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- 저자 : Enrique Montero (검색결과 2 건)
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Influence of the shape of head anchors on the durability of reinforced concrete elements
Martinez-Echeverria, M. Jose,Gil-Martin, Luisa Maria,Montero, Jose Rodriguez,Hernandez-Montes, Enrique Techno-Press 2020 Advances in concrete construction Vol.10 No.1
This paper looks into how the shape of headed bars may influence the durability of reinforced concrete structures. Nowadays the only heads used in site works are cylindrical in shape. An alternative shape of head is studied in this piece of work. The new head reduces the concentration of stresses and so the appearance of cracks. In this work durability is studied based on both, first cracking and failure mode. An experimental campaign of 12 specimens and finite element modelling are described. The specimens were subjected to an accelerated corrosion process using an electrical current supply. Direct current was impressed on the specimens until breaking. Test results and the results obtained from numerical models are presented. Results are presented in term of comparison between the two shapes of heads studied. It was shown that the shape of the head has a significant influence on durability of reinforced concrete structures with headed reinforcing bars.
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Murine Mammary Carcinoma Induces Chronic Systemic Inflammation and Immunosuppression in BALB/c Mice
Dasha Fuentes,Alejandro Cabezas-Cruz,Circe Mesa,Tania Carmenate,Darel Martínez,Anet Valdés-Zayas,Enrique Montero,Rolando Pérez 한국유방암학회 2022 Journal of breast cancer Vol.25 No.3
Purpose: The F3II cell line is a highly invasive variant of mammary carcinoma. Although it is frequently used as a model to evaluate the efficacy of immunotherapy, its impact on the immune system remains poorly understood. The main objectives of this study were to evaluate the effects of F3II tumors on the development of chronic inflammation and to characterize tumor-associated immunosuppression. Methods: Following the experimental implantation of F3II tumors in BALB/c mice, alterations in the liver and spleen anatomy and the numbers of circulating leukocytes, myeloid-derived suppressor cells (MDSCs), and regulatory T cells were measured using hematological techniques, histopathological analysis, and flow cytometry. The capacity of the F3II tumor-bearing mice to reject MB16F10 allogeneic tumor transplantation was also evaluated. In addition, the restoration of immune parameters in tumor-bearing mice was evaluated after standard breast cancer chemotherapy and surgical tumor excision. Results: F3II tumor implantation increased the levels of chronic inflammatory markers, such as the neutrophil-to-lymphocyte and platelet-to-lymphocyte ratios, and caused myeloid alterations, including extramedullary granulopoiesis and megakaryopoiesis, along with the recruitment of MDSCs to the spleen. Chemotherapy or surgical F3II tumor removal completely rescued the tumor-associated extramedullary granulopoiesis and megakaryopoiesis. Notably, the presence of F3II tumors reduced the capacity of BALB/c mice to reject MB16F10 allogeneic tumor transplantation. Conclusion: These results support the occurrence of F3II tumor-mediated immune cell dysfunction, which mimics the immune alterations characterized by chronic systemic inflammation and immunosuppression observed in breast cancer in clinical settings. Thus, the F3II tumor model is relevant for evaluating novel breast cancer immunotherapies and combinations in preclinical studies. This model could also be useful for identifying appropriate therapeutic targets and developing proof-of-concept experiments in the future.
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