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Yasemin Sahan,Emine Aydin,Ayse Inkaya Dundar,Dilek Dulger Altiner,Guler Celik,Duygu Gocmen 한국식품과학회 2019 Food Science and Biotechnology Vol.28 No.5
In presented study total phenolic contents, antioxidant capacities and their bioaccessibilities from cookies supplemented with oleaster flour were investigated. Oleaster flours (OFs) were produced using two different methods (peeled oleaster flour: POF and unpeeled oleaster flour: UPOF) from two different genotypes. OFs were used to replace wheat flour in the cookie formulation (control) at the levels of 5, 10, 15, 20 and 25% (w/w). According to the results, enrichment of OFs clearly increased total phenolic contents, antioxidant capacities and bioaccessibilities of cookies. The highest bioaccessible antioxidant capacities (ABTS, CUPRAC, and FRAP) of the samples were obtained from cookie samples enriched with 25% UPOF-1. In conclusion, the increases in phenolic contents, antioxidant capacities, and bioaccessibilities from cookies supplemented with OFs suggest the potential enhancement of beneficial health effect of cookie due to increased content of bioactive compounds present in oleaster flour.
G. Sener,O. Sacan,R. Yanardaca,G. Ayanoallu-Dulger 한국식품영양과학회 2002 Journal of medicinal food Vol.5 No.1
In diabetes mellitus, increased free radical formation raises the incidence of atherosclerosisand cardiovascular diseases. Regardless of the type of diabetes, the objective of the therapyis to achieve normoglycemia and to prevent or delay the complications. Chard (Beta vulgarisL. var. cicla) is used as a hypoglycemic agent by diabetic patients in Turkey. The aim of thisstudy was to investigate the effect of feeding chard on diabetes-induced free radical medi-ated injury in rat aorta and heart tissues. Female Swiss albino rats were randomly dividedinto four groups: control, diabetic, chard, and diabetic 1 chard. Rats were subjected to in-traperitoneal streptozotocin (STZ, 65 mg/kg) to induce diabetes. Chard extract (2 g/kg) wasgiven for 28 days beginning on the 14th day of the study. Aorta and heart tissue lipid perox-idation and glutathione levels as well as blood glucose levels were determined. The resultsof the present study indicate that lipid peroxidation was increased and glutathione levelswere decreased in both aorta and heart tissue of the diabetic rats. However, treatment withchard extract reversed the effects of diabetes on blood glucose and tissue lipid peroxidationand glutathione levels.37
Multicenter Epidemiologic Study on Hepatocellular Carcinoma in Turkey
Can, Alper,Dogan, Erkan,Bayoglu, Ibrahim Vedat,Tatli, Ali Murat,Besiroglu, Mehmet,Kocer, Murat,Dulger, Ahmet Cumhur,Uyeturk, Ummugul,Kivrak, Derya,Orakci, Zuat,Bal, Oznur,Kacan, Turgut,Olmez, Sehmus,T Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.6
Background: Hepatocellular cancer (HCC) is one of the important health problems in Turkey, being very common and highly lethal. The aim of this study was to determine clinical, demographic features and risk factors. Materials and Methods: Nine hundred and sixth-three patients with HCC from 13 cities in Turkey were included in this study. Results: Only 205 (21%) of the 963 patients were women, with a male:female predominance of 4.8:1 and a median age of 61 years. The etiologic risk factors for HCC were hepatitis B in 555 patients (57.6%), 453 (81%) in men, and 102 (19%) in women, again with male predominance, hepatitis C in 159 (16.5%), (14.9% and 22.4%, with a higher incidence in women), and chronic alcohol abuse (more than ten years) in 137 (14.2%) (16.8% and 4.9%, higher in males). The Child-Pugh score paralleled with advanced disease stage amd also a high level of AFP. Conclusions: According to our findings the viral etiology (hepatitis B and hepatitis C infections) in the Turkish population was the most important factor in HCC development, with alcohol abuse as the third risk factor. The Child-Pugh classification and AFP levels were determined to be important prognostic factors in HCC patients.
Effect of Maternal Depression on Brain-derived Neurotrophic Factor Levels in Fetal Cord Blood
Erdem Onder Sonmez,Faruk Uguz,Mine Sahingoz,Gulsum Sonmez,Nazmiye Kaya,Mehmet Akif Camkurt,Zeynel Gokmen,Mustafa Basaran,Kazim Gezginc,Sami Sait Erdem,Hasan Haluk Dulger,Erkan Tasyurek 대한정신약물학회 2019 CLINICAL PSYCHOPHARMACOLOGY AND NEUROSCIENCE Vol.17 No.2
Objective: We aimed to assess the association between cord blood brain-derived neurotrophic factor (BDNF) concentration and maternal depression during pregnancy. Methods: A total of 48 pregnant women, admitted for elective caesarean section to Department of Obstetrics and Gynecology, The Konya Research and Training Hospital and Konya Necmettin Erbakan University Meram Medical Faculty, were included in this study. The study group included 23 women diagnosed as having depression during pregnancy and the control group included 25 pregnant women who did not experience depression during pregnancy. Results: The groups had similar sociodemographic characteristics. Cord blood BDNF concentration was significantly lower in babies born to mothers with major depression as compared with those in the control group. We didn’t find any correlation between the umbilical cord blood BDNF levels and BDI scores. Conclusion: The results suggest that the existence of major depression in pregnant women may negatively affect fetal circulating BDNF levels.