Genetic Variants of CYP2D6 Gene and Cancer Risk: A HuGE Systematic Review and Meta-analysis

Zhou, Li-Ping,Luan, Hong,Dong, Xi-Hua,Jin, Guo-Jiang,Man, Dong-Liang,Shang, Hong Asian Pacific Journal of Cancer Prevention 2012 Asian Pacific journal of cancer prevention Vol.13 No.7

Objective: Genetic polymorphisms in metabolic enzymes are associated with numerous cancers. A large number of single nucleotide polymorphisms (SNPs) in the CYP2D6 gene have been reported to associate with cancer susceptibility. However, the results are controversial. The aim of this Human Genome Epidemiology (HuGE) review and meta-analysis was to summarize the evidence for associations. Methods: Studies focusing on the relationship between CYP2D6 gene polymorphisms and susceptibility to cancer were selected from the Pubmed, Cochrane library, Embase, Web of Science, Springerlink, CNKI and CBM databases. Data were extracted by two independent reviewers and the meta-analysis was performed with Review Manager Version 5.1.6 and STATA Version 12.0 software. Odds ratios (ORs) with 95% confidence intervals (95%CIs) were calculated. Results: According to the inclusion criteria, forty-three studies with a total of 7,009 cancer cases and 9,646 healthy controls, were included in the meta-analysis. The results showed that there was a positive association between heterozygote (GC) of rs1135840 and cancer risk (OR=1.92, 95%CI: 1.14-3.21, P=0.01). In addition, we found that homozygote (CC) of rs1135840 might be a protective factor for cancer (OR=0.58, 95%CI: 0.34-0.97, P=0.04). Similarly, the G allele and G carrier (AG + GG) of rs16947 and heterozygote (A/del) of rs35742686 had negative associations with cancer risk (OR=0.69, 95%CI: 0.48-0.99, P=0.04; OR=0.60, 95%CI: 0.38-0.94, P=0.03; OR=0.50, 95%CI: 0.26-0.95, P=0.03; respectively). Conclusion: This meta-analysis suggests that CYP2D6 gene polymorphisms are involved in the pathogenesis of various cancers. The heterozygote (GC) of rs1135840 in CYP2D6 gene might increase the risk while the homozygote (CC) of rs1135840, G allele and G carrier (AG + GG) of rs16947 and heterozygote (A/del) of rs35742686 might be protective factors.

Clinical Significance of Expression and Amplification of the DcR3 Gene in Pancreatic Carcinomas

Zhou, Jian,Song, Shi-Duo,Li, De-Chun,Zhou, Jin,Zhu, Dong-Ming,Zheng, Shi-Ying Asian Pacific Journal of Cancer Prevention 2012 Asian Pacific journal of cancer prevention Vol.13 No.2

This study aimed to investigate the clinical significance of expression and amplification of decoy receptor 3 (DcR3) in pancreatic carcinomas (PC). mRNA expression was detected by PQ-PCR, and amplification was determined. DcR3 protein expression was detected by immunohistochemistry and ELISA. Correlations between DcR3 expression and clinical pathological factors were analyzed. The relative amount of DcR3 in PC tissues and non-cancerous tissues showed a statistically significant difference, 21 cases displaying more than two fold DcR3 amplification, while no such amplification was found in normal pancreatic tissues. DcR3 positive cell staining was located in the cytoplasm. The positive rate of DcR3 in PC and non-cancerous tissues showed a significant difference. DcR3 mRNA expression was correlated with clinical staging, size of the tumor, lymph node metastasis and histological staging, while protein expression was correlated with clinical data like tumor size. DcR3 gene amplification only correlated with tumor size. The level of DcR3 in serum of the PC resectable group before operation was $72.2{\pm}10.2$ pg/ml, showing a significant difference compared to gallbladder carcinoma group (GC) or pancreatic benign tumor (PBT) group (P < 0.01). In conclusion, DcR3 amplification is correlated with DcR3 expression in PC tissues, especially those clinical pathological factors which reflect tumor progression. Assessment of DcR3 level in sera of PC patients may be helpful for the early diagnosis and prognostic judgement.

Analysis of three-dimensional thermal gradients for arch bridge girders using long-term monitoring data

Zhou, Guang-Dong,Yi, Ting-Hua,Chen, Bin,Zhang, Huan Techno-Press 2015 Smart Structures and Systems, An International Jou Vol.15 No.2

Thermal loads, especially thermal gradients, have a considerable effect on the behaviors of large-scale bridges throughout their lifecycles. Bridge design specifications provide minimal guidance regarding thermal gradients for simple bridge girders and do not consider transversal thermal gradients in wide girder cross-sections. This paper investigates the three-dimensional thermal gradients of arch bridge girders by integrating long-term field monitoring data recorded by a structural health monitoring system, with emphasis on the vertical and transversal thermal gradients of wide concrete-steel composite girders. Based on field monitoring data for one year, the time-dependent characteristics of temperature and three-dimensional thermal gradients in girder cross-sections are explored. A statistical analysis of thermal gradients is conducted, and the probability density functions of transversal and vertical thermal gradients are estimated. The extreme thermal gradients are predicted with a specific return period by employing an extreme value analysis, and the profiles of the vertical thermal gradient are established for bridge design. The transversal and vertical thermal gradients are developed to help engineers understand the thermal behaviors of concrete-steel composite girders during their service periods.

Anti-Fatigue Effects of Fermented Rhodiola rosea Extract in Mice

Dong-Zhou Kang,Hee-Do Hong,Kyung-Im Kim,Sang Yoon Choi 한국식품영양과학회 2015 Preventive Nutrition and Food Science Vol.20 No.1

Rhodiola rosea is a perennial plant which grows in the alpine regions of Europe and Asia. Although the protective effects of R. rosea extract from fatigue due to exercise stress have been reported, studies on fermented R. rosea extract remain insufficient to date. Therefore, this study was conducted to examine the protective effects of fermented R. rosea extract against fatigue and exercise stress. As a result, fermented R. rosea extract was found to significantly increase swimming time, hepatic superoxide dismutase content, and serum lactate dehydrogenase in mice, while decreasing serum blood urea nitrogen content compared to R. rosea extract. Given the above results, it is considered that fermented R. rosea extract effectively protects against fatigue caused by strenuous exercise.

Effects of Fermented Ginseng Extracts on Tumor Metastasis in Mice

Dong Zhou Kang,Dan Liu,Seon Yoong Jo,강태봉,Jin Moo Lee,서형주,Ae-jung Kim,윤택준 한국식품과학회 2010 Food Science and Biotechnology Vol.19 No.6

This study was demonstrated that the fermentation of gingseng increases its biological activities,by comparing the anti-tumor and immunostimulating activities of fermented gingseng extracts (FginE) with those of non-fermented ginseng (GinE). In the experimental lung metastasis of colon26-M3.1 carcinoma, the intraperitoneal (i.p.) or peroral (p.o.) administration of FginE showed stronger anti-tumor metastatic activities than those of GinE. When stimulating 2 kinds of extract on macrophages,FginE was shown to have a higher production of interleukin (IL)-12 than GinE. In addition, treatment with FginE induced tumoricidal activity of peritoneal macrophages against colon26-M3.1 cells. When Peyer's patch was cocultured with FginE, the proliferation of these cells and granulocyte macrophage-colony stimulating factor (GMCSF)production were induced. In an assay for natural killer (NK) cell activity, an i.p. administration of FginE significantly augmented NK cytotoxicity against Yac-1tumor cells. Fermented ginseng extracts promotes antitumor activities to inhibit tumor metastasis, and its antitumor effects are associated with the enhancement of systemic as well as mucosal immune systems.

Characteristics of the multiphase flow field with super-cavitation induced by successively fired projectiles under-water and cross-medium

Dong-Hui Zhou,Hong-Hui Shi,Hui-Xia Jia 대한기계학회 2022 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.36 No.1

The multiphase flow field with supercavitation induced by successively fired underwater projectiles is very complicated. It involves the interaction of two or more supercavitating flow fields, which is very different from the supercavitating flow of single underwater projectile. In the paper, the multiphase flow field with supercavitation induced by two successively fired projectiles underwater and cross-media (water-entry and water-exit) was simulated. The interaction effect between supercavities induced by two projectiles was particularly analyzed. The influence mechanism of the supercavity evolution on the motion of two projectiles was also analyzed. The results indicate that, the supercavitating flow fields of two successively fired underwater projectiles interact on each other. The coalescence, separation and collapse of cavities occur during the interaction stage of the supercavitating flow fields, which causes that the second-fired projectile enters the supercavity of the first one. The second-fired projectile can catch up with the first one and then a rear-end collision happens. The collision causes disturbances on the supercavity contour. The impact load of the secondfired projectile during the water-entry period is smaller than that of the first one. The cavities induced by the first- and second-fired projectiles coalesce each other into a cavity, and the second-fired projectile is finally completely wrapped by a supercavity. During the water-entry process, a rear-end collision also happens. In the process of water-exit, the supercavity induced by the first-fired projectile is blocked under the free surface, and then the first-fired projectile flies into the air after throwing off the water layer. Under the influence of the supercavity separated by the first-fired projectile, the second-fired projectile can escape from its own supercavity, and then enter the supercavity of the first-fired projectile. With the supercavity collapse of the first-fired projectile, a new partial cavity generates around the second-fired projectile.

Characterization of SiC/C Nanocomposite Powders Synthesized by Arc-Discharge

Zhou, Lei,Yu, Jie Yi,Gao, Jian,Wang, Dong Xing,Gan, Xiao Rong,Xue, Fang Hong,Huang, Hao,Dong, Xing Long Korean Society of Microscopy 2015 Applied microscopy Vol.45 No.4

In this paper, three carbon sources, i.e., solid graphite, gaseous CH4 and liquid ethanol, and one solid silicon source were employed to synthesize SiC/C nanocomposite powders by arc-discharge plasma. The processing conditions such as the component ratios of raw materials, atmospheric gases, etc. were adjusted for controllable synthesis of the nanopowders. It is indicated that both of solid graphite and silicon can be co-evaporated and reacted to form nanophases of cubic ${\beta}$-SiC with ~50 nm in mean size and a little free graphite; the carbon atoms decomposed from gaseous $CH_4$ favor to combine with the evaporated silicon atoms to form the dominant SiC nanophase; liquid carbon source of ethanol can also be used to harvest the main ${\beta}$-SiC and minor 6H-SiC phases in the assembly of nanoparticles. The as-prepared SiC/C nanocomposite powders were further purified by a heat-treatment in air and their photocatalytic performances were then greatly improved.

Association Between XRCC5, 6 and 7 Gene Polymorphisms and the Risk of Breast Cancer: A HuGE Review and Meta-analysis

Zhou, Li-Ping,Luan, Hong,Dong, Xi-Hua,Jin, Guo-Jiang,Man, Dong-Liang,Shang, Hong Asian Pacific Journal of Cancer Prevention 2012 Asian Pacific journal of cancer prevention Vol.13 No.8

Objective: Non-homologous end joining (NHEJ) is a pathway for repairing DNA double-strand breaks. Recent publications indicated that XRCC5, XRCC6 and XRCC7 genes may participate in the pathogenesis of breast cancer. The aim of this Human Genome Epidemiology (HuGE) review and meta-analysis was to investigate associations between XRCC5, XRCC6 and XRCC7 genetic polymorphisms in the NHEJ pathway and breast cancer risk. Methods: Studies focusing on the relationship between genetic polymorphisms in XRCC5, XRCC6 and XRCC7 genes and susceptibility to breast cancer were selected from the Pubmed, Cochrane library, Embase, Web of Science, Springerlink, CNKI and CBM databases. Data were extracted by two independent reviewers. The meta-analysis was performed with Review Manager Version 5.1.6 and STATA Version 12.0 software. The odds ratio (OR) with 95% confidence interval (95%CI) was calculated based on the extracted data. Results: According to the inclusion criteria, we final included seven studies with a total of 2,864 breast cancer cases and 3,060 healthy controls. Meta-analysis results showed that rs3835 (G>A) and rs828907 (G>T) in XRCC5 gene, and rs132793 (G>A) in XRCC6 gene might increase the risk of breast cancer, while rs132788 G>T and rs6002421 (A>G) might be protective factors. However, there was no relationship between XRCC7 genetic polymorphisms and the risk of breast cancer. Conclusion: This meta-analysis suggests that the rs3835 G>A and rs828907 G>T in XRCC5 gene, rs6002421 (A>G), rs132788 (G>T) and rs132793 (G>A) in XRCC6 gene might be risk factors for breast cancer, while the rs132788 (G>T) and rs6002421 (A>G) in XRCC6 gene might be protective.

The Funding system for Shanghai Metro And The Practical Experiences of Utilizing Foreign Funds

Zhou Yao Dong 대한교통학회 1998 대한교통학회 기타자료 Vol.1998 No.-

Metro, as a kind of city rail transit, is a modem city passenger transit system with mass transportation and independent special rails. It has become a backbone of the traffic in the metropolis and an important modern symbol of a city. A modem traffic system is indispensable for Shanghai to be an international metropolis of finance, trade and economy. At present, Shanghai metro line No. 1 and its extension have been put into operation, metro line No.2 will be put into trial operation by the end of 1999, the Pearl Line, an elevated rail transit system is under construction and other lines will be constructed later according to the plan. But the funding of the city rail transit construction (both metro and light rail) is a big difficult problem to the infrastructure construction of the metropolises either at home or abroad, which is also a problem to restrict the development of the city rail transit of Shanghai. We have learned from the internal and external experiences of the rail transit construction that it is an important means to deal with the funds of the city rail transit construction to actively utilize foreign funds. It makes up the shortage of the internal funds on the one hand, the external advanced science and technology and the management experiences can be introduced on the other hand. In order to discuss and study conveniently with you together the new problems appearing in the metro construction and to open up a new train of thought, this article will give out a certain analysis and description to the funding method in the metro construction of Shanghai and the characteristics of utilizing foreign funds in the rail transit construction as well as the problems which we are faced with.

Antimicrobial activity and synergism of ursolic acid 3-O-α-L-arabinopyranoside with oxacillin against methicillin-resistant Staphylococcus aureus

Zhou, Tian,Li, Zhi,Kang, Ok-Hwa,Mun, Su-Hyun,Seo, Yun-Soo,Kong, Ryong,Shin, Dong-Won,Liu, Xiang-Qian,Kwon, Dong-Yeul UNKNOWN 2017 INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE Vol.40 No.4