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Kang, Dong Woo,Choi, Chi Yeol,Cho, Yong-Hee,Tian, Huasong,Di Paolo, Gilbert,Choi, Kang-Yell,Min, Do Sik The Rockefeller University Press 2015 The Journal of experimental medicine Vol.212 No.8
<▼1><P>Kang et al. show that genetic or pharmacological inactivation of the enzyme phospholipase D1 (PLD1) disrupts colitis-associated intestinal tumorigenesis by suppressing the self-renewal capacity of colon cancer stem cells.</P></▼1><▼2><P>Expression of the Wnt target gene phospholipase D1 (PLD1) is up-regulated in various carcinomas, including colorectal cancer (CRC). However, the mechanistic significance of its elevated expression in intestinal tumorigenesis remains unknown. In this study, we show that genetic and pharmacological targeting of PLD1 disrupts spontaneous and colitis-associated intestinal tumorigenesis in <I>Apc<SUP>Min/+</SUP></I> and azoxymethane/dextran sodium sulfate mice models. Intestinal epithelial cell–specific PLD1 overexpression in <I>Apc<SUP>Min/+</SUP></I> mice accelerated tumorigenesis with increased proliferation and nuclear β-catenin levels compared with <I>Apc<SUP>Min/+</SUP></I> mice. Moreover, PLD1 inactivation suppressed the self-renewal capacity of colon cancer–initiating cells (CC-ICs) by decreasing expression of β-catenin via E2F1-induced microRNA (miR)-4496 up-regulation. Ultimately, low expression of PLD1 coupled with a low level of CC-IC markers was predictive of a good prognosis in CRC patients, suggesting in vivo relevance. Collectively, our data reveal that PLD1 has a crucial role in intestinal tumorigenesis via its modulation of the E2F1–miR-4496–β-catenin signaling pathway. Modulation of PLD1 expression and activity represents a promising therapeutic strategy for the treatment of intestinal tumorigenesis.</P></▼2>
공동화 마을의 예술적 재생 - 산동성(山東省) 쯔보시(淄博市) 아장(峨莊) 지역을 대상으로 -
( Yu Dong-ming ),( Xia Tian-tian ),( Kang Tai-ho ) 한국전통조경학회(구 한국정원학회) 2016 Journal of Korean Institute of Traditional Landsca Vol.14 No.-
도시화와 새마을 건설의 물결에 따라 적지 않는 마을에 질적 변화가 발생하고 있다. 공동화 마을은 그중의 하나이다. 본 연구는 공동화 마을의 부정적 효과를 분석하기 위하여 산동성(山東省) 쯔보시(淄博市) 아장(峨莊) 지역을 대상으로 지역의 현황과 특성, 예술적 맥락을 토대로 한 재생 방안을 수행하였다. 연구 결과 날로 공동화가 진행되어 가고 있는 마을의 예술 자원(전통 주택, 거리와 골목, 노거수 등)의 보호 및 발굴, 예술 체험(현장 사생, 예술 작품 감상, 작품 원형 전시 등), 예술가 작업실(미술, 서예, 수석, 뿌리 조각품, 도예, 자기, 마을 민속관 등) 입주, 벽화마을 조성, (사진, 연극, 영화, 드라마)촬영지 홍보, 예술 생활 및 생산품 전시, 마을의 조경 및 정원의 예술화 등을 이용한 마을의 활성화 전략을 모색하여 지역 특색이 있는 마을 조성 방안을 제시하였다. In the process of urbanization and new village construction, a number of villages witnessed qualitative changes. The hollowed village is a representative. Base on the analysis of the negative effects of hollow village, this paper takes the villages in E`zhuang area in Zibo City, Shandong Province as an example and explores the artistic means of revitalization for the villages. With the method of field investigation and in accordance with the regional features and artistic context, some revitalization approaches were proposed. For instance, the protection and exploration of the artistic resources such as traditional residences, streets and ancient trees, the artistic activities including sketching, artistic works appreciation and visiting the archetype in the villages, the foundation of artistic studios of paintings, calligraphy, rocks, root carving, pottery, porcelain, folk museum etc., the construction of mural villages, the advertising of photography, opera, film and television shooting spots, the exhibition of the artistic life and production, and the introduction of landscape to the courtyards, and so on. It aims to build a new village with regional features.
Hu, Li-Dong,Li, Xiao-Fei,Wang, Xiu-Yue,Guo, Tian-Kang Asian Pacific Journal of Cancer Prevention 2016 Asian Pacific journal of cancer prevention Vol.17 No.9
Purpose: To systematically review efficacyand safety of robotic gastrectomy (RG) compared with conventional laparoscopic gastrectomy (LG) for gastric carcinoma. Materials and Methods: A systematic literature search was carried out using PubMed, Cochrane Library, CBM, CNKI, WanFang, VIP and other sources like relevant references to obtain comparative studies assessing the effectiveness and safety between RG and LG published between 2013 and 2016. Then the literature was screened and the data were extracted by 2 independent reviewers. The quality of the literature was assessed, and the data analyzed using Stata/SE 14 software. Fixed effects or random effects models wereapplied according to heterogeneity. Results: A total of 12 non-randomized observational clinical studies involving 3,580 patients were included, of which 1,096 had undergone RG and 2,484 had received LG. The results of the meta-analysis showed in terms of effectiveness, RG was associated with less blood loss, less time to first flatus and greater number of harvested lymph nodes, but there were no significant differences in proximal and distal resection margins, compared with LG. In terms of efficiency, RG was associated with shorter hospital stay, but longer operative time. In terms of safety, there were no statistically significant differences in complications, mortality and conversions between RG and LG. Conclusions: RG can achieve comparable or better short-term and radical effects than LG, with respect to effectiveness, efficiency and safety in treatment of gastric carcinoma. Future studies involving RG should focus on decreasing operative time and reducing cost. Moreover, there is a need for randomized controlled trials comparing the two techniques with long-term follow-up.
Detection of mercury in fish organs with a two-photon fluorescent probe
Su Lim, Chang,Won Kang, Dong,Shun Tian, Yu,Hee Han, Ji,Lim Hwang, Hye,Rae Cho, Bong Royal Society of Chemistry 2010 Chemical communications Vol.46 No.14
<P>We report a two-photon fluorescent probe (AHg1) that can be excited by 780 nm femto-second pulses, shows high photostability and negligible toxicity, and can visualize the site of Hg<SUP>2+</SUP> accumulation, but can also estimate trace amounts of mercury ions in fresh fish organs by two-photon microscopy.</P> <P>Graphic Abstract</P><P>We report a two-photon probe (AHg1) that can selectively detect Hg<SUP>2+</SUP> in the live cells and fish organs at 80–150 μm depth without interference from other metal ions and the membrane-bound probes. <IMG SRC='http://pubs.rsc.org/services/images/RSCpubs.ePlatform.Service.FreeContent.ImageService.svc/ImageService/image/GA?id=b922305c'> </P>