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Trends in Intraoperative Neuromonitoring for Thyroid Surgery: A Point-Prevalence Survey in Korea
Dawon Park,Young Jun Chai,Hoon Yub Kim,Woong Youn Chung,Kang Dae Lee,Kwang-Yoon Jung,Jeong Soo Kim 대한신경모니터링학회 2021 Journal of Neuromonitoring & Neurophysiology Vol.1 No.1
Background and Objectives To determine the trends in the use of intraoperative recurrent laryngeal nerve (RLN) monitoring during thyroid surgery in Korea. Materials and Methods A web-based anonymous survey was sent to 594 members of the Korean Intraoperative Neural Monitoring Society (KINMoS), who perform thyroid surgeries in Korea. Topics included in the survey covered the demographics, practice setting, surgical volume, access and familiarity with intraoperative neuromonitoring (IONM) technology, use of IONM, perceived advantages or disadvantages, and qualitative and quantitative descriptions of IONM usage. The χ² test was used to examine associations between the use of IONM and dependent variables. Results A total of 78 (13.1%) people completed the survey. Of the respondents, 78.1% answered that they use IONM in at least some thyroid cases: 28% answered that they always use it and 50% used it occasionally. The most common reason for using IONM was because “it is helpful in special cases,” while “cost” was the most common reason for not using IONM. Among the study population, surgeons in tertiary hospitals and those with high surgical volumes used IONM frequently. Surgeons using IONM were often involved in medical education and were more likely to recommend the use of IONM. Statistical correlation was also confirmed between laryngeal examination and IONM utilization. Conclusion IONM is used for thyroid surgeries at a relatively high rate in Korea. Its use is associated with training, hospital setting of the current surgical practice, annual number of surgeries, involvement in medical training/education, familiarity with IONM, and device availability.
Dawon Park,Se-Jin Baek,Jung-Myun Kwak,Jin Kim,Seon-Hahn Kim 대한외과학회 2018 Annals of Surgical Treatment and Research(ASRT) Vol.94 No.4
Purpose: An oxaliplatin-based regimen is the most common adjuvant chemotherapy for patients with stage II/III colorectal cancer, but many patients experience dose reduction or early termination of chemotherapy due to side effects. We conducted this study to verify the range of reduction with oncologic safety. Methods: Patients with stage II/III colorectal cancer who received adjuvant FOLFOX chemotherapy were enrolled in this study. The total amount of oxaliplatin administered per patient was calculated as a percentile based on 12 cycles of fulldose FOLFOX as a standard dose. The cutoff values showing significant differences in survival were calculated, and the clinicopathologic outcomes of patient groups classified by the value were compared. Results: Among a total of 611 patients, there were 107 stage II patients, and 504 stage III patients. At 60% of the standard dose of oxaliplatin, the patients in the dose reduction group were older (62 years vs. 58 years, P = 0.003), had lower body mass index (BMI) (23.1 kg/m2 vs. 24.0 kg/m2, P = 0.005), and were more exposed to neoadjuvant treatment (18.0% vs. 9.1%, P = 0.003) in comparison to the standard group. At 60% of the standard dose, there were no significant differences in 5-year disease-free survival (DFS) and overall survival (OS) between the 2 groups (5-year DFS: 73.5% vs. 74.2%, P = 0.519; 5-year OS: 71.9% vs. 81.5%, P = 0.256, respectively). Conclusion: Patients with old age, low BMI, and more frequent exposure to neoadjuvant treatment tended to show lower compliance with chemotherapy. More than 60% dose should be administered to patients with stage II/III colorectal cancer as adjuvant chemotherapy to achieve acceptable oncologic outcomes.
Correlating thermal conductivity of carbon fibers with mechanical and structural properties
Dawon Jang,Sungho Lee 한국공업화학회 2020 Journal of Industrial and Engineering Chemistry Vol.89 No.-
Thermal conductivity of carbonfibers (CFs), being one of the important properties, is not easily quantifieddue to practical difficulties in measuring it. We suggest a universal correlation between the thermalconductivity of CFs and their electrical and mechanical properties in order to estimate it without directmeasurement. Crystalline structural information did not show a clear correlation with thermalconductivity, especially for commercially available polyacrylonitrile- or isotropic pitch-based CFs thathave less than a few nanometers of La and Lc. However, in a correlation between tensile modulus andthermal conductivity, there are three distinct regions and two properties increase with a differentinclination in each region. We envisage tensile modulus to be utilized to estimate thermal conductivitywithout a direct measurement for all kinds of CFs.
Expression and identification of CatSper3 channel in mouse brain and testis
Dawon Kang,Jaehee Han 한국발생생물학회 2010 한국발생생물학회 학술발표대회 Vol.29 No.-
Sperm specific non selective cation (CatSper) channels belong to the CatSper family of genes and are expressed only in sperm and testis. In general, gene expression profiles in the brains of humans and mice share the highest similarity with those in testis. Therefore, to identify whether CatSper genes are expressed in the mouse brain, we performed reverse transcriptase-polymerase chain reaction (RT-PCR) and Western blotting. RT-PCR detected all four CatSper mRNAs in both the testis and the brain, with CatSper3 being the most highly expressed. Consistent with RT-PCR data, Western blot analysis showed that CatSper3 was expressed in the brain. We cloned CatSper3 variant 2 from eight-week mouse brain. We named the gene as CatSper3 variant 1 (V1) because the mouse CatSper3 is orthologous to human CatSper3, and another mouse CatSper3 variant (variant 2, V2) with truncated second transmembrane helix was identified. The open reading frame of mCatSper3 V1 consists of 1185 nucleotides and encodes a putative 395-amino acid protein. At the amino acid level, CatSper3 isolated from brain is 100 and 64.8% identical to that isolated from mouse testis and human CatSper3, respectively. Based on comparison between the mCatSper3 V1 ORF and mCatSper3 V2 using TopPred software, the alignment of amino acid sequences shows that the differences exist mainly in segment 2. The CatSper3 transcript consists of eight exons and seven introns, and alternative splice is present within the third exon. In HT22 cell, a mouse hippocampal neuronal cell line, H2O2-induced changes in CatSper3 expression were studied. H2O2 dramatically increased CatSper3 expression in HT22 cells in a dose-and time-dependent manner. The H2O2-induced increase in CatSper3 expression was offset by the addition of N-acetylcysteine (NAC), which is an antioxidant. Taken together, these data strongly indicate that CatSper3 is expressed in mouse brain as variant 1 and suggest that CatSper3 could be a potential target for the modulation of ROS.
Transoral Robotic Thyroidectomy
( Dawon Park ),( Hong Kyu Kim ),( Hoon Yub Kim ) 대한갑상선학회 2018 International Journal of Thyroidology Vol.11 No.1
Transoral approach for thyroidectomy recently gains a lot of attention among the thyroid surgeons, with definite merits over previously developed remote-access approaches. The approach not only resulted in the ideal cosmetic outcome but less postoperative pain with smaller dissection plane in comparison with other approaches. We have successfully introduced the robotic surgical system and its related techniques to this transoral surgical approach for thyroidectomy, which enables the surgeon to have the three-dimentional operative vision and to use the articulating instruments to enhance th eoptimal surgical outcomes. Herein, our unique procedures of transoral robotic thyroidectomy (TORT) are described, and possible advantages and disadvantages of the operation are discussed.
TASK-2 Expression Levels are Increased in Mouse Cryopreserved Ovaries
Dawon Kang,Changyong Choe,Chang-Woon Kim,Ae Jin Goo,Jaehee Han 한국수정란이식학회 2015 한국동물생명공학회지 Vol.30 No.4
Cryopreservation affects osmotic tolerance and intracellular ion concentration through changes in expression levels of water and ion channels. Control of these changes is important for cell survival after cryopreservation. Relatively little is known about changes in K+ channel expression compared to water channel expression. This study was performed to investigate changes in TASK-2 channel (KCNK5: potassium channel, subfamily K, member 5), a member of two-pore domain K+ channel family, in cryopreserved mouse ovaries. Cryopreservation increased TASK-2 mRNA expression in mouse ovaries. In addition, TASK-2 protein expression was upregulated in vitrified and slowly frozen ovaries. TASK-2 protein was expressed in all area of granulosa cells that surround the oocyte within the follicle, except nucleus. Viability of cells overexpressed with TASK-2 was higher than that of vector-transfected cells. Our results found that TASK-2 expression was increased by cryopreservation and overexpression of TASK-2 decreased cryopreservation-induced cell death. These results suggest that TASK-2 upregulation might reduce cryodamage.