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Park, Dongsun,Joo, Seong Soo,Kim, Tae Kyun,Lee, Sun Hee,Kang, Hyomin,Lee, Hong Jun,Lim, Inja,Matsuo, Akinori,Tooyama, Ikuo,Kim, Yun-Bae,Kim, Seung U Pergamon Press ; Elsevier Science Ltd ; Elsevier S 2012 Cell transplantation Vol.21 No.1
<P>Alzheimer disease (AD) is a progressive neurodegenerative disease, which is characterized by loss of memory and cognitive function. In AD patients dysfunction of the cholinergic system is the main cause of cognitive disorders, and decreased activity of choline acetyltransferase (ChAT), an enzyme responsible for acetylcholine (ACh) synthesis, is observed. In the present study we investigated if brain transplantation of human neural stem cells (NSCs) genetically modified to encode ChAT gene improves cognitive function of kainic acid (KA)-induced learning deficit rats. Intrahippocampal injection of KA to hippocampal CA3 region caused severe neuronal loss, resulting in profound learning and memory deficit. F3.ChAT human NSCs transplanted intracerebroventricularly improved fully the learning and memory function of KA-induced learning deficit animals, in parallel with the elevation of ACh levels in cerebrospinal fluid. F3.ChAT human NSCs migrated to the KA-induced injury site (CA3) and differentiated into neurons and astrocytes. The present study demonstrates that human NSCs expressing ChAT have lesion-tropic property and improve cognitive function of learning deficit model rats with hippocampal injury by increasing ACh level.</P>
SATEEC 시스템을 이용한 객토 토양의 토성고려에 따른 도암댐 유역의 토양유실 및 유사량 분석
유동선 ( Dongsun Yoo ),안재훈 ( Jaehun Ahn ),윤정숙 ( Jongsuk Yoon ),허성구 ( Sunggu Heo ),박윤식 ( Younshik Park ),김종건 ( Jonggun Kim ),임경재 ( Kyoung Jae Lim ),김기성 ( Ki-sung Kim ) 한국농공학회 2007 한국농공학회 학술대회초록집 Vol.2007 No.-
There have been serious soil erosion and water pollution problems caused by highland agriculture practices at Doam-dam watershed. Especially agricultural activities, chemical and organic fertilizer and pesticide applications, soil reconditioning to maintain soil fertility are known as primary causes of soil erosion and water qaulity degradation in the receiving water bodies. Among these, soil reconditioning can accelerate soil erosion rates. To develop soil erosion prevention practices, it is necessary to first estimate the soil erosion from the watershed. Thus, the Universal Soil Loss Equation (USLE) model has been developed and utilized to assess soil erosion. However, the USLE model cannot be used at watershed scale because it does not consider sediment delivery ratio (SDR) for watershed application. For this reason, the Sediment Assessment Tool for Effective Erosion Control (SATEEC) was developed to assess the sediment yield at any point in the watershed. The USLE-based SATEEC system can estimate the SDR using area-based SDR and slope-based SDR module. In this study, the SATEEC system was used to estimate soil erosion and sediment yield at the Doam-dam watershed using the soil properties from reconditioned agricultural fields. Based on the soil sampling and analysis, the USLE K factor was calculated and used in the SATEEC system to analyze the possible errors of previous USLE application studies using soil properties from the digital soil map, compared with that using soil properties obtained in this study. The estimated soil erosion at the Doam-dam watershed without using soil properties obtained in the soil sampling and analysis is 1,791,400 ton/year (123 ton/ha/year), while the soil erosion amounts is 2,429,900 ton/year (166.8 ton/ha/year) with the use of soil properties from the soil sampling and analysis. There is 35% increases in estimated soil erosion and sediment yield with the use of soil properties from soil reconditioned agricultural fields. Since significant amounts of soil erosion are known to be occurring from the agricultural fields, the soil erosion and sediment yield from only agricultural fields was assessed. The soil erosion rate is 45.9 ton/ha/year without considering soil properties from soil reconditioned agricultural fields, while 105.3 ton/ha/year after considering soil properties obtained in this study, increased in 129%. This study shows it is very important to use correct soil properties to assess soil erosion and sediment yield simulation. It is recommended that further studies are needed to develop environment friendly soil reconditioning method should be developed and implemented to decrease the speed of soil erosion rates and water quality degradation.
단순언어장애 아동과 일반 아동의 KBPR (Korean Brief Parent Report)과 작업기억 능력 간의 관계 : 음운루프, 일화적 완충기를 중심으로
임동선(Dongsun Yim),신현지(Hyunji Shin),임나은(Naeun Lim),정예영(Yeyoung Jung),한지민(Jimin Han),양윤희(Yoonhee Yang) 한국언어청각임상학회 2021 Communication Sciences and Disorders Vol.26 No.2
배경 및 목적: Korean Brief Parent Report (KBPR)과 작업기억(음운루프, 언어 및 비언어적 일화적 완충기)의 상관관계와 아동의 언어 능력을 유의하게 예측할 수 있는 과제를 알아보고자 한다. 방법: 51-80개월(평균 63개월) 학령전기 단순언어장애 아동 21명, 일반 아동 31명을 대상으로 KBPR과 작업기억 과제(비단어 따라말하기, 단어목록회상, 대칭-비대칭 매트릭스)를 실시하였다. 결과: 첫째, 집단 간 KBPR 영역별 점수 및 총 점수에서 (b) 현재 언어 수준, (c) 행동 패턴 및 활동 선호도, 총 점수에서 집단 간 유의한 차이를 보였다. 둘째, 음운루프, 언어적 일화적 완충기에서 집단 간 유의한 차이가 있었다. 셋째, 집단 간 KBPR의 각 영역 점수 결과와 작업기억 간 상관관계는 일반 아동 집단에서 언어적 일화적 완충기(문장어순)이 (a) 영역을 제외하고 일관되게 나타났으며, 단순언어장애 아동 집단에서는 (a) 영역은 음운루프, (b) 영역은 언어적 일화적 완충기(문장어순), (c) 영역은 비언어적 일화적 완충기(대칭, 비대칭)와 유의한 상관관계를 보였다. 넷째, KBPR 총 점수에 가장 유의한 예측요인은 일반 아동 집단은 언어적 일화적 완충기(문장어순), 단순언어장애 아동 집단은 음운루프였다. 논의 및 결론: 두 집단의 KBPR 점수 및 작업기억 과제는 영역별 유의한 차이를 보였다. 또한, 각 집단 간 KBPR 총 점수를 가장 유의하게 예측할 수 있는 요인으로 단순언어장애 아동 집단은 음운루프, 일반 아동 집단은 언어적 일화적 완충기(문장어순)였다. Objectives: This study examined whether there is a significant relationship between Korean Brief Parent Report (KBPR) and Working Memory (phonological loop, episodic buffer); and investigated the significant predictor of children’s language ability. Methods: A total of 52 children from 4 to 6 years old participated in this study composed of children with Specific Language Impairment (SLI), and typically developing (TD) children. Experimental tasks including KBPR, Non-Word Repetition (NWR), Word List Recall and a Symmetric-Asymmetric Matrix were used. One-way ANOVA, correlational, and multiple stepwise regression analysis were used. Results: 1) There was a significant difference between groups in section B (Current abilities) and C (Behavior patterns and activity preferences). 2) There was a statistically significant difference in phonological loop and linguistic episodic buffer (EB). 3) The correlation between each section score of KBPR and working memory in the TD group showed consistent linguistic sentential order in the EB task with all the other sections except for section A. In the SLI group, section A had correlation with phonological loop, section B had correlation with linguistic EB, and section C had correlation with non-linguistic EB 4) The most significant predictor of the KBPR total score in the TD group was linguistic sentential order EB, and in the SLI group was phonological loop. Conclusion: Both the KBPR score and working memory task competency of the SLI and TD groups showed significant differences. In addition, the meaningful predictor in the total score of KBPR in each group respectively was NWR in the SLI group and linguistic sentential order EB in the TD group.
Scalability of Roll-to-Roll Gravure-Printed Electrodes on Plastic Foils
Jinsoo Noh,Dongsun Yeom,Chaemin Lim,Hwajin Cha,Jukyung Han,Junseok Kim,Yongsu Park,Subramanian, Vivek,Gyoujin Cho IEEE 2010 IEEE transactions on electronics packaging manufac Vol.33 No.4
<P>Roll-to-roll (R2R) gravure printing is considered to be a leading technology for the production of flexible and low-cost printed electronics in the near future. To enable the use of R2R gravure in printed electronics, the limits of overlay printing registration accuracy (OPRA) and the scalability of printed features with respect to the physical parameters of the gravure system, including given plastic substrates and inks, should be characterized. Important parameters of printed lines include surface roughness, thickness, line widening, and line-edge roughness. To date, there are no comprehensive reports regarding the limits of OPRA and the scalability of printed electrodes, including the control of surface roughness, thickness, line widening, and line-edge roughness using R2R gravure printing. In this paper, we examine ways of evaluating the OPRA limit of our gravure system. We find that OPRA is limited in the web moving direction to 40 μm and in the perpendicular direction to 16 μm, showing the importance of web handling on registration. Furthermore, we demonstrate the scalability of printed electrodes formed using a R2R gravure system to linewidths of 317 μm, with 440 nm thickness, 30 nm of surface roughness and edge waviness of 4 μm on PET foils, and describe optimization strategies to realize improved surface roughness, thickness, line widening, and line-edge roughness for future printed electronics applications.</P>
가중치를 이용한 실화 검출 알고리즘의 성능 향상에 대한 연구
임지훈(Jihoon Lim),김동선(Dongsun Kim),이태연(Taeyeon Lee),김일구(Ealgoo Kim),홍성률(Sungrul Hong),성진호(Jinhoo Sung),박재홍(Jaehong Park),윤형진(Hyungjin Yoon),정연광(Yeongwang Jeong),이재형(Jaehyung Lee),박진서(Jinseo Park),김창현(Ch 한국자동차공학회 2004 한국자동차공학회 춘 추계 학술대회 논문집 Vol.- No.-
This paper presents a misfire monitoring method by using the weight factor. In this misfire monitoring method, the ECU performs misfire detection better than original method when there is misfire in "misfire no detection range". The weight factor is determined the time after a detection the real misfire. The probability of misfire detection for this algorithm is calculated and the results show the feasibility of the algorithm. The experimental results also show that the presented algorithm has better detection probability.