C12)/2, of thedisordered state, which shows a nonlinear dependence on x, indicates that a deviation from thestoichiometric composition Ni2MnGa (x = 0) enhances the elastic tetragonal anisotropy.
Double-edged Sword Role of Iron-loaded Ferritin in Extracellular Vesicles
Shinya Toyokuni,Yingyi Kong,Hao Zheng,Danyang Mi,Misako Katabuchi,Yashiro Motooka,Fumiya Ito 대한암예방학회 2021 Journal of cancer prevention Vol.26 No.4
Human epidemiological and animal studies have demonstrated that excess iron is a risk for cancer. The responsible mechanisms are: 1) increased intracellular iron catalyzes the Fenton reaction to generate hydroxyl radicals, leading to mutagenic oxidative DNA lesions; 2) iron is necessary for cellular proliferation as cofactors of many enzymes. Thus, iron-excess milieu promotes selecting cellular evolution to ferroptosis-resistance, a major basis for carcinogenesis. Ferritin is a 24-subunit nanocage protein required for iron storage under the regulation of the iron-regulatory protein (IRP)/iron-responsive element (IRE) system. Ferritin is a serum marker, representing total body iron storage. However, how ferritin is secreted extracellularly has been unelucidated. We recently discovered that an exosomal marker CD63 is regulated by the IRP/IRE system and that iron-loaded ferritin is secreted as extracellular vesicles under the guidance of nuclear receptor coactivator 4 (NCOA4). On the other hand, we found that macrophages under asbestos-induced ferroptosis emit ferroptosis-dependent extracellular vesicles (FedEVs), which are received by nearby mesothelial cells, resulting in significant mutagenic DNA damage. Therefore, cells, including macrophages, can share excess iron with other cells, via iron-loaded ferritin packaged in extracellular vesicles as safe non-catalytic iron. However, similar process, such as one involving FedEVs, may cause accumulation of excess iron in other specific cells, which may eventually promote carcinogenesis. Key Words Ferritin, Extracellular vesicles, Iron, Ferroptosis, Asbestos