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Gustavo Batista de Castro Souza,Flávio Henrique Teles Vieira,Cláudio Ribeiro Lima,Getúlio Antero de Deus Júnior,Marcelo Stehling de Castro,Sérgio Granato de Araujo,Thiago Lara Vasques 한국전자통신연구원 2016 ETRI Journal Vol.38 No.1
Smart metering systems have become widespread around the world. RF mesh communication systems have contributed to the creation of smarter and more reliable power systems. This paper presents an algorithm for positioning GPRS concentrators to attain delay constraints for a ZigBee-based mesh network. The proposed algorithm determines the number and placement of concentrators using integer linear programming and a queueing model for the given mesh network. The solutions given by the proposed algorithm are validated by verifying the communication network performance through simulations.
Ana Amélia de Carvalho Melo-Cavalcante,Sandra Maria Mendes de Moura Dantas,Aracelli de Sousa Leite,Leomá Albuquerque Matos,João Marcelo de Castro e Sousa,Jaqueline Nascimento Picada,Juliana da Silva 한국식품영양과학회 2011 Journal of medicinal food Vol.14 No.7
Cashew apple juice and cajuina (processed juice) are drinks widely consumed in northeast Brazil. In vitro studies have shown that both juices have antimutagenic activity as well as antioxidant effects. These juices contain vitamins, carotenoids, and phenolic compounds. This in vivo study assessed the antigenotoxic and anticlastogenic effects of both drinks against genotoxicity and mutagenicity induced by cyclophosphamide. The comet, micronucleus, and chromosome aberrations tests were used. Male Swiss mice were divided into 6 groups (5 animals per group) and received the following by gavage, 0.15 mL/10 g body weight: group 1, water; group 2, cashew apple juice; group 3, cajuina juice; group 4, cashew apple juice and cyclophosphamide (50 mg/kg); group 5, cajuina juice and cyclophosphamide; group 6: cyclophosphamide. Both drinks significantly reduced DNA damage of peripheral blood cells (P<.001), with modulation percentages of 60.82% (cashew apple juice) and 82.19% (cajuina) when compared with the cyclophosphamide group. Cashew apple juice and cajuina modulated cyclophosphamide-induced micronucleus frequency, with up to 80.0% inhibition. Cashew apple juice and cajuina decreased the average number of cells with chromosome aberrations in bone marrow of mice by 53% and 65%, respectively. These findings demonstrate the high antigenotoxic and anticlastogenic potential of cashew apple juice and cajuina in vivo, which can be related to the antioxidant compounds found in both drinks.
Sérgio Lúcio Pereira de Castro Lopes,Isadora Luana Flores,Thiago de Oliveira Gamba,Rivea Ines Ferreira-Santos,Mari Eli Leonelli de Moraes,Aline Alvarez Cabello,Paula Nascimento Moutinho 대한구강악안면외과학회 2017 대한구강악안면외과학회지 Vol.43 No.2
Maxillofacial images must be examined to find pathologies not identified during clinical examination. Unicystic ameloblastoma (UA) extending to the mandibular body and ramus was neglected on initial panoramic radiographic examination. After orthodontic therapy, a huge lesion was observed clinically and through imaging exams. After the conservative surgery, no recurrence was observed during five years of follow-up. This case emphasized the need for careful evaluation of patient images focusing on the oral diagnosis before any dental treatment planning, including orthodontic therapy.
de Camargo, Elaine Aparecida,da Silva, Glenda Nicioli,Gobette, Camila Pereira,de Castro Marcondes, Joao Paulo,Salvadori, Daisy Maria Favero Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.10
Tumor response to antineoplastic drugs is not always predictable. This is also true for bladder carcinoma, a highly recurrent neoplasia. Currently, the combination of cisplatin and gemcitabine is well accepted as a standard protocol for treating bladder carcinoma. However, in some cases, this treatment protocol causes harmful side effects. Therefore, we investigated the roles of the genes TP53, RASSF1A (a tumor suppressor gene) and hMLH1 (a gene involved in the mismatch repair pathway) in cell susceptibility to cisplatin/gemcitabine treatment. Two bladder transitional carcinoma cell (TCC) lines, RT4 (wild-type TP53) and 5637 (mutated TP53), were used in this study. First, we evaluated whether the genotoxic potential of cisplatin/gemcitabine was dependent on TP53 status. Then, we evaluated whether the two antineoplastic drugs modulated RASSF1A and hMLH1 expression in the two cell lines. Increased DNA damage was observed in both cell lines after treatment with cisplatin or gemcitabine and with the two drugs simultaneously, as depicted by the comet assay. A lack of RASSF1A expression and hypermethylation of its promoter were observed before and after treatment in both cell lines. On the other hand, hMLH1 downregulation, unrelated to methylation status, was observed in RT4 cells after treatment with cisplatin or with cisplatin and gemcitabine simultaneously (wild-type TP53); in 5637 cells, hMLH1 was upregulated only after treatment with gemcitabine. In conclusion, the three treatment protocols were genotoxic, independent of TP53 status. However, cisplatin was the most effective, causing the highest level of DNA damage in both wild-type and mutated TP53 cells. Gemcitabine was the least genotoxic agent in both cell lines. Furthermore, no relationship was observed between the amount of DNA damage and the level of hMLH1 and RASSF1A expression. Therefore, other alternative pathways might be involved in cisplatin and gemcitabine genotoxicity in these two bladder cancer cell lines.
Castro de Moura, Manuel,Miro, Francesc,Han, Jung Min,Kim, Sunghoon,Celada, Antonio,Ribas de Pouplana, Lluí,s Public Library of Science 2011 PLoS neglected tropical diseases Vol.5 No.11
<▼1><P>Immunological pressure encountered by protozoan parasites drives the selection of strategies to modulate or avoid the immune responses of their hosts. Here we show that the parasite <I>Entamoeba histolytica</I> has evolved a chemokine that mimics the sequence, structure, and function of the human cytokine HsEMAPII (<I>Homo sapiens</I> endothelial monocyte activating polypeptide II). This <I>Entamoeba</I> EMAPII-like polypeptide (EELP) is translated as a domain attached to two different aminoacyl-tRNA synthetases (aaRS) that are overexpressed when parasites are exposed to inflammatory signals. EELP is dispensable for the tRNA aminoacylation activity of the enzymes that harbor it, and it is cleaved from them by <I>Entamoeba</I> proteases to generate a standalone cytokine. Isolated EELP acts as a chemoattractant for human cells, but its cell specificity is different from that of HsEMAPII. We show that cell specificity differences between HsEMAPII and EELP can be swapped by site directed mutagenesis of only two residues in the cytokines' signal sequence. Thus, <I>Entamoeba</I> has evolved a functional mimic of an aaRS-associated human cytokine with modified cell specificity.</P></▼1><▼2><P><B>Author Summary</B></P><P>Amebiasis caused by the parasite <I>Entamoeba histolytica</I> is one of the leading causes of dysentery worldwide, with an estimated annual mortality of 100.000. In 10% of patients, the intestinal infection can spread to internal organs causing hepatic, lung, and brain abscesses. Little is known about the strategies used by the parasite to evade or minimize the inflammatory and immune responses of its host. In this manuscript we report the discovery that <I>Entamoeba</I> has evolved a polypeptide that functionally mimics the activity of a human cytokine (EMAPII) involved in the regulation of inflammation. This polypeptide termed EELP (<I>Entamoeba</I> EMAPII-Like Polypeptide) is capable of attracting human cells, just like its human counterpart but, unlike EMAPII, EELP does not act on inflammatory cells. We have characterized the dynamics of gene expression that regulate EELP synthesis, and we demonstrate that the protein is produced when <I>Entamoeba</I> encounter inflammation signals produced by their human host. Our working hypothesis is that EELP is used by the parasite to shield itself from human inflammation. In general, the discovery of EELP opens a new avenue of research into the mechanisms used by <I>Entamoeba</I> to survive their host's environment.</P></▼2>
Castro, Ana Paula Gomes De,Goulart, Alexandre Moura Cintra,Andrade, Ednalva Patricia De,Cares, Juvenil Enrique,Carvalho, Daniel Diego Costa The Korean Society of Plant Pathology 2012 Plant Pathology Journal Vol.28 No.3
Populations of plant-parasitic nematodes were evaluated in soil and root samples from areas planted with passion fruit, or covered with adjacent native cerrado vegetation, in five different cropping regions of the Brazilian Federal District. From July 2007 to January 2008, twenty samples had been collected in five Rural Centers (N$\acute{u}$cleo Rural-NR) planted with passion fruit. In five sites, samples were also collected in native cerrado vegetation. Specimens of nine genera of plant-parasitic nematodes (Meloidogyne, Helicotylenchus, Rotylenchulus, Scutellonema, Pratylenchus, Paratylenchus, Hemicycliophora, Xiphinema and Criconemoides) were found in the present survey. Important nematode pathogens, such as Rotylenchulus reniformis and Meloidogyne spp. were observed in the passion fruit plantations throughout five major producing regions of the Brazilian Federal District.