http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
Genetic Association of the PERIOD3 (Per3) Clock Gene with Bipolar Disorder
Paulo Marcos Brasil Rocha,Simone Becho Campos,Fernando Silva Neves,Humberto Corrêa da Silva Filho 대한신경정신의학회 2017 PSYCHIATRY INVESTIGATION Vol.14 No.5
Objective: Circadian rhythms have been linked to psychiatric disorders such as Depression and Bipolar Disorder (BD). Given previous evidences of sleep/circadian disturbances as well as the genetic susceptibility for BD, we decided to investigate the possible link between the PERIOD3 (Per3) circadian gene and BD. Methods: This is a genetic association case (BD) vs. control study of the Per3 gene. We further subdivided our BD sample into “good sleepers” (PSQI ≤5) and “poor sleepers” (PSQI>5) according to the Pittsburgh Sleep Quality Index (PSQI) global score, and then we assessed genetic association of the Per3 gene with sleep quality in the BD group. Results: There were 209 cases and 213 controls in our sample. The GT genotype of the SNP rs707467 significantly associated with BD (χ2=8.80; p-value=0.01; adjusted residual=±2.6). We also found significant association of the SNP rs10462020 allele T with BD (χ2=5.81; p-value=0.01) as well as the genotype TT (χ2= 6.01; p-value=0.04; adjusted residual=±2.4). Conclusion: In this study we demonstrated evidences of genetic association between the Per3 gene and BD. The results of association between the Per3 gene and BD in our sample may bring additional evidence to the former findings of association between the Per3 gene and BD.
Thiago Torres Martins Rocha,Sara Isabel De Melo Resende,H elio Augusto Goulart Diniz,Fernando Antônio Rodrigues Filho,Raphael Nunes De Oliveira 대한설비공학회 2020 International Journal of Air-Conditioning and Refr Vol.28 No.4
In this work, the performance of an existing algebraic solution for adiabatic coiled capillary tubes, in subcritical cycles, is investigated. However, the C-M&N friction factor, commonly used, was replaced by Schmidt friction factor, which is less complex. Two existing dimensionless correlations were also evaluated for comparison. To assess the effect of altering the friction factor, experimental data collected in the literature were used as reference. Analyzing the present results and that with C-M&N friction factor, it was observed that adopting the Schmidt friction factor does not cause a relevant impact on the solution. The deviations of the predicted versus experimental mass flow rates were comprised in a range between –8% and 12%, with average deviation (AD), absolute average deviation (AAD) and root mean square (RMS) error of –0.1%, 2.7% and 3.4%, respectively. The empirical correlations presented unsatisfactory results, with maximum deviation around 40%. Therefore, it was concluded that using the Schmidt friction factor is adequate to reduce the complexity of the algebraic solution and to maintain the accuracy.
Geochemistry of mudrock units from the Meso-Cenozoic Algarve Basin, Portugal
Maria J. Trindade,Maria I. Dias,Fernando Rocha,Maria I. Prudêncio,Rosa Marques 한국지질과학협의회 2018 Geosciences Journal Vol.22 No.5
Geochemistry of mudrock units deposited in the sedimentary basin of Algarve (South Portugal) during Mesozoic and Cenozoic depositional cycles were studied, aiming a better knowledge of the evolution of the Basin. Two types of mudrock units were found: (i) silicic and Ca-poor (Cretaceous and Cenozoic), and (ii) calcareous (Middle–Upper Jurassic Ca-rich mudrock units and Upper Triassic to Lower Jurassic Mg-rich redbeds). LILE appear to be controlled by a K-bearing phyllosilicate, which is consistent with the abundant illite in the redbeds. Positive trends of: (i) Sc, Cr, Th, LREE with Al2O3 suggests their incorporation in clay minerals, and (ii) HREE with TiO2, Zr and Hf point to their presence in heavy minerals. The source area of the Algarve mudrock units was dominated by felsic rocks; features typical of a mafic source occur in some Upper Triassic to Lower Jurassic samples. Carboniferous metasediments of the basement were probably the first order source for the Algarve sedimentary basin. A more severe weathering in the Cenozoic and Cretaceous mudrock units occurred, whereas diagenetic enrichment in potassium is observed in the Upper Triassic to Lower Jurassic continental redbeds.
Carolina R. Barbosa,Gabriel H. Machado,Hugo M. Azevedo,Fernando S. Rocha,José C. Filho,Arielly A. Pereira,Otávio L. Rocha 대한금속·재료학회 2020 METALS AND MATERIALS International Vol.26 No.3
In this work, solidification and T6-heat treatment experiments were performed with the Al7Si0.3Mg alloy in order to investigatethe effect of processes parameters on the microstructure and microhardness (HV). A directional solidification devicewas used, and the solidification thermal parameters investigated were the growth and cooling rates (VL and TR). The heattreatment applied was the T6 (T6-HT), under the following conditions: solution treatment for 3 h at 520 ± 2 °C, followed byquenching in warm water (70 ± 20 °C), aging for 1, 2, 3 and 4 h at 155 ± 2 °C and air-cooling. The microstructure observedin both as-cast and T6-heat treated samples is composed of a primary phase consisting of an Al-rich dendritic network andsecondary eutectic phases, located within the interdendritic regions, formed by Si and Mg2Siparticles and Fe-intermetallicphases. The dendritic microstructure was characterized by secondary dendritic spacing (λ2) and, for both investigated samples,a single mathematical expression was proposed on the λ2 dependence with the position in the ingot. Spheroidized-likeeutectic Si particles have been found in both analyzed samples for finer microstructures. Elements quantitative and qualitativemicroanalysis by SEM/EDS as well as HV measurement at the dendritic and interdendritic regions attest to the effectivenessof the T6-heat treatment. It is highlighted in this work that mathematical expressions have been proposed to characterizethe HV dependence on aging time.
Jorge Espinha Marques,José M. Marques,Helder I. Chaminé,Paula M. Carreira,Paulo E. Fonseca,Fernando A. Monteiro,Rui Moura,Javier Samper,Bruno Pisani,José Teixeira,José Martins Carvalho,Fernando Rocha 한국지질과학협의회 2013 Geosciences Journal Vol.17 No.3
Mountains are often considered as the world’s water towers. This paper presents a critical review on the research concerning the integrated assessment of groundwater resources of the mountain hydrogeologic system of Serra da Estrela Natural Park (central Portugal). The study area is the Zzere river basin upstream of Manteigas village located at the Serra da Estrela Mountain in Central Portugal. It provides the source of strategic water resources for the Portuguese mainland, including normal groundwaters, thermomineral waters and surface waters. An integrated approach has been used to formulate a conceptual model for this complex mountain hydrogeological system by integrating the geological, morphotectonic, hydroclimatic, unsaturated soil zone, hydrogeological, hydrogeophysical, hydrogeochemical and isotopic data. This model has been useful to: i) evaluate the water resources; ii) provide the basis for a sustainable management of water resources, iii) design measures for groundwater exploitation and contamination control; and iv) set up land-use policies.