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Apalutamide Treatment and Metastasis-free Survival in Prostate Cancer
Smith, Matthew R.,Saad, Fred,Chowdhury, Simon,Oudard, Sté,phane,Hadaschik, Boris A.,Graff, Julie N.,Olmos, David,Mainwaring, Paul N.,Lee, Ji Youl,Uemura, Hiroji,Lopez-Gitlitz, Angela,Trudel, G&e New England Journal of Medicine 2018 The New England journal of medicine Vol.378 No.15
<P>Among men with nonmetastatic castration-resistant prostate cancer, metastasis-free survival and time to symptomatic progression were significantly longer with apalutamide than with placebo.</P>
Simpson, David C.,Ahn, Seonghee,Pasa-Tolic, Ljiljana,Bogdanov, Bogdan,Mottaz, Heather M.,Vilkov, Andrey N.,Anderson, Gordon A.,Lipton, Mary S.,Smith, Richard D. WILEY-VCH Verlag 2006 Electrophoresis Vol.27 No.13
<P>Bottom-up proteomics (analyzing peptides that result from protein digestion) has demonstrated capability for broad proteome coverage and good throughput. However, due to incomplete sequence coverage, this approach is not ideally suited to the study of modified proteins. The modification complement of a protein can best be elucidated by analyzing the intact protein. 2-DE, typically coupled with the analysis of peptides that result from in-gel digestion, is the most frequently applied protein separation technique in MS-based proteomics. As an alternative, numerous column-based liquid phase techniques, which are generally more amenable to automation, are being investigated. In this work, the combination of size-exclusion chromatography (SEC) fractionation with RPLC-Fourier-transform ion cyclotron resonance (FTICR)-MS is compared with the combination of RPLC fractionation with CIEF-FTICR-MS for the analysis of the Shewanella oneidensis proteome. SEC-RPLC-FTICR-MS allowed the detection of 297 proteins, as opposed to 166 using RPLC-CIEF-FTICR-MS, indicating that approaches based on LC-MS provide better coverage. However, there were significant differences in the sets of proteins detected and both approaches provide a basis for accurately quantifying changes in protein and modified protein abundances.</P>
Established and Emerging Therapies in Acute Spinal Cord Injury
Ron Gadot,David N. Smith,Marc Prablek,Joey K. Grochmal,Alfonso Fuentes,Alexander E. Ropper 대한척추신경외과학회 2022 Neurospine Vol.19 No.2
Acute spinal cord injury (SCI) is devastating for patients and their caretakers and has an annual incidence of 20–50 per million people. Following initial assessment with appropriate physical examination and imaging, patients who are deemed surgical candidates should undergo decompression with stabilization. Earlier intervention can improve neurological recovery in the post-operative period while allowing earlier mobilization. Optimized medical management is paramount to improve outcomes. Emerging strategies for managing SCI in the acute period stem from an evolving understanding of the pathophysiology of the injury. General areas of focus include ischemia prevention, reduction of secondary injury due to inflammation, modulation of the cytotoxic and immune response, and promotion of cellular regeneration. In this article, we review established, emerging, and novel experimental therapies. Continued translational research on these methods will improve the feasibility of bench-to-bedside innovations in treating patients with acute SCI.
York R. Smith,David Heermance,Ryan N. Smith 한국유변학회 2016 Korea-Australia rheology journal Vol.28 No.1
The effect of illumination on the viscosity of titania suspensions in silicone oil (insulating medium) and an aqueous buffer (conducting medium) was investigated. Commercially available P25 anatase titania was suspended at a volume fraction of 0.5%. A 12.3% increase in viscosity was observed when silicone oil suspension was used as the medium, while a 2.47% decrease in viscosity was observed for the aqueous buffer suspension after exposure to UV-vis irradiation. The capability of the suspension medium to scavenge photoinduced charges results in the observed photorheological effects. The results presented here demonstrate a new method for influencing the rheological properties of nanoparticle suspensions.
Ming-Chieh Lin,Peter H. Stoltz,David N. Smithe,Hoyoung Song,김형종,최진주,김선주,Sung Hoon Jang 한국물리학회 2012 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.60 No.5
The feasibility of designing and modeling a multistage depressed collector (MDC) by using 3D conformal finite-difference time-domain (CFDTD) particle-in-cell (PIC) simulations as implemented in 3D PIC code, VORPAL has been studied. A simple circuit model employing feedback mechanisms has been implemented to provide stable time-dependent voltages for each stage of the depressed collector, and an arbitrary space-time dependent spent-beam distribution is given in our timedomain simulations. We demonstrate the design of a five-stage depressed collector recovering a triangular-like spent-beam distribution imported from a large signal simulation, achieving an energy recovery efficiency of 75%. The MDC after optimization can be integrated into the limited space of an S-band traveling wave tube for a compact microwave power module (MPM).