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Rohana P. Dassanayake,Thomas C. Truscott,Dongyue Zhuang,David A. Schneider,Sally A. Madsen-Bouterse,Alan J. Young,James B. Stanton,William C. Davis,Katherine I. O’Rourke 대한수의학회 2015 Journal of Veterinary Science Vol.16 No.2
Scrapie is diagnosed antemortem in sheep by detecting misfolded isoforms of prion protein (PrPSc) in lymphoid follicles of the rectal mucosa and nictitating membranes. Assay sensitivity is limited if (a) the biopsy is collected early during disease development, (b) an insufficient number of follicles is collected, or (c) peripheral accumulation of PrPSc is reduced or delayed. A blood test would be convenient for mass live animal scrapie testing. Currently approved techniques, however, have their own detection limits. Novel detection methods may soon offer a non-animal-based, rapid platform with detection sensitivities that rival the prion bioassay. In anticipation, we sought to determine if diseased animals could be routinely identified with a bioassay using B lymphocytes isolated from blood sample volumes commonly collected for diagnostic purposes in small ruminants. Scrapie transmission was detected in five of six recipient lambs intravenously transfused with B lymphocytes isolated from 5∼10 mL of blood from a naturally scrapie-infected sheep. Additionally, scrapie transmission was observed in 18 ovinized transgenic Tg338 mice intracerebrally inoculated with B lymphocytes isolated from 5∼10 mL of blood from two naturally scrapie-infected sheep. Based on our findings, we anticipate that these blood sample volumes should be of diagnostic value.
Mutations in multiple components of the nuclear pore complex cause nephrotic syndrome
Braun, Daniela A.,Lovric, Svjetlana,Schapiro, David,Schneider, Ronen,Marquez, Jonathan,Asif, Maria,Hussain, Muhammad Sajid,Daga, Ankana,Widmeier, Eugen,Rao, Jia,Ashraf, Shazia,Tan, Weizhen,Lusk, C. Pa American Society for Clinical Investigation 2018 The Journal of clinical investigation Vol.128 No.10
Kim, Beum Jun,Park, Joon Ho,Park, Tai Hyun,Bronstein, Philip A.,Schneider, David J.,Cartinhour, Samuel W.,Shuler, Michael L. American Society for Microbiology 2009 Applied and environmental microbiology Vol.75 No.9
<B>ABSTRACT</B><P>Although chemically defined media have been developed and widely used to study the expression of virulence factors in the model plant pathogen <I>Pseudomonas syringae</I>, it has been difficult to link specific medium components to the induction response. Using a chemostat system, we found that iron is the limiting nutrient for growth in the standard <I>hrp</I>-inducing minimal medium and plays an important role in inducing several virulence-related genes in <I>Pseudomonas syringae</I> pv. <I>tomato</I> DC3000. With various concentrations of iron oxalate, growth was found to follow Monod-type kinetics for low to moderate iron concentrations. Observable toxicity due to iron began at 400 μM Fe<SUP>3+</SUP>. The kinetics of virulence factor gene induction can be expressed mathematically in terms of supplemented-iron concentration. We conclude that studies of induction of virulence-related genes in <I>P. syringae</I> should control iron levels carefully to reduce variations in the availability of this essential nutrient.</P>
Dietary wheat germ oil and age influences fatty acid compositions in adult oriental fruit flies
Chiou Ling Chang,Eric Haas,Athena M.M. Mina,Josephione A. Bustamante,Danielle Schneider,Emma Mitchel,Morgan Freilich,David Stanley 한국응용곤충학회 2013 Journal of Asia-Pacific Entomology Vol.16 No.3
The oriental fruit fly, Bactrocera dorsalis (Hendel) (Diptera: Tephritidae) is a serious pest of fruit crops in Asia,several Pacific Islands and sometimes the western United States, particularly California. Sterile insect technique programs have been developed for management of several tephritid fruit fly pests. These programs are based on continuous production of adult fruit flies. The high expense of mass-rearing oriental fruit flies drives research to improve the cost effectiveness of rearing programs. One recent improvement for mass rearing oriental fruit flies involves adding wheat germ oil (WGO) to the larval culture medium, which improved several parameters of biological performance. The performance enhancing influence of WGO is due to the presence of polyunsaturated fatty acids (PUFAs), some of which are nutritionally essential for many insect species. We considered the issue of whether WGO supplementation of the larval culture medium influences the fatty acid make up of adult tissues. We report that WGO supplementation led to substantial increases in adult tissue C18 PUFAs. Unlike the outcomes of unrelated nutritional studies on moths, the PUFA components of WGO did not improve adult fruit fly performance. Taken with recent publications reporting that WGO in larval diets influences gene expression, we conclude that dietary WGO improves biological performance of adults through changes in tissue C18 PUFAs and gene expression.
Modelling the redshift-space three-point correlation function in SDSS-III
Guo, Hong,Zheng,Jing, Y. P.,Zehavi, Idit,Li, Cheng,Weinberg, David H.,Skibba, Ramin A.,Nichol, Robert C.,Rossi, Graziano,Sabiu, Cristiano G.,Schneider, Donald P.,McBride, Cameron K. Oxford University Press 2015 Monthly notices of the Royal Astronomical Society. Vol.449 No.1