A Note on Central Separable Cancellative Semialgebras

Deore, R.P.,Patil, K.B. Department of Mathematics 2005 Kyungpook mathematical journal Vol.45 No.4

Here we define Central separable semialgebras and to prove some structure theorems for central separable cancellative, semialgebras over a commutative and cancellative semiring.

Omega 3 fatty acids as a host modulator in chronic periodontitis patients: a randomised, double-blind, palcebo-controlled, clinical trial

Deore, Girish D.,Gurav, Abhijit N.,Patil, Rahul,Shete, Abhijeet R.,NaikTari, Ritam S.,Inamdar, Saurabh P. Korean Academy of Periodontology 2014 Journal of Periodontal & Implant Science Vol.44 No.1

Purpose: Periodontitis is an infectious disease caused predominantly by gram-negative anerobes. The host inflammatory response to these bacteria causes alveolar bone loss that is characterized as periodontitis. Omega-3 fatty acids (${\omega}$-3 FAs) have anti-inflammatory properties, thus have been used to treat some chronic inflammatory diseases such as cardiovascular disease and rheumatoid arthritis. We aimed to evaluate the effect of dietary supplementation with ${\omega}$-3 FAs as a host modulating agent in patients with chronic periodontitis. Methods: Sixty otherwise healthy subjects with moderate and severe chronic periodontitis were enrolled in our randomised, double-blind, placebo-controlled trial. The control group (CG, n=30) was treated with scaling and root planing (SRP) and given a placebo; the treatment group (TG, n=30) was treated with SRP and dietary supplementation of ${\omega}$-3 FAs (one 300 mg tablet daily for 12 weeks). Periodontal clinical parameters and serum C-reactive protein (CRP) levels were evaluated in all patients at baseline, a 6-week and 12-week period after treatment. Results: A significant reduction in the gingival index, sulcus bleeding index, pocket depth, and clinical attachment level was found in the TG compared to the CG at a 12-week period. However, no statistically significant changes in serum CRP levels were found. Conclusions: Our findings suggest that ${\omega}$-3 FAs can successfully reduce gingival inflammation, pocket depth, and attachment level gain. Dietary supplementation with ${\omega}$-3 FAs may have potential benefits as a host modulatory agent in the prevention and/or C management of chronic periodontitis.

Herbal anti-inflammatory immunomodulators as host modulators in chronic periodontitis patients: a randomised, double-blind, placebo-controlled, clinical trial

Deore, Girish D.,Gurav, Abhijit N.,Patil, Rahul,Shete, Abhijeet R.,Naiktari, Ritam S.,Inamdar, Saurabh P. Korean Academy of Periodontology 2014 Journal of Periodontal & Implant Science Vol.44 No.2

Purpose: Host modulatory therapy has been proposed as a treatment for periodontal diseases. A class of herbal medicines, known to be immunomodulators, alters the activity of immune function through the regulation of informational molecules such as cytokines. In the current study, we tested the hypothesis that herbal immunomodulator drugs act as an adjuvant to scaling and root planing (SRP) in alleviating periodontal inflammation by improving clinical and biochemical parameters. Methods: Sixty healthy subjects (30 in each group) with moderate and severe chronic periodontitis were enrolled in a double-blind, placebo-controlled, double-masked randomised controlled trial. The control group was treated with SRP and a placebo, whereas the test group was treated with SRP followed by dietary supplementation of Septilin for 3 weeks. Periodontal clinical parameters and serum C-reactive protein (CRP) levels were evaluated for all patients at the baseline, 3 weeks, and 6 weeks. Results: Improved gingival index scores found in the test group as compared to the control group were found to be statistically significant only after 3 weeks (P<0.001). In contrast, the decrease in the sulcus bleeding index and pocket depth scores was statistically highly significant in the test group as compared to the control group after 3 weeks and 6 weeks (P<0.001). However, reduced clinical attachment level and CRP scores, as reflected in the test group as compared to the control group, were not found to be statistically significant after both 3 weeks (P>0.05) and 6 weeks (P>0.05). Conclusions: The results of this clinical-biochemical study suggest that dietary supplementation with herbal immunomodulatory agents may be a promising adjunct to SRP and may aid in improving periodontal treatment outcomes.

Omega 3 fatty acids as a host modulator in chronic periodontitis patients: a randomised, double-blind, palcebo-controlled, clinical trial

Girish D. Deore,Abhijit N. Gurav,Rahul Patil,Abhijeet R. Shete,Ritam S. NaikTari,Saurabh P. Inamdar 대한치주과학회 2014 Journal of Periodontal & Implant Science Vol.44 No.1

Purpose: Periodontitis is an infectious disease caused predominantly by gram-negative anerobes. The host inflammatory response to these bacteria causes alveolar bone loss that ischaracterized as periodontitis. Omega-3 fatty acids (ω-3 FAs) have anti-inflammatory properties,thus have been used to treat some chronic inflammatory diseases such as cardiovasculardisease and rheumatoid arthritis. We aimed to evaluate the effect of dietary supplementationwith ω-3 FAs as a host modulating agent in patients with chronic periodontitis. Methods: Sixty otherwise healthy subjects with moderate and severe chronic periodontitiswere enrolled in our randomised, double-blind, placebo-controlled trial. The control group(CG, n=30) was treated with scaling and root planing (SRP) and given a placebo; thetreatment group (TG, n=30) was treated with SRP and dietary supplementation of ω-3FAs (one 300 mg tablet daily for 12 weeks). Periodontal clinical parameters and serum Creactiveprotein (CRP) levels were evaluated in all patients at baseline, a 6-week and 12-week period after treatment. Results: A significant reduction in the gingival index, sulcus bleeding index, pocket depth,and clinical attachment level was found in the TG compared to the CG at a 12-week period. However, no statistically significant changes in serum CRP levels were found. Conclusions: Our findings suggest that ω-3 FAs can successfully reduce gingival inflammation,pocket depth, and attachment level gain. Dietary supplementation with ω-3 FAsmay have potential benefits as a host modulatory agent in the prevention and/or adjunctivemanagement of chronic periodontitis.

Herbal anti-inflammatory immunomodulators as host modulators in chronic periodontitis patients: a randomised, double-blind, placebo-controlled, clinical trial

Girish D. Deore,Abhijit N. Gurav,Rahul Patil,Abhijeet R. Shete,Ritam S. Naiktari,Saurabh P. Inamdar 대한치주과학회 2014 Journal of Periodontal & Implant Science Vol.44 No.2

Purpose: Host modulatory therapy has been proposed as a treatment for periodontal diseases. A class of herbal medicines, known to be immunomodulators, alters the activity ofimmune function through the regulation of informational molecules such as cytokines. Inthe current study, we tested the hypothesis that herbal immunomodulator drugs act as anadjuvant to scaling and root planing (SRP) in alleviating periodontal inflammation by improvingclinical and biochemical parameters. Methods: Sixty healthy subjects (30 in each group) with moderate and severe chronic periodontitiswere enrolled in a double-blind, placebo-controlled, double-masked randomisedcontrolled trial. The control group was treated with SRP and a placebo, whereas the testgroup was treated with SRP followed by dietary supplementation of Septilin for 3 weeks. Periodontal clinical parameters and serum C-reactive protein (CRP) levels were evaluatedfor all patients at the baseline, 3 weeks, and 6 weeks. Results: Improved gingival index scores found in the test group as compared to the controlgroup were found to be statistically significant only after 3 weeks (P<0.001). In contrast,the decrease in the sulcus bleeding index and pocket depth scores was statistically highlysignificant in the test group as compared to the control group after 3 weeks and 6 weeks(P<0.001). However, reduced clinical attachment level and CRP scores, as reflected in thetest group as compared to the control group, were not found to be statistically significantafter both 3 weeks (P>0.05) and 6 weeks (P>0.05). Conclusions: The results of this clinical-biochemical study suggest that dietary supplementationwith herbal immunomodulatory agents may be a promising adjunct to SRP and mayaid in improving periodontal treatment outcomes.

Utilizing Additive Friction Stir Processing to Fabricate B4C Reinforced Ti–6Al–4V Matrix Surface Composite: Microstructure Refinement and Enhancement in Mechanical Properties

H. A. Deore,J. Mishra,A. G. Rao,B. D. Bhanushali,V. D. Hiwarkar 대한금속·재료학회 2022 METALS AND MATERIALS International Vol.28 No.1

Ti–6Al–4V/B4C surface composite, having uniform dispersion of reinforcement, was successfully fabricated via additive friction stir processing (AFSP) technique. The chemical reaction between B4C particles and Ti matrix resulted in the formationof intermetallics like TiBX and TiC. Optical microscopy, scanning electron microscopy, electron backscattered difractionand X-ray difraction were carried out to investigate the infuence of FSP, B4C reinforcement and post-FSP heat treatment onmicrostructure evolution. Microhardness, Charpy impact and pin on disc wear tests were performed to examine mechanicaland wear properties. Fully β transformed microstructure composed of basket-weave lamellar α/β together with the needle-likeultrafne martensite α′ was observed in FSPed stir zone. B4C particles brought about additional microstructure refnementby pinning prior β grain boundaries (Zener pinning) and enhancing the nucleation rate (particle stimulated nucleation). Surface composites fabricated via AFSP exhibited higher hardness, wear-resistance and impact toughness compared to thebase metal Ti–6Al–4V and FSPed Ti–6Al–4V.

Synthesis and characterization of doxorubicin hydrochloride drug molecule-intercalated DNA nanostructures

GNAPAREDDYBRAMARAMBA,Pragati Madhukar Deore,Sreekantha Reddy Dugasani,김승재,박성하,Sung Ha Park 한국물리학회 2018 Current Applied Physics Vol.18 No.11

In this paper, we demonstrate the feasibility of constructing DNA nanostructures (i.e. DNA rings and doublecrossover (DX) DNA lattices) with appropriate doxorubicin hydrochloride (DOX) concentration and reveal significant characteristics for specific applications, especially in the fields of biophysics, biochemistry and medicine. DOX-intercalated DNA rings and DX DNA lattices are fabricated on a given substrate using the substrateassisted growth method. For both DNA rings and DX DNA lattices, phase transitions from crystalline to amorphous, observed using atomic force microscopy (AFM) occurred above a certain concentration of DOX (at a critical concentration of DOX, 30 μM of [DOX]C) at a fixed DNA concentration. Additionally, the coverage percentage of DNA nanostructures on a given substrate is discussed in order to understand the crystal growth mechanism during the course of annealing. Lastly, we address the significance of optical absorption and photoluminescence characteristics for determining the appropriate DOX binding to DNA molecules and the energy transfer between DOX and DNA, respectively. Both measurements provide evidence of DOX doping and [DOX]C in DNA nanostructures.

Does Segmental Kyphosis Affect Surgical Outcome after a Posterior Decompressive Laminectomy in Multisegmental Cervical Spondylotic Myelopathy?

Akshay Jain,Tarush Rustagi,Gautam Prasad,Tushar Deore,Shekhar Y. Bhojraj 대한척추외과학회 2017 Asian Spine Journal Vol.11 No.1

Study Design: Retrospective analysis. Purpose: To compare results of laminectomy in multisegmental compressive cervical myelopathy (CSM) with lordosis versus segmental kyphosis. Overview of Literature: Laminectomy is an established procedure for decompression in CSM with cervical lordosis. However in patients with segmental kyphosis, it is associated with risk of progression of kyphosis and poor outcome. Whether this loss of sagittal alignment affects functional outcome is not clear. Methods: We retrospectively reviewed 68 patients who underwent laminectomy for CSM from 1998 to 2009. As per preoperative magnetic resonance images, 36 patients had preoperative lordosis (Group 1) and 32 had segmental kyphosis (Group 2). We studied age at the time of surgery, duration of preoperative symptoms, recovery rate, magnitude of postoperative backward shifting of spinal cord and loss of sagittal alignment. Results: Mean follow up was 5.05 years (range, 2–13 years) and mean age at the time of surgery 61.88 years. Group 1 had 20 men and 16 women and Group 2 had 19 men and 13 women. Mean recovery rate in Group 1 was 60.32%, in Group 2 was 63.7% without any statistical difference (p -value 0.21, one tailed analysis of variance). Two patients of Group 1 had loss of cervical lordosis by five degrees. In Group 2 seven patients had progression of segmental kyphosis by 5–10 degrees and two patients by more than 10 degrees. Mean cord shift was more in Group 1 (mean, 2.41 mm) as compared to Group 2 (mean, –1.97 mm) but it had no correlation to recovery rate. Patients with younger age (mean, 57 years) and less duration of preoperative symptoms (mean, 4.86 years) had better recovery rate (75%). Conclusions: Clinical outcome in CSM is not related to preoperative cervical spine alignment. Thus, lordosis is not mandatory for planning laminectomy in CSM. Good outcome is expected in younger patients operated earliest after onset of symptoms.