G0/G1 Switch 2 Induces Cell Survival and Metastasis through Integrin-Mediated Signal Transduction in Human Invasive Breast Cancer Cells

( Eunah Cho ),( Yeo-jung Kwon ),( Dong-jin Ye ),( Hyoung-seok Baek ),( Tae-uk Kwon ),( Hyung-kyoon Choi ),( Young-jin Chun ) 한국응용약물학회 2019 Biomolecules & Therapeutics(구 응용약물학회지) Vol.27 No.6

Human breast cancer cell line, MDA-MB-231, is highly invasive and aggressive, compared to less invasive cell line, MCF-7. To explore the genes that might influence the malignancy of MDA-MB-231, DNA microarray analysis was performed. The results showed that G0/G1 switch 2 (G0S2) was one of the most highly expressed genes among the genes upregulated in MDA-MB-231. Although G0S2 acts as a direct inhibitor of adipose triglyceride lipase, action of G0S2 in cancer progression is not yet understood. To investigate whether G0S2 affects invasiveness of MDA-MB-231 cells, G0S2 expression was inhibited using siRNA, which led to decreased cell proliferation, migration, and invasion of MDA-MB-231 cells. Consequently, G0S2 inhibition inactivated integrinregulated FAK-Src signaling, which promoted Hippo signaling and inactivated ERK1/2 signaling. In addition, G0S2 downregulation decreased β-catenin expression, while E-cadherin expression was increased. It was demonstrated for the first time that G0S2 mediates the Hippo pathway and induces epithelial to mesenchymal transition (EMT). Taken together, our results suggest that G0S2 is a major factor contributing to cell survival and metastasis of MDA-MB-231 cells.

Broad-Band Photocurrent Enhancement in MoS₂ Layers Directly Grown on Light-Trapping Si Nanocone Arrays

Cho, Yunae,Cho, Byungjin,Kim, Yonghun,Lee, Jihye,Kim, Eunah,Nguyen, Trang Thi Thu,Lee, Ju Hyun,Yoon, Seokhyun,Kim, Dong-Ho,Choi, Jun-hyuk,Kim, Dong-Wook American Chemical Society 2017 ACS APPLIED MATERIALS & INTERFACES Vol.9 No.7

<P>There has been growing research interest in realizing optoelectronic devices based on the two-dimensional atomically thin semiconductor MoS2 owing to its distinct physical properties that set it apart from conventional semiconductors. However, there is little optical absorption in these extremely thin MoS2 layers, which presents an obstacle toward applying them for use in high efficiency light-absorbing devices. We synthesized trilayers of MoS2 directly on SiO2/Si nanocone (NC) arrays using chemical vapor deposition and investigated their photodetection characteristics. The photoresponsivity of the MoS2/NC structure was much higher than that of the flat counterpart across the whole visible wavelength range (for example, it was almost an order of magnitude higher at lambda = 532 nm). Strongly concentrated light near the surface that originated from a Fabry-Perot interference in the SiO2 thin layers and a Mie-like resonance caused by the Si NCs boosted the optical absorption in MoS2. Our work demonstrates that MoS2/NC structures could provide a useful means to realize high-performance optoelectronic devices.</P>

In vitro Biological Activities of Astaxanthin, H aematococcus pluvialis extract and Inclusion Complex of Astaxanthin and Cyclodextrin

Eunah Cho,Soyoung Kim,Jimin Yoo,Hee Jeong Chae 한국생물공학회 2008 한국생물공학회 학술대회 Vol.2008 No.10

Case Study on Small Group Art Therapy for Social Skill Improvement of Children with Developmental Disability

CHO Eunah,KIM Yongseob 아시아장애사회학회 2014 아시아장애사회학연구 Vol.13 No.-

This study seeks to find out what kind of effects small- group art therapy has on the social skill development of children with developmental disability This research is to verify the small group art therapy program for social skill improvement of children with development disorders and studied one male and female child each from May to December 2011 for 28 rounds of sessions. Test tools were Gresham & Elliott’s Social Skills Rating System (SSRS) (1987) and compared change results before and after the therapy program. The findings are as follows: First, small group art therapy activities were found to have positive effects on the cooperation skill improvement of children with developmental disability Second, small group art therapy activities were found to have positive effects on the self-assertion skill improvement of children with developmental disability. Third, small group art therapy activities were found to have positive effects on the self-control skill improvement of children with developmental disability.

Solubility and Storage Stability of Astaxanthin

Eunah Cho,Soyoung Kim,Jimin Yoo,Hee Jeong Chae 한국생물공학회 2008 한국생물공학회 학술대회 Vol.2008 No.4

Extraction Process of Astaxanthin from Haematococcus pluvialis using β-glucanase

Eunah CHO,Soyoung KIM,Jimin YOO,Man-Jin IN,Dong Chung KIM,Hee Jeong CHAE 한국생물공학회 2009 한국생물공학회 학술대회 Vol.2009 No.10

중국 일대일로(一帶一路) 정책의 집단주의 문화와 한국 공공외교의 방향성

조은아(Eunah Cho) 아시아문화콘텐츠연구소 2022 문화·경영·기술 Vol.2 No.2

‘일대일로(一帶一路)’는 시진핑 정권이 내세우는 중화민족의 위대한 부흥 이라는 ‘중국몽(中國夢)’의 구체적이며 장기적인 실현 방안이다. 중국은 일대일로를 통해 참여국들과 함께 세계평화와 발전에 이바지하며 각국의 협력과 상생을통해 공동번영의 길로 그리고 운명공동체로 나아갈 것임을 주장한다. 여기서 중국몽은 중국의 인민들에게 희망을 제시하고 그를 중심으로 단결을 이루기 위한 정책으로 집단주의적 성향이 매우 강하다. 또한, 중국몽을 실현시키기 위한 방안인 일대일로의 정책은 주변국과의 긴밀한 협력을 전제하는 것으로 이 역시 강력한 집단주의 문화를 바탕에 두고 있다. 그렇다면 우리는 이러한 중국의 일대일로 정책에 어떻게 대응해야 하는 것일까? 본 논문은 이에 대한 해답으로 공공외교를 제시하며, 공공외교의 방향은 중국과의 지속적인 문화교류를 통한 그들의 체면문화 활용과 일대일로가 직면한 문제 중 하나인 환경문제와 인권문제에 대한 적극적 공공외교 수행으로 정리하였다. ‘One Belt, One Road’ is a concrete and long-term realization plan of the ‘China Dream’ which is great revival of the Chinese nation promoted by the Xi Jinping administration. China asserts that the plan will contribute to world peace and development together with participating countries, and advance toward a common prosperity and a community of destiny through cooperation and coexistence of e ach country. T he C hinese d ream i s a policy t o b ring h ope to t he C hinese p eople and to achieve unity around it, having a very strong collectivism. In addition, the One Belt, One Road policy, which is a plan to realize the Chinese dream, presupposes close cooperation with neighboring countries, and this is also based on a strong collectivist culture. So, how should we respond to China's One Belt, One Road policy? This paper presents public diplomacy as the answer to this. And the direction of public diplomacy is summarized as using their face culture through continuous cultural exchange with China and actively conducting public diplomacy on environmental and human rights issues, which are one of the problems faced by the One Belt and One Road Initiative.

시적 조우 -장률의 <경계>에 나타난 몽골 노마드와 탈북 난민의 언어, 모빌리티, 젠더-

조은아 ( Cho Eunah ) 국제한국문학문화학회 2023 사이 Vol.34 No.-

2007년 발표 된 장률 감독의 독립 영화 <경계>는 탈북인과 몽골인 노마드의 만남에 대한 이야기이다. 이 글은 데리다의 ‘환대’에 대한 사유와 들뢰즈와 가타리의 ‘노마디즘’ 이론을 토대로 장률의 <경계>를 독해한다. 탈북 모자(순희와 창호)가 이방인으로서 주인인 노마드(항가이)에게 가져온 질문에 대해 살펴보고 이후 탈북인에 대한 문제에 대해 고찰한다. 서로의 말을 알아듣지 못하는 탈북자와 노마드의 동거는 역설적으로 이들의 모국어 문제에 대해 사유할 수 있게 한다. 본디 이방인은 주인이 말하는 법과 계약에 낯설고 그럼에도 불구하고 이를 번역해서 서투르게 환대를 청해야 할 것이 요구된다. 하지만 <경계>에서 항가이는 탈북자의 이름이나 성을 묻지 않고 자신의 언어로의 번역 역시 강요하지 않는다. 위계가 설정될 수 없는 상황에서 주인과 객은 서로의 자리를 바꾸고, 주인은 이방인의 언어를 배우며 그들의 언어로 넘어간다. 폴리스의 벽을 공격하는 전위적인 주체로서 낭만화되던 노마드에 대한 서구중심적 이해와 달리, 항가이는 사막에 묘목을 심으며 식물과 본인의 정착 가능성에 매달린다. 사막에서 늘 이방인인 존재로서 유목인은 공간을 점유하고자 하는 자들이며, 사막에서 죽고 사막에 매장되고자 한다. 난민과 노마드는 “이동하는 죽음”으로 그들의 발걸음은 죽음과 그의 짝인 모국어를 끌고 다닌다. 남성중심주의적 모델을 따르는 환대의 법에 의거하여 <경계>에서 순희의 자리는 무의식-꿈에 제한된다. 이 글은 영화에서 문제적인 순희에 대한 젊은 군인의 강간을 여성혐오적인 환대의 조건으로 독해하며 어째서 환대의 불가능성은 젠더적 폭력에 대한 상상으로 입증되어왔는지 문제 제기한다. Zhang Lu’s independent film, Desert Dream (2007), explores the relationship between Mongolian nomads and North Korean refugees in the Gobi Desert. Drawing on Jacques Derrida’s thoughts on hospitality and Gilles Deleuze and Felix Guattari’s nomadology, this paper examines the interactions and relationships between these two groups. Firstly, it outlines the questions raised by the presence of strangers, the North Korean refugees, and secondly, it delves into the gender aspects of their interactions. The language barrier between the nomads and refugees, which makes mutual understanding impossible, paradoxically leads us to contemplate the issue of mother language. In our common understanding, strangers who are unfamiliar with the host’s language and laws are expected to translate their own language to that of host in order to request hospitality. However, in Desert Dream, Hangai, a nomad, never asked the refugees to identify themselves nor did he force them to translate their language into his own. By relinquishing the establishment of hierarchy, both the host and guest exchange their status, and the host even crosses the threshold by learning the guest’s language. Hangai seeks a fixed life by planting trees in the desert, which is different from the romanticized Western perception of nomads as individuals who can defy the walls of the polis or the nation-state. The nomads, who are always strangers in the desert, aim to occupy a space and die there, buried under the desert. As a transhumant death, both the nomads and refugees carry death and mother tongue with them. With the male-centric model of hospitality, which should be criticized, the position of Soon-hui in Desert Dream can be understood as being limited to unconsciousness or dreams. This paper argues that the young soldier’s rape of Soon-hui exemplifies the concept of conditional hospitality in the film, prompting the question of why the impossibility of hospitality is portrayed through gendered violence.

Mie resonance-mediated antireflection effects of Si nanocone arrays fabricated on 8-in. wafers using a nanoimprint technique

Kim, Eunah,Cho, Yunae,Park, Kwang-Tae,Choi, Jun-Hyuk,Lim, Seung-Hyuk,Cho, Yong-Hoon,Nam, Yoon-Ho,Lee, Jung-Ho,Kim, Dong-Wook Springer US 2015 NANOSCALE RESEARCH LETTERS Vol.10 No.1

<P>We fabricated 8-in. Si nanocone (NC) arrays using a nanoimprint technique and investigated their optical characteristics. The NC arrays exhibited remarkable antireflection effects; the optical reflectance was less than 10% in the visible wavelength range. The photoluminescence intensity of the NC arrays was an order of magnitude larger than that of a planar wafer. Optical simulations and analyses suggested that the Mie resonance reduced effective refractive index, and multiple scattering in the NCs enabled the drastic decrease in reflection.</P><P><B>PACS:</B> 88.40.H-; 88.40.jp; 81.07.Gf</P>

중년기 성인의 노화불안이 심리적 안녕감에 미치는 영향 : 인지적 유연성과 자기자비의 순차매개효과

조은아 ( Cho Eunah ),유성진 ( Yoo Seongjin ) 한국정치사회연구소 2023 한국과 국제사회 Vol.7 No.6

이 연구의 목적은 중년기 성인의 노화불안이 인지적 유연성과 자기자비의 수준을 감소시키는 순차매개효과를 통해서 심리적 안녕감에 부정적 영향을 미친다는 가설을 경험적으로 검증하는 것이었다. 이를 위해, 40~64세 연령의 중년기 성인 남녀 371명의 자기보고 자료를 수집하여 통계적으로 분석하였다. 분석 결과, 중년기 성인의 노화불안은 인지적 유연성, 자기자비, 심리적 안녕감과 모두 통계적으로 유의미한 부적 상관관계를 나타냈다. 또한 중년기 성인의 노화불안이 심리적 안녕감에 미치는 부정적 영향을 인지적 유연성과 자기자비가 순차적으로 매개하는 것으로 밝혀져서, 이 연구의 가설이 검증되었다. 이것은 노화불안을 경험하고 있는 중년기 성인의 심리적 안녕감을 향상시키는 데 인지적 유연성을 회복하고 자기자비를 함양하는 개입전략이 유익할 수 있음을 시사하는 결과였다. 마지막으로 이러한 결과의 임상적 함의 및 연구의 한계를 논의하였다. The aim of this study was to investigate the serial mediating effects of cognitive flexibility and self-compassion on the relationship between aging anxiety and psychological well-being of middle age adults. Self-report data collected from 371 male and female adults were analyzed. The results showed that cognitive flexibility and self-compassion serially mediated the relationship between aging anxiety and psychological well-being. Based on the findings, authors discussed clinical implications and methodological limitations of this study in the context of psychological intervention.