Neuroprotective effects of green coffee bean extract against Alzheimer’s and Parkinson’s disease: a mini review

Renalison Farias-Pereira(Renalison Farias-Pereira ),Lynnea Young(Lynnea Young),Yeonhwa Park(Yeonhwa Park) 한국축산식품학회 2021 Food and Life Vol.2021 No.1

Green coffee bean extract (GCBE) is known as an anti-obesity dietary supplement, but its neuroprotective effects have been recently reported. Since GCBE and its main phenolic acids, chlorogenic acids (CGA), share similar physiological effects, this mini review summarizes the most current research of the neurobiological effects of GCBE and CGA. GCBE and/or CGA act on acetylcholine, glutamate, and insulin signaling pathways to reduce the risk of Alzheimer’s disease by reducing amyloid-β proteins (Aβ) and tau proteins in the brain of rodents. Clinical trials, although limited, further suggest that CGA improves cognition, which was associated with changes in blood Aβ levels. In addition, CGA modulates the dopamine metabolism to reduce neurotoxicity in animal models of Parkinson’s disease, although there is no direct association between GCBE and Parkinson’s disease in humans. The antioxidant and anti-inflammatory effects of GCBE and CGA are suggested to be the underlying mechanisms that help to protect from the development of these diseases. GCBE and CGA have potential benefits to prevent the development of neurodegenerative diseases, but there is still a great need to further investigate their effects on Alzheimer’s and Parkinson’s disease.

Molecular diversity of phytoplankton in the East China Sea around Jeju Island (Korea), unraveled by pyrosequencing

Faria, Daphne Georgina,Lee, Man-Duck,Lee, Joon-Baek,Lee, Juyun,Chang, Man,Youn, Seok Hyun,Suh, Young Sang,Ki, Jang-Seu Springer-Verlag 2014 Journal of oceanography Vol.70 No.1

Effect of eigenvalue solution on the characteristics of double diffusive salt fingers

Faria Rehman,Manoj Dhiman,O. P. Singh 대한기계학회 2016 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.30 No.6

Double diffusive finger convection is driven by the varying diffusivity of the two components, contributing to the density variation. When the faster diffusing component heat stabilizes the system, and slow diffusing component salinity destabilizes the system with the overall density stratification remaining stable, the convection takes the form of rising and sinking fingers, which are known as salt fingers. We considered previous theories on the salt fingers’ growth rate, and show how different approaches to solve the same Eigen value equation lead to a different prediction of finger characteristics. We precisely solved the Eigen value growth rate equations, and show that the assumptions taken in the previous theories lead to unphysical system behavior in the limit of density ratio approaching unity. We show that the finger system becomes transient in this limit, and steady state assumption is not a valid approximation. Furthermore, other theories have also been proposed, and wide fingers are generally believed to transport larger fluxes when compared with thin fingers. In this paper, we show through numerical simulation that the assumption of wide finger-large flux ratio is not physically consistent in light of recent findings.

A modified device for intraoral radiography to assess the distal osseous defects of mandibular second molar after impacted third molar surgery

Faria-Inocencio Ana,Gallas-Torreira Mercedes 대한구강악안면방사선학회 2011 Imaging Science in Dentistry Vol.41 No.3

Purpose This article is to describe a modified device for intraoral radiography which was developed to obtain reproducible radiographic images for assessment of distal osseous defects of the mandibular second molar (2 Mm) after impacted third molar (3 Mm) surgery. Materials and Methods A commercial available alignment system for posterior region was modified by adding a reference gauge pin (millimetric) and threading a hollow acrylic cylinder at the ring of the radiographic positioner to attach the X-ray collimator. The design included customized resin acrylic stent for the occlusal surface of the 2Mm in maximum intercuspal position, individualizing the biteblock positioner. Periapical radiographs were taken before and after surgical extraction of 3 Mm, employing the radiographic technique of parallelism described by Kugelberg (1986) with this modified film holder and inserting the gauge pin on the deepest bone probing depth point. Results This technique permitted to obtain standardized periapical radiographs with a moderate to high resolution, repeatability, and accuracy. There was no difference between the measurements on the pre- and post-operative radiographs. This technique allowed better maintenance of the same geometric position compared with conventional one. The insertion of the gauge pin provided the same reference point and localized the deepest osseous defect on the two-dimensional radiographs. Conclusion This technique allowed better reproducibility in posterior radiographic records (distal surface of 2 Mm) and more accurate measurements of radiographic bone level by the use of a millimetric pin.

Impact of Shift Work on the Eating Pattern, Physical Activity and Daytime Sleepiness Among Chilean Healthcare Workers

Farias, Rut,Sepulveda, Alejandro,Chamorro, Rodrigo Occupational Safety and Health Research Institute 2020 Safety and health at work Vol.11 No.3

We evaluated the eating pattern, physical activity, and daytime sleepiness level in Chilean shift workers. Fifty, middle-aged adult health workers from a public hospital in Santiago, Chile, were included: a group undergoing shift work (shift workers, including at least one "night shift" and one "long day", n = 33), and day workers under traditional schedule (from 8:00 to 17:00h, n = 17). Body composition, physical activity, and daytime sleepiness levels, and diet characteristics (diet composition, meals' timing, and diet quality) were assessed. Despite similar total energy intake, shift worker showed lower carbohydrate (% of energy) and higher protein intake (both P < 0.01), decreased diet quality, an irregular eating pattern, and delayed meal timing (all P < 0.05). Physical activity and daytime sleepiness levels did not differ between groups. Findings from this first Chilean study in healthcare shift workers support the fact that meal timing and diet quality appear as critical factors for upcoming intervention studies in this group.

Gas expulsion in highly substructured embedded star clusters

Farias, J P,Fellhauer, M,Smith, R,Domí,nguez, R,Dabringhausen, J Oxford University Press 2018 MONTHLY NOTICES- ROYAL ASTRONOMICAL SOCIETY Vol.476 No.4

Auxin Production and Detection of the Gene Coding for the Auxin Efflux Carrier (AEC) Protein in Paenibacillus polymyxa

Fabio Faria Da Mota,Eliane Aparecida Gomes,Lucy Seldin 한국미생물학회 2008 The journal of microbiology Vol.46 No.3

Different species of Paenibacillus are considered to be plant growth-promoting rhizobacteria (PGPR) due to their ability to repress soil borne pathogens, fix atmospheric nitrogen, induce plant resistance to diseases and/or produce plant growth-regulating substances such as auxins. Although it is known that indole-3-acetic acid (IAA) is the primary naturally occurring auxin excreted by Paenibacillus species, its transport mechanisms (auxin efflux carriers) have not yet been characterized. In this study, the auxin production of P. polymyxa and P. graminis, which are prevalent in the rhizospheres of maize and sorghum sown in Brazil, was evaluated. In addition, the gene encoding the Auxin Efflux Carrier (AEC) protein from P. polymyxa DSM36T was sequenced and used to determine if various strains of P. polymyxa and P. graminis possessed this gene. Each of the 68 P. polymyxa strains evaluated in this study was able to produce IAA, which was produced at concentrations varying from 1 to 17 μg/ml. However, auxin production was not detected in any of the 13 P. graminis strains tested in this study. Different primers were designed for the PCR amplification of the gene coding for the AEC in P. polymyxa, and the predicted protein of 319 aa was homologous to AEC from Bacillus amyloliquefaciens, B. licheniformis, and B. subtilis. However, no product was observed when these primers were used to amplify the genomic DNA of seven strains of P. graminis, which suggests that this gene is not present in this species. Moreover, none of the P. graminis genomes tested were homologous to the gene coding for AEC, whereas all of the P. polymyxa genomes evaluated were. This is the first study to demonstrate that the AEC protein is present in P. polymyxa genome.

Pomegranate Juice Effects on Cytochrome P450s Expression: In Vivo Studies

Ana Faria,Rosario Monteiro,Isabel Azevedo,Conceicao Calhau 한국식품영양과학회 2007 Journal of medicinal food Vol.10 No.4

Beneficial health effects have recently been claimed for pomegranate juice. In vitroand in vivo studies havedemonstrated its anti-atherosclerotic capacity, chemoprevention and chemotherapy of prostate cancer, and antiproliferative,apoptotic, and antioxidant activity, among others. On the other hand, there is a complex interplay between tumor initiation,promotion, and progression and xenobiotic biotranformation. This led us to investigate the effect of pomegranate juice con-sumption on cytochrome P450 (CYP) activity and expression. For this purpose, male mice consumed this fruit juice for 4over, the activity of CYP isoform 2E1 and expression of the main CYP isoforms, namely, CYP1A1/2, CYP2E1, and CYP3A,were also assessed. It was found that pomegranate juice consumption decreased total hepatic CYP content as well as the ex-pression of CYP1A2 and CYP3A. Prevention of procarcinogen activation through CYP activity/expression inhibition may beinvolved in pomegranate juice’s effect on tumor initiation, promotion, and progression.

Mechanisms of action of coffee bioactive components on lipid metabolism

Renalison Farias-Pereira,박천석,박연화 한국식품과학회 2019 Food Science and Biotechnology Vol.28 No.5

Coffee consumption is associated with reduced risk of metabolic syndrome, obesity and diabetes, which may be related to the effects of coffee and its bioactive components on lipid metabolism. Coffee contains caffeine, a known neuromodulator that acts as an adenosine receptor antagonist, as well as other components, such as chlorogenic acids, trigonelline, cafestol and kahweol. Thus, this review discusses the up-to-date knowledge of mechanisms of action of coffee and its bioactive compounds on lipid metabolism. Although there is evidence that coffee and/or its bioactive compounds regulate transcription factors (e.g. peroxisome proliferator-activated receptors and sterol regulatory element binding proteins) and enzymes (e.g. AMP-activated protein kinase) involved in lipogenesis, lipid uptake, transport, fatty acid β-oxidation and/or lipolysis, needs for the understanding of coffee and its effects on lipid metabolism in humans remain to be answered.

The Ketone Bridge Between the Heart and the Bladder: How Fast Should We Go?

Gabriel Faria-Costa,João Oliveira,Inês Vilas-Boas,Inês Campelo,Elisa Azeredo Silva,Carmen Brás-Silva,Susana Maria Silva,Tiago Antunes-Lopes,Ana Charrua 대한배뇨장애요실금학회 2024 International Neurourology Journal Vol.28 No.-

Metabolic syndrome (MS) is associated with both cardiovascular and bladder dysfunction. Insulin resistance (IR) and central obesity, in particular, are the main risk factors. In these patients, vicious pathological cycles exacerbate abnormal carbohydrate metabolism and sustain an inflammatory state, with serious implications for both the heart and bladder. Ketone bodies serve as an alternative energy source in this context. They are considered a “super-fuel” because they generate adenosine triphosphate with less oxygen consumption per molecule, thus enhancing metabolic efficiency. Ketone bodies have a positive impact on all components of MS. They aid in weight loss and glycemic control, lower blood pressure, improve lipid profiles, and enhance endothelial function. Additionally, they possess direct anti-inflammatory, antioxidant, and vasodilatory properties. A shared key player in dysfunction of both the heart and bladder dysfunction is the formation of the NLRP3 inflammasome, which ketone bodies inhibit. Interventions that elevate ketone body levels—such as fasting, a ketogenic diet, ketone supplements, and sodium-glucose cotransporter 2 inhibitors—have been shown to directly affect cardiovascular outcomes and improve lower urinary tract symptoms derived from MS. This review explores the pathophysiological basis of the benefits of ketone bodies in cardiac and bladder dysfunction.