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      • KCI우수등재

        Growth performance, carcass traits, muscle fiber characteristics and skeletal muscle mRNA abundance in hair lambs supplemented with ferulic acid

        ( Edgar Fernando Peña-torres ),( Candelario Castillo-salas ),( Ismael Jiménez-estrada ),( Adriana Muhlia-almazán ),( Etna Aida Peña-ramos ),( Araceli Pinelli-saavedra ),( Leonel Avendaño-reyes ),( Cin 한국축산학회 2022 한국축산학회지 Vol.64 No.1

        Ferulic acid (FA) is a phytochemical with various bioactive properties. It has recently been proposed that due to its phytogenic action it can be used as an alternative growth promoter additive to synthetic compounds. The objective of the present study was to evaluate the growth performance, carcass traits, fiber characterization and skeletal muscle gene expression on hair-lambs supplemented with two doses of FA. Thirty-two male lambs (n = 8 per treatment) were individually housed during a 32 d feeding trial to evaluate the effect of FA (300 and 600 mg d<sup>-1</sup>) or zilpaterol hydrochloride (ZH; 6 mg d<sup>-1</sup>) on growth performance, and then slaughtered to evaluate the effects on carcass traits, and muscle fibers morphometry from Longissimus thoracis (LT) and mRNA abundance of β2-adrenergic receptor (β<sub>2</sub>-AR), MHC-I, MHC-IIX and IGF-I genes. FA increased final weight and average daily gain with respect to non-supplemented animals (p < 0.05). The ZH supplementation increased LT muscle area, with respect to FA doses and control (p < 0.05). Cross-sectional area (CSA) of oxidative fibers was larger with FA doses and ZH (p < 0.05). Feeding ZH increased mRNA abundance for β<sub>2</sub>-AR compared to FA and control (p < 0.05), and expression of MHC-I was affected by FA doses and ZH (p < 0.05). Overall, FA supplementation of male hair lambs enhanced productive variables due to skeletal muscle hypertrophy caused by MHC-I up-regulation. Results suggest that FA has the potential like a growth promoter in lambs.

      • KCI등재후보

        Bovine Dialyzable Leukocyte Extract Modulates the Nitric Oxide and Pro-Inflammatory Cytokine Production in Lipopolysaccharide-Stimulated Murine Peritoneal Macrophages In Vitro

        Cristina Rodriguez-Padilla,Moises A. Franco-Molina,Edgar Mendoza-Gamboa,Leonardo Castillo-Le?,Reyes S. Tamez-Guerra,Cristina Rodriguez-Padilla 한국식품영양과학회 2005 Journal of medicinal food Vol.8 No.1

        Lipopolysaccharides (LPS) released from Gram-negative bacteria after infection initiate an exagerated responsethat leads to a cascade of pathophysiological events termed sepsis. Monocytes or macrophages produce many of the media-tors found in septic patients. Targeting of these mediators, especially tumor necrosis factor (TNF)-. and nitric oxide (NO),has been pursued as a mean of reducing mortality in sepsis. Bovine dialyzable leukocyte extract (bDLE) is a dialysate of aheterogeneous mixture of low-molecular-weight substances released from disintegrated leukocytes of the blood or tissue lym-phoid. In this study, to determine whether bDLE modulates NO and pro-inflammatory cytokine production, murine peritonealmacrophages were treated with bDLE (0.05 or 0.5 U/mL) before LPS (20 mg/mL) stimulation, and also LPS-stimulated murineperitoneal macrophages were treated with bDLE (0.05 or 0.5 U/mL) at 0, 4, 8, 12, and 24 hours. The bDLE significantly de-creased NO production, and also decreased TNF-. and interleukin (IL)-6 but increased IL-10 production in LPS-stimulatedmurine peritoneal macrophages. Our results demonstrate that bDLE plays an important role in modulating TNF-., IL-6, andNO production through IL-10, and this may offer therapeutic potential in clinical endotoxic shock.

      • KCI등재

        The thickness of BaTiO3 tape castings as function of the slip system

        Román Nava,Sophie Guillemet-Fritsch,Juan Aguilar-Garib,Edgar Reyes,Bernard Durand 한양대학교 세라믹연구소 2012 Journal of Ceramic Processing Research Vol.13 No.2

        One of the most popular techniques in the fabrication of multilayer ceramic capacitor (MLCC) is tape casting, which requires the preparation of a slip that could be either solvent or water-based. A requirement of MLCC miniaturization has pushed improvement of this technique up to the point of fabricating ceramic films below 10μm. However, less information on a direct comparison of aqueous and non-aqueous slips systems using BaTiO3 for dielectric tapes below 3.5 μm is available in the literature. Therefore, solvent and water-based systems were studied in this research aimed to weight the different factors on the thickness reduction; in particular the relation between slip viscosity and ceramic tape thickness was established for both slips formulations. It was found that viscosity below 100 mPa·s is a not a general rule since there is an important influence of the solvent medium; nevertheless adhesion tape-substrate plays an important role over the thinning of water-based formulations. The slip viscosity is defined by the dispersant type of aqueous systems and the binder of non aqueous systems, while reduction of the powder size is more sensitive to the solvent medium as for polar/non –polar mixtures. Ceramic tape homogeneity is strongly affected by the presence of hard aggregation and should be accounted for with the use of nanoparticles. A condition was also demonstrated where low viscosities and thinner layers are related.

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