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Kim, Dayeong,Soundrarajan, Nagasundarapandian,Lee, Juyeon,Cho, Hye-sun,Choi, Minkyeung,Cha, Se-Yeoun,Ahn, Byeongyong,Jeon, Hyoim,Le, Minh Thong,Song, Hyuk,Kim, Jin-Hoi,Park, Chankyu American Society for Microbiology 2017 Antimicrobial Agents and Chemotherapy Vol.61 No.9
<P>In this study, we sought to identify novel antimicrobial peptides (AMPs) in Python bivittatus through bioinformatic analyses of publicly available genome information and experimental validation. In our analysis of the python genome, we identified 29 AMP-related candidate sequences. Of these, we selected five cathelicidin-like sequences and subjected them to further in silico analyses. The results showed that these sequences likely have antimicrobial activity. The sequences were named Pb-CATH1 to Pb-CATH5 according to their sequence similarity to previously reported snake cathelicidins. We predicted their molecular structure and then chemically synthesized the mature peptide for three putative cathelicidins and subjected them to biological activity tests. Interestingly, all three peptides showed potent antimicrobial effects against Gram-negative bacteria but very weak activity against Gram-positive bacteria. Remarkably,Delta Pb-CATH4 showed potent activity against antibiotic-resistant clinical isolates and also was observed to possess very low hemolytic activity and cytotoxicity. Delta Pb-CATH4 also showed considerable serum stability. Electron microscopic analysis indicated that. Delta Pb-CATH4 exerts its effects via toroidal pore preformation. Structural comparison of the cathelicidins identified in this study to previously reported ones revealed that these Pb-CATHs are representatives of a new group of reptilian cathelicidins lacking the acidic connecting domain. Furthermore, Pb-CATH4 possesses a completely different mature peptide sequence from those of previously described reptilian cathelicidins. These new AMPs may be candidates for the development of alternatives to or complements of antibiotics to control multidrug-resistant pathogens.</P>
Fundamental research on a cerenkov radiation sensor based on optical glass for detecting beta-rays
Kim, Jae Seok,Jang, Kyoung Won,Shin, Sang Hun,Jeon, Dayeong,Hong, Seunghan,Sim, Hyeok In,Kim, Seon Geun,Yoo, Wook Jae,Lee, Bongsoo,Moon, Joo Hyun,Park, Byung Gi 한국물리학회 2015 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol. No.
<P>In this study, a Cerenkov radiation sensor for detecting low-energy beta-particles was fabricated using various Cerenkov radiators such as an aerogel and CaF2-, SiO2-, and Al(2)O(3-)based optical glasses. Because the Cerenkov threshold energy (CTE) is determined by the refractive index of the Cerenkov radiator, the intensity of Cerenkov radiation varies according to the refractive indices of the Cerenkov radiators. Therefore, we measured the intensities of Cerenkov radiation induced by beta-particles generated from a radioactive isotope as a function of the refractive indices of the Cerenkov radiators. Also, the electron fluxes were calculated for various Cerenkov radiators by using a Monte Carlo N-Particle extended transport code (MCNPX) to determine the relationship between the intensities of the Cerenkov radiation and the electron fluxes.</P>
Kim, Dayeong,Seo, Jungmok,Shin, Sera,Lee, Soonil,Lee, Kilsoo,Cho, Hyeonjin,Shim, Wooyoung,Lee, Han-Bo-Ram,Lee, Taeyoon American Chemical Society 2015 Chemistry of materials Vol.27 No.14
<P>Adhesion control of various liquid droplets on a liquid-repellent surface is a fundamental technique in novel open channel microfluidic systems. Herein, we demonstrate reversible liquid droplet adhesion switching on superamphiphobic Pd-decorated Ag dendrites (Pd/Ag dendrites). Although adhesion between liquids and the superamphiphobic surfaces was extremely low under ambient air, high adhesion was instantly achieved by exposure of the dendrites to 8% hydrogen gas. Transition from low to high adhesion and the reverse case were successfully repeated more than 10 times by switching from atmospheric ambient air to 8% hydrogen gas. This is the first technique that allows real-time reversible adhesion change with various liquid droplets to a surface using gas-induced structural changes and can potentially be used to realize various functions for droplet-based microfluidics.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/cmatex/2015/cmatex.2015.27.issue-14/acs.chemmater.5b01038/production/images/medium/cm-2015-01038d_0007.gif'></P><P><A href='http://pubs.acs.org/doi/suppl/10.1021/cm5b01038'>ACS Electronic Supporting Info</A></P>