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Fan Jiayao,Xu Huiqing,Liu Bing,Jing Fangyuan,He Qingfang,Zheng Shasha,Shi Haining,Jiao Lefei,Fan Chunhong 한국유전학회 2022 Genes & Genomics Vol.44 No.7
Background: TP73-AS1 is a novel antisense long noncoding RNA and plays an important role in cell proliferation and cancer development. However, the link between TP73-AS1 and colorectal cancer (CRC) has not yet been reported. Objective: To explore the association of genetic variants in TP73-AS1 and its expression with CRC susceptibility and prognosis. Methods: A case-control study (including 507 CRC cases and 503 controls) and bioinformatics analysis were conducted. Results: rs9800 polymorphism was significantly related to higher risk in CRC [adjusted odds ratio (AOR) = 1.33, 95% confidence interval (CI) = 1.02-1.75, P = 0.034 in heterozygote codominant model]. There was no difference between TP73-AS1 polymorphisms and different tumor node metastasis (TNM) stages in the adjusted model. Moreover, TP73-AS1 expression level was positively related to different TNM stages. After adjusted for age, gender and TNM, higher TP73-AS1 expression levels were related to shorter recurrence-free survival time [hazard ratio (HR) = 1.66, 95% CI = 1.02-2.71, P = 0.043]. Conclusion: TP73-AS1 polymorphisms and expression may be associated with susceptibility and prognosis of CRC.
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A review of the current in-situ fouling control strategies in MBR: Biological versus physicochemical
Qiang Liu,Jiayao Ren,Yongsheng Lu,Xiaolei Zhang,Felicity A. Roddick,Linhua Fan,Yufei Wang,Huarong Yu,Ping Yao 한국공업화학회 2021 Journal of Industrial and Engineering Chemistry Vol.98 No.-
Fouling in membrane bioreactors (MBR) is a bottleneck problem limiting their application. In-situfouling control strategies have been continuously developed for decades, and can be mainlycategorized as biological and physicochemical approaches. However, the mechanisms and performanceof these methods as well as their application prospects have not been thoroughly discussed andcompared in a systematic manner. This study was aimed at providing a detailed review on the variousin-situ biological and physicochemical methods in terms of fouling control performance, foulingreduction mechanisms and practicability. This involves a comparison of the popular biological controlstrategies including quorum quenching (QQ)) and physicochemical approaches such as NaClObackflushing, hybrid electrochemical MBR and anti-biofouling membrane development, with theanalysis of their potential, existing issues and practicality in full-scale applications. Future work is alsorecommended for developing more sustainable and more widely applicable MBR fouling controlstrategies.
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