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      • KCI등재

        Evaluation of prophylactic and therapeutic effects of ruscogenin on acute radiation proctitis

        Erkan,Yavuz,Onur,Olgac,Karagulle,Gulcin,Ercan,Atilla,Celik,Hakan,Yigitbas,Busra,Yaprak,Bayrak,Rumeysa,Tartar,Ramazan,Kusaslan,Yuksel,Altine,Osman,Bilgin,Gulcicek 대한외과학회 2018 Annals of Surgical Treatment and Research Vol.94 No.4

        Purpose: Radiation proctitis (RP) is inflammation and damage to the rectum, manifested secondary to ionizing radiation utilized for treatment. In this study, we evaluated the anti-inflammatory therapeutical and protective effects of ruscogenin in a model of acute RP. Methods: Thirty-two Sprague-Dawley rats were divided into 4 groups (n = 8) as sham, control, treatment, and prophylaxis groups. Prophylaxis group and treatment group were dosed ruscogenin by oral gavage for 14 days pre- and postradiation. At the end of the 28th day, all subjects were sacrificed. Results: Histopathological analysis showed a significant increase in cryptitis abscess, cryptitis and reactive atypia, and depth of lymphocytic infiltration of the control group, compared to the other groups (P < 0.05), while treatment and prophylaxis groups showed significant decreases (P < 0.05). Immunohistochemical analysis indicated that immunoreactivity were significantly higher in control group (P < 0.05, P < 0.001, and P < 0.01, respectively), but vice versa for treatment and prophylaxis groups. There was not any significant difference for fibroblast growth factor 2 immunoreactivity. The epithelium of control rectums indicated an increase in TNF-α immunoreactivity while other groups had significant decrease (P < 0.01). Electron microscopical findings were parallel to light microscopy. Conclusion: In this study, ruscogenin was observed to be effective on prophylaxis or treatment of acute RP. Although there are various reports on the treatment of the rectum damaged by acute RP in the literature, this could be the first study since there is no research indicating the ultrastructural effect of ruscogenin.

      • KCI등재SSCISCOPUS

        How Game Addiction Rates and Related Psychosocial Risk Factors Change Within 2-Years: A Follow-Up Study

        Erkan,Baysak,Fatma,Duygu,Kaya,Yertutanol,I˙lker,Dalg˘,ar,Selçuk,Candansayar 대한신경정신의학회 2018 PSYCHIATRY INVESTIGATION Vol.15 No.11

        Objective Prospective data of risky online gamers in Turkey is missing. Therefore, we aimed to investigate the change in gaming behaviors and addiction rates of Travian players within two years to search diagnostic stability of internet gaming disorder and some psychosocial risk factors. Methods 110 responders completed the whole questionnaire package including 21-item Game Addiction Scale (GAS), Satisfaction with Life Scale (SLS), Rosenberg Self-Esteem Scale (RSES), and Multi-dimensional Scale of Perceived Social Support (MSPSS). A hierarchical linear modeling approach was followed to test the linear change in game addiction scores of the participants from 2013 to 2015. Results GAS scores of gamers significantly decreased within two years (p=0.026). MSPSS scores significantly and negatively associated with GAS scores (p<0.001) and the negative association of time remained significant (p=0.035). Decrement in the MSPSS scores in two years was associated with increment in GAS scores. 9 (90%) of 10 participants with internet gaming disorder according to monothetic format and 26 (52%) of 50 participants with internet gaming disorder according to polythetic format were found to not to meet the diagnosis in the follow-up. 33 out of all participants reported that they were not playing any online games for at least last 6 months. Conclusion Social support seems to be a protective factor for game addiction and diagnosis of internet gaming disorder has low temporal stability among Travian players in Turkey.

      • KCI등재SCIESCOPUS

        A Novel Grounded Inductor Realization Using a Minimum Number of Active and Passive Components

        Erkan,Yuce,Shahram,Minaei,Oguzhan,Cicekoglu 한국전자통신연구원 2005 ETRI Journal Vol.27 No.4

        In this study, we present a new topology for realizing a grounded inductor employing only a single current conveyor, called a negative-type modified inverting second-generation current conveyor (MICCII-), and a minimum number of passive components, two resistors, and one capacitor. The non-ideality effects of the MICCII- on a simulated inductor are investigated. To demonstrate the performance of the presented inductance simulator, we use it to construct a third order Butterworth high-pass filter and a parallel resonant circuit. Simulation results are given to confirm the theoretical analysis.

      • KCI등재SCOPUS

        Solving design optimization problems via hunting search algorithm with Levy flights

        Erkan,Doğan 국제구조공학회 2014 Structural Engineering and Mechanics, An Int'l Jou Vol.52 No.2

        This study presents a hunting search based optimum design algorithm for engineering optimization problems. Hunting search algorithm is an optimum design method inspired by group hunting of animals such as wolves, lions, and dolphins. Each of these hunters employs hunting in a different way. However, they are common in that all of them search for a prey in a group. Hunters encircle the prey and the ring of siege is tightened gradually until it is caught. Hunting search algorithm is employed for the automation of optimum design process, during which the design variables are selected for the minimum objective function value controlled by the design restrictions. Three different examples, namely welded beam, cellular beam and moment resisting steel frame are selected as numerical design problems and solved for the optimum solution. Each example differs in the following ways: Unlike welded beam design problem having continuous design variables, steel frame and cellular beam design problems include discrete design variables. Moreover, while the cellular beam is designed under the provisions of BS 5960, LRFD-AISC (Load and Resistant Factor Design-American Institute of Steel Construction) is considered for the formulation of moment resisting steel frame. Levy Flights is adapted to the simple hunting search algorithm for better search. For comparison, same design examples are also solved by using some other well-known search methods in the literature. Results reveal that hunting search shows good performance in finding optimum solutions for each design problem.

      • KCI등재SCOPUS

        Effect of Partial Removal of Prolamins on Some Chemical and Functional Properties of Barley Flours

        Erkan,Yalçın 한국식품과학회 2010 Food Science and Biotechnology Vol.19 No.3

        In this study, some chemical and functional properties of hulled (BF-1) and hull-less (BF-2) barley flours and their partial prolamin removed forms (PPRF-1and PPRF-2, respectively) were determined. Total dietary fiber and resistant starch values increased on dry weight basis, conversely β-glucan levels slightly decreased after partial prolamin removing (PPR). Sodium dodecyl sulphatepolyacrylamide gel electrophoresis (SDS-PAGE) patterns of PPRF-1 and PPRF-2 exhibited that PPR was highly achieved. Rapid visco analyzer (RVA) peak and breakdown viscosity values of PPRF-1 and PPRF-2 were higher than BF-1 and BF-2, conversely their setback, trough, and final viscosity values were lower than that of the BF-1 and BF-2, respectively. PPR also caused an increase in water binding capacity and resulted in a decrease on water solubility values of barley flours. Protein solubility of PPRF-1 and PPRF-2 were lower than BF-1 and BF-2,respectively. Emulsifying properties of PPRF-2 were affected negatively from the PPR.

      • KCI등재

        Long-Term Palliative Effect of Stenting in Gastric Outlet Obstruction Due to Transarterial Chemoembolization with Yttrium-90 in a Patient with Metastatic Neuroendocrine Tumor

        Erkan,Caglar,Gulen,Doğusoy,Levent,Kabasakal,Ahmet,Dobrucali 대한소화기내시경학회 2016 Clinical Endoscopy Vol.49 No.5

        Internal radioembolization with yttrium-90 is a promising treatment method, predominantly for liver tumors. However, the shifting of yttrium-90-loaded spherules into the arteries and veins that supply the duodenum and stomach, leading to ulceration, hemorrhage, perforation, and outlet obstruction of these organs, is one of the major undesirable consequences of this technique. We report a case of gastric outlet obstruction (GOO) due to antropyloric stenosis with ulceration, edema, and inflammation following transarterial yttrium-90 treatment for a metastatic neuroendocrine tumor in a 58-year-old man. Stenting was used for palliation in this case. GOO improved after stenting and recovery of oral intake was permanent after stent removal.

      • KCI등재

        Concordance of Endoscopic Ultrasonography-Guided Fine Needle Aspiration Diagnosis with the Final Diagnosis in Subepithelial Lesions

        Erkan,Çağlar,İbrahim,Hatemi,Deniz,Atasoy,Gürhan,Şişman,Hakan,Şentürk 대한소화기내시경학회 2013 Clinical Endoscopy Vol.46 No.4

        Background/Aims: In this study we aimed to determine the rate of concordance of endoscopic ultrasonography (EUS)-guided fine needle aspiration (FNA) diagnosis with the final diagnosis obtained by surgery or endoscopic resection and follow-up in upper gastrointestinal subepithelial lesions. Methods: We retrospectively studied patients with subepithelial lesions who underwent EUS at our center from 2007 to 2011. Results: We had a final diagnosis in 67 patients (mean age±SD, 51.23±12.48 years, 34.3% [23] female, 65.6% [44] male). EUS-FNA was performed in all of the patients. On-site pathology was not performed. In nine of the patients, the obtained material which was obtained was insufficient. The cytologic examination was benign in 31 and malignant in 27 of the patients. Based on the final diagnosis, the EUS-FNA had a sensitivity of 96%, a specificity of 100%, and a diagnostic yield of 85%. Conclusions: The diagnostic yield of EUS-FNA, in the absence of the on-site cytopathologist, is feasible for the diagnosis of subepithelial lesions of the upper gastrointestinal system.

      • SCIESCOPUSKCI등재

        Internalized Stigma in Pediatric Psoriasis: A Comparative Multicenter Study

        ( Erkan Alpsoy Mualla Polat ), ( Ibrahim Halil Yavuz ), ( Pelin Kartal ), ( Didem Didar Balci ), ( Ayse Serap Karadag ), ( Asli Bilgic Ercan Arca ), ( Bilge Fettahlioglu Karaman ), ( Selma Emre ), ( Esra Adis) 대한피부과학회 2020 Annals of Dermatology Vol.32 No.3

        Background: Internalized stigma, adoption of negative attitudes and stereotypes of the society regarding persons' illness, has not been studied previously in pediatric psoriasis patients. Objective: We aimed to investigate the internalized stigma in pediatric psoriasis patients and to determine differences according to factors affecting internalized stigma compared to adult psoriasis patients. Methods: This multicenter, cross-sectional, comparative study included 125 pediatric (55 female, 70 male; mean age±standard deviation [SD], 14.59±2.87 years) and 1,235 adult psoriasis patients (577 female, 658 male; mean age±SD, 43.3±13.7 years). Psoriasis Internalized Stigma Scale (PISS), Dermatology Life Quality Index (DLQI), Perceived Health Status (PHS), and the General Health Questionnaire (GHQ)-12 were the scales used in the study. Results: The mean PISS was 58.48±14.9 in pediatric group. When PISS subscales of groups were compared, the pediatric group had significantly higher stigma resistance (p=0.01) whereas adult group had higher scores of alienation (p=0.01) and stereotype endorsement (p=0.04). There was a strong correlation between mean values of PISS and DLQI (r=0.423, p=0.001). High internalized stigma scores had no relation to either the severity or localization of disease in pediatric group. However, poor PHS (p=0.007) and low-income levels (p=0.03) in both groups, and body mass index (r=0.181, p=0.04) in the pediatric group were related to high PISS scores. Conclusion: Internalized stigma in pediatric patients is as high as adults and is related to poor quality of life, general health, and psychological illnesses. Unlike adults, internalized stigma was mainly determined by psoriasis per se, rather than disease severity or involvement of visible body parts, genitalia or folds. (Ann Dermatol 32(3) 181∼188, 2020)

      • KCI등재

        Blockchain Suitability Assessment of Manufacturing Functions Defined by the ISA95 Standard

        Erkan,Yalcinkaya,Antonio,Maffei 대한산업공학회 2020 Industrial Engineeering & Management Systems Vol.19 No.4

        The number of security incidents related to the manufacturing industry has been steadily increasing over the past decade. The most prominent security risks impacting the manufacturing industry are intellectual property theft, supply chain interruptions, industrial espionage, data breaches, and ransomware attacks. Blockchain is an emerging technology that offers distributed, highly available, resilient, and traceable ledger-based databases and thus opens new ways of dealing with conventional security challenges in the confidentiality, integrity, and availability domains. ISA95 outlines manufacturing functions in a number of areas and characterizes the information flows. Moreover, ISA95 constitutes a common blueprint for the manufacturing industry and this research paper systematically assesses the suitability of the blockchain technology for the ISA95 enterprise core functions and sub-functions as a way to ultimately increase the confidentiality, integrity, and availability of manufacturing systems.

      • KCI등재SCIE

        Pretreatment Photopenia on 18F-Fluorodeoxyglucose Positron Emission Tomography-Computed Tomography Scans Predicts Poor Prognosis in Nasopharyngeal Cancer Patients Undergoing Concurrent Chemoradiotherapy

        Erkan,Topkan,Ugur,Selek,Hüseyin,Mertsoylu,Yurday,Ozdemir,Ahmet,Kucuk,Nese,Torun,Ali,Ayberk,Besen 대한이비인후과학회 2020 Clinical and Experimental Otorhinolaryngology Vol.13 No.4

        Objectives. To investigate the influence of pretreatment primary tumor or nodal photopenia (PP) on 18F-fluorodeoxyglucose positron emission tomography-computed tomography (FDG PET-CT), an indicator of tumor ischemia, on survival results of nasopharyngeal cancers (NPCs) treated with concurrent chemoradiotherapy (C-CRT). Methods. The pre-C-CRT FDG PET-CT scans of 104 patients with NPC (cT1-4 N0-3 M0) were retrospectively examined to determine the presence of PP (PP+). Our primary endpoint was the influence of PP+ on overall survival (OS), while the progression-free survival (PFS) and locoregional PFS (LRPFS) constituted the secondary endpoints. Results. The PP+ was detected in 29 (27.9%): nine (8.7%), seven (6.7%), and 13 (12.5%) in the primary tumor alone, primary tumor plus neck nodes, and neck nodes alone, respectively. Because the PP+ cases were small by count per location, all comparative analyses were performed according to overall PP+/ PP– status instead of per detected site. At a median follow-up of 67.8 months (range, 9 to 130 months), the median survival times were not reached (NR) for the entire population, while 5-year OS, LRPFS, and PFS rates were 73.3%, 68.2%, and 63.4%, respectively. Comparatively the PP+ patients exhibited significantly poorer median OS (49.8 months vs. NR, P<0.001), LRPFS (40.7 months vs. NR, P=0.001), and PFS (31.8 months vs. NR, P=0.002) durations than their PP– counterparts. Furthermore, the PP+ retained its independent prognostic significance in multivariate analysis (P<0.001). Conclusion. Present results uncovered the pre-C-CRT PP as an independent predictor of poor prognosis for NPC patients, which underscore the requirement for the fortification of the local and systemic treatments in hypoxic NPCs.

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