Investigation on the Biodegradability and Antibacterial Properties of Nanohybrid Suture Based on Silver Incorporated PGA-PLGA Nanofibers

Farzaneh Rouhollahi,Seyed Abdolkarim Hosseini,Farzaneh Alihosseini,Alireza Allafchian,Fatemeh Haghighat 한국섬유공학회 2018 Fibers and polymers Vol.19 No.10

Polyglycolic acid-poly lactic glycolic acid (PGA-PLGA) electrospun nanofibers containing silver nanoparticles have been produced and twisted into the nanofibrous yarn. The morphology of nanofibers and produced yarns, as well as the mechanical properties of the yarns, were investigated. Furthermore, in vitro antibacterial properties and in vitro degradation behavior of yarns containing various silver nanoparticles were studied. SEM images confirmed that the addition of the silver nanoparticles into the polymer solution increases the fiber diameters. The result of the mechanical test of the yarns alone and used in two different forms of the knots was measured and results showed that the strength of the yarns without the knot was significantly more than that of others. The biodegradability test showed that the mechanical properties and the weight of the yarns were quickly reduced after subjecting to in vitro condition. The result of the antibacterial test indicated that the nanofiber yarns containing %3 silver nanoparticles were the most appropriate sample with a considerably antibacterial activity against both gram-positive bacterium Staphylococcus aureus and gram-negative bacterium Escherichia Coli with inhibition zones of 8.1 and 9.5 mm, respectively; which demonstrated that silver nanoparticles retained their effectiveness after the electrospinning process. Therefore the nanofibrous yarns containing silver nanoparticles could be successfully produced by the electrospinning process with the proper antibacterial property as a candidate for the surgical sutures.

Iranian Olive Cultivars Micro Propagation

Farzaneh Tabesh,Maryam Peivandi,Farah Farahani,Seyed Mehdi Hosseini Mazinani 한국원예학회 2006 한국원예학회 기타간행물 Vol.- No.-

On the Cultural Schema and Iranian EFL Learners` Reading Performance: A Case of Local and Global Items

( Farzaneh Dehghan ),( Firooz Sadighi ) 범태평양응용언어학회 2011 범태평양응용언어학회지 Vol.15 No.2

Reading skill has taken on an important role in most EFL teaching situations. While linguistic knowledge is only one aspect of this skill, background knowledge including culture can also play an important role (Alptekin, 2006; Johnson, 1981; Pritchard, 1990; Steffensen, Chitra, & Anderson, 1979). This study investigated the effect of cultural background or cultural schema on the performance of Iranian EFL students on local (bottom-up) and global (top-down) processes. Sixty-six female pre-university students took part in the study. They read five texts with familiar cultural themes and five texts with culturally unfamiliar topics (total=10). The multiple-choice items were designed in a way to test both bottom-up processing (word recognition, literal comprehension and finding referents of pronouns) and top-down processing (making inferences, skimming, scanning, etc). The findings showed that our students performed significantly better on local items compared with global items both for (un)familiar texts. It was also observed that their overall performance was mostly influenced by text familiarity. Their higher scores on local items can be explained by the fact that these items are totally easier to process due to the linguistic context available. In contrast, the difficulty of the global items can be explained because our EFL learners need extra linguistic knowledge to process such items. Also, this difference could be attributed to the teaching situation in which language teachers do not teach students how to read at all and learners are not familiar with higher-level, global processes being important in reading comprehension.

A Review of Pharmacological Treatments for Vaginal Atrophy in Postmenopausal Women in Iran

Farzaneh Rashidi Fakari,Masoumeh Simbar,Maryam Beheshti Nasab,Masoumeh Ghazanfarpour,Fahimeh Rashidi Fakari 대한폐경학회 2020 대한폐경학회지 Vol.26 No.2

Vaginal atrophy is one of the most common menopausal complications and is often overlooked. There are various pharmacological and non-pharmacological treatment approaches to reduce vaginal atrophy; however, no comprehensive study on a convenient, affordable, inexpensive, and noninvasive treatment with fewer complications has been conducted so far. Thus, the current study aimed to provide a systematic review of pharmacological treatment for vaginal atrophy in postmenopausal women in Iran. In this systematic review, all Iranian articles published in Persian or English during 2009 to 2019 were collected and analyzed by searching the Scopus, PubMed, Web of Science, Magiran, Iranian Registry of Clinical Trials (IRCT), and Cochrane Library databases. The inclusion criteria were clinical trials for vaginal atrophy and menopause. Based on the selection criteria, articles with a Jadad scale score of 3 and above were included in the study and qualitatively analyzed. Overall, 15 clinical trials met the inclusion criteria. In total, 12 articles examined the efficacy of pharmacological treatments (including three herbal medicines, three vitamins and dietary supplements, and two chemical drugs) in treating vaginal atrophy in postmenopausal women. Various types of medication have been used to improve vaginal atrophy, and effective treatments include licorice, chamomile, royal jelly, vitamin E, vitamin D, hyaluronic acid, and Vagifem; however, the results of studies on fennel have been inconsistent. However, considering the small number of studies reviewed, further studies with a stronger methodology are needed to confirm the efficacy of these medications.

Multi-walled CNT decoration by ZIF-8 nanoparticles: O-MWCNT@ZIF-8/ epoxy interfacial, thermal–mechanical properties analysis via combined DFT-D computational/experimental approaches

Farzaneh Ozeiry,Mohammad Ramezanzadeh,Bahram Ramezanzadeh,Ghasem Bahlakeh 한국공업화학회 2022 Journal of Industrial and Engineering Chemistry Vol.108 No.-

Here, to fabricate an epoxy coating (EP) possessing premier mechanical and thermal features, a nanocompositeof oxidized multiwall nano carbon tube/ ZIF-8 (O-MWCNT@ZIF-8) was prepared through a onestepfabrication approach of ZIF-8 on the O-MWCNT surface through two-different hydrothermal andco-precipitation methods, that are labeled as O-MWCNT-ZIF-8-H/EP and O-MWCNT-ZIF-8-CO/EP, respectively. After introducing the prepared nanocomposite into the epoxy resin, DMTA and tensile tests wereapplied on the prepared coatings to identify the interactions between the EP/Particles and investigate theresultant thermomechanical properties of the final composites. It was indicated that through the incorporationof 0.15 wt.% of the prepared nanoparticles into the EP matrix, a remarkable enhancement couldbe achieved on its thermomechanical properties. It is also worth noting that the storage modulus showeda rise of about 7.5% and 1.1% and tensile strength increased about 70% and 40%, while Tg reduced about12 C and 16 C in the case of O-MWCNT-ZIF-8-CO/EP and O-MWCNT-ZIF-8-H/EP samples, respectively,in comparison to the unmodified epoxy (Neat EP) sample. Moreover, the remaining weights of 75% and77% for O-MWCNT-ZIF-8 compared with 82% for O-MWCNT at 600 C evidenced the lower thermal stabilityof the ZIF-8 modified CNT.

Discoloration of teeth due to different intracanal medicaments

Farzaneh Afkhami,Sadaf Elahy,Alireza Mahmoudi Nahavandi,Mohamadjavad Kharazifard,Aidin Sooratgar 대한치과보존학회 2019 Restorative Dentistry & Endodontics Vol.44 No.1

Objectives: The objective of this study was to assess coronal discoloration induced by the following intracanal medicaments: calcium hydroxide (CH), a mixture of CH paste and chlorhexidine gel (CH/CHX), and triple antibiotic paste (3Mix). Materials and Methods: Seventy extracted single-canal teeth were selected. Access cavities were prepared and each canal was instrumented with a rotary ProTaper system. The specimens were randomly assigned to CH, CH/CHX, and 3Mix paste experimental groups ( n = 20 each) or a control group ( n = 10). Each experimental group was randomly divided into 2 subgroups (A and B). In subgroup A, medicaments were only applied to the root canals, while in subgroup B, the root canals were completely filled with medicaments and a cotton pellet dipped in medicament was also placed in the pulp chamber. Spectrophotometric readings were obtained from the mid-buccal surface of the tooth crowns immediately after placing the medicaments (T1) and at 1 week (T2), 1 month (T3), and 3 months (T4) after filling. The ∆E was then calculated. Data were analyzed using 2-way analysis of variance (ANOVA), 3-way ANOVA, and the Scheffé post hoc test. Results: The greatest color change (ΔE) was observed at 3 months ( p < 0.0001) and in 3Mix subgroup B ( p = 0.0057). No significant color change occurred in the CH ( p = 0.7865) or CH/ CHX ( p = 0.1367) groups over time, but the 3Mix group showed a significant ΔE ( p = 0.0164). Conclusion: Intracanal medicaments may induce tooth discoloration. Use of 3Mix must be short and it must be carefully applied only to the root canals; the access cavity should be thoroughly cleaned afterwards.

Sensory and Motor Behavior Evidences Supporting the Usefulness of Conditioned Medium from Dental Pulp-Derived Stem Cells in Spinal Cord Injury in Rats

Farzaneh Dehghani,Reza Asadi-Golshan,Vahid Razban,Esmaeil Mirzaei,Abdolkarim Rahmanian,Sahar Khajeh,Zohreh Mostafavi-Pour 대한척추외과학회 2018 Asian Spine Journal Vol.12 No.5

Study Design: Experimental animal study. Purpose: This study aimed to assess effects of conditioned medium (CM) of dental pulp-derived stem cells loaded in collagen hydrogel on functional recovery following spinal cord injury (SCI). Overview of Literature: SCI affects sensory and motor functions, and behavioral recovery is the most essential purpose of therapeutic intervention. Recent studies have reported that CM from dental pulp-derived stem cells has therapeutic benefits. In addition, collagen hydrogel acts as a drug delivery system in SCI experiments. Methods: Stem cells from human exfoliated deciduous teeth (SHEDs) were cultured, and SHED-CM was harvested and concentrated. Collagen hydrogel containing SHED-CM was prepared. The rats were divided into five groups receiving laminectomy, compressive SCI with or without intraspinal injection of biomaterials (SHED-CM), and collagen hydrogel with or without SHED-CM. Basso, Beattie, and Bresnahan (BBB) scoring, inclined plane, cold allodynia, and beam walk tests were performed for 6 weeks to assess locomotor, motor, sensory, and sensory-motor performances, respectively. Results: Scores of the rats receiving SHED-CM loaded in collagen hydrogel were significantly better than those of the other injured groups at 1-week post-injury for BBB, 2 weeks for inclined plane, 2 weeks for cold allodynia, and 4 weeks for beam walk tests (p <0.05). The differences remained significant throughout the study. Conclusions: Intraspinal administration of SHED-CM loaded in collagen hydrogel leads to improved functional recovery and proposes a cell-free therapeutic approach for SCI.

Electrochemical study for simultaneous detection of procaine hydrochloride and its metabolite in biological samples using a nanostructured strong sensor

Farzaneh Haghighian,Sayed Mehdi Ghoreishi,Abdolmohammad Attaran,Fahimeh Zeraatkar Kashani,Asma Khoobi 한국화학공학회 2023 Korean Journal of Chemical Engineering Vol.40 No.3

Procaine belongs to a type of medicine that excessive dosage creates cardiac arrest and also several allergenic reactions. Thus, continuous monitoring of the drug and its metabolite is necessary for sustainable health management during treatment. The innovative aspect of nanostructure materials has great importance in the advancement of research on modified sensors. In the present study, the electrocatalytic performance of multi-walled carbon nanotubes modified carbon paste electrode was investigated for the simultaneous analysis of procaine hydrochloride and p-aminobenzoic acid with high accuracy and sensitivity. The nanostructured sensor is characterized by microscopic and electrochemical techniques, such as scanning electron microscopy and electrochemical impedance spectroscopy using [Fe(CN)6]3−/4− as the redox probes. The modified sensor shows an improved voltammetric peak current than the unmodified carbon paste electrode. The electrochemical behavior of the modified sensor was studied by cyclic voltammetry and differential pulse voltammetry. The sensor kinetic parameters containing electron transfer rate constant (ks=0.47 s−1) and charge transfer coefficient (α=0.23) were calculated using cyclic voltammetry. The differential pulse voltammetry technique was also investigated in terms of linearity, lower limit of detection, lower limit of quantitation, accuracy and precision, which indicate acceptable results. Under optimized experimental conditions, the concentration linear range for procaine and PABA was obtained in the range of 2.4 to 100.0 µM. The limit of detection values (S/N=3) were calculated to be 62.0 and 49.0 nM for detection of procaine and p-aminobenzoic acid, respectively. Also, the effects of interfering materials, repeatability and stability of the modified sensor were studied. Finally, the proposed sensor was applied for simultaneous and sensitive detection of p-aminobenzoic acid and procaine in real media such as plasma and pharmaceutical products with satisfactory results.

Influence of Mannitol and Sucrose on the Olive in vitro Culture for Iranian Cultivars (Zard and Dezful)

Farzaneh Tabesh,Maryam Peivandi,Farah Farahani,Seyed Mehdi Hosseini Mazinani 한국원예학회 2006 한국원예학회 기타간행물 Vol.- No.-

Analysis of CYP17, CYP19 and CYP1A1 Gene Polymorphisms in Iranian Women with Breast Cancer

Farzaneh, Farah,Noghabaei, Giti,Barouti, Esmat,Pouresmaili, Farkhondeh,Jamshidi, Javad,Fazeli, Atena,Taghavi, Shaghayegh,Emamalizadeh, Babak,Darvish, Hossein Asian Pacific Journal of Cancer Prevention 2016 Asian Pacific journal of cancer prevention Vol.17 No.no.sup3

Breast cancer (BC) is the most common cancer and the second cause of mortality in women all around the world. It is caused by several factors including genetic determinants, so that both genetic susceptibility factors and environmental factors are involved in the etiology. Significance of genes functioning in steroid hormone synthesis and metabolism are well established in breast cancer susceptibility. In this study, 134 women with BC and 135 normal controls were analyzed for their genotypes for the polymorphisms, rs743572, rs10046 and rs4646903, resided in CYP17, CYP19 and CYP1A1 genes, respectively. Significant differences in distributions of allele and genotype frequencies were found for the rs10046 polymorphism in CYP19 (p-value=0.01, OR (CI 95%) =1.59 (1.1-2.3), p-value=0.04, OR (CI 95%) =1.7 (1.1-2.5) respectively). For rs743,572 and rs 4646903 polymorphisms, no significant associations were observed. A significant association was observed between the rs10046 polymorphism of the CYP19gene and breast cancer in Iranian patients. Due to inconsistent previous results, more studies in different populations with larger sample sizes are indicated.