한국인 알코올 의존 환자에서 알코올 대사 효소 유전자형 빈도의 남녀 차이

김성곤,김철민,이덕기,황인복,이현숙,김성연,전은숙,송영상,박제민,최병무,김명정 大韓神經精神醫學會 2005 신경정신의학 Vol.44 No.2

Objectives : There are a number of preceding epidemiological studies reporting gender differences in the genetic etiology of alcohol dependence. The author investigated gender difference in the frequencies of ADH2 and ALDH2 genoypes between the patients with alcohol dependence and normal control. Methods : The subjects were 141 alcohol dependent patients (104 males, 37 females) and 138 normal control (79 males, 59 females). The frequencies of 1/1 and 1/2+2/2 (2+ afterward) genotypes for ADH2 and ALDH2 were investigated in male and female between alcohol dependence and normal control group. DNA was extracted from WBC in peripheral venous blood and PCR-RFLP method was used out for genotyping. Results : First, the frequency of ADH2 1/1 genotype was significantly higher in alcohol dependent patients than normal control in both genders. Second, while there was no gender difference in the frequency of ADH2 1/1 genotype in normal controls, in the patient group however, the frequency was significantly higher in females than males. Third, in male subjects with alcohol dependence, the frequency of ALDH2 1/1 genotype was significantly higher than in male normal control subjects. On the other hand, in female subjects with alcohol dependence, the frequency of ALDH2 2+ genotype was significantly higher than in female normal control subjects. Conclusion : These results suggest that while the risk of alcohol dependence is predominantly affected by ALDH2 1/1 geno-type in male, the female ADH2 1/1 genotype is mainly associated with the risk of alcohol dependence. This means that there are gender differences in the genetic etiology of alcohol dependence.

方向분산성이 고려된 海浜流 流動特性에 관한 연구

최은주,유수진,권정곤 부산대학교 환경문제연구소 1994 環境硏究報 Vol.12 No.-

This study was managed to develope the existing numerical calculation model of near shore current and wave fields where wave and current coexist around shallow water region, and analyse their problems. Until now, nearshore current model that include longshore current and on-off shore current had shown wave characteristic based on regular wave theory. In this study, however, nearshore current characteristic was changed by directional dispersion. So the effect of directional dispersion of multidirectional irregular wave was examined numerically by the basic study of nearshore current calculation due to multidirectional wave that was driving force of pollutant material at shallow water region.

한국 지방정치의 실증연구에 관한 비판적 고찰

이달곤,강은숙 서울대학교 행정대학원 2001 行政論叢 Vol.39 No.2

이 글은 한국의 지방정부에 관한 실증적인 연구의 일부인 지방정치에 관한 연구를 주제별로 정리한 것이다. 지방자치제의 부활로 한국의 지방정치에 대한 관심이 급속하게 증대되고 있으며 적지 않은 논문들이 현실의 변화를 추적하고 있다. 여기서는 주민들의 의식의 변화와 참여행태, 지방의 정치권력의 구조와 운영, 지방의회와 단체장의 역할과 활동, 그리고 지방정부의 이념에 관한 논문으로 구별하여 한국의 지방정치의 변화모습을 주요한 실증연구로서 파악하고자 하였다. 이러한 연구를 통해서 볼 때, 그리 빠른 속도로 그리고 규범적인 성격을 내재화하면서 움직이는 것은 아니지만 한국의 지방정치가 나름대로 중앙정치와는 독자적인 방향으로 진보하는 과정(evolution process)에 있음을 파악할 수 있다.

백내장 수술환자의 진료결과에 미치는 요인 : 사전 연구를 중심으로 Pilot study

박은철,홍영재,임승정,강형곤,최윤정,김한중,조우현,손명세 한국의료QA학회 1998 한국의료질향상학회지 Vol.5 No.1

Backgroud : This study is to identify preoperative patient characteristics associated with a lack of improvement on one or more measures perioperatively, postoperative 3-4 months, and postoperative 12 months. Methods : For the assessment, prospective study was performed with 92 patients who had undergone either one eye or both eye cataract surgery by 3 ophthalmologists practicing at a university hospital. The criteria of improvement were (1) Snellen visual acuity, (2) a cataract-related symptom score(possible range: 0. 0 of 6 symptoms present or bothersome, to 18. all 6 symptoms very bothersome), and (3) VF-14 score - a measure of functional impairment in patient with cataract - (possible range: 0, inability to perform any of the applicable activities, to 100, no difficulty in performing any of the applicable activities). Results : Although 14 patients (15.2%) failed to improve on one or more of the outcome measures assessed, no one failed to improve on all three measures. Both eyes of surgery than one eye, preoperative cataract symptom score of 1-4, 5 or higher than 0 were associated independently with the increased likelihood of improvement (odds ratio 8.95, 7.16, 8.87 respectively). And the preoperative level of Snellen visual acuity was not associated with the likelihood of improvement Conclusion : We conclude that specific preoperative characteristics (both eyes, cataract symptom score) are independent predictors of patient outcome after cataract surgery,

수영만 해역의 오염물질 거동에 대한 小考

이은주,한동진,권정곤 부산대학교 환경문제연구소 1994 環境硏究報 Vol.12 No.-

This study aims to make it clear the mechanism on the behavior of pollutant in Suyeong Bay using the Alternating Direction Implicit method which was used for forecasting coastal water quality with good capability in stability and calculative velocity. And the flow fields for diffusion calculation were consisted of tidal current, tidal residual flow and constant flow(tidal residual flow+wind-induced flow) which are depth-averaged in total time, respectively.

금속표면의 식삭이 도재소부용 니켈-크롬 합금과 도재의 결합강도에 미치는 영향

이은희,정현곤 慶北大學校 齒科大學 1990 慶北齒大論文集 Vol.7 No.1

A study of the shear bond strength between dental alloy and porcelain according to the order of etching and degassing was established. Group Ⅰ, as a control group, was degassed only, group Ⅱ was etched and degassed, and group Ⅲ was degassed and etched. The specimens were installed in an Instron universal testing machine and the shear bonding strength was measured. After the specimens were fractured, the fractured surfaces were surveyed with SEM. The obtained results were as follows: 1. The shear bonding strength of the etched and degassed group(group Ⅱ)was the strongest of all, and the shear bonding strengths of group Ⅰ and group Ⅲ were not statistically significantly different(p>0.05). 2. The scanning electron microscopic views of the fractured surfaces showed no dendritic structures in group Ⅰ, many adhering porcelain chips on the roughened surface in group Ⅱ, and partially exposed dendritic structures in group Ⅲ. J. Kyungpook Univ. Sch. Dent. Vol. 7, No. 1,157∼167,1990

백악질 변연을 갖는 2급 와동에 충전된 4종 복합레진의 미세누출

조영곤,한세희,김은성 대한치과보존학회 2001 Restorative Dentistry & Endodontics Vol.26 No.6

The purpose of this study was to evaluate four different composite resins in vitro for microleakage in Class II box-type restorations that have gingival margins apical to the cementoenamel junction. Forty caries-free extracted human molars were used in this study. The Class II cavities were prepared 1.0mm below cementoenamel junction with a # 701 carbide bur. The teeth were randomly divided into four groups, each group comprising 20 treated cavities according to adhesives and filing materials ; Group 1 : Scotchbond Multipurpose/z-100, Group 2: Ariston Liner/Ariston pHc, Group 3: One-Step/pyramid, Group 4: Prime & Bond NT/SureFil. To simulate the clinical situation during restoration placement, a restoration template was fabricated and composite resin was filled using a three sited light-curing incremental technique. The specimens were stored in the 100% humidity for 7 days prior to thermocycling. The specimens were immersed in 2% methylene blue dye solution for 24 hours and then embeded in transparent acrylic resin and sectioned mesiodistally with a diamond wheel saw. The degree of marginal leakage was scored under the stereomicroscope(×20) and the data were analyzed by Kruskal-Wallis test and Mann-Whitney test. The results were as follows : 1. Microleakage was minimal in the hybrid composite resin type, Z-100. 2. In the condensable types, Pyramid shows the most microleakage compared to Ariston pHc. And SureFil(p<0.001) . 3. There was no statistically significant difference between Ariston pHc and SureFil(p>0.001). Key words : Microleakage, Cemental margin, Hybride composite resin.

백내장 수술환자 진료결과들간의 관계 : 사전 연구를 중심으로 Pilot study

박은철,김한중,홍영재,조우현,손명세,임승정,강형곤,최윤정 한국의료QA학회 1998 한국의료질향상학회지 Vol.5 No.1

Background : This study was done to assess the relationship among multiple patient outcomes of cataract surgery perioperatively, 3-4 months and 12 months after surgery. The patient outcomes include changes in visual acuity(operated eye, better eye), visual function(VF-14), patient satisfaction, subjective satisfaction with vision, and subjective overall health status. Methods : For the assessment of relationship, prospective study was performed with 92 patients who had undergone either one or both eye cataract surgery by 3 ophthalmologists practicing at a university hospital. Patients were interviewed, and clinical data were obtained. Doctors were questioned with self-entered questionnaire forms. Medical record was examined to understand surgery process. The survey was conducted at 4 stages : preoperatively, perioperatively, postoperative 3-4 months, and postoperative 12 months. Results : The correlations within patient outcomes at 4 stages - the visual acuity of operated eye and that of better eye, patient satisfaction and VF-14, subjective overall health status and relative health status as against others - were found to be positively correlated. The change in the visual acuity of operated eye and better eye was correlated with VF-14 as well as with patient satisfaction. The change was also correlated with overall health status. However, the correlations between variables were decreased as the postoperative period got longer. Conclusion : As for the postoperative clinical patient outcomes, VF-14 is acted to linker between visual acuity - clinical outcomes and overall health status - endpoint outcomes. Therefore, VF-14 is the index of patient-sided and disease-specific outcome for cataract surgery.

고속무선통신을 위한 Space-Time 부호화의 성능 평가

김성곤,김병주,장은영,변건식 동아대학교 정보기술연구소 2002 情報技術硏究所論文誌 Vol.10 No.1

In recent years there have been advances in Multiple Input Multiple Output(MIMO) communications systems, specifically the concept of Space-Time Coding(STC) for wireless communications. The STC algorithms use the independent modes of the MIMO transfer function to effectively attain multiple parallel transmission pipes, giving an increase in the effective available transmission bandwidth and allowing for greater transmission bit rates. In this paper, we simulated the BER performance of the MIMO system using both the Differential Space-Time Modulation and the Space-Time Trellis Code according to increasing number of Tx antennas and Rx antennas. The simulation gave the result which the Differential Space-Time Modulation is the better about 2-3dB than the Space-Time Trellis Code at the BER of 10^-2.

p-형 Si(100) 기판 위에 성장시킨 Bi_(3.25)La_(0.75)Ti₃O_(12) (BLT) 박막의 전기적 특성

최은경,박문흠,김현주,하태곤,강민주,김상수 昌原大學校 基礎科學硏究所 2003 基礎科學硏究所論文集 Vol.15 No.-

Bi₃zsLa(0.75)Ti₃0_(12) (BLT) thin film have been grown on p-type Si(l00) substrates by a sol-gel spin coating process. The structure and surface morphology of the film were analyzed by X-ray diffraction (XRD) and scanning electron microscopy (SEMI. Furthermore, the electrical properties were examined by capacitance-voltage ( C-V) characteristics by using a LF Impedance Analyzer(HP 4192A). XRD measurement show layered perovskite structure with a single phase in BLT thin film annealed at 700C for 30 min in oxygen. The measured grain size of BLT on Si is about 0.04 - 0.1 pn. From the cross-sectional SEM image, BLT film thickness is measured to be 0.4 pm. The C-V characteristic hysteresis curves show that the NIFS (metal-fexroelectric-semiconductor) structure has memory effect. The memory window decreases, with increasing frequency at MFS structure. And it is found that the memory window increases as the applied voltage to the ferroelectric capacitor is increased. These phenomena may be due to polarization reversals of the BLT ferroelectric film and because of the charge injection from Si substrate into the ferroelectric thin film. The results obtained indicate that the present BLT films are suitable for making ferroelectric field effect transistor(FeFET) memory.