http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
Michael Fritzsche,Carl-Fredrik Mandenius,Joachim Fritzsche,Jonas O. Tegenfeldt 한국바이오칩학회 2014 BioChip Journal Vol.8 No.2
Fabrication and application of a non-fluorescent and UV-transparent microfluidic biochip in fused silica that allows sensitive autofluorescence detection are described. The biochip is particularly useful in cell-based assays where the most informative autofluorescence signals from the cells reside in the ultraviolet spectral range and where plastic labware materials commonly used in cell culture work severely disturb such measurements. In this study the fused silica biochip was used for measuring intrinsic autofluorescence from liver cells in order to assess hepatotoxic effects of drugs. The assessment assay was carried out with the human liver cell line HepG2 under perfusionconditions in the microfluidics of the biochip. The autofluorescence from the liver cells exposed to quinidine was readily recorded without background disturbance and correlated well with reference toxicity data.
The Physics of Flavor - Callenge for the Future
Harald Fritzsch 한국물리학회 2004 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.45 No.2
This is the Summary Talk for the theoretical part of ICFP03. The contents of the talk are reviewed, and a general outlook is given.
Effects of Microgravity on Vestibular Development and Function in Rats: Genetics and Environment
Ronca, April-E.,Fritzsch, Bernd,Alberts, Jeffrey-R.,Bruce, Laura-L. The Korean Society for Integrative Biology 2000 Korean journal of biological sciences Vol.4 No.3
Our anatomical and behavioral studies of embryonic rats that developed in microgravity suggest that the vestibular sensory system, like the visual system, has genetically mediated precesses of development that establish crude connections between the periphery and the brain. Environmental stimuli also regulate connection formation including terminal branch formation and fine-tuning of synaptic contacts. Axons of vestibular sensory neurons from grabistatic as well as linear acceleration receptors reach their targets in both microgravity and norm81 gravity, suggesting that this is a genetically regulated component of development. However, microgravity exposure delays the development of terminal branches and synapses in gravistatic but not linear acceleration-sensitive neurons and also produces behavioral changes. These latter changes reflect environmentally controlled processes of development.
Glasco, D.M.,Sittaramane, V.,Bryant, W.,Fritzsch, B.,Sawant, A.,Paudyal, A.,Stewart, M.,Andre, P.,Cadete Vilhais-Neto, G.,Yang, Y.,Song, M.R.,Murdoch, J.N.,Chandrasekhar, A. Academic Press 2012 Developmental Biology Vol.369 No.2
During development, facial branchiomotor (FBM) neurons, which innervate muscles in the vertebrate head, migrate caudally and radially within the brainstem to form a motor nucleus at the pial surface. Several components of the Wnt/planar cell polarity (PCP) pathway, including the transmembrane protein Vangl2, regulate caudal migration of FBM neurons in zebrafish, but their roles in neuronal migration in mouse have not been investigated in detail. Therefore, we analyzed FBM neuron migration in mouse looptail (Lp) mutants, in which Vangl2 is inactivated. In Vangl2<SUP>Lp/+</SUP> and Vangl2<SUP>Lp/Lp</SUP> embryos, FBM neurons failed to migrate caudally from rhombomere (r) 4 into r6. Although caudal migration was largely blocked, many FBM neurons underwent normal radial migration to the pial surface of the neural tube. In addition, hindbrain patterning and FBM progenitor specification were intact, and FBM neurons did not transfate into other non-migratory neuron types, indicating a specific effect on caudal migration. Since loss-of-function in some zebrafish Wnt/PCP genes does not affect caudal migration of FBM neurons, we tested whether this was also the case in mouse. Embryos null for Ptk7, a regulator of PCP signaling, had severe defects in caudal migration of FBM neurons. However, FBM neurons migrated normally in Dishevelled (Dvl) ½ double mutants, and in zebrafish embryos with disrupted Dvl signaling, suggesting that Dvl function is essentially dispensable for FBM neuron caudal migration. Consistent with this, loss of Dvl2 function in Vangl2<SUP>Lp/+</SUP> embryos did not exacerbate the Vangl2<SUP>Lp/+</SUP> neuronal migration phenotype. These data indicate that caudal migration of FBM neurons is regulated by multiple components of the Wnt/PCP pathway, but, importantly, may not require Dishevelled function. Interestingly, genetic-interaction experiments suggest that rostral FBM neuron migration, which is normally suppressed, depends upon Dvl function.
Update on <i>ɛ</i><sub><i>K</i></sub> with lattice QCD inputs
Jang, Yong-Chull,Lee, Weonjong,Lee, Sunkyu,Leem, Jaehoon,Della Morte, M.,Fritzsch, P.,Gá,miz Sá,nchez, E.,Pena Ruano, C. EDP Sciences 2018 The European Physical Journal Conferences Vol.175 No.-
<P>We report updated results for <I>ɛ</I><I>K</I>, the indirect CP violation parameter in neutral kaons, which is evaluated directly from the standard model with lattice QCD inputs. We use lattice QCD inputs to fix [see formula in PDF], and <I>m</I><I>c</I>(<I>m</I><I>c</I>). Since Lattice 2016, the UTfit group has updated the Wolfenstein parameters in the angle-only-fit method, and the HFLAV group has also updated |<I>V</I><I>cb</I>|. Our results show that the evaluation of <I>ɛ</I><I>K</I> with exclusive |<I>V</I><I>cb</I>| (lattice QCD inputs) has 4.0σ tension with the experimental value, while that with inclusive |<I>V</I><I>cb</I>| (heavy quark expansion based on OPE and QCD sum rules) shows no tension.</P>
Bailey, Jon A.,Jang, Yong-Chull,Lee, Weonjong,Leem, Jaehoon,Della Morte, M.,Fritzsch, P.,Gá,miz Sá,nchez, E.,Pena Ruano, C. EDP Sciences 2018 The European Physical Journal Conferences Vol.175 No.-
<P>The CKM matrix element |<I>V</I><I>cb</I>| can be extracted by combining data from experiments with lattice QCD results for the semileptonic form factors for the <I>B̅</I> → <I>D(*)lv̅</I> decays. The Oktay-Kronfeld (OK) action was designed to reduce heavy-quark discretization errors to below 1%, or through O(λ<SUP>3</SUP>) in HQET power counting. Here we describe recent progress on bottom-to-charm currents improved to the same order in HQET as the OK action, and correct formerly reported results of our matching calculations, in which the operator basis was incomplete.</P>
Bailey, Jon A.,Bhattacharya, Tanmoy,Gupta, Rajan,Jang, Yong-Chull,Lee, Weonjong,Leem, Jaehoon,Park, Sungwoo,Yoon, Boram,Della Morte, M.,Fritzsch, P.,Gá,miz Sá,nchez, E.,Pena Ruano, C. EDP Sciences 2018 The European Physical Journal Conferences Vol.175 No.-
<P>We present the first preliminary results for the semileptonic form factor <I>h</I><I>A</I>1 (<I>w</I> = 1)/<I>ρ</I><I>A</I><I>j</I> at zero recoil for the <I>B</I> → <I>D*l</I><I>v</I> decay using lattice QCD with four flavors of sea quarks. We use the HISQ staggered action for the light valence and sea quarks (the MILC HISQ configurations), and the Oktay-Kronfeld (OK) action for the heavy valence quarks.</P>