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G. Sener,O. Sacan,R. Yanardaca,G. Ayanoallu-Dulger 한국식품영양과학회 2002 Journal of medicinal food Vol.5 No.1
In diabetes mellitus, increased free radical formation raises the incidence of atherosclerosisand cardiovascular diseases. Regardless of the type of diabetes, the objective of the therapyis to achieve normoglycemia and to prevent or delay the complications. Chard (Beta vulgarisL. var. cicla) is used as a hypoglycemic agent by diabetic patients in Turkey. The aim of thisstudy was to investigate the effect of feeding chard on diabetes-induced free radical medi-ated injury in rat aorta and heart tissues. Female Swiss albino rats were randomly dividedinto four groups: control, diabetic, chard, and diabetic 1 chard. Rats were subjected to in-traperitoneal streptozotocin (STZ, 65 mg/kg) to induce diabetes. Chard extract (2 g/kg) wasgiven for 28 days beginning on the 14th day of the study. Aorta and heart tissue lipid perox-idation and glutathione levels as well as blood glucose levels were determined. The resultsof the present study indicate that lipid peroxidation was increased and glutathione levelswere decreased in both aorta and heart tissue of the diabetic rats. However, treatment withchard extract reversed the effects of diabetes on blood glucose and tissue lipid peroxidationand glutathione levels.37