http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
- 中文 을 입력하시려면 zhongwen을 입력하시고 space를누르시면됩니다.
- 北京 을 입력하시려면 beijing을 입력하시고 space를 누르시면 됩니다.
RISS 인기검색어
- 검색키워드
- 저자 : Andrea S. Calheiros (검색결과 2 건)
- 무료
- 기관 내 무료
- 유료
-
Antinociceptive Activity of Aqueous Extract of Bowdichia virgilioides in Mice
Juliane P. Silva,Renato S. Rodarte,Andrea S. Calheiros,Cristiane Z. Souza,Fabio C. Amendoeira,Marco A. Martins,Patrı´cia Machado R. Silva,Valber S. Frutuoso,Emiliano Barreto 한국식품영양과학회 2010 Journal of medicinal food Vol.13 No.2
Bowdichia virgilioides Kunth (Family Fabaceae) is a plant that is distributed widely in the tropical and subtropical regions of the world. In the northeast region of Brazil, where B. virgilioides is called “sucupira-preta,” the stem bark is used in folk medicine to treatment of inflammatory and painful diseases. This study aimed to evaluate the antinociceptive activity of the aqueous extract of the dried stem bark of B. virgilioides. The aqueous extract of B. virgilioides in doses of 50, 100, 200, and 400mg/kg was administered orally 1 hour prior to pain induction. Only the doses of 200 and 400mg/kg produced an inhibition by 61% and 74%, respectively, in the number of abdominal writhings induced by acetic acid. This antinociceptive effect was not reversed by pretreatment with naloxone, indicating that the effect is not associated with the activation of opioid receptors. In the formalin test, using the two highest doses, the extract had no effect in the first phase but produced an analgesic effect on the second phase with the inhibition of licking time (P<.001). In the hot plate test, no effect was seen at the dose of 400mg/㎏ p.o. Our findings show that B. virgilioides contains pharmacologically active constituents that possess antinociceptive activity justifying its popular therapeutic use in treating conditions associated with the painful conditions.
-
José A.A. Santos,Antonio Augusto Fidalgo-Neto,Robson X. Faria,Ana Simo˜es,Andrea S. Calheiros,Ana Luiza Be´renger,Hugo C.C. Faria-Neto,Maria Raquel Figueiredo,Valber S. Luiz Frutuoso,Luiz Anastacio Al 한국식품영양과학회 2011 Journal of medicinal food Vol.14 No.9
Recently, the P2X_7 receptor has been reported to be associated with chronic inflammatory and neuropathic pain. Because Rheedia longifolia extract has analgesic and anti-inflammatory activity, we evaluated the in vitro inhibitory potential of methanol extract and fractions from its leaves on the P2X_7 purinergic receptor. The activity of P2X_7 was studied with a dye uptake assay and with the whole-cell patch clamp technique in mouse peritoneal macrophages treated with methanol extract of R. longifolia leaves and fractions. The dye uptake was evaluated by flow cytometry and fluorescence microscopy. The R. longifolia extract and some fractions showed an inhibitory effect on the P2X_7 purinergic receptor in a dose-dependent manner. The ethyl acetate fraction exhibited the most potent inhibitory effects. The methanol extract and the butanol fraction showed the same inhibitory effects, despite their lower potency compared with the other fractions. The R. longifolia extract and some of its fractions may be anti-inflammatory because of their inhibitory effect on the P2X_7 receptor. Further investigation is needed to determine the pattern of inhibition and selectivity. Chromatographic analysis indicated the presence of bisflavonoids in the methanol extract fractions. A member of this chemical family is the most probable active compound responsible for the P2X_7 inhibitory effects present in the R. Longifolia extract and fractions.
연관 검색어 추천
이 검색어로 많이 본 자료
활용도 높은 자료
