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( Dinesh Kumar Patel ),( Kanika Patel ) 대한간학회 2020 춘·추계 학술대회 (KASL) Vol.2020 No.1
Aims: Plants derived natural products are well known for their contributions to human health. Inflammation and oxidative stress are key parameters for the development of liver disorders and molecule having good antioxidant potential could be used for the treatment of liver damage. Oxidative stress, inflammation and apoptosis cause scar formation in the liver cells, however inflammatory mediators such as IL-1, ICAM-1 and TNFa also play important role in hepatic failure. Antioxidant enzyme such as Catalase, SOD, and GSH-Px are used as indexes to evaluate the level of oxidative stress. Acute infection damages the liver cells and killed healthy tissue and formed scar tissue which is called fibrosis. Methods: Different electronic database have been searched to collect needed information of senegin for their medicinal importance in acute liver inflammation and infection and all the information have been analyzed through statistically. Pharmacological activity of senegin has been also validated through different experimental work. Molecular study has been investigated in the present work through interaction of senegin with ligand to know their mode of action. Molecular docking and dynamic experiments were performed with senegin against nuclear factor kappa B (NF-κB), superoxide dismutase (SOD) and Catalase to know how senegin fit on active site. Results: Data analysis revealed the importance of senegin for the treatment of various form of inflammatory disorders including hepatic disorders. Senegin have been found to have neuroprotective and anti-inflammatory activity which are used for the treatment of Hepatic disorders. Scientific databases analysis has also proved their importance as immunomodulatory, hypoglycemic and anticancer potential in the medicine. Database analysis also demonstrates that senegin could prevent liver damage and therefore play important role in the Hepatic inflammation. In-silico studies showed that senegin exhibited a higher docking score against NF-κB, SOD and Catalase which signified their therapeutic potential and role in the various form of hepatic inflammation and complication. Conclusions: Senegin prevent liver damage through its antioxidants and anti-inflammatory potential. However protective effect of senegin in Hepatic cells could be due to interaction of NF-κB, SOD and Catalase.
( Dinesh Kumar Patel ),( Kanika Patel ) 대한간학회 2020 춘·추계 학술대회 (KASL) Vol.2020 No.1
Aims: Plant based drugs have numerous phytochemicals mainly belongs to the phenolic flavonoid and carotenoids class chemicals. These phytochemicals play important role in the plant’s defence mechanism and used for the treatment of numerous human disorders in the modern system of medicine. Plants and their derived products contain important class of phytochemicals which are still considered as one of the important sources of materials for the development of noble molecule with better therapeutic goal. Cytochromes P450 enzymes are capable of catalyzing the oxidative biotransformation of numerous drugs in the human body. Rutin is a low molecular weight polyphenolic compound mainly found to be present in various citrus class drugs. Rutin have important physiological functions both in the human body and plants. Methods: To know the beneficial effect of rutin in liver system, various scientific databases have been searched and analyzed in the present investigation to know the therapeutic potential of Rutin in the biological system. Pharmacological importance of rutin in Hepatic system have been searched and analyzed. Molecular simulation database of rutin against cytochrome P-450, superoxide dismutase (SOD), catalase (CAT) and malondialdehyde (MDA) have been searched to know the importance of rutin in liver antioxidant systems. Binding energy and type of molecular interactions have been also analyzed in the present investigation through databases analysis to uncoil the molecular mechanism of rutin against hepatic disorders. Results: Scientific research databases analysis revealed the importance of rutin in the hepatic system as higher intake of rutin for 20 days in rat tissues showed improve liver antioxidant level and reduced systemic inflammation and oxidative stress. However, rutin significantly reduced transaminases and phosphatases enzymes in liver and restores oxidative damage. Molecular simulation study database analysis signified the importance of cytochrome P-450 in liver disorders. Further investigation also revealed the importance of the SOD, CAT and MDA in the treatment of hepatic disorders. Conclusions: Present investigation revealed the importance of rutin as hepatoprotective agent and signified their role in the oxidative stress and could be used for the development of newer medicine to treat liver disorders.
Patel Priya,Singh Shailesh,Patel Arvind Kumar,Kumar Bhupendra,Singh Arvind Kumar,Kumar Dinesh 한국응용곤충학회 2020 Journal of Asia-Pacific Entomology Vol.23 No.2
Parthenium hysterophorus L. (Asteraceae) is a toxic weed of agricultural farms, pastures and wastelands with a pan-tropical distribution. The weed causes a reduction in crop production of agricultural fields and severe health problems in humans. The Mexican beetle, Zygogramma bicolorata Pallister (Coleoptera: Chrysomelidae) is among the most promising candidates for the weed biocontrol. However, no previous study has evaluated assimilation of nutrients in this beetle. In the present study, feeding attributes and assimilation of nutrients by larvae of Z. bicolorata were assessed on the weed. Results revealed that the first larval instars of Z. bicolorata exhibited lowest consumption rates, and accumulated minimum concentrations of glucose, proteins and triglycerides in their body. They showed compensatory feeding, and displayed highest food utilization efficiencies and developmental rates. In contrast, the fourth larval instars exhibited higher food consumption rates and conversion efficiencies, but displayed lowest developmental rates. Accumulation of food reserves was also recorded maximum for the fourth larval instars. Overall, the findings may aid current mass-rearing efforts for Z. bicolorata in laboratories, but field trials are still needed to strengthen the present findings.