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- 저자 : Fenglin Zhang (검색결과 4 건)
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Fenglin Xiao,Shengyuan Wang,Zhiyong Zhang,Hai Yu,Mingxu Li 대한독성 유전단백체 학회 2021 Molecular & cellular toxicology Vol.17 No.3
Background Peritoneal dialysis has greatly improved patient survival for patients with chronic kidney disease. However, peritoneal fibrosis is a progressive fibrotic peritoneal disease caused by dialysis, which may lead to ineffective dialysis or dialysis failure. It is well known that the EMT of peritoneal mesenchymal cells has been known to contribute to peritoneal fibrosis. Therefore, at present, inhibiting the formation and development of EMT has become the focus of peritoneal fibrosis. Objectives Pirfenidone has shown clinically relevant benefits in patients with pulmonary fibrosis, however, there is no research on peritoneal fibrosis. Thus, we examined the effect of pirfenidone on AGE-driven EMT in peritoneal mesenchymal cells and assessed its efficacy in inhibiting peritoneal fibrosis. Results AGEs were added with or without pirfenidone to the culture medium of HMrSV5 cells and we detected the changes of EMT and the signaling pathways involved. AGEs greatly reduced the E-cadherin level and augmented the α–SMA and vimentin expression. However, these effects were dramatically suppressed by pirfenidone treatment. Meanwhile, the reactive oxygen species (ROS) induced by AGEs were suppressed by pirfenidone. Furthermore, under the action of AGEs, pirfenidone activated the nuclear transport of Nrf2, and accelerated the production of antioxidant factors. Conclusion Pirfenidone could attenuate AGE-mediated EMT in HPMCs and might be a promising therapeutic drug to antagonize peritoneal fibrosis.
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Inhibition of SKP2 Sensitizes Bromocriptine-Induced Apoptosis in Human Prolactinoma Cells
Jinxiang Huang,Fenglin Zhang,Lei Jiang,Guohan Hu,Wei Sun,Chenran Zhang,Xuehua Ding 대한암학회 2017 Cancer Research and Treatment Vol.49 No.2
Purpose Prolactinoma (prolactin-secreting pituitary adenoma) is one of the most common estrogenrelated functional pituitary tumors. As an agonist of the dopamine D2 receptor, bromocriptine is used widely to inhibit prolactinoma progression. On the other hand, it is not always effective in clinical application. Although a dopamine D2 receptor deficiency contributes to the impaired efficiency of bromocriptine therapy to some extent, it is unknown whether there some other underlying mechanisms leading to bromocriptine resistance in prolactinoma treatment. That is the main point addressed in this project. Materials and Methods Human prolactinoma samples were used to analyze the S-phase kinase associated protein 2 (SKP2) expression level. Nutlin-3/adriamycin/cisplatin-treated GH3 and MMQ cells were used to analyze apoptosis in SKP2 overexpression or knockdown cells. SKP2 expression and the interaction partners of SKP2 were also detected after a bromocriptine treatment in 293T. Apoptosis was analyzed in C25 and bromocriptine-treated GH3 cells. Results Compared to normal pituitary samples, most prolactinoma samples exhibit higher levels of SKP2 expression, which could inhibit apoptosis in a p53-dependent manner. In addition, the bromocriptine treatment prolonged the half-life of SKP2 and resulted in SKP2 overexpression to a greater extent, which in turn compromised its pro-apoptotic effect. As a result, the bromocriptine treatment combined with C25 (a SKP2 inhibitor) led to the maximal apoptosis of human prolactinoma cells. Conclusion These findings indicated that SKP2 inhibition sensitized the prolactinoma cells to bromocriptine and helped promote apoptosis. Moreover, a combined treatment of bromocriptine and C25 may contribute to the maximal apoptosis of human prolactinoma cells.
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Li Li,Huan Wang,Fenglin Hua,Mingming Wang,Yuanshuo Zhang,Hui Xi,Jing Yang,Zhiwang Yang,Ziqiang Lei 한국고분자학회 2021 Macromolecular Research Vol.29 No.9
An effective ternary organic-inorganic composite flame retardant of reduced graphene oxide-poly-dopamine@graphitic carbon nitride@10-(2,5-dihydroxyphenyl)- 10-H-9-oxa-10-phosphaphenanthrene-10-oxide (RGO-PDA@g-C3N4@ODOPB) was successfully fabricated by co-precipitation method. Its property concerning the intrinsic flame retardancy and the mechanical performance was well studied when it was used as co-additives in combination with ammonium polyphosphate (APP) in epoxy resin (EP) samples. The surface morphology and the structure of RGO-PDA@g-C3N4 @ODOPB were characterized by SEM, and the molecular structure and compositions were investigated by FT-IR, powder XRD and 1H NMR. TGA, limit oxygen index (LOI), vertical burning test (UL-94), cone calorimeter test, and SEM were also used to investigate the thermal properties and flame retardancy of materials. As expected, the flame retardancy of EP was significantly heightened after adding of RGOPDA@ g-C3N4@ODOPB composites. It showed that with the 20% adding of RGO-PDA@g-C3N4@ODOPB/APP into EP led to the decreasing of the peak heat release rate and the total heat release at 78% and 62.5%, respectively. Meanwhile, the LOI value of the EP composites was as high as 29% and reached UL-94 V-0 rate. It was deemed that the excellent flame retardancy was attributed to the forming of compact and stable carbon layer, which was being catalytic carbonization by APP existed in the RGO-PDA@g-C3N4@ODOPB/APP composites. At the same time, the non-combustible gas released from thermal cracking of g-C3N4 during the combustion also benefited the flame retardant performance of EP.
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Yanjun Zhao,Chenglin Liu,Hua Zhang,Licheng Wang,Baokun Liu,Fenglin Lv 한국지질과학협의회 2015 Geosciences Journal Vol.19 No.1
The Shulu Sag is a typical rift valley basin in easternChina, where the formation mechanism of Cenozoic salt-bearingseries has been poorly understood. In this paper, petrologic analysis,X-ray powder Diffraction (XRD) analysis and the analysis ofhalite ion concentrations of the first member of the Shahejie Formationfrom two drilling cores were conducted to interpret theformation mechanism of these salt-bearing series in Shulu Sag. Theresults indicated that the salt-bearing series is mainly composed of calcilutiteor mudstone at top and bottom, and anhydrite-bearing haliteand thin interbeds of salt-bearing calcilutite and dark grey shale inthe middle part. These thin interbeds with porphyritic or petalshapedglauberite crystals or some thinner dark grey shale interbedsseparated halites into several members with the average thicknessof only 9~12 cm in the two drilling holes. This typical rhythmicpattern due to frequent alternation of concentration was evidencedby the variation of chemical composition and hydrogen isotopes ofhalite fluid inclusions. The presence of large number of primaryfluid inclusions within chevron crystals and vertically orientedbottom-growth crystals showed that the halite were precipitated inshallow water (<60 cm). These features are direct evidence for thisfrequent alternation of dissolution and concentration of brines andterrigenous detrital-chemical shallow-water sedimentary model ofthese small rift-valley basins in eastern China.
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