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Eshun, Derek,Saraf, Rabya,Bae, Soochan,Jeganathan, Jelliffe,Mahmood, Feroze,Dilmen, Serkan,Ke, Qingen,Lee, Dongwon,Kang, Peter M.,Matyal, Robina American Physiological Society 2017 environmental and exercise physiology Vol.122 No.6
<P>NEW & NOTEWORTHY Our research project proposes a novel method for drug delivery. Our patented PVAX nanoparticle can detect areas of ischemia and oxidative stress. Although there have been studies about delivering angiogenic molecules to areas of ischemic injury, there are drawbacks of nonspecific delivery as well as short half-lives. Our study is unique because it can specifically deliver NPY3-36 to ischemic tissue and appears to extend the amount of time therapy is available, despite NPY3-36's short half-life.</P>
Kinetics of penetration influence the apparent potency of vanilloids on TRPV1.
Lazar, Jozsef,Braun, Derek C,Tó,th, Attila,Wang, Yun,Pearce, Larry V,Pavlyukovets, Vladimir A,Blumberg, Peter M,Garfield, Susan H,Wincovitch, Stephen,Choi, Hyun-Kyung,Lee, Jeewoo American Society for Pharmacology and Experimental 2006 Molecular pharmacology Vol.69 No.4
<P>Evidence that the ligand binding site of TRPV1 lies on the inner face of the plasma membrane and that much of the TRPV1 itself is localized to internal membranes suggests that the rate of ligand entry into the cell may be an important determinant of the kinetics of ligand action. In this study, we synthesized a BODIPY TR-labeled fluorescent capsaicin analog (CHK-884) so that we could directly measure ligand entry. We report that CHK-884 penetrated only slowly into Chinese hamster ovary (CHO) cells expressing rat TRPV1, with a t1/2 of 30 +/- 4 min, and localized in the endoplasmic reticulum and Golgi. Although CHK-884 was only weakly potent for TRPV1 binding (Ki = 6400 +/- 230 nM), it was appreciably more potent when assayed by intracellular calcium imaging and was 3.2-fold more potent with a 1-h incubation time (37 nM) than with a 5-min incubation time. Olvanil, a highly lipophilic vanilloid, yielded an EC50 of 4.3 nM upon intracellular calcium imaging with an incubation time of 1 h, compared with an EC50 value of 29.5 nM for calcium imaging assayed at 5 min. Likewise, the antagonist 5-iodo-resiniferatoxin (5-iodo-RTX) displayed a Ki of 4.2 pM if incubated with CHO-TRPV1 cells for 2 h before addition of capsaicin compared with 1.5 nM if added simultaneously. We conclude that some vanilloids may have slow kinetics of uptake; this slow uptake may affect assessment of structure activity relations and may represent a significant factor for vanilloid drug design.</P>
Performance Progress and Leadership Behavior
Frode Moen,Rune Hoigaard,Derek M. Peters 한국코칭능력개발원 2014 International Journal of Coaching Science Vol.8 No.1
The aim of this study was to investigate the relationship between athletes’ perceptions of their coaches’ leadership behaviours and their rating of their own satisfaction with their performance progress whilst under the guidance of this coach. Participants were 120 competitive athletes (M age = 20.3 years, SD =4.6) from different individual sports. Participants completed the Leadership Scale for Sports (LSS) and rated their own perceived satisfaction with their own performance progress underneath their present coach on a scale of 1 ‘extremely dissatisfied’ to 7 ‘extremely satisfied’. A one-way ANOVA analyses was used to test the differences between three composite satisfaction categories of ‘not satisfied (1-4)’, ‘satisfied’ (5) and ‘more than satisfied’ (6-7). The results indicate that the athletes who are most satisfied with their performance progress, evaluate their coaches’ leadership behavior higher in the following domains: Training and Instruction, Democratic behavior, Social Support, and Positive Feedback. Findings from the present study highlight the importance of coaches’ training and instruction behavior. The present study also highlights that the coach-athlete relationship must entail elements of reciprocity, trust, as well as being of a genuine and helping nature, and that coach’s democratic behaviour, supportive style and their ability to give positive feedback seem to support such values.
Team Identification Reduces Social Loafing and Promotes Social Laboring in Cycling
( Rune Høigaard ),( Filip Boen ),( Bert De Cuyper ),( Derek M Peters ) 한국스포츠정책과학원(구 한국스포츠개발원) 2013 International Journal of Applied Sports Sciences Vol.25 No.1
The purpose was to examine if heightened team identification reduced social loafing and promoted social laboring in 1 and 3 minute cycling time-trials with participants alone and then in either salient or non-salient teams. Salient teams were created using 30 minutes of team building activities prior to their team time trials. Social loafing occurred in both team trials in the non-salient teams (P < .05). In the salient teams, social loafing was eliminated in the 1 minute team trial and social laboring was apparent in the 3 minute team trial (P < .05). Heightened team identification therefore reduced social loafing and significantly enhanced team performance.