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Lee, Dug Keun,Choi, Kyoung Baek,Oh, In Suk,Song, Sun U.,Hwang, Sally,Lim, Chae-Lyul,Hyun, Jong-Pil,Lee, Hyeon-Youl,Chi, Guang Fan,Yi, Youngsuk,Yip, Vivian,Kim, Jeannie,Lee, Eun Byul,Noh, Moon Jong,Lee Mary Ann Liebert 2005 Tissue engineering Vol.11 No.1
<P>One of the most important factors in the production of cartilage is transforming growth factor beta1 (TGF-beta1). To obtain sustained release of TGF-beta1, a cell-mediated gene therapy technique was introduced. We infected chondrocytes with a retroviral vector carrying the TGF-beta1 gene. The single clone derivative showed sustained TGF-beta1 secretion. It also showed constitutive type II collagen expression. Whereas the TGF-beta1 protein itself is unable to induce formation of cartilage in vivo, human chondrocytes engineered to express a retroviral vector encoding TGF-beta1 showed cartilage formation in vivo when cells were injected into nude mice intradermally. These data suggest that cell-mediated gene therapy using TGF-beta1 as a transgene would be a promising treatment for osteoarthritis.</P>
Antiplatelet Action of Ilexoside D, a Triterpenoid Saponin from Ilex pubescens
Lee, Dug-Keun,Lee, Hye-Sun,Huh, Min-Do,Lee, Chul-Hoon,Lee, Young-Su,Kim, Hyun-Su,Han, Yong-Nam The Pharmaceutical Society of Korea 1991 Archives of Pharmacal Research Vol.14 No.4
The anti-platelet activity of ilexoside D isolated from the roots of Ilex pubescens Hook. et Arn. was investigated in in vitro and ex vivo models of platelet aggregation induced by ADP, thrombin or collagen in rats. In vitro ilexoside D inhibited more effectively platelet aggregation induced by ADP and thrombin than by collagen as compared with aspirin. Ex vivo ilexoside D also inhibited platelet aggregation induced by ADP and collagen, but not by thrombin, and the inhibitory action of ilexoside D was more effective than that of aspirin. However, in vitro ilexoside D inhibited very poorly the generation of malonyldialdehyde, which is known to be concomitantly released with thromboxane $A_2$ during platelet aggregation. These results suggest that the anti-platelet activity of ilexoside D may not be responsible for prostaglandin synthesis in platelets.
Quantitative Assay for the Binding of Jun-Fos Dimer and Activator Protein-1 Site
Lee, Sang-Kyou,Park, Se-Yeon,Jun, Gyo,Hahm, Eun-Ryeong,Lee, Dug-Keun,Yang, Chul-Hak Korean Society for Biochemistry and Molecular Biol 1999 Journal of biochemistry and molecular biology Vol.32 No.6
The Jun and Fos families of eukaryotic transcription factors form heterodimers capable of binding to their cognate DNA enhancer elements. We are interested in searching for inhibitors or antagonists of the binding of the Jun-Fos heterodimer to the activator protein-1 (AP-1) site. The basic-region leucine zipper (bZIP) domain of c-Fos was expressed as a fusion protein with glutathione S-transferase, and allowed to form a heterodimer with the bZIP domain of c-Jun. The heterodimer was bound to glutathione-agarose, to which were added radiolabeled AP-1 nucleotides. After thorough washing, the gel-bound radioactivity was counted. The assay is faster than the coventional electrophoretic mobility shift assay because the gel electrophoresis step and the autoradiography step are eliminated. Moreover, the assay is very sensitive, allowing the detection of picomolar quantities of nucleotides, and is not affected by up to 50% dimethylsulfoxide, a solvent for hydrophobic inhibitors. Curcumin and dihydroguaiaretic acid, recently known inhibitors of Jun-Fos-DNA complex formation, were applied to this Jun-GST-fused Fos system and revealed to decrease the dimer-DNA binding.
세계적 재난 발생에 따른 국제방재전략 및 표준지원체계 조사 연구
박덕근(Dug keun Park),오정림(Jeong rim Oh),송영갑(Young karb Song),이민석(Min seok Lee) 한국방재안전학회 2009 한국방재안전학회 논문집 Vol.2 No.3
The magnitude and frequency of international disaster recovery aids and supports by the United Nations and other donor countries to least developed countries are increasing due to the emerging risks such as super typhoons and consequently worsened impacts by those disasters. With emergency recovery aids, systems for disaster mitigation and preparedness are also needed to the countries hit by disasters. Through the KOICA programs, the Korean government is trying to establish an effective disaster support system for disaster-hit countries. This study reviews current post-disaster aid systems of various countries and international organizations and proposes improved disaster aid system for the Korean government. The improved system can be used in the assistance of effective and enlarged international recovery activities promoting Korean government's status in the international disaster management society. 기후변화 등에 따른 세계 재해의 발생빈도 및 규모가 증가함에 따라 UN 등 국제사회에서는 피해지역에 대한 재해복구 지원과 원조를 확대해 나가고 있다. 또한 저개발국가의 재해경감을 위한 다양한 지원프로그램을 추진하고 있어, 우리나라에서도 KOICA 프로그램의 활성화 및 체계적인 국제지원체계구축의 필요성이 대두되고 있다. 본 연구는 국제적 재해에 대한 UN 국제기구, 선진국가의 체계를 분석하여 우리 나라가 효과적으로 지원할 수 있는 체계를 제안함으로써 국제사회의 재해경감 노력에 참여하고 국제사회에서의 국가위상을 제고하고자 하였다.
압축블록의 압축률 분포를 고려해 설계한 내장캐시 및 주 메모리 압축시스템
임근수(Keun Soo Yim),이장수(Jang-Soo Lee),홍인표(Inpyo Hong),김지홍(Jihong Kim),김신덕(Shin-Dug Kim),이용석(Yong Surk Lee),고 건(Kern Koh) 한국정보과학회 2004 정보과학회논문지 : 시스템 및 이론 Vol.31 No.1·2
최근에 프로세서-메모리간 성능격차 문제를 완화하기 위하여 내장캐시의 접근실패율을 낮추고 메모리 대역폭을 확장하는 내장캐시 압축시스템이 제안되었다. 내장캐시 압축시스템은 데이타를 압축해 저장함으로써 내장캐시의 실질적 저장공간을 확장하고, 메모리 버스에서 데이타를 압축해 전송함으로써 실질적 메모리 대역폭을 확장한다. 본 논문에서는 이와 같은 내장캐시 압축시스템을 확장해 기존의 주 메모리 압축시스템과 병합해 설계한 이종 메모리 압축시스템을 제안한다. 주 메모리의 기억공간을 효율적으로 확장하고, 내장캐시의 접근실패율을 낮추고, 메모리 대역폭을 확장하고, 압축캐시의 복원시간을 줄이고, 설계 복잡도를 낮추기 위하여 몇 가지 새로운 기법들을 제시한다. 제안하는 시스템과 비교대상 시스템의 성능은 슈퍼스칼라 구조의 마이크로프로세서 시뮬레이터를 수정하여 실행기반 시뮬레이션을 통해 검증한다. 본 논문에서 사용한 실험방법은 기존의 트레이스기반 시뮬레이션과 비교해 보다 높은 정확도를 갖는다. 실험결과 주 메모리 확장에 따른 이득을 고려하지 않은 경우에 제안하는 시스템은 일반 메모리시스템에 비하여 수행시간을 내장캐시의 크기에 따라 최대 4-23%가량 단축한다. 제안하는 시스템의 데이타 메모리와 코드메모리의 확장비율은 각각 57-120%와 27-36%이다. Recently, an on-chip compressed cache system was presented to alleviate the processor-memory performance gap by reducing on-chip cache miss rate and expanding memory bandwidth. This research presents an extended on-chip compressed cache system which also significantly expands main memory capacity. Several techniques are attempted to expand main memory capacity, on-chip cache capacity, and memory bandwidth as well as reduce decompression time and metadata size. To evaluate the performance of our proposed system over existing systems, we use execution-driven simulation method by modifying a superscalar microprocessor simulator. Our experimental methodology has higher accuracy than previous trace-driven simulation method. The simulation results show that our proposed system reduces execution time by 4-23% compared with conventional memory system without considering the benefits obtained from main memory expansion. The expansion rates of data and code areas of main memory are 57-120% and 27-36%, respectively.
이향이(Lee Hyang ee),박덕근(Park Dug keun) 한국방재학회 2017 한국방재학회논문집 Vol.17 No.2
본 연구는 부처별로 분산 관리되고 있는 안전기준을 체계적으로 관리ㆍ운용하기 위한 통합 관리 체계의 방안으로 안전기준 메타데이터 요소의 설계를 제안한다. 이를 위해 대표적인 기술적 메타데이터인 더블린코어와 법령 및 안전기준 관련 선행연구를 분석하여 안전기준 메타데이터 요소를 선정하였다. 또한 국민안전처의 안전기준 관리대장 항목과 안전기준 및 메타데이터 설계 관련 전문가와의 면담 결과를 추가하여 실무적인 측면을 반영하였다. 분석 결과 식별영역, 법령영역, 내용영역, 이용영역의 네 가지 영역을 중심으로 총 27개의 메타데이터 요소들을 제안하였다. 선정된 메타데이터 요소는 앞으로 안전기준 통합관리시스템의 구축에 도움이 될 것으로 기대한다. This study suggests an optimal design of the metadata elements for safety standards, which are currently managed by various ministries dispersively. For a system that enables consolidated and systematic management of safety standards operations, the metadata elements of safety standards are designed based not only on the Dublin Core, which is representative descriptive metadata, but also on previous studies for safety standards regulations. Followed by the interview with specialists of safety standards and metadata design, the practical side of the safety standards management ledger from the Ministry of Public Safety and Security (MPSS) is also reviewed. Twenty seven metadata elements are allocated into four representative areas: Identity Area, Law Area, Content Area, and Use Area. These elements are expected to be utilized as a foundation for developing a consolidated and integrated management system for safety standards.
신규 퀴놀론 항균제 DW-116 의 in vitro 및 in vovp 항균활성
이진(Jin Lee),정용호(Yong Ho Chung),윤성준(Sung June Yoon),이덕근(Dug Keun Lee),황연하(Yun Ha Hwang),한경오(Kyung Oh Han),양희복(Hee Bog Yang) 한국응용약물학회 1997 Biomolecules & Therapeutics(구 응용약물학회지) Vol.5 No.2
The in vitro and in vivo antibacterial activity of DW-116, a newly synthesized fluoroquinolone, were compared with those of other quinolones. DW-116 exhibited more potent antibacterial activity than rufloxacin and lower activity than ofloxacin and ciprofloxacin in in vitro assay. But, DW-116 particularly showed strong activity against the family of staphylococci including methicillin-sensitive staphylococcus and its activity was more active than that of ciprofloxacin. The time-kill curve studies showed rapid bactericidal activity for DW-116. The post-antibiotic effect of DW-116 was observed between 0.66 and 5 hours. The therapeutic efficacy of DW-116 against respiratory infection with P. aeruginosa was as strong as that of ciprofloxacin and its effect against urinary tract infection with E. coli was more effective than rufloxacin. The excellent therapeutic efficacy of DW-116 against these local infections is due to its good pharmacokinetic profiles.
Synthesis and Cytotoxic Activity of 1-(1-Benzoylindoline-5-sulfonyl)-4-phenylimidazolidinones
정상헌,Hui-Soon Lee,Nam-Soo Kim,Hwan-Mook Kim,Moonsun Lee,최동락,Jung-Ah Lee,Yong-Ho Chung,문은이,황현숙,성승규,Dug-Keun Lee 대한약학회 2004 Archives of Pharmacal Research Vol.27 No.5
The novel 1-(1-benzoylindoline-5-sulfonyl)-4-phenyl-4,5-dihydroimidazolones 2 shows highly potent and broad cytotoxicities. Their cytotoxicities against human lung carcinoma A549, human chronic myelogenous leukemia K562, and human ovarian adenocarcinoma SK-OV-3 are compatible with doxorubicin. Compound 2p (1-[(4-aminobenzoyl)indoline-5-sulfonyl])-4- phenyl-4,5-dihydroimidazolone) exhibits a cytotoxicity that is far more potent than doxorubicin and also exhibits highly effective antitumour activities against murine (3LL, Colon 26) and human xenograft (NCI-H23, SW620) tumor models.