일부 의과대학생의 음주 실태와 관련 요인

류소연,윤혜은,김기순,박종,강명근,박계남 朝鮮大學校 附設 醫學硏究所 2004 The Medical Journal of Chosun University Vol.29 No.2

Objectives : This study was performed to investigate the drinking status and the related factors with problem drinking in some medical students. Methods : The study subjects were 345 premedical students (freshmen and sophomore) and medical students (sophomore) in a medical school who replied to the self-administered questionnaire survey during March 2002. The questionnaire was composed of general characteristics, drinking status, social value about drinking, health status, satisfaction of life and alcohol use disorders identification test (AUDIT) . Results : The experience rate of drinking was 88.8% in male and 88.3% in female and it was tended to increase with going up the grade. Prevalence of hazardous, dependence, harmful and problem drinking classified by AUDIT score criteria were 66.2%, 3.0%, 7.0% and 5.1% in male and 34.9%, 0.9%, 1.9%, 1.9% in female. In male, the statistically significant related factors to Al JDIT scores were grade, religion, maternal drinking status, social value about drinking, affectionate feelings of those around one and satisfaction of life. Only social value about drinking was statistically significant correlated factor with AUDIT scores in female. As a result of multiple regression analysis, the related factors with AUDIT scores were sex, maternal drinking status, satisfaction of life and social value a bout drinking. Conclusion : The experience rate of drinking in medical students was higher than that in other college students. Grade, family drinking history, negative psychological feelings, social value about drinking were risk factors to problem drinking.

체질량지수와 간기능 이상과의 관련성

윤혜은,류소연,강명근,박종,김기순 朝鮮大學校 附設 醫學硏究所 2005 The Medical Journal of Chosun University Vol.30 No.1

Objective: To investigate the relationship between body mass index (BMI) and liver function abnormalities in the general population in Korea. Methods: The study subjects were 5765 persons who were received questionnaire survey and health examination of national health and nutrition survey in 1998, 20-59 years in age and had no history of viral hepatitis. BMI was categorized by quartile and abnormal liver functions were defined aspartate aminotransferase (AST) >30 U/L or alanine aminotransferase (ALT) >35 U/L in serum level. In order to identify the association of BMI and abnormal liver function, chi-square test and multivariate logistic regression analysis were used. Results: The abnormality rates of AST were 35.0% in male and 13.4% in female. The abnormality rates of ALT were 35.8% in male and 11.1% in female. After controlling for the other covariates, the multivairate logistic regression analysis showed that BMI was the significant related factor of abnormal AST (male; odds ratio=1.25; 95% confidence interval=1.15-1.36, female; odds ratio=1.14; 95% confidence interval=1.02-1.26) and abnormal ALT (male; odds ratio=1.87; 95% confidence interval=1.71-2.04, female; odds ratio=1.56; 95% confidence interval=1.38-175). Conclusions: We identify that BMI was the significant risk factor of non-viral liver disease with abnormal liver functions. A large-scale investigation will be suggested in the future to demonstrate the causal-effect issue between abnormal liver function and obesity.

Bacillus subtilis 接種이 土壤微生物相에 미치는 影響(Ⅰ) : 볏짚 및 크로버 添加區에서의 微生物相의 變動 Changes in Microflora by Application of Straw and Clover

孔惠淑,柳恩珠,梁昌述 建國大學校 附設 農業資源開發硏究所 1993 農資源開發論集 Vol.18 No.-

토양으로부터 분리한 B. subtilis를 有機物이 施用된 토양에 還元 接種하여 有機物 種類에 따른 B. subtilis의 토양중에서 適應·定着性 및 B.subtilis가 다른 土壤微生物相에 미치는 영향을 經時的으로 조사하였다. 또한 有機物이 시용된 토양중에서 B,subtilis와 植物 病原菌인 F. oxysporum을 동시에 接種하여 상호간의 拮抗的 關係를 검토한 결과는 다음과 같다. 1) B. subtilis菌數는 對照區에서보다 B. subtilis 接種區에서 增加를 보였고 단지 볏짚 및 크로버만을 사용한 區에서보다 볏짚 및 크로버 施用區에 B. subtilis를 접종한 區가 약 2배 정도 B. subtilis菌數의 증가를 보였다. 특히 B.subtilis를 有機物 施用區에 접종했을 때 볏짚 시용구가 크로버 시용구에서보다 B. subtilis菌數가 약 3배 정도 현저하게 증가하였다. 2) 細菌과 絲狀菌數는 대조구보다 B.subtilis 接種區에서 각각 23% 및 20%씩 감소하였으므로 또한 크로버 시용구에서보다 크로버+B. subtilis 접종구에서도 각각 33% 및 16%씩 감소하였고, 볏짚 시용구에서는 볏짚+B. subtilis 접종구에서 각각 29% 및 32%씩 감소경향을 나타내었다. 3) 胞子形成菌數는 대조구보다 B. subtilis 접종구에서 약 10배 정도 증가하였으며 단지 有機物만을 시용한 區보다도 크로버+B. subtilis 접종구와 +B. subtilis 접종구에서 각각 2배, 4배 정도의 증가경향을 보였다. 또한 gram(-)細菌도 胞子形成菌數와 비슷한 경향을 나타내었고, B. subtilis接種이 그람 음성 세균수의 변동에는 영향을 미치지 않았다. 4) F. oxysporum의 菌數는 크로버 시용구에서보다 크로버+F. oxysporum 접종구에서 25배 정도 증가하였으나 크로버+B. subtilis 접종구에서는 크로버+F. oxysporum 접종구보다 약 5배 정도의 감소경향을 나타내었다. 또한 F. oxysporum菌數는 볏짚+F. oxysporum區에서 볏짚 單獨施用區보다 3배 정도 증가하였으나 볏짚+B. subtilis+F. oxysporum접종구는 볏짚+F. oxysporum접종구보다 F. oxysporum의 數가 약 17배 정도 감소경향을 나타내었다. 더욱이 F. oxysporum菌數는 크로버+B. subtilis+F. oxysporum접종구보다 볏짚+B. subtilis+F. oxysporum접종구에서 약 40배 정도의 감소경향을 나타내었다. 5) 크로버 시용구의 토양 pH는 약 ph 9에 이르러 토양 ph가 alkali화되었으며 볏짚시용구의 토양 ph는 큰 변화 없이 약산성을 유지하였다. This study has been conducted to investigate the adaptation of Bacillus subtilis to the soil and the antagonistic interaction between B. subtilis and pathogen Fusarium oxysporum as well as the periodic change of soil microflora when B. subtilis was inoculated to the soil treated with organic matters. Some results obtained from this study are as follows : 1) The number of B. subtilis was more increased about 6 times in the plot inoculated with B.subtilis than in control plot. It was relatively double in the organic matter+ B. subtilis plot than in the only organic matter plot. B. subtilis was particuraly increased about 3 times in the straw +B. subtilis plot, compared with the clover +B. subtilis plot. 2) The number of total bacteria and fungi was decreased by 23% and 20% in the plot inoculated with B.subtilis respectively than in control plot. It was not only decreased by 33% and 16% in the clover+B. subtilis plot respectively than in the only clover plot but it was also decreased by 29% and 32% in the straw+B. subtilis plot respectively than in the only straw plot. 3) The number of spore-forming bacteria was increased about 10 times in the plot inoculated with B.subtilis than in the control plot. It was also increased 2 times and 4 times in the clover+B.subtilis plot and in the straw+B. subtilis plot respectively than in each organic matter plot. The number of gram-negative bacteria and the spore-forming bacteria were slightly increased in all the plot inoculated with B. subtilis. 4) The number of F. oxysporum was increased about 25 times in the clover+ F. oxysporum plot than in the only clover plot. But it was decreased about 5 times in the clover+B.subtilis+ F. oxysporum plot than in the clover +F. oxysporum plot. Furthermore, F. oxysporum was remarkably decreased about 40times in the straw+B. subtilis+ F. oxysporum plot than in the clover+b. subtilis+ F. oxysporum plot. It occured that B. subtilis had inhibited the growth of pathogen F. oxysporum when B. subtilis was inoculation to the soil treated with straw. 5) Soil pH was changed to pH 9 in the plot treated with clover to become the alkalification of experimental soil. Meanwhile it was not changed in the plot treated with straw.

여름철에 스타킹과 양말 착용시의 생리적 반응 및 착용감

박은실,류현혜,성수광 대구효성가톨릭대학교 응용과학연구소 1997 응용과학연구논문집 Vol.6 No.1

The purpose of this study was to obtain the basic data for designing the physiologically comfortable stocking. The study investigated physiological responses and wearing sensation of healty female adults in twenties in wearing support type stocking and socks according to ambient temperature and humidity in summer. The various factors, such as rectal temperature, skin temperature, body weight loss, blood pressure pulse rate, wearing sensation were statistically analyzed according to the warm temperature ambient condition and ensemble of clothes. The results were as follows : 1. Mean skin temperature showed significant differences with ambient temperature and clothes. In the low humidity and temperature, mean skin temperature was highest in support stocking in order high supporting stocking 〉socks. In the high humidity and temperature, no significant difference on ensemble of clothes was indicated at the end of exercise. 2. Under the certain ambient humidity, mean skin temperature increased in proportion to the increasa of ambient temperature in all ensemble of clothes under the certain ambient temperature, 70% RH higher mean skin temperature was indicated without relation to ensemble of clothes in high temperature. 3. Maximum blood pressure showed significant differences with the increase or decrease of ambient temperature. But, minimum blood pressure increased according to the decreased of ambient temperature. Pluse rate increased in proportion to the increase of ambient temperature during exercise. 4. Comfort showed 0.1% of significant differences with ambient temperature, clothes and time. Phychological responces showed 'very hot' 'very uncomfortable' as exercise and ambient temperature op up. Under the high humidity and temperature, high humudaty and temperature, high support stocking was most comfortable.

장기 이식 환자에서 Voriconazole 과 Cyclosporine 또는 Tacrolimus의 상호작용

한혜원,김재연,송영천,김승은,유성길 한국병원약사회 2009 병원약사회지 Vol.26 No.1

Abstract: In organ transplant patients, the opportunity of fungi infections such as invasive aspergillosis increase by use of immunosuppresant drugs and voriconazole is recommended as primary treatment drug. When voriconazole is administered with cyclosporine(CsA) or tacrolimus(FK506), caution about increment of blood CsA or FK506 concentrations that caused by the change of CYP3A4 activity is required but few domestic cases of interaction were reported yet, The purpose of this study was to assess the effect of voriconazole on the blood CsA or FK506 concentrations in transplant recipients and the factors of recipients that have an effect on the results. 25 transplant recipients who were administered voriconazole with CsA or FK506 from January 1 of 2006 to August 17 of 2008 in Asan Medical Center were objects (12 patients on CsA coadministration arm - 9 males, 3 females; 41~62years;2 liver, 2 kidney, 3 bone marrow, 5 heart transplant recipients, and 13 on FK506 coadministration arm - 7 males, 6 females;26~65years; 10 liver, 2 kidney, 1 heart transplant recipients). Blood CsA or FK506 concentrations before and after coadministration of voriconazole, and maximum concentration in one month from the first day of coadministration were monitored retrospectively. In most cases CsA or FK506 were administered as recommended doses regardless of coadministration of voriconazole, and blood concentration increased from 239.42±126. 77ng/ml to maximum 411.92±225. 76ng/ml in CsA coadministration arm(p=0.003), and from 7.72±2.79ng/ml to maximum 19.16±9.35ng/ml in FK506 coadministration arm(p=0.003). Gender, age, and the kind of transplant organ did not affect to the change of blood concentration in both two arms. In consequences, administration of voriconazole could affect on the blood CsA or FK506 concentration, and in cases of administra tion of voriconazole in transplant recipients treated with CsA or FK506, close monitoring and dose adjustment is needed.

류마티스 관절염과 전신경화증의 중복증후군 1예

이은지,서광원,유충헌,박봉수,허민영,김지현,김혜란,김동욱 인제대학교 2008 仁濟醫學 Vol.29 No.-

Overlap syndrome is a disease that combines major features of more than one rheumatic disease in the same patient. A 58 year-old female who was diagnosed as rheumatoid arthritis (RA) developed skin thickening and dyspnea. Clinical and laboratory findings revealed that she was affected by systemic sclerosis (SSc) and interstitial lung disease. Finally, she was diagnosed as overlap syndrome consistent with RA combined with SSc. The authors report a case of RA-SSc overlap syndrome with relevant literatures.

유아교육기관의 운영관리 및 유아기 프로그램 평가

이소은,하진희,류혜선,박영주,주은혜,이종순 충북대학교 교육생활연구소 2001 생활과학연구논총 Vol.4 No.-

This purposes of this study were to assess the state of current administration and program contents in early childhood institutes. Using APECP(Assessnt Profile for Early Childhood Programs), assesment data were gathered from 27 apprentices in child care centers and 6 apprentices in Kindergarten in Cheongju. Descriptive statistics and Mann-Whitney test were used to analyze data. The result were as follows : (1) The distribution of percentile rate in administration was from 55% to 78%, and the area of Program Development scored the lowest. The assessments for Kindergarten were higher than those of child care center in the areas of Physical Facility, Food Service, and Program Management. (2) As for the program contents, percentile rate was from 62% to 80%, and generally the assessments for Kindergarten were higher than those of child care center. It appears that the certification and assessment system for ealry childhood institutions should be supervised more strongly in order to improve the qulaity of those institutions.

젊은 성인 남자의 흡연과 혈청 지질과의 관련성

조선,류소연,박종,강명근,김은숙,김형철,박광희,윤혜은,노희송 朝鮮大學校 附設 醫學硏究所 2007 The Medical Journal of Chosun University Vol.32 No.2

Objectives: This study was performed to find the association of cigarette smoking and blood lipid profiles in healthy young adults. Methods: The data was collected by a self-administered questionnaire and health examination in 489 professional soldiers from 6 to 12 May, 2004. The status of cigarette smoking was classified by non-smoking, ex-smoked, ≤4.9, 5-9.9, and ≥10 pack-years. The statistical analysis were used by chi-square test, analysis of variance and analysis of covariates. Results: In status of subjects cigarette smoking, current smoking, ex-smoked, and non-smoking were 71.8%, 11.2%, and 17.0%, respectively, In distribution by amount of smoking, non-smoking, ex-smoked, ≤4.9 pack-years, 5-9.9 pack-years, and ≥10 pack-years were 17.0%, 11.2%, 37.4%, 21.3%, and 13.1%, respectively. At other confounding variables were controlled, total cholesterol and LDL-cholesterol were increased significantly when amount of smoking was increased. However, triglyceride and HDL-cholesterol did not showed statistically significant differences, Conclusion: Smoking has relevant to total cholesterol and LDL-cholesterol and it is need to perform the further study for finding how blood lipid profiles are affected its level by cigarette smoking and to find an influence of cigarette smoking on cardiovascular disease.

방사선 치료를 받는 암 환자들의 사회적 지지와 삶의 질과의 관계

정주희,류소연,윤혜은,남택근,오윤경,안현옥,박계남,이영선 朝鮮大學校 附設 醫學硏究所 2002 The Medical Journal of Chosun University Vol.27 No.2

Objective : This study was performed to investigate the relationship between social support and quality of life among cancer patients receiving radiation therapy. Matehals and Methods : The data were collected from 98 patients, who were receiving radiation therapy at two university hospitals located in GwangUJu, used by structured questionnaire. For statistical analyses of the association between quality of life and various characteristics, data were analyzed using t-test, ANOVA, Pearson 's correlation, and multiple regression analysis. Results: 1. There were 56(57.1%) males and 42(42.9%) females. Age ranged from 21 to 82 years. The primary sites of cancer were gastrointestinal tract (24.5%), lung (23.5%), breast (21.4%), and head and neck (11.2%) in order. 2. The mean scores of social, family, and medical support were 4.30 0.58, 4.49 0.78, 4.11 0.65, respectively. The score of quality of life was 5.83 1.63 (range: 1.95 ~ 9.05). 3. An analysis of the association between several factors of patients and quality of life showed that the statistically significant factors were age, the presence of distant metastasis, family support, medical support and social support. 4. As a result of the multiple regression analysis, only social support was significant (β=0.932, P=0.02) with quality of life, but age and presence of distant metastasis were not significant. Conclusion : This suggests that quality of life in cancer patients could be improved by strengthening the social support which consists of family and medical support. Further study would be necessary to evaluate separately several aspects of quality of life among cancer patients.

입원 정신질환자들의 수면의 질과 관련요인에 관한 연구

김명주,윤혜은,박연주,류소연 朝鮮大學校 附設 醫學硏究所 2009 The Medical Journal of Chosun University Vol.33 No.S

본 연구는 입원 정신질환자들의 생활습관과 수면의 질과의 관련요인을 알아보고자 시도되었다. 전남 나주시 국립나주병원 개방병동에 입원한 정신질환자 154명을 대상으로 2008년 7월 17일부터 7월 25일까지 인구사회학적 특성, 임상적 특성, 입원 생활습관, 입원병력특성 등을 설문지 및 병록지로 조사하였으며, Leeds Sleep Evaluation Questionnaire(LSEQ) 변형도구를 이용하여 수면의 질을 측정하였다. 입원 정신질환자들의 수면의 질 점수는 17.53±5.03점이었으며, 단순분석상에서 수면의 질은 인구사회학적 특성 등과는 관련이 없었다. 그러나 다중회귀분석 결과 과체중군에서, 입원횟수가 많을수록, 통증 정도가 심할수록 수면의 질은 나빴다. 반면, 수면제를 복용한 사람이 복용하지 않은 사람에 비해 수면의 질이 좋았다. 생활습관과 수면의 질과 유의한 차이가 없었던 것은 입원이라는 동일 환경의 한계 때문이라고 생각된다. 이상의 결과로 볼 때 입원 정신질환자들의 수면의 질을 높이기 위해서는 수면제 복용의 약물치료와 함께 체중조절을 고려하고, 통증에 대한 적극적인 대처가 이루어져야 할 것으로 생각된다. Objectives : This study was performed to identify the relations between daily habits and quality of sleep of the psychiatric inpatients. Methods: We interviewed 154 the psychiatric inpatients of open ward in Naju national hospital, Chonnam Naju, from July 17, 2008 to July 25 of the same year. Data was collected using disease records and a questionnaire about socio- demographic characteristics, clinical characteristics, habits in hospital, and characteristics in history of hospitalization. And we measured the quality of sleep using the subjective sleep questionnaire modified from Leeds Sleep Evaluation Questionnaire (LSEQ). Results: The scores of quality of sleep of inpatients were 17.53±5.03. Quality of sleep had no statistically significant relationship with various characteristics in the simple analysis. However, as a result of the multiple regression analysis, the sleep quality of the overweight group was low, and the higher frequency of hospitalization and more pain they had, the worse sleep quality was. However, the sleep quality of those who took hypnotics was higher than that of those who did not. Conclusions: This study suggests that there was no significant difference between daily habits in the hospital and the sleep quality because of limits to the same environment of being in hospital. Based on the results above, in order to enhance the sleep quality of the psychiatric inpatients, we should consider both medication which takes hypnotics and weight control and actively deal with the pain.