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Cristina Rodriguez-Padilla,Moises A. Franco-Molina,Edgar Mendoza-Gamboa,Leonardo Castillo-Le?,Reyes S. Tamez-Guerra,Cristina Rodriguez-Padilla 한국식품영양과학회 2005 Journal of medicinal food Vol.8 No.1
Lipopolysaccharides (LPS) released from Gram-negative bacteria after infection initiate an exagerated responsethat leads to a cascade of pathophysiological events termed sepsis. Monocytes or macrophages produce many of the media-tors found in septic patients. Targeting of these mediators, especially tumor necrosis factor (TNF)-. and nitric oxide (NO),has been pursued as a mean of reducing mortality in sepsis. Bovine dialyzable leukocyte extract (bDLE) is a dialysate of aheterogeneous mixture of low-molecular-weight substances released from disintegrated leukocytes of the blood or tissue lym-phoid. In this study, to determine whether bDLE modulates NO and pro-inflammatory cytokine production, murine peritonealmacrophages were treated with bDLE (0.05 or 0.5 U/mL) before LPS (20 mg/mL) stimulation, and also LPS-stimulated murineperitoneal macrophages were treated with bDLE (0.05 or 0.5 U/mL) at 0, 4, 8, 12, and 24 hours. The bDLE significantly de-creased NO production, and also decreased TNF-. and interleukin (IL)-6 but increased IL-10 production in LPS-stimulatedmurine peritoneal macrophages. Our results demonstrate that bDLE plays an important role in modulating TNF-., IL-6, andNO production through IL-10, and this may offer therapeutic potential in clinical endotoxic shock.