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Hunter, Randy L.,Dragicevic, Natasa,Seifert, Kristen,Choi, Dong Young,Liu, Mei,Kim, Hyoung‐,Chun,Cass, Wayne A.,Sullivan, Patrick G.,Bing, Guoying Blackwell Publishing Ltd 2007 Journal of Neurochemistry Vol.100 No.5
<P><B>Abstract</B></P><P>Evidence suggests that chronic inflammation, mitochondrial dysfunction, and oxidative stress play significant and perhaps synergistic roles in Parkinson’s disease (PD), where the primary pathology is significant loss of the dopaminergic neurons in the substantia nigra. The use of anti‐inflammatory drugs for PD treatment has been proposed, and inhibition of cyclo‐oxygenase‐2 (COX‐2) or activation of peroxisome proliferator‐activated receptor gamma (PPAR‐γ) yields neuroprotection in MPTP‐induced PD. Lipopolysaccharide (LPS) induces inflammation‐driven dopaminergic neurodegeneration. We tested the hypothesis that celecoxib (Celebrex, COX‐2 inhibitor) or pioglitazone (Actos, PPAR‐γ agonist) will reduce the LPS‐induced inflammatory response, spare mitochondrial bioenergetics, and improve nigral dopaminergic neuronal survival. Rats were treated with vehicle, celecoxib, or pioglitazone and were intrastriatally injected with LPS. Inflammation, mitochondrial dysfunction, oxidative stress, decreased dopamine, and nigral dopaminergic neuronal loss were observed post‐LPS. Celecoxib and pioglitazone provided neuroprotective properties by decreasing inflammation and restoring mitochondrial function. Pioglitazone also attenuated oxidative stress and partially restored striatal dopamine as well as demonstrated dopaminergic neuroprotection and reduced nigral microglial activation. In summary, intrastriatal LPS served as a model for inflammation‐induced dopaminergic neurodegeneration, anti‐inflammatory drugs provided protective properties, and pioglitazone or celecoxib may have therapeutic potential for the treatment of neuro‐inflammation and PD.</P>
Khachatryan, V.,Sirunyan, A. M.,Tumasyan, A.,Adam, W.,Bergauer, T.,Dragicevic, M.,Erö,, J.,Friedl, M.,Frü,hwirth, R.,Ghete, V. M.,Hartl, C.,Hö,rmann, N.,Hrubec, J.,Jeitler, M.,Kiesenhofer, Springer Berlin Heidelberg 2015 European Physical Journal C Vol.75 No.4
<P>A search has been performed for long-lived particles that could have come to rest within the CMS detector, using the time intervals between LHC beam crossings. The existence of such particles could be deduced from observation of their decays via energy deposits in the CMS calorimeter appearing at times that are well separated from any proton–proton collisions. Using a data set corresponding to an integrated luminosity of 18.6[FORMULA OMISSION] of 8[FORMULA OMISSION] proton–proton collisions, and a search interval corresponding to 281 h of trigger livetime, 10 events are observed, with a background prediction of [FORMULA OMISSION] events. Limits are presented at 95 % confidence level on gluino and top squark production, for over 13 orders of magnitude in the mean proper lifetime of the stopped particle. Assuming a cloud model of R-hadron interactions, a gluino with mass [FORMULA OMISSION]1000[FORMULA OMISSION] and a top squark with mass [FORMULA OMISSION]525[FORMULA OMISSION] are excluded, for lifetimes between 1 [FORMULA OMISSION]s and 1000[FORMULA OMISSION]. These results are the most stringent constraints on stopped particles to date.</P>
Khachatryan, V.,Sirunyan, A. M.,Tumasyan, A.,Adam, W.,Bergauer, T.,Dragicevic, M.,Erö,, J.,Fabjan, C.,Friedl, M.,Frü,hwirth, R.,Ghete, V. M.,Hartl, C.,Hö,rmann, N.,Hrubec, J.,Jeitler, M.,K Institute of Physics Pub 2015 The journal of high energy physics Vol.2015 No.4
<P>Dimuon and dielectron mass spectra, obtained from data resulting from protonproton collisions at 8TeV and recorded by the CMS experiment, are used to search for both narrow resonances and broad deviations from standard model predictions. The data correspond to an integrated luminosity of 20.6 (19.7) fb(-1) for the dimuon (dielectron) channel. No evidence for non-standard-model physics is observed and 95% confidence level limits are set on parameters from a number of new physics models. The narrow resonance analyses exclude a Sequential Standard Model Z(SSM)' resonance lighter than 2.90TeV, a superstring-inspired Z(psi)' lighter than 2.57TeV, and Randall-Sundrum Kaluza-Klein gravitons with masses below 2.73, 2.35, and 1.27TeV for couplings of 0.10, 0.05, and 0.01, respectively. A notable feature is that the limits have been calculated in a model-independent way to enable straightforward reinterpretation in any model predicting a resonance structure. The observed events are also interpreted within the framework of two non-resonant analyses: one based on a large extra dimensions model and one based on a quark and lepton compositeness model with a left-left isoscalar contact interaction. Lower limits are established on M-S, the scale characterizing the onset of quantum gravity, which range from 4.9 to 3.3TeV, where the number of additional spatial dimensions varies from 3 to 7. Similarly, lower limits on Lambda, the energy scale parameter for the contact interaction, are found to be 12.0 (15.2) TeV for destructive (constructive) interference in the dimuon channel and 13.5 (18.3) TeV in the dielectron channel.</P>
Khachatryan, V.,Sirunyan, A. M.,Tumasyan, A.,Adam, W.,Bergauer, T.,Dragicevic, M.,Erö,, J.,Friedl, M.,Frü,hwirth, R.,Ghete, V. M.,Hartl, C.,Hö,rmann, N.,Hrubec, J.,Jeitler, M.,Kiesenhofer, Springer Berlin Heidelberg 2015 European Physical Journal C Vol.75 No.11
<P>The normalized differential cross section for top quark pair ([FORMULA OMISSION]) production is measured in pp collisions at a centre-of-mass energy of 8[FORMULA OMISSION] at the CERN LHC using the CMS detector in data corresponding to an integrated luminosity of 19.7[FORMULA OMISSION]. The measurements are performed in the lepton[FORMULA OMISSION]jets ([FORMULA OMISSION][FORMULA OMISSION]jets) and in the dilepton ([FORMULA OMISSION], [FORMULA OMISSION], and [FORMULA OMISSION]) decay channels. The [FORMULA OMISSION] cross section is measured as a function of the kinematic properties of the charged leptons, the jets associated to b quarks, the top quarks, and the [FORMULA OMISSION] system. The data are compared with several predictions from perturbative quantum chromodynamic up to approximate next-to-next-to-leading-order precision. No significant deviations are observed relative to the standard model predictions.</P><P><B>Electronic supplementary material</B></P><P>The online version of this article (doi:10.1140/epjc/s10052-015-3709-x) contains supplementary material, which is available to authorized users.</P>
Khachatryan, V.,Sirunyan, A. M.,Tumasyan, A.,Adam, W.,Bergauer, T.,Dragicevic, M.,Erö,, J.,Friedl, M.,Frü,hwirth, R.,Ghete, V. M.,Hartl, C.,Hö,rmann, N.,Hrubec, J.,Jeitler, M.,Kiesenhofer, American Physical Society 2015 PHYSICAL REVIEW D - Vol.92 No.11
<P>The per-event yield of the highest transverse momentum charged particle and charged-particle jet, integrated above a given p(T)(min) threshold starting at p(T)(min) = 0.8 and 1 GeV, respectively, is studied in pp collisions at root s = 8 TeV. The particles and the jets are measured in the pseudorapidity ranges vertical bar n vertical bar < 2.4 and 1.9, respectively. The data are sensitive to the momentum scale at which parton densities saturate in the proton, to multiple partonic interactions, and to other key aspects of the transition between the soft and hard QCD regimes in hadronic collisions.</P>
Search for the associated production of the Higgs boson with a top-quark pair
Khachatryan, V.,Sirunyan, A. M.,Tumasyan, A.,Adam, W.,Bergauer, T.,Dragicevic, M.,Erö,, J.,Fabjan, C.,Friedl, M.,Frü,hwirth, R.,Ghete, V. M.,Hartl, C.,Hö,rmann, N.,Hrubec, J.,Jeitler, M.,K Springer-Verlag 2014 Journal of high energy physics Vol.2014 No.9
Khachatryan, V.,Sirunyan, A. M.,Tumasyan, A.,Adam, W.,Bergauer, T.,Dragicevic, M.,Erö,, J.,Friedl, M.,Frü,hwirth, R.,Ghete, V. M.,Hartl, C.,Hö,rmann, N.,Hrubec, J.,Jeitler, M.,Kiesenhofer, American Physical Society 2015 PHYSICAL REVIEW D - Vol.91 No.5
<P>A search is performed for long-lived particles that decay into final states that include a pair of electrons or a pair of muons. The experimental signature is a distinctive topology consisting of a pair of charged leptons originating from a displaced secondary vertex. Events corresponding to an integrated luminosity of 19.6 (20.5) fb(-1) in the electron (muon) channel were collected with the CMS detector at the CERN LHC in proton-proton collisions at root s TeV. No significant excess is observed above standard model expectations. Upper limits on the product of the cross section and branching fraction of such a signal are presented as a function of the long-lived particle's mean proper decay length. The limits are presented in an approximately model-independent way, allowing them to be applied to a wide class of models yielding the above topology. Over much of the investigated parameter space, the limits obtained are the most stringent to date. In the specific case of a model in which a Higgs boson in the mass range 125-1000 GeV/c(2) decays into a pair of long-lived neutral bosons in the mass range 20-350 GeV= c(2), each of which can then decay to dileptons, the upper limits obtained are typically in the range 0.2-10 fb for mean proper decay lengths of the long-lived particles in the range 0.01-100 cm. In the case of the lowest Higgs mass considered (125 GeV/c(2)), the limits are in the range 2-50 fb. These limits are sensitive to Higgs boson branching fractions as low as 10(-1).</P>
Khachatryan, V.,Sirunyan, A. M.,Tumasyan, A.,Adam, W.,Bergauer, T.,Dragicevic, M.,Erö,, J.,Fabjan, C.,Friedl, M.,Frü,hwirth, R.,Ghete, V. M.,Hartl, C.,Hö,rmann, N.,Hrubec, J.,Jeitler, M.,K American Physical Society 2015 PHYSICAL REVIEW D - Vol.91 No.5
<P>Measurements of differential cross sections are presented for the production of a Z boson and at least one hadronic jet in proton-proton collisions at root s = 7 TeV, recorded by the CMS detector, using a data sample corresponding to an integrated luminosity of 4.9 fb(-1). The jet multiplicity distribution is measured for up to six jets. The differential cross sections are measured as a function of jet transverse momentum and pseudorapidity for the four highest transverse momentum jets. The distribution of the scalar sum of jet transverse momenta is also measured as a function of the jet multiplicity. The measurements are compared with theoretical predictions at leading and next-to-leading order in perturbative QCD.</P>
Khachatryan, V.,Sirunyan, A. M.,Tumasyan, A.,Adam, W.,Bergauer, T.,Dragicevic, M.,Erö,, J.,Fabjan, C.,Friedl, M.,Frü,hwirth, R.,Ghete, V. M.,Hartl, C.,Hö,rmann, N.,Hrubec, J.,Jeitler, M.,K Institute of Physics Pub 2015 The journal of high energy physics Vol.2015 No.1
<P>The ratio of the production cross sections times branching fractions (sigma(B-c(+/-))B(B-c(+/-) -> J/psi pi(+/-)))/(sigma(B-+/-)B(B-+/- -> J/psi K-+/-)) is studied in proton-proton collisions at a center-of-mass energy of 7TeV with the CMS detector at the LHC. The kinematic region investigated requires B-c(+/-) and B-+/- mesons with transverse momentum p(T) > 15 GeV and rapidity vertical bar y vertical bar < 1.6. The data sample corresponds to an integrated luminosity of 5.1 fb(-1). The ratio is determined to be [0.48 +/- 0.05 (stat) +/- 0.03 (syst) +/- 0.05 (tau(Bc))]%. The B-c(+/-) -> J/psi pi(+/-)pi(+/-)pi(-/+) decay is also observed in the same data sample. Using a model-independent method developed to measure the efficiency given the presence of resonant behaviour in the three-pion system, the ratio of the branching fractions B-c(+/-) -> J/psi pi(+/-)pi(+/-)pi(-/+)/B(B-c(+/-) -> J/psi pi(+/-)) is measured to be 2.55 +/- 0.80 (stat) +/- 0.33 (syst)(-0.01)(+0.04) (tau(Bc)), consistent with the previous LHCb result.</P>
Khachatryan, V.,Sirunyan, A. M.,Tumasyan, A.,Adam, W.,Bergauer, T.,Dragicevic, M.,Erö,, J.,Fabjan, C.,Friedl, M.,Frü,hwirth, R.,Ghete, V. M.,Hartl, C.,Hö,rmann, N.,Hrubec, J.,Jeitler, M.,K Springer Berlin Heidelberg 2014 The European physical journal. C, Particles and fi Vol.74 No.9
<P>A measurement of the cross section for the production of top quark–antiquark pairs ([FORMULA OMISSION]) in association with a vector boson V (W or Z) in proton-proton collisions at [FORMULA OMISSION][FORMULA OMISSION] is presented. The results are based on a dataset corresponding to an integrated luminosity of 19.5 fb[FORMULA OMISSION] recorded with the CMS detector at the LHC. The measurement is performed in three leptonic (e and [FORMULA OMISSION]) channels: a same-sign dilepton analysis targeting [FORMULA OMISSION] events, and trilepton and four-lepton analyses designed for [FORMULA OMISSION] events. In the same-sign dilepton channel, the [FORMULA OMISSION] cross section is measured as [FORMULA OMISSION], corresponding to a significance of 1.6 standard deviations over the background-only hypothesis. Combining the trilepton and four-lepton channels, a direct measurement of the [FORMULA OMISSION] cross section, [FORMULA OMISSION], is obtained with a significance of 3.1 standard deviations. The measured cross sections are compatible with standard model predictions within their experimental uncertainties. The inclusive [FORMULA OMISSION] process is observed with a significance of 3.7 standard deviations from the combination of all three leptonic channels.</P>