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Estrella D?az,Roc?o Carranza,Carlos S?nchez-Camacho,?gueda Esteban,David Mart?n-Consuegra 글로벌지식마케팅경영학회 2023 Global Marketing Conference Vol.2023 No.07
Smart technologies are critical for businesses to develop these dynamic connections, as technologies enable them to network with others and exchange resources seamlessly. This fact makes it possible to modify the tasks performed by employees of tourism organizations that are in contact with consumers/tourists.
Sintering Stainless Steels with Boron Addition in Nitrogen Base Atmosphere
Abenojar J.,Esteban D.,Martinez M.A.,Velasco F. 한국분말야금학회 2006 한국분말야금학회 학술대회논문집 Vol.2006 No.1
Due to the increasing use that the stainless steel is getting recently in the nuclear industry, this document proposes the study of the stainless steel 316L with boron addition. With the final product, the properties of the stainless steel 316L (good mechanical properties and high corrosion resistance) with the boron neutron absorption properties are claimed to unify. The P/M technologies allow adding higher boron quantities than with the solidification conventional technologies, where segregation is produced.
Culture Conditions for Mycelial Growth and Anti-Cancer Properties of Termitomyces
Tharavecharak Suphachai,D’Alessandro-Gabazza Corina N.,Toda Masaaki,Yasuma Taro,Tsuyama Taku,Kamei Ichiro,Gabazza Esteban C. 한국균학회 2023 Mycobiology Vol.51 No.2
Termitomyces sp. that grow in symbiosis with fungus-farming Termites have medicinal properties. However, they are rare in nature, and their artificial culture is challenging. The expression of AXL receptor tyrosine kinase and immune checkpoint molecules favor the growth of cancer cells. The study evaluated the optimal conditions for the artificial culture of Termitomyces and their inhibitory activity on AXL and immune checkpoint molecules in lung adenocarcinoma and melanoma cell lines. The culture of 45 strains of Termitomyces was compared. Five strains with marked growth rates were selected. Four of the selected strains form a single cluster by sequence analysis. The mycelium of 4 selected strains produces more fungal mass in potato dextrose broth than in a mixed media. The bark was the most appropriate solid substrate for Termitomyces mycelia culture. The mycelium of all five selected strains showed a higher growth rate under normal CO2 conditions. The culture broth, methanol, and ethyl acetate of one selected strain (T-120) inhibited the mRNA relative expression of AXL receptor tyrosine kinase and immune checkpoint molecules in cancer cell lines. Overall, these results suggest the potential usefulness of Termitomyces extracts as a co-adjuvant therapy in malignant diseases.
The Medicinal Mushroom, Grifola gargal, Ameliorates Allergic Bronchial Asthma
Etsuko Harada,Corina N. D’Alessandro-Gabazza,Masaaki Toda,Toshihiro Morizono,Toshiaki Totoki,Taro Yasuma,Kota Nishihama,Tetsu Kobayashi,Toshimitsu Sumiya,Hirokazu Kawagishi,Esteban C. Gabazza 한국식품영양과학회 2018 Journal of medicinal food Vol.21 No.2
Grifola gargal Singer, a medicinal mushroom, has been found to be effective for the prevention and treatment of various chronic inflammatory diseases. However, the effects of G. gargal on allergic diseases are unknown. The present study investigated the effect of G. gargal extract on allergic bronchial asthma. Asthma was induced in mice by ovalbumin sensitization and inhalation. The grade of asthma was compared between mice fed with chow containing G. gargal extract and mice given standard chow. The human mast cell and eosinophilic cell lines were used for in vitro studies. G. gargal extract significantly reduced airway hyperresponsiveness, lung eosinophilic infiltration, lung interleukin (IL)-13 expression, and plasma IgE level and significantly increased IL-10 plasma levels compared to untreated control mice. Spleen regulatory T cells were significantly increased in mice treated with the G. gargal extract compared with untreated control mice. G. gargal extract significantly suppressed expression of cytokines in mast cells and eosinophils compared with control cells. Overall, these observations show that G. gargal extract augments the lung population of regulatory T cells and ameliorates allergic inflammation and airway hyperresponsiveness in mice with allergic bronchial asthma, suggesting the potential therapeutic benefit of G. gargal extract in allergic diseases.