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鍼鎭痛이 中樞神經系의 5-HT와 endorphin에 미치는 影響에 對한 考察
金利和,金昊顯 세명대학교 한의학연구소 2001 韓醫學硏究所 論文集 Vol.3 No.-
The recent scientific interest in acupuncture and its mechanisms shows a timewise coincidence with the discovery of the endogenous opioids, the endorphins and 5-HT. It has been commonplace to assume that acupuncture acts via release of these substances and research along this line has provided ample evidence for the existence of such a connection. However, it has also become clear that other neuronal systems are involved. This is not unexpected in view of the complex and integrated nature of the nervous system. It may therefore be more appropriate to discuss pathways and circuits activated by acupuncture rather than single systems.
Kim, Ee-Hwa,Kim, Younhee,Jang, Mi-Hyun,Lim, Baek-Vin,Kim, Youn-Jung,Chung, Joo-Ho,Kim, Chang-Ju 경희대학교 동서의학연구소 2001 東西醫學硏究所 論文集 Vol.2001 No.-
The aim of the present study was to investigate whether stimulation of auricular acupuncture point has any effects on the expression of neuropeptide Y (NPY), appetite-inducing factor particularly abundant in the mammalian hypothalamus. In food-deprived condition, enhanced NPY expression was detected in both the arcuate nucleus (ARN) and the paraventricular nucleus (PVN) of the hypothalamus via immunohistochemistry in Sprague-Dawley rats. Needling the unfed rats on the auricular point resulted in decreased NPY levels in both the ARN and PVN, while it increased NPY levels in the ARN and PVN offed rats. The present findings indicate auricular acupuncture may affect NPY expression in the ARN and PVN of the hypothalamus. ⓒ 2001 Elsevier Science lreland Ltd. All rights reserved.
Kim Eun Sun,Kim Ee-Kyung,Kim Sae Yun,Song In Gyu,Jung Young Hwa,Shin Seung Han,Kim Han-Suk,Kim Johanna Inhyang,Kim Bung Nyun,Shin Min-Sup 대한의학회 2021 Journal of Korean medical science Vol.36 No.39
Background: School-aged children born very preterm have been suggested to have worse cognitive and behavioral outcomes than children born full-term. Executive function (EF) is a higher level of cognitive function related to academic achievement. The present study aimed to evaluate the cognitive (including EF) and behavioral outcomes of Korean children born extremely preterm (EP) and to analyze any biological or socioeconomic risk factors for poor cognitive outcomes in this population. Methods: A total of 71 infants weighing < 1,000 g at birth or born before 30 weeks of gestation (EP group) who were admitted to the neonatal intensive care unit from 2008 to 2009 were included in this study and compared with 40 term-birth controls. The Korean Wechsler Intelligence Scale for Children-Fourth Edition, Advanced Test of Attention (ATA), Stroop test, Children's Color Trails Test (CCTT), and Wisconsin Card Sorting Test (WCST) were used. Additionally, the Korean Child Behavior Checklist (K-CBCL) and Korean ADHD Rating Scale (K-ARS) were completed. Perinatal and demographic data were collected and analyzed. Results: The mean full-scale intelligence quotient (FSIQ) score in the EP group was significantly lower than that of the term control group (89.1 ± 18.3 vs. 107.1 ± 12.7; P < 0.001). In the EP group, 26 (37%) children had an FSIQ score below 85, compared to only one child (3%) in the control group. Furthermore, the EP group showed significantly worse EF test results (ATA, Stroop test, CCTT, WCST). Except for the higher social immaturity subscore in the EP group, the K-CBCL and K-ARS scores were not different between the two groups. EP children who received laser treatment for retinopathy of prematurity (ROP) had an 8.8-fold increased risk of a low FSIQ score, and a 1-point increase in the discharge weight Z-score decreased the risk of a low FSIQ score by approximately half in this EP cohort. Conclusion: This is the first Korean study to investigate the cognitive and behavioral outcomes of school-aged children born EP. In the study cohort, EP children exhibited significantly lower FSIQ scores and EF than their full-term peers, and 37% of them had cognitive problems. Nonetheless, except for social immaturity, the behavioral problems were not different in EP children. Severe ROP and low discharge weight Z-score were identified as independent risk factors for low FSIQ score after adjusting for birth weight.
Kim, Ee-Hwa,Jang, Mi-Hyeon,Shin, Min-Chul,Lim, Baek-Vin,Kim, Hyun-Bae,Kim, Youn-Jung,Chung, Joo-Ho,Kim, Chang-Ju WHO COLLABORATING CENTRE FOR TRADITIONAL MEDICINE 2002 東西醫學硏究所 論文集 Vol.2002 No.-
In this study, effects of acupuncture at zusanli acupoint on cell proliferation and expression of neuropeatide Y(NPY) in the dentate gyrus (DG) of streptozotocin-induced diabetic rats were investigated. Sprague-Dawley rats were divided into six groups: the control group, the non-diabetic and Zusanli-acupunctured group, the non-diabetic and non-acupoint-acupunctured group, the streptozotocin-induced-diabetes group, the streptozotocin-induced-diabetes and Zusanli-acupunctured group, and the streptozotocin-induced-diabetes and non-acupoint-acupunctured group. In the streptozo-tocin-induced diabetes group, the mean 5-bromo-2'-deoxyuridine-positive and NPY-positive cell counts in the DG were significantly decreased compared to the control group. Stimulation of the Zusanli resulted in increased cell proliferation and neuropeptide Y levels in the diabetic group. In the present results, it can be suggested that acupuncture may affert cell proliferation in the DG of streptozotocin-induced diabetic rats by regulating neuropeptide Y expression. ⓒ 2002 Elsevier Science Ireland Ltd. All rights reserved.
Protective effects of a novel herbal decoction on focal cerebral ischemia in a rodent model
Kim, Myung-Gyou,Choi, Jae-Hwan,Lim, Jong-Pil,Kim, Dae-Keun,Shin, Tae-Yong,Boo, Yungmin,Kim, Sun-Yeou,Kim, Hocheol,Ha, Eunyoung,Park, Hun-Kuk,Kim, Jeongseon,Lim, Ha-Sup,Kim, Ee-Hwa,Kim, Jeung-Beum,Leem Informa UK (TaylorFrancis) 2007 Neurological research Vol.29 No.suppl1
감비수 향 흡입이 절식을 유도한 쥐의 시상하부에서 섭식관련 신경전달물질의 발현과 인지력에 미치는 영향
김동현(Dong-Hyun Kim),고일규(Il-Gyu Ko),김성은(Sung-Eun Kim),김지은(Ji-Eun Kim),강연호(Yeon-Ho Kang),김태운(Tae-Woon Kim),지은상(Eun-Sang Ji),김용민(Yong-Min Kim),김이화(Ee-Hwa Kim),김정범(Jeong-Beum Kim),김동희(Dong-Hee Kim),김창주(Cha 대한스트레스학회 2010 스트레스硏究 Vol.18 No.3
본 연구는 절식을 유도한 ICR계 생쥐에서 감비수 향 흡입이 시상하부에서 leptin과 neuropeptide Y (NPY)의 발현에 미치는 영향과 단기 기억력에 미치는 효과를 알아보고자 하였다. ICR 계열 수컷 쥐 24마리를 무작위 추출법에 의해 대조군, 절식군, 절식과 감비수 향 흡입군(각 군 n=8)의 3군으로 분류하였다. 실험결과, 절식은 시상하부에서 leptin의 발현을 감소시켰고 NPY의 발현은 증가시켰다. 또한, 절식에 의하여 단기 기억력과 해마에서의 신경성장인자인 BDNF의 발현이 감소되었다. 반면에, 절식 중 감비수 향을 흡입 시 시상하부에서 leptin의 발현은 증가되었고 NPY의 발현은 감소되었다. 그리고 감비수 향의 흡입에 의하여 단기 기억력이 향상 되었고 해마에서의 신경성장인자인 BDNF의 발현이 증가되었다. 본 실험 결과, 감비수 향 흡입은 절식 시 증가된 음식섭취에 대한 욕구를 억제할 수 있으며 절식에 의하여 감소된 단기 기억력을 향상시키는 효과가 있음을 알 수 있었다. In the present study, we investigated the effects of Gambisu inhalation on the expressions of neurotransmitters implicated in the food intake in the hypothalamus and cognition using starved mice. For this, the effects of Gambisu inhalation on the expressions of leptin and neuropeptide Y (NPY) in the paraventricular nucleus (PVN) of hypothalamus of starved mice were evaluated by immunohistochemistry. Short-term memory of the mice was also assessed using a passive avoidance task and brain-derived neurothrophic factor (BDNF) expression in the hippocampus was determined by Western blot analysis. ICR mice were divided into three groups: control group, starvation group, and starvation with Gambisu inhalation group. The mice in the food-deprivation group were restricted food for 48 h. The mice in the Gambisu inhalation group were exposed to inhale Gambisu for 60 min twice a day for 2 consecutive days. The present results showed that food-deprivation decreased leptin expression and increased NPY expression in the PVN of the hypothalamus. Food-deprivation decreased short-term memory ability and also suppressed BDNF expression in the hippocampus. However, Gambisu inhalation increased leptin expression and decreased NPY expression in the PVN of hypothalamus under the starvation conditions. Gambisu inhalation alleviated starvation-induced short-term memory impairment and enhanced BDNF expression in the hippocampus under the starvation conditions. The present study revealed that Gambisu inhalation might suppress desire for food intake and exert beneficial effect on cognition by enhancing BDNF expression in the hippocampus under the starvation conditions. (Korean J Str Res 2010;18:209∼217)
KIM, Hong,JANG, Mi-Hyeon,SHIN, Min-Chul,CHANG, Hyun-Kyung,LEE, Taeck-Hyun,LIM, Baek-Vin,JUNG, Chang-Young,LEE, Choong-Yeol,KIM, Ee-Hwa,KIM, Chang-Ju WHO COLLABORATING CENTRE FOR TRADITIONAL MEDICINE 2003 東西醫學硏究所 論文集 Vol.2003 No.-
The possibility has been raised that Folium mort is clinically effective for the treatment and prevention of diabetes In the present study, the effects of Folium mori on cell proliferation and expression of neuropeptide Y(NPY) in the dentate gyrus of rats with streptozotocin (STZ)-induced diabetes were investigated by 5-bromo-2'deoxyuridine (BrdU) immunohistochemistry and NPY immunohistochemistry. In rats with STZ-induced diabetes, cell proliferation and NPY expression in the dentate gyrus were suppressed, and treatment with Folium mori was shown to increase new cell formation and NPY expression in the gyrus in both normal rats and those with STZ-induced diabetes. In light of previous studies, this result appears to indicate that increased expression of NPY in the dentate gyrus induced by treatment with Folium mori is associated with the observed effect of Folium mori extract on cell proliferation. Based on the present results, it is suggested that Folium mori treatment may aid in the recovery from the central nervous system complications of diabetes mellitus.
KIM, Ee-Hwa,JANG, Mi-Hyeon,SHIN, Min-Chul,SHIN, Mal-Soon,KIM, Chang-Ju WHO COLLABORATING CENTRE FOR TRADITIONAL MEDICINE 2003 東西醫學硏究所 論文集 Vol.2003 No.-
Ginseng radix, the root of Panax C. A. MEYER (Araliaceae), is one of the best-known Oriental medicinal herbs with numerous therapeutic applications. To investigate whether Ginseng radix possesses a protective effect against 1-methyl-4-phenylpyridine (MPP^(+))-induced cytotoxicity in neuronal cells, 3-(4,5-dimethylthiazol-2yl)-2.5-diphenyltetrazolium bromide (MTT) assay, flow cytometry, DNA fragmentation assay, reverse transcription-polymerase chain reaction (RT-PCR), Western blotting, and caspase-3 enzyme assay were performed on PC12 neuronal cells. Cells treated with MPP^(+) exhibited various apoptotic features, while cell pretreated with Ginseng radix prior to MPP^(+) exposure showed a decrease in the occurrence of apoptotic features. These results suggest that Ginseng radix may exert a protective effect against MPP^(+)-induced apoptosis in PC12 cells.
Kim, Jeung-Beum,Kim, Min-Su,Kim, Ee-Hwa,Kim, Sung-Hoon The Physiological Society of Korean Medicine and T 2005 동의생리병리학회지 Vol.19 No.1
The purpose of this study was to examine the effects of Citrus Reticulata(CR) on the Cell Detachment and Apoptosis in Human Gastric Cancer SNU-668 Cells. The effect of CR on apoptosis was investigated through MTT assay, DAPI staining, and TUNEL assay. We also performed RT-PCR for apoptotic genes including BCL-2, BAX, and caspase-3, the caspase-3 activity assay, and western blotting for pro-CASP-3. Then, to detect that adhesion of cell to ECM was reduced by CR, we investigated mRNA expression of CDH1 and PTK2 using RT-PCR, and their protein expressions using western blotting, and immunocytochemistry in SNU-668 cells. In this study, the results showed that treatment of CR induced time and dose-dependent cell death in SNU-668 cells. Downregulated mRNA expression of BCL-2, and upregulated mRNA expressions of BAX and CASP-3 indicated that the cell death was due to apoptosis. Protein expression of inactivated CASP-3, and caspase-3 activity assay also showed that apoptosis was induced in CR-treated cells.