Shakespeare, Nicole Kidman and Contemporary Translation Theory

Dror ABEND-DAVID 한국통역번역학회 2012 FORUM Vol.10 No.2

Three “DS” - Elements for Successful Weight Loss Outcomes: Role of Healthcare Professionals

( Dror Dicker ),( Assim A Alfadda ),( Pernille Auerbach ),( Ian D Caterson ),( Ada Cuevas ),( Jason Halford ),( Masato Iwabu ),( Jae-Heon Kang ),( Rita Nawar ),( Ricardo Arturo Reynoso Mendoza ),( Nic 대한간학회 2020 춘·추계 학술대회 (KASL) Vol.2020 No.1

Aims: In people with obesity (PwO), body weight loss of ≥5% is generally considered to be clinically meaningful. Some PwO do receive treatment and guidance from healthcare professionals (HCPs), but there remains a substantial unmet medical outcomes and weight maintenance need. To identify aspects that might contribute to a successful weight loss outcome (WLO; ≥5% body weight loss maintained for ≥1 year), we investigated the characteristics and experience of PwO with and without successful WLOs using data from the ACTION-IO study (NCT03584191). Methods: An online survey was completed by adults with obesity and HCPs in 11 countries: Australia, Chile, Israel, Italy, Japan, Mexico, Saudi Arabia, South Korea, Spain, UAE and UK. A successful WLO was defined as ≥5% body weight loss in the past 3 years maintained for ≥1 year. Results: A total of 14,502 PwO completed the survey. General characteristics were similar between those who had a successful WLO (n=1,559; 11%) vs those who had not (n=12,943; 89%): 53% vs 52% were male; the mean age was 49 vs 48 years; the mean number of comorbidities was 2.0 vs 1.8. The mean number of serious weight loss attempts was 4 for both groups. However, more PwO who had a successful WLO weighed themselves every day (20%) compared with those who had not had a successful WLO (10%). In terms of interactions with HCPs, more PwO who had a successful WLO had discussed weight (58%) with an HCP within the past 5 years than those who did not have a successful WLO (53%). In addition, more PwO who had a successful WLO compared with those who did not had been diagnosed with obesity (42% vs 35%) and had subsequent direction through the scheduling of a follow-up appointment (25% vs 21%). Conclusions: A 3D approach from HCPs (diagnosis, discussion and direction) appears to be a key element in facilitating a successful WLO. Neither gender, nor age, nor number of weight loss attempts was associated with a successful WLO.

Model and Analysis of Piezoelectric Actuator in Practical Three-Stage Mechanism

Dror A. Levy,Amir Shapiro 한국정밀공학회 2020 International Journal of Precision Engineering and Vol.21 No.9

Piezoelectric elements (PEMs) are used in a variety of applications. In this paper we developed a full analytical model of a piezoelectric actuator which includes piezo stack elements and a three-stage amplification mechanism. The model was derived separately for each unit of the system. Next, the units were combined, while taking into account their coupling. The hysteresis phenomenon, which is significant in piezoelectric materials, was extensively described. A number of hysteresis calculating algorithms were investigated and a new simple method of examining piezoelectric hysteresis was demonstrated. The theoretical model was verified in a laboratory setup. This setup includes a piezoelectric actuator, measuring devices and an acquisition system. The measured results were compared to the theoretical results, while taking into account the nonlinear phenomena of the piezoelectric materials and the three-stage amplification mechanism, and were found to be very similar. Due to its simplicity, this model can easily be modified in order to be applied to other PEMs or other amplification mechanism methods. The main novelty of this work lies in its system-level approach for piezoelectric actuators. All of the system elements include non-linear phenomena, which mutually influence each other. First, each part of the system will be described separately and then, the combined subsystems and the coupling between their parts will be represented. Finally we treat this system as one whole unit.

기고논문 ; 정책학박사학위과정 설치를 위한 시안

Yehezkel Dror 서울대학교 한국행정연구소 1969 行政論叢 Vol.7 No.2

The localization and photosensitization of modified chlorin photosensitizers in artificial membranes

Ben Dror, Shimshon,Bronshtein, Irena,Garini, Yuval,O'Neal, William G.,Jacobi, Peter A.,Ehrenberg, Benjamin Korean Society of Photoscience 2009 Photochemical & photobiological sciences Vol.8 No.3

In this work we investigate the localization and photophysical properties of twelve synthetically derived chlorins in artificial membranes, with the goal of designing more effective photosensitizers for photodynamic therapy (PDT). The studied chlorins incorporate substituents of varying lipophilicity at the $C_5$-meso-position (H to $C_5H_{11}$), while the $C_{13}$- and $C_{17}$-positions have carboxylate "anchoring" groups tethered to the tetrapyrrole by alkyl chains $(CH_2)_n$ (n = 1-3). It was found that as n increases, the chromophoric part of the molecule, and thus the point of generation of singlet oxygen, is located at a deeper position in the bilayer. The vertical insertion of the sensitizers was assessed by two fluorescence-quenching techniques: by iodide ions that come from the aqueous phase and by spin-probe-labeled phospholipids that are incorporated into the bilayer, using the parallax method. These results demonstrate that elongation of the side chains endows the modified molecules with a larger affinity for artificial membranes and also causes the tetrapyrrole ring to be localized deeper in the lipid membrane. This location leads to a higher effective quantum yield for the chemical reaction of singlet oxygen with its chemical target 9,10-dimethylanthracene (DMA).

악조건하의 핵심적 정책결정

( Yehezkel Dror ) 서울대학교 행정대학원 1986 Journal of Policy Studies Vol.1 No.-

Louis Zukofsky and The West Wing : Metaphors of Mentorship, Yiddish, and Translation at Street Level

Dr. Dror ABEND-DAVID 한국통역번역학회 2010 FORUM Vol.8 No.1

Innovative, DPN‑Based Method for Analyzing the Early Stages of Mg Corrosion Under Natural Conditions

Moshe Zohar,Dror Shamir,Guy Ben‑Hamu,Ariela Burg 대한금속·재료학회 2020 METALS AND MATERIALS International Vol.26 No.11

Mg and its alloys are highly prone to corrosion, which is an important consideration in many industries and applications. However, most available methods for studying the buildup of Mg corrosion layers as a function of time—an indirect measureof corrosion rate—are not sufficiently sensitive to monitor the early stages of the process. In this letter, a simple and innovativemethod is reported for monitoring changes in Mg corrosion layer thickness in various solutions, under close-to-naturalconditions and starting from the first minutes of the process. Dip-pen nanolithography (DPN) was first used to patternpoly(methyl methacrylate) (PMMA) reference lines on the surface of the Mg alloy AE53, so as to indicate the initial conditions. Then, AFM was used—for the first time to the best of our knowledge—to measure the thickness of corrosion layersforming on three adjacent 100 μm × 100 μm surface areas at several time points (5–30 min) after immersion in solution. Testsolutions included either saline or phosphate-buffered saline (PBS), in each case either with or without the addition of Fentonreagents, which are known to accelerate corrosion and are highly relevant for biological implants that employ Mg alloys asdegradable substrates. In all tested solutions, the buildup of corrosion layers showed the expected dynamics—namely, anincrease followed by a decrease and again an increase in layer thickness; however, the layers were considerably thicker inPBS than in saline, and in solutions with Fenton reagents than in those without them. These results demonstrate the uniqueadvantage of the AFM instrument, as compared with other methods (such as SEM and potentiodynamic polarization), formeasuring corrosion buildup, as the layer growth process can be accurately measured under natural conditions, in the presenceof solutions, and from its very early stages.

The Effect of Schroth Therapy on Thoracic Kyphotic Curve and Quality of Life in Scheuermann’s Patients: A Randomized Controlled Trial

Tomer Bezalel,Eli Carmeli,Dror Levi,Leonid Kalichman 대한척추외과학회 2019 Asian Spine Journal Vol.13 No.3

Study Design: Randomized controlled single-blinded clinical trial. Purpose: To evaluate the efficacy of Schroth therapy on thoracic curve angle, pain, and self-perceived body image (SPBI) of the back in Scheuermann’s patients in comparison with the efficacy of classic anti-gravitation exercises. Overview of Literature: Scheuermann disease is the most common cause of hyperkyphosis of the thoracic and thoracolumbar spine during adolescence. However, very few studies evaluated the effect of exercises on the progression of kyphosis in Scheuermann patients. Schroth three-dimensional exercise therapy was found in several studies to be effective in the treatment of adolescent scoliosis; however, we found no randomized controlled trials that evaluated the efficacy of this method in Scheuermann patients. Methods: A total of 50 young adults (males and females) with Scheuermann’s disease were randomly divided into either the experimental group (Schroth therapy treatment, n=25) or the control group (classic anti-gravitation exercises, n=25). Participants in both the groups were provided a course of individual treatment sessions during few weeks, with one appointment per week. They were required to perform the exercises daily throughout the study period (12 months) and fill their performance in a research log. We evaluated the thoracic Cobb angle (main outcome measure), pain, SPBI, flexion of the shoulder (supine), flexion of the shoulder (standing), kyphotic deformity measured using inclinometer, and L5 kyphosis apex line (L5-KAL) as well as administered the Scoliosis Research Society-22 Questionnaire for the participants before the treatment, after 6 months, and 1 year postoperatively. These results were then compared. Results: In the mixed analysis of variance, the main effect of time was significant in the thoracic kyphosis (F [1]=5.72, p=0.02), and in the L5-KAL (F [1]=5.76, p=0.02). The main effect of time on the kyphotic deformity, measured using an inclinometer, did not reach the significance level; however, it showed the tendency (F [1]=2.80, p=0.07). In the group-by-time interaction, a significant difference was found in the thoracic kyphosis (F [1]=4.91, p=0.03) and in the kyphotic deformity, measured using an inclinometer (F [1]=4.05, p=0.02). Thus, the Schroth therapy group showed significantly greater improvement than the classic anti-gravitation exercises group. Conclusions: The present findings indicate that back exercises in general, and Schroth therapy in particular, is an effective treatment for preventing and significantly improving the thoracic Cobb angle and symptomatic representation in Scheuermann’s patients.

A New Concept in Antidiabetic Therapeutics: A Concerted Removal of Labile Iron and Intracellular Deposition of Zinc

Vladimir Vinokur,Eduard Berenshtein,Mordechai Chevion,Dror Chevion 대한당뇨병학회 2024 Diabetes and Metabolism Journal Vol.48 No.1

Background: The inflammatory process is known to be an integral part of the pathophysiology of type 2 diabetes mellitus (T2DM). The “labile,” redox-active iron, serving as a catalyst in Fenton reaction, producing the deleterious reactive oxygen species, triggering and maintaining inflammation, is hypothesized to play a causative role in this process. Concenter Biopharma continued the development of a new platform of iron chelators (Zygosids), first initiated at the Hebrew University of Jerusalem, Israel (HUJI), acting via the novel mechanism, based on a sequestration of the labile redox-active iron and its substitution by zinc or gallium. The mode of action of Zygosids is based on the higher affinity of the metal-binding moiety of the complex to Fe³⁺ in comparison to already bound ion, leading to rapid release of the ion of another metal and chelation of Fe³⁺. Concomitantly, zinc ion, released by the complex, is known for its antidiabetic and anti-inflammatory role.Methods: The therapeutic effect of zinc-desferrioxamine (Zygosid-50) and gallium-desferrioxamine, was tested on fat sand rat (<i>Psammomys obesus</i>) model of diet-induced T2DM and on Lepr^db transgenic diabetic mice.Results: Zygosids demonstrated an ability to noticeably reduce blood glucose and insulin levels and improve the lipid profile. Moreover, an ability to mitigate insulin resistance by >90% was shown on the sand rat model. In addition, a potent anti-inflammatory effect, expressed as a diminishment of the proinflammatory cytokines in tissue levels, was demonstrated.Conclusion: Zygosids demonstrated robust therapeutic efficacy in treatment of T2DM. Importantly, no adverse effects were detected, in all the experiments, indicating high safety profile.