Poverty Does Not Limit Tobacco Consumption among Tribal Populations: Evidence from Central India

Kumar, Surendra,Kumar, Dinesh,Muniyandi, Malaisamy,Soan, Visheshwar,Pandey, Maya,Mishra, Dinesh Kumar Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.10

Highly Efficient Photocatalytic Studies on Bi36 Fe2 O57 Ceramic Synthesized by Chemical Route

Manish Kumar Verma,Vinod Kumar,Upakar Patel,Vishnu Shankar Rai,Anup Kumar,Arup Kumar De,Aditya Kumar Prajapati,Dinesh Prajapati,Kedar Sahoo,Tapas Das,N. B. Singh,K. D. Mandal 한국전기전자재료학회 2023 Transactions on Electrical and Electronic Material Vol.24 No.5

Bi36 Fe2 O57 (BFO) polycrystalline ceramic was synthesized by economical chemical route. The single-phase formation of BFO ceramic was confirmed by powder X-ray diffraction studies. Nanosized formation of BFO ceramics established by XRD and TEM analysis. The bimodal distribution of grain size is observed with size ranging from 50 to 600 nm. It observed that the Bi36 Fe2 O57 photocatalyst exhibited higher catalytic activity for the degradation of Methylene Blue (MB) under visible-light irradiation The oxidation state of elements present in the BFO ceramic, was confirmed by XPS studies. The pseudocapacitive nature of BFO ceramic was observed by cyclic Voltammetry. The dielectric constant of BFO ceramic was found 375 at 1 kHz at 300 K. The dielectric loss was found 0.51 at 100 kHz and 300 K.

Combinatorial Effect of Ligand Aromaticity, Torsion Number and Hydrophobicity on the Predictability of AutoDock for Protein-Ligand Binding Conformation

Dinesh Kumar Sriramulu,이선구 한국생물공학회 2023 KSBB Journal Vol.38 No.1

Molecular docking method helps predict the protein- ligand binding conformation, but its prediction accuracy is still limited and varies depending on the target ligand's structure and physicochemical properties. Therefore, understanding the ligand-dependent prediction accuracy is crucial in efficiently using the docking tool. In this study, we investigated how the prediction accuracy of AutoDock, a popular molecular docking tool, is affected by the aromaticity of the target ligand structure, ligand torsion number, and ligand hydrophobicity. The ligands with an aromatic ring showed substantially lower prediction accuracy than those without an aromatic ring. The ligands with lower torsion number showed higher prediction accuracy in the ligands with and without an aromatic ring. The hydrophobicity of ligands did not significantly influence the prediction accuracy in the case of ligands with an aromatic ring structure. However, the ligands without ring structure showed a clear difference in prediction accuracy depending on their hydrophobicity. These results are expected to be employed as a reference in molecular docking studies using AutoDock.

Tribochemistry of contact interfaces of nanocrystalline molybdenum carbide films

Kumar, D. Dinesh,Kumar, N.,Panda, Kalpataru,Kamalan Kirubaharan, A.M.,Kuppusami, P. Elsevier 2018 APPLIED SURFACE SCIENCE - Vol.447 No.-

<P><B>Abstract</B></P> <P>Transition metal carbides (TMC) are known for their improved tribological properties and are sensitive to the tribo-atmospheric environment. Nanocrystalline molybdenum carbide (MoC) thin films were deposited by DC magnetron sputtering technique using reactive CH<SUB>4</SUB> gas. The friction and wear resistance properties of MoC thin films were significantly improved in humid-atmospheric condition as compared to high-vacuum tribo-condition. A comprehensive chemical analysis of deformed contact interfaces was carried out by X-ray photoelectron spectroscopy (XPS), energy dispersive X-ray spectroscopy (EDX) and Raman spectroscopy. XPS and Raman spectroscopy showed the formation of stable molybdenum-oxide (MoO), molybdenum carbide (MoC) and amorphous carbon (a-C) tribo-phases. Moreover, during the sliding in humid-atmospheric condition, these phases were extensively deposited on the sliding steel ball counter body which significantly protected against undesirable friction and wear.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Reactive DC magnetron sputtered cubic phase of nanocrystalline MoC thin films. </LI> <LI> Chemical bonding analysis of MoC films using X-ray photoelectron spectroscopy. </LI> <LI> Tribological properties of MoC films in ambient and high-vacuum tribo-atmospheres. </LI> <LI> Comprehensive tribochemical analysis of contact interfaces. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>Friction and wear behavior of nanocrystalline MoC films under atmospheric and high-vacuum conditions.</P> <P>[DISPLAY OMISSION]</P>

Hepatoprotective Activity of Rutin Against Liver Damage Through Interaction with Cytochromes P450 and Antioxidant Enzymes: In-vivo and In-vitro Experimental Data Analysis and Molecular Modelling

( Dinesh Kumar Patel ),( Kanika Patel ) 대한간학회 2020 춘·추계 학술대회 (KASL) Vol.2020 No.1

Aims: Plant based drugs have numerous phytochemicals mainly belongs to the phenolic flavonoid and carotenoids class chemicals. These phytochemicals play important role in the plant’s defence mechanism and used for the treatment of numerous human disorders in the modern system of medicine. Plants and their derived products contain important class of phytochemicals which are still considered as one of the important sources of materials for the development of noble molecule with better therapeutic goal. Cytochromes P450 enzymes are capable of catalyzing the oxidative biotransformation of numerous drugs in the human body. Rutin is a low molecular weight polyphenolic compound mainly found to be present in various citrus class drugs. Rutin have important physiological functions both in the human body and plants. Methods: To know the beneficial effect of rutin in liver system, various scientific databases have been searched and analyzed in the present investigation to know the therapeutic potential of Rutin in the biological system. Pharmacological importance of rutin in Hepatic system have been searched and analyzed. Molecular simulation database of rutin against cytochrome P-450, superoxide dismutase (SOD), catalase (CAT) and malondialdehyde (MDA) have been searched to know the importance of rutin in liver antioxidant systems. Binding energy and type of molecular interactions have been also analyzed in the present investigation through databases analysis to uncoil the molecular mechanism of rutin against hepatic disorders. Results: Scientific research databases analysis revealed the importance of rutin in the hepatic system as higher intake of rutin for 20 days in rat tissues showed improve liver antioxidant level and reduced systemic inflammation and oxidative stress. However, rutin significantly reduced transaminases and phosphatases enzymes in liver and restores oxidative damage. Molecular simulation study database analysis signified the importance of cytochrome P-450 in liver disorders. Further investigation also revealed the importance of the SOD, CAT and MDA in the treatment of hepatic disorders. Conclusions: Present investigation revealed the importance of rutin as hepatoprotective agent and signified their role in the oxidative stress and could be used for the development of newer medicine to treat liver disorders.

Health beneficial properties and protective effect of linarin against various form of hepatic failure: An phytotherapeutic approach

Dinesh Kumar PATEL,Kanika PATEL 한국간담췌외과학회 2022 Annals of hepato-biliary-pancreatic surgery Vol.26 No.-

CERTAIN RESULTS ON EXTENDED GENERALIZED τ-GAUSS HYPERGEOMETRIC FUNCTION

Kumar, Dinesh,Gupta, Rajeev Kumar,Shaktawat, Bhupender Singh The Honam Mathematical Society 2016 호남수학학술지 Vol.38 No.4

The main aim of this paper is to introduce an extension of the generalized ${\tau}$-Gauss hypergeometric function $_rF^{\tau}_s(z)$ and investigate various properties of the new function such as integral representations, derivative formulas, Laplace transform, Mellin trans-form and fractional calculus operators. Some of the interesting special cases of our main results have been discussed.

Three-dimensional human activity recognition by forming a movement polygon using posture skeletal data from depth sensor

Dinesh Kumar Vishwakarma,Konark Jain 한국전자통신연구원 2022 ETRI Journal Vol.44 No.2

Human activity recognition in real time is a challenging task. Recently, a plethora of studies has been proposed using deep learning architectures. The implementation of these architectures requires the high computing power of the machine and a massive database. However, handcrafted features-based machine learning models need less computing power and very accurate where features are effectively extracted. In this study, we propose a handcrafted model based on three-dimensional sequential skeleton data. The human body skeleton movement over a frame is computed through joint positions in a frame. The joints of these skeletal frames are projected into two-dimensional space, forming a “movement polygon.” These polygons are further transformed into a one-dimensional space by computing amplitudes at different angles from the centroid of polygons. The feature vector is formed by the sampling of these amplitudes at different angles. The performance of the algorithm is evaluated using a support vector machine on four public datasets: MSR Action3D, Berkeley MHAD, TST Fall Detection, and NTU-RGB+D, and the highest accuracies achieved on these datasets are 94.13%, 93.34%, 95.7%, and 86.8%, respectively. These accuracies are compared with similar state-of-the-art and show superior performance.

Effect of successive extracts of Stachys tibetica Vatke (Lamiaceae) in anxiety

Kumar, Dinesh,Bhat, Zulfiqar Ali,Shah, M.Y. 경희한의학연구센터 2012 Oriental Pharmacy and Experimental Medicine Vol.12 No.4

Stachys tibetica Vatke (Lamiaceae) is an important medicinal plant in the folk medicine of Ladakh, India and Tibet for the treatment of various mental disorders. Infusion and decoction of the whole plant is used as a cup of tea in severe fever, headache and to relieve tension. Present study is aimed to evaluate the anxiolytic effect of successive extracts of Stachys tibetica Vatke (SES). Stachys tibetica Vatke (1 kg) was subjected to successive extraction in a soxhlet apparatus with different solvents of increasing polarity like petroleum ether ($40-60^{\circ}C$), chloroform, ethyl acetate, methanol and finally decocted with water (yield 7.08 %, 3.98 %, 2.02 %, 16.40 % and 21.53 % w/w respectively). All successive extracts were subjected to phytochemical screening. Rutin was identified by TLC method in the extracts. SES were evaluated for anxiolytic activity using elevated plus maze and light/dark arena tests in rats. Phytochemical studies showed the presence of flavonoids, terpenoids, saponins, glycosides, tannins, alkaloids etc. which might be responsible for anxiolytic activity. TLC analysis of the extracts also showed the presence of flavonoids (rutin). SES increased number of entries and time spent in open arms on the elevated plus maze test while as in the light/dark arena test; they showed an increase in number of crossings and time spent in light arena. The results of both the models of anti-anxiety studies were reflected on the 1st, 3rd and 7th day. Methanol and aqueous showed the most, chloroform and petroleum ether ($40-60^{\circ}C$) intermediate and ethyl acetate the least anxiolytic activity ($^*P$ <0.05, $^{**}P$ <0.01, $^{***}P$ <0.001) in both the models. The results strongly justify the use of this plant for treatment of anxiety. Further studies are in progress in our laboratory to isolate and identify the components responsible for anxiolytic activity and the mechanism of action involved.

Feasibility of Use of a Barbed Suture (V-Loc 180) for Quilting the Donor Site in Latissimus Dorsi Myocutaneous Flap Breast Reconstruction

Dinesh Kumar Thekkinkattil,Tasadooq Hussain,Tapan Kumar Mahapatra,Penelope Louise McManus,Peter John Kneeshaw 대한성형외과학회 2013 Archives of Plastic Surgery Vol.40 No.2

Background  Latissimus dorsi  (LD) myocutaneous  flap  is a popular method of breast reconstruction which can be associated with high  incidence of seroma formation. Quilting sutures at the harvest site are used to reduce this. Barbed sutures are self anchoring sutures which avoid multiple knotting and can be useful in quilting. Methods  A retrospective analysis of prospectively maintained database of patients who underwent LD flap breast reconstruction between January 2009 and January 2011 was carried out. Seroma formation at the harvest site, wound related complications,  inpatient stay and duration of surgery were analysed and a comparison was made between two groups where quilting was done with barbed (V-Loc) suture and conventional polydioxanone (PDS) II sutures. Results  Fifty-seven patients were included of which 33 had quilting by V-Loc sutures and in 24 patients PDS II suture was used. Median age in the PDS group was 55 years (interquartile range [IQR)], 45 to 61 years) which was comparable to the V-Loc group (53 years [IQR, 48 to 59 years]; P-value 0.948). Sixteen patients  (28%) had significant seroma formation and 5  (9%) patients developed superficial wound dehiscence.  Incidences of seroma or wound complications were comparable (P-value 0.378 and 1.00, respectively). Secondary outcomes such as total duration of surgery, total inpatient stay, total amount of drain at the donor site were also similar in two groups. Conclusions  Use of barbed sutures for quilting the donor site in LD flap reconstruction is a feasible option and the associated seroma formation and wound complications are comparable with conventional sutures.