Hepatitis C Virus Associations with Non Hodgkin's Lymphoma: Insights on Inflammation/Angiogenesis and CD Markers

El-Maadawy, Eman A,Talaat, Roba M,Sadek, Rawia F,El-Sherbini, Sherif M,Abdel-Bary, Naser,Abdel-Aziz, Amal A Asian Pacific Journal of Cancer Prevention 2016 Asian Pacific journal of cancer prevention Vol.17 No.9

We aimed to investigate any association between hepatitis C virus (HCV) infection and non-Hodgkin's lymphoma (NHL) in the view of cytokines that control inflammation/angiogenesis and their correlation with certain CD markers. NHL patients with or without HCV infection were studied. CD5, CD30, CD3, CD20 and CD45 were immunohistochemically evaluated. Plasma levels of vascular endothelial and platelet derived growth factors (VEGF, and PDGF), tumor necrosis factor (TNF-${\alpha}$), transforming growth factor (TGF-${\beta}$), interleukin-6 (IL-6), IL-8, IL-4, IL-12 and interferon gamma (IFN-${\gamma}$) were detected by enzyme-linked immunosorbent assay (ELISA). HCV+ve NHL patients showed a significant reduction in VEGF, PDGF, IFN-${\gamma}$, CD5 and CD45 and a significant increase in IL-12 and IL-8. In conclusion, there was a significant change in cytokine secretion and expression of CD markers in HCV+ve NHL patients. Based on our results, HCV infection in NHL patients requires more in-depth investigations to explore any role in lymphoma progression.

Synthesis of Hydrazone Derivatives of 4-(2-Chloroethyl) semicarbazide : A New Class of Cytotoxic Agents

El-Sabbagh, O.I.,El-Sadek, M.E.,Aboukull, M.E.,Shallal, H.M. Korean Chemical Society 2009 대한화학회지 Vol.53 No.1

새로운 종류의 히드라존 유도체는 4-(2-chloroethyl) semicarbazides로 부터 합성되었고, 인간 두 뇌(U251)와 간(Hepg2)의 암세포 에 대해 항증식성을 보였다. 히드라존 화합물은 벤즈알데히드, 아세토 페논, 3-formylindole 유도체이다. 아세토페논 유도체중에 3e (p-methoxy substituted)와 and 3f (p-nitro substituted)는 Hepg2 세포 (각각I$C_{50}$ = 6 ,8 $\mu$g/mL) 에 대해 가장 높은 세포독성활성을 보인다. 3-Formylindole 유도체중에 4a (hydrazone of 3-formylindole)은 U251 (I$C_{50}$ = 21 $\mu$g/mL)와 Hepg2 (I$C_{50}$ = 7 $\mu$g/mL)에 강한 세포독성활성을 보인다. A new series of hydrazone derivatives were synthesized from 4-(2-chloroethyl)semicarbazide and their antiproliferative activity against human brain (U251) and liver (Hepg2) carcinoma cell lines were evaluated. The hydrazone compounds are benzaldehyde (2a-2g), acetophenone (3a-3f), and 3-formylindole derivatives (4a-4d). Among the acetophenone derivatives, 3e (p-methoxy substituted) and 3f (p-nitro substituted) showed the highest cytotoxic activity against Hepg2 cell line (I$C_{50}$ = 6 and 8 $\mu$g/ml, respectively). Among the 3-formylindole derivatives, 4a (hydrazone of 3-formylindole itself) showed a pronounced cytotoxic activity against both U251 (I$C_{50}$ = 21 $\mu$g/ml) and Hepg2 (I$C_{50}$ = 7 $\mu$g/ml).

apoptosis in N-acetyl-p-aminophenol-induced liver injury in mice is tissue factor dependent

Mohamed Sadek Abdel-Bakky,Gouda Kamel Helal,El-Sayed Mohamed El-Sayed,Elham Amin,Abdulmajeed Alqasoumi,Ahmad Alhowail,Eman Sayed Said Abdelmoti,Ahmed Saad Saad 대한생리학회-대한약리학회 2021 The Korean Journal of Physiology & Pharmacology Vol.25 No.5

Tissue factor (TF) activates the coagulation system and has an important role in the pathogenesis of various diseases. Our previous study stated that retinoid receptors (RAR-α and RXR-α) are released as a lipid droplet in monocrotaline/ lipopolysaccharide-induced idiosyncratic liver toxicity in mice. Herein, the interdependence between the release of retinoid receptors RAR-α and RXR-α and TF in Nacetyl- p-aminophenol (APAP)-induced mice liver toxicity, is investigated. Serum alanine transaminase (ALT) level, platelet and white blood cells (WBCs) counts, protein expression of fibrin, TF, cyclin D1 and cleaved caspase-3 in liver tissues are analyzed. In addition, histopathological evaluation and survival study are also performed. The results indicate that using of TF-antisense (TF-AS) deoxyoligonucleotide (ODN) injection (6 mg/kg), to block TF protein synthesis, significantly restores the elevated level of ALT and WBCs and corrects thrombocytopenia in mice injected with APAP. TF-AS prevents the peri-central overexpression of liver TF, fibrin, cyclin D1 and cleaved caspase- 3. The release of RXR-α and RAR-α droplets, in APAP treated sections, is inhibited upon treatment with TF-AS. In conclusion, the above findings designate that the released RXR-α and RAR-α in APAP liver toxicity is TF dependent. Additionally, the enhancement of cyclin D1 to caspase-3-dependent apoptosis can be prevented by blocking of TF protein synthesis.

The role of potassium tellurite as tellurium source in mercaptoacetic acid-capped CdTe nanoparticles

M.S. Abd El-sadek,J. Ram Kumar,S. Moorthy Babu 한국물리학회 2010 Current Applied Physics Vol.10 No.1

Water-soluble CdTe nanoparticles were synthesized in aqueous solution with the assistance of mercaptoacetic acid (MAA) molecules by wet chemical route and microwave-assisted method. A series of cadmium telluride (CdTe) nanoparticles capped with a bifunctional molecule, which contains both thiols and carboxylic acid groups were prepared using different pH values and using potassium tellurite as tellurium source. Thiol-capped nanocrystals of CdTe can be isolated as powders using 2-propanol. The synthesized thiol-capped CdTe were characterized with EDAX, TEM, Raman, FT–IR, UV–Visible absorption,fluorescence spectroscopy and X-ray diffraction (XRD) for the particle size determination and to understand their optical properties. The particles crystallize predominantly in cubic phase with narrow photoluminescence emission. Potassium tellurite as source of tellurium improves the photoluminescence efficiency and also avoids the cumbersome processes associated with H2Te or NaHTe sources.

A controlled approach for synthesizing CdTe@CrOOH (core-shell) composite nanoparticles

M.S. Abd El-sadek,S. Moorthy Babu 한국물리학회 2011 Current Applied Physics Vol.11 No.3

A seed-mediated growth approach was used to synthesize CdTe@CrOOH core-shell composite nanoparticles in aqueous solution. Chromium oxyhydroxide shell was developed around a small quantum dot that can lead to composite particles which is expected to lead to some new properties and applications. The aqueous synthesized CdTe nanoparticles with bi-functional molecules (Mercaptoacetic Acid (MAA))at pH = 11.2 served as cores, and CrOOH was deposited on them to form core-shell nanoparticles in aqueous solution. The effect of refluxing time and the concentration of Cr^3+ on the preparation of these samples were measured using UV―Visible absorption and photoluminescence analysis. The emission peak of the resulted core-shell composite nanoparticles (CdTe@CrOOH) shifted from 605 (CdTe seed) to 630 nm. The sizes of CdTe nanoparticles averaged about 3.22 nm, and the CdTe@CrOOH composite nanoparticles averaged about 6.68 nm. The particles after coating with hydroxide shell were bigger than the uncoated CdTe seeds. The synthesized CdTe@CrOOH core-shell nanoparticles were characterized with XRD, EDAX, FT-IR, EPR, TEM, and thermal analysis (TG/DTG curves). The synthesized core-shell composite nanoparticles were subjected to suitable magnetic field to understand the effect on UV ―visible absorption and photoluminescence spectra. The results show that as-prepared nanoparticles with core/shell structure exhibit interesting optical properties.

Utilization of alternative marine fuels for gas turbine power plant onboard ships

El Gohary, M. Morsy,Seddiek, Ibrahim Sadek The Society of Naval Architects of Korea 2013 International Journal of Naval Architecture and Oc Vol.5 No.1

Marine transportation industry is undergoing a number of problems. Some of these problems are associated with conventional marine fuel-oils. Many researchers have showed that fuel-oil is considered as the main component that causes both environmental and economic problems, especially with the continuous rising of fuel cost. This paper investigates the capability of using natural gas and hydrogen as alternative fuel instead of diesel oil for marine gas turbine, the effect of the alternative fuel on gas turbine thermodynamic performance and the employed mathematical model. The results showed that since the natural gas is categorized as hydrocarbon fuel, the thermodynamic performance of the gas turbine cycle using the natural gas was found to be close to the diesel case performance. The gas turbine thermal efficiency was found to be 1% less in the case of hydrogen compared to the original case of diesel.

Magnetic resonance imaging and 3-dimensional transperineal ultrasound evaluation of pelvic floor dysfunction in symptomatic women: a prospective comparative study

Dahlia O. El-Haieg,Nadia M. Madkour,Mohammad Abd Alkhalik Basha,Reda A. Ahmad,Somayya M. Sadek,Rania M. Al-Molla,Engy Fathy Tantwy,Hosam Nabil Almassry,Khaled Mohamed Altaher,Nader E. M. Mahmoud,Sameh 대한초음파의학회 2019 ULTRASONOGRAPHY Vol.38 No.4

Purpose: The purpose of this study was to investigate magnetic resonance imaging (MRI) and 3-dimensional transperineal ultrasound (3D-TPUS) features of pelvic floor dysfunction (PFD) in symptomatic women in correlation with digital palpation and to define cut-offs for hiatal dimensions predictive of muscle dysfunction. Methods: This prospective study included 73 women with symptoms suggesting PFD. 3D-TPUS, MRI, and digital palpation of the levator ani muscle were performed in all patients. Levator hiatal antero-posterior (LHap) diameter and area (LH area) were measured at rest and at maximum muscle contraction. Results: The reduction in LHap diameter and LH area during contraction was significantly less in women with underactive pelvic floor muscle contraction (UpfmC) than in those who had normal pelvic floor muscle contraction by digital palpation (P<0.001). Statistically significant positive correlations (P<0.001) were found between the Modified Oxford Score and 3D-TPUS and MRI regarding the reduction in the LHap diameter (r=0.80 and r=0.82, respectively) and LH area (r=0.60 and r=0.70, respectively). A reduction in LHap of <6.5% on 3D-TPUS and <7.6% on MRI predicted UpfmC with sensitivities of 46.2% and 82.7%, respectively. A reduction in LH area of <3.4% on 3D-TPUS and <3.8% on MRI predicted UpfmC with sensitivities of 75.0% and 88.5%, respectively. MRI was more sensitive in detecting levator avulsion (63.4%) than 3D-TPUS (27.1%). Conclusion: MRI and 3D-TPUS had strong positive correlations with findings on palpation, and at certain cut-offs for hiatal dimensions, they can be used as complementary and objective tools to improve the accuracy of diagnosis and management planning of PFD.

Utilization of alternative marine fuels for gas turbine power plant onboard ships

M. Morsy El Gohary,Ibrahim Sadek Seddiek 대한조선학회 2013 International Journal of Naval Architecture and Oc Vol.5 No.1

Marine transportation industry is undergoing a number of problems. Some of these problems are associated with conventional marine fuel-oils. Many researchers have showed that fuel-oil is considered as the main component that causes both environmental and economic problems, especially with the continuous rising of fuel cost. This paper investigates the capability of using natural gas and hydrogen as alternative fuel instead of diesel oil for marine gas turbine, the effect of the alternative fuel on gas turbine thermodynamic performance and the employed mathematical model. The results showed that since the natural gas is categorized as hydrocarbon fuel, the thermodynamic performance of the gas turbine cycle using the natural gas was found to be close to the diesel case performance. The gas turbine thermal efficiency was found to be 1% less in the case of hydrogen compared to the original case of diesel.

ADSORPTION CHARACTERISTICS AND HEAT OF ADSORPTION MEASUREMENTS OF R-134a ON GRANULAR ACTIVATED CARBON

M. ATTALLA,S. SADEK,W. ABD EL-FADEEL 대한설비공학회 2014 International Journal Of Air-Conditioning and Refr Vol.22 No.3

The objective of this study is to investigate the adsorption characteristics of granular activated carbon GAC/R-134a pair in the temperature range of 20–60°C and pressure up to 10 bars. The Dubinin–Astakhov adsorption equilibrium model is fit to experimental data with acceptable error limit. The pressure–temperature–concentration (P–T–X) diagram of the pair is also presented. The isosteric heat of adsorption of R-134a on AC has been calculated using the Clausius–Clapeyron equation as a function of adsorption capacity. The maximum adsorption capacity was found to be 1.92 kgR134a/kgcarbon at 20°C after 1200 s. The experimental results also shows that the increase of heat transfer area improves the adsorption capacity per kg of adsorber, which lead to the design of a finned tubes heat exchanger adsorption unit.

Studying the self-healing reaction based on zirconium silicide in the Thermal Barrier Coating system

Z. I. Zaki,Q. Mohsen,S. H. Alotaibi,M. H. El-Sadek 한양대학교 세라믹연구소 2020 Journal of Ceramic Processing Research Vol.21 No.2

This work investigated the behaviour of introducing ZrSi2 layer between the top coat layer Yttria-stabilized zirconia (YSZ)and the bond coat layer CoNiCrAlY in thermal barrier coatings where ZrSi2 layer helped self-healing of the cracks. Powdermixtures of ZrSi2/8YSZ and ZrSi2 /CoNiCrAlY were used to imitate the real case. At 800 °C under argon, there was no changein the chemical composition of both ZrSi2 and 8YSZ. ZrSi2 was oxidized in case of treatment in air atmosphere at 800 °C withno evidence for any self-healing reactions. At 1000 and 1200 °C under argon the formation of ZrSiO4 phase was detected whichwas a strong evidence of self-healing reaction. ZrSiO4 phase was also detected at 1200 °C in air with the appearance of SiO2phase. A limited interaction was detected at 1000 °C between ZrSi2 and CoNiCrAlY under vacuum. Si was detected in thesurface of CoNiCrAlY grains and Ni was detected in the composition of ZrSi2. This behavior could contribute to a chemicalbonding between ZrSi2 and CoNiCrAlY layers. The obtained data were confirmed by XRD, SEM and EDX analyses.