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- 저자 : Enrique Zayas (검색결과 2 건)
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Parameter selection in the design of displacement and motion functions by means of B-splines
Enrique Zayas,Salvador Cardona-Foix,Lluïsa Jordi-Nebot 대한기계학회 2018 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.32 No.5
This work analyses the incidence of the parameter selection of B-spline curves, used in the design of displacement and motion functions, on its degree of freedom and shape. A complete design process based on the use of non-parametric B-spline curves and the convenience of selecting the curve parameters from the point of view of its practical application is shown. In order to make easy the design and use of the displacement function, the algorithms for derivation and integration of the B-splines used are presented. Three case studies validate the proposed design process and the selection of the adequate parameters. The first case presents the design of a displacement function of a roller follower driven by a disk cam; the corresponding cam profile and its prototype are shown. The second case presents the design of the motion function corresponding to the cutting unit of a manufacturing cardboard tube machine. The third case exposes the design of the displacement function of the bar feeding mechanism in a single-spindle automatic lathe, to produce a partial thread screw of hexagonal head.
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Murine Mammary Carcinoma Induces Chronic Systemic Inflammation and Immunosuppression in BALB/c Mice
Dasha Fuentes,Alejandro Cabezas-Cruz,Circe Mesa,Tania Carmenate,Darel Martínez,Anet Valdés-Zayas,Enrique Montero,Rolando Pérez 한국유방암학회 2022 Journal of breast cancer Vol.25 No.3
Purpose: The F3II cell line is a highly invasive variant of mammary carcinoma. Although it is frequently used as a model to evaluate the efficacy of immunotherapy, its impact on the immune system remains poorly understood. The main objectives of this study were to evaluate the effects of F3II tumors on the development of chronic inflammation and to characterize tumor-associated immunosuppression. Methods: Following the experimental implantation of F3II tumors in BALB/c mice, alterations in the liver and spleen anatomy and the numbers of circulating leukocytes, myeloid-derived suppressor cells (MDSCs), and regulatory T cells were measured using hematological techniques, histopathological analysis, and flow cytometry. The capacity of the F3II tumor-bearing mice to reject MB16F10 allogeneic tumor transplantation was also evaluated. In addition, the restoration of immune parameters in tumor-bearing mice was evaluated after standard breast cancer chemotherapy and surgical tumor excision. Results: F3II tumor implantation increased the levels of chronic inflammatory markers, such as the neutrophil-to-lymphocyte and platelet-to-lymphocyte ratios, and caused myeloid alterations, including extramedullary granulopoiesis and megakaryopoiesis, along with the recruitment of MDSCs to the spleen. Chemotherapy or surgical F3II tumor removal completely rescued the tumor-associated extramedullary granulopoiesis and megakaryopoiesis. Notably, the presence of F3II tumors reduced the capacity of BALB/c mice to reject MB16F10 allogeneic tumor transplantation. Conclusion: These results support the occurrence of F3II tumor-mediated immune cell dysfunction, which mimics the immune alterations characterized by chronic systemic inflammation and immunosuppression observed in breast cancer in clinical settings. Thus, the F3II tumor model is relevant for evaluating novel breast cancer immunotherapies and combinations in preclinical studies. This model could also be useful for identifying appropriate therapeutic targets and developing proof-of-concept experiments in the future.
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