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- 저자 : Feifei Shen (검색결과 4 건)
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Feifei Shen,Meihong Wang,Lingxiang Huang,Feng Qian 한국공업화학회 2021 Journal of Industrial and Engineering Chemistry Vol.93 No.-
In chemical industry, most processes face the challenge of high energy consumption. The approachpresented in this study can reduce the energy footprint and increase efficiency. The energy system of aseparation process in ethylene manufacturing is used to demonstrate the effectiveness of the approach. The chilling train system of the separation process in a typical ethylene plant consumes most cooling andprovides appropriate feed for distillation columns. The steady state simulation of system was presentedand the simulation results were proved accurate. The conventional exergy analysis identifies thatDephlegmator No.1 (a heat exchange and mass transfer device) has the highest exergy destruction(1401.28 kW). Based on advanced exergy analysis, Dephlegmator No.1 has the highest rate of avoidableexergy destruction (89.04 %). Finally, a multi-objective optimisation aiming to maximise system exergyefficiency and to minimise operational cost was performed and the Pareto frontier was obtained. Themulti-objective optimized exergy efficiency is 79.53 % (improved by 0.61 %) and the operational cost is0.02031 yuan/kg (saved by 11.19 %). This study will guide future research to reduce energy consumptionin process manufacturing.
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Altered Protein Expression Patterns of Mycobacterium tuberculosis Induced by ATB107
Hongbo Shen,Enzhuo Yang,Feifei Wang,Ruiliang Jin,Shengfeng Xu,Qiang Huang,Honghai Wang 한국미생물학회 2010 The journal of microbiology Vol.48 No.3
ATB107 is a potent inhibitor of indole-3-glycerol phosphate synthase (IGPS). It can effectively inhibit the growth of clinical isolates of drug-resistant Mycobacterium tuberculosis strains as well as M. tuberculosis H37Rv. To investigate the mechanism of ATB107 action in M. tuberculosis, two-dimensional gel electrophoresis coupled with MALDI-TOF-MS analysis (2-DE-MS) was performed to illustrate alterations in the protein expression profile in response to ATB107. Results show that ATB107 affected tryptophan biosynthesis by decreasing the expression of protein encoded by Rv3246c, the transcriptional regulatory protein of MtrA belonging to the MtrA-MtrB two-component regulatory system, in both drug-sensitive and drug-resistant virulent strains. ATB107 might present a stress condition similar to isoniazid (INH) or ethionamide for M. tuberculosis since the altered expression in response to ATB107 of some genes, such as Rv3140, Rv2243, and Rv2428, is consistent with INH or ethionamide treatment. After incubation with ATB107, the expression of 2 proteins encoded by Rv0685 and Rv2624c was down-regulated while that of protein encoded by Rv3140 was up-regulated in all M. tuberculosis strains used in this study. This may be the common response to tryptophan absence; however, relations to ATB107 are unknown and further evaluation is warranted.
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Zou Feifei,Guo Qin,Shen Bo,Lv Yuan 한국응용곤충학회 2024 Journal of Asia-Pacific Entomology Vol.27 No.1
Aedes albopictus with a worldwide distribution, has been a vector for more than 20 arboviruses such as dengue, chikugunya, Zika and West Nile, but insecticide resistance in A. albopictus has become more and more serious, as a result of improper application of pyrethroid insecticides for mosquito control. The P450 gene cluster is known to be involved in metabolic mechanisms of pyrethroid resistance in other mosquito species. However, little is known about metabolic resistance in field A. albopictus in China. In this study, we collected five different field strains and first revealed the larval and adult resistance status of A. albopictus to deltamethrin in Jiangsu province of China. A combination of comparative genomics and P450 gene cluster analysis was conducted to investigate the underlying CYP6-mediated metabolic resistance mechanisms against deltamethrin in these field mosquitoes. The significance of three CYP6 genes, AALF024122, AALF024124 and AALF018944 in deltamethrin resistance was identified in our study. Furthermore, RNA interference-mediated silencing of three genes all increased the sensitivity of mosquitoes to deltamethrin in vivo, showing that these genes may be viable biomarkers for pyre throid resistance management in field A. albopictus.
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Wang Yingshuang,Feng Feifei,Zheng Pingping,Wang Lijuan,Wang Yanjun,Lv Yaogai,Shen Li,Li Kexin,Feng Tianyu,Chen Yang,Liu Zhigang,Yao Yan 한국유전학회 2022 Genes & Genomics Vol.44 No.1
Background: Long non-coding RNAs (lncRNAs) are widely involved in gene transcription regulation and which act as epigenetic modifiers in many diseases. Objective: To determine whether lncRNAs are involved in ischemic stroke (IS), we analyzed the expression profile of lncRNAs and mRNAs in IS. Methods: RNA sequencing was performed on the blood of three pairs of IS patients and healthy controls. Differential expression analysis was used to identify differentially expressed lncRNAs (DElncRNAs) and mRNAs (DEmRNAs). Based on the co-expression relationships between lncRNA and mRNA, a series of bioinformatics analysis including GO and KEGG enrichment analysis and PPI analysis, were conducted to predict the function of lncRNA. Results: RNA sequencing produced a total of 5 DElncRNAs and 144 DEmRNAs. Influenza A pathway and Herpes simplex infection pathway were the most significant pathways. EP300 and NFKB1 were the most important target proteins, and Human leucocyte antigen (HLA) family were the key genes in IS. Conclusions: Analysis of this study revealed that dysregulated lncRNAs in IS may lead to IS by affecting the immune and inflammation system.
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