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Yi-Xin Zou,Jia Qiao,Hua-Yuan Zhu,Rui-Nan Lu,Yi Xia,Lei Cao,Wei Wu,Hui Jin,Wen-Jie Liu,Jin-Hua Liang,Jia-Zhu Wu,Li Wang,Lei Fan,Wei Xu,Jian-Yong Li 대한암학회 2019 Cancer Research and Treatment Vol.51 No.2
Purpose Chronic lymphocytic leukemia (CLL) is one of the most frequent type of B-cell chronic lymphoproliferative disorders and chronic inflammation takes part in the development of CLL. However, there has been no valid immune biomarker to predict the prognosis of untreated CLL patients. Materials and Methods In this retrospective study, we analyzed the clinical correlations and prognostic value of albumin-to-fibrinogen ratio (AFR) detected at diagnosis in 191 CLL patients. Results The cut-off value of AFR was 9.7 calculated by X-tile. Patients who were more than 65 years old were often accompanied by low level of AFR (p < 0.001). Survival analysis showed that patients with low level of AFR had shorter overall survival (OS) than patients with high level of AFR (p < 0.001). Multivariate analysis illustrated that AFR had a negative impact on OS (p=0.003) and was independent of parameters involved in CLL international prognostic index and other prognostic markers such as CD38 and ZAP-70. Conclusion These data provide a comprehensive view of AFR and shows that AFR at diagnosis is an adverse prognostic factor in untreated CLL patients.
Yi Hang Fan,Wen Yuan Wang,Zhao Peng Hao,Hengyi Yuan 한국정밀공학회 2021 International Journal of Precision Engineering and Vol.22 No.4
CBN (Cubic Boron Nitride) tool is suitable for precision machining of nickel-based alloy due to its high hardness and chemical inert. Nickel-based alloys are difficult-to-cut material. When high-speed cutting nickel-based alloys with CBN tool, the temperature at tool-workpiece interface is very high. The atoms in workpiece material diff use into the tool surface and change the performance of cutting tool, resulting in diffusion wear. Inconel 718, which is one kind of widely used nickel-based alloy, is mainly composed of nickel (Ni), iron (Fe) and chromium (Cr). In this paper, the cutting model which describes the single crystal CBN tool cutting Ni–Fe–Cr three-component alloy, and the compression and impact model of CBN tool crystal are established by using molecular dynamics (MD) method to study the diffusion of Ni, Fe and Cr atoms into CBN tool and the effects of diffusion on the properties of CBN crystal tool. The results show that the diffusion of Ni, Fe and Cr atoms into CBN tool decreases the compressive strength and impact toughness of CBN crystals and the effects degree of atom diffusion on the properties of CBN crystals are different.
Yi-Fan Peng,Hai-Feng Li,Zhen-Rong Zheng,Xin-Xing Xia,Zhi Yao,Xu Liu 한국정보디스플레이학회 2012 Journal of information display Vol.13 No.2
The crosstalk evaluation of multiview autostereoscopic three-dimensional (3D) displays is discussed, with both the human and technical factors investigated via image quality assessment. In the imaging performance measurements and analysis for a multiview autostereoscopic display prototype equipment, it was inferred that crosstalk would have both a positive and a negative effect on the imaging performance of the equipment. The importance of the attached diaphragm in the crosstalk evaluation was proposed and then experimentally verified, using the developed prototype equipment. The luminance distribution and crosstalk situation were given, with two different diaphragm arrays applied. The analysis results showed that the imaging performance of this 3D display system can be improved with minimum changes to the system structure.
Survival Analysis of Oral Squamous Cell Carcinoma in a Subgroup of Young Patients
Fan, Yi,Zheng, Lei,Mao, Ming-Hui,Huang, Ming-Wei,Liu, Shu-Ming,Zhang, Jie,Li, Sheng-Lin,Zheng, Lei,Zhang, Jian-Guo Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.20
Oral squamous cell carcinoma (OSCC) is predominantly a disease of middle-aged men with long-term exposure to tobacco and alcohol. An increasing trend has been reported at a younger age worldwide. Clinical records of 100 patients under the age of 45 years treated specifically for oral cavity SCC in our hospital during a 10-year period were retrospectively analyzed to calculate the survival rates. An obvious male predominance coincided with smoking trend among Chinese young individuals and female patients were more likely to have no traditional risk factors such as smoking or drinking. The 5-year overall survival rate and disease-free survival rate were 61.0% and 75.5%, respectively, consistent with other published series over the decade showing a relatively better survival among the young. No significant differences clearly correlated with outcome when comparing non-smokers non-drinkers to ever-smokers and ever drinkers (P>0.05). Overall survival rate and disease free survival rate was found to be significantly higher in patients with early-stage disease than with advanced stage disease (P=0.001, P=0.009 respectively). The strong influence of clinical stage on prognosis emphasizes the importance of early diagnosis and treatment of oral malignancies for this unique clinical subgroup.
( Yi-fan Hong ),( Yoon-doo Lee ),( Jae-yeon Park ),( Seongjae Kim ),( Youn-woo Lee ),( Boram Jeon ),( Deepa Jagdish ),( Hangeun Kim ),( Dae Kyun Chung ) 한국미생물 · 생명공학회 2016 Journal of microbiology and biotechnology Vol.26 No.6
Lactic acid bacteria (LAB) have beneficial effects on intestinal health and skin diseases. Lipoteichoic acid (LTA), a cell wall component of gram-positive bacteria, is known to induce the production of several cytokines such as TNF-α, IL-1β, and IL-8 and affect the intestinal microflora, anti-aging, sepsis, and cholesterol level. In this study, Weissella cibaria was isolated from Indian dairy products, and we examined its immune-enhancing effects. Live and heatkilled W. cibaria did not induce the secretion of immune-related cytokines, whereas LTA isolated from W. cibaria (cLTA) significantly increased the secretion of TNF-α, IL-1β, and IL-6 in a dose-dependent manner. cLTA increased the phosphorylation of nuclear factor kappalight-chain-enhancer of activated B cells, p38 mitogen-activated protein kinases, and c-Jun Nterminal kinases in THP-1 cells. The secretion of TNF-α and IL-6 was also increased in the cLTA-treated mouse splenocytes. These results suggest that cLTA, but not W. cibaria whole cells, has immune-boosting potential and can be used to treat immunosuppression diseases.
Fan-Yi Meng,Qun Wu,Erni, D.,Ke Wu,Jong-Chul Lee IEEE 2012 IEEE transactions on microwave theory and techniqu Vol.60 No.10
<P>A polarization-independent metamaterial analog of electromagnetically induced transparency (EIT) at microwave frequencies for normal incidence and linearly polarized waves is experimentally and numerically demonstrated. The metamaterial consists of coupled “bright” split-ring resonators (SRRs) and “dark” spiral resonators (SRs) with virtually equal resonance frequencies. Normally incident plane waves with linear polarization strongly couple to the SRR, but are weakly interacting with the SR, regardless of the polarization state. A sharp transmission peak (i.e., the transparency window) with narrow spectral width and slow wave property is observed for the metamaterial at the resonant frequency of both, the bright SRR and the dark SR. The influence of the coupling strength between the SRR and SR on the frequency, width, magnitude, and quality factor of the metamaterial's transparency window is theoretically predicted by a two-particle model, and numerically validated using full-wave electromagnetic simulation. In addition, it is numerically demonstrated that the EIT-like metamaterial can be employed as a refractive-index-based sensor with a sensitivity of 77.25 mm/RIU, which means that the resonance wavelength of the sensor shifts 77.25 mm per unit change of refractive index of the surrounding medium.</P>
( Yi Fan Hong ),( Hangeun Kim ),( Hye Rim Kim ),( Min Geun Gim ),( Dae Kyun Chung ) 한국미생물 · 생명공학회 2014 Journal of microbiology and biotechnology Vol.24 No.12
It is known that lactic acid bacteria (LAB) have many beneficial health effects, including antioxidative activity and immune regulation. In this study, the immune regulatory effects of Lactobacillus sakei and Lactobacillus plantarum, which are found in different types of kimchi, were evaluated. L. sakei and its lipoteichoic acid (LTA) have greater immune stimulating potential in IL-12, IFN-γ, and TNF-α production as compared with L. plantarum in an in vitro condition. On the other hand, L. plantarum is assumed to repress the Th1 immune response in murine experiments. After being injected with LPS, L. plantarum-fed mice maintained a healthier state, and the level of TNF-α in their blood was lower than in other bacterial strainfed mice and in the LPS-only control mice. Additionally, IL-12 production was significantly decreased and the production of IL-4 was greatly increased in the splenocytes from L. plantarum-fed mice. Further experiments revealed that the pre-injection of purified LTA from L. plantarum (pLTA), L. sakei (sLTA), and S. aureus (aLTA) decreased TNF-α and IL-4 production in LPS-injected mice. Mouse IL-12, however, was significantly increased by aLTA pre-injection. In conclusion, the L. sakei and L. plantarum strains have immune regulation effects, but the effects differ in cytokine production and the regulatory effects of the Th1/Th2 immune response.
Decomposition Properties of Trifluoroiodomethane under Discharges and Interruptions
Fan-Yi Cai,Dong-Xian Tan,Bai-Jie Zhou,Jian Xue,Deng-Ming Xiao 대한전기학회 2018 Journal of Electrical Engineering & Technology Vol.13 No.6
This paper is devoted to detecting decomposition characteristics of Iodotrifluoromethane (CF3I) under alternating current (AC) discharges or load current interruptions. The decomposition products are measured utilizing chromatography-mass spectroscopy. It is found that less than 1% CF3I gas decomposed after several interruptions at load current of 200 A or hundred times of AC discharges. However, under interruptions at a current of 400 A, more than 95% CF3I gas decomposed into carbon tetrafluoride (CF4) and hexafluoroethane (C2F6). The equilibrium compositions based on Gibbs free energy minimization of CF3I was calculated to explain the decomposition mechanism.