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A Clustered Dwarf Structure to Speed up Queries on Data Cubes
Bao, Yubin,Leng, Fangling,Wang, Daling,Yu, Ge Korean Institute of Information Scientists and Eng 2007 Journal of Computing Science and Engineering Vol.1 No.2
Dwarf is a highly compressed structure, which compresses the cube by eliminating the semantic redundancies while computing a data cube. Although it has high compression ratio, Dwarf is slower in querying and more difficult in updating due to its structure characteristics. We all know that the original intention of data cube is to speed up the query performance, so we propose two novel clustering methods for query optimization: the recursion clustering method which clusters the nodes in a recursive manner to speed up point queries and the hierarchical clustering method which clusters the nodes of the same dimension to speed up range queries. To facilitate the implementation, we design a partition strategy and a logical clustering mechanism. Experimental results show our methods can effectively improve the query performance on data cubes, and the recursion clustering method is suitable for both point queries and range queries.
A Clustered Dwarf Structure to Speed up Queries on Data Cubes
Yubin Bao,Fangling Leng,Daling Wang,Ge Yu 한국정보과학회 2007 Journal of Computing Science and Engineering Vol.1 No.2
Dwarf is a highly compressed structure, which compresses the cube by eliminating the semantic redundancies while computing a data cube. Although it has high compression ratio, Dwarf is slower in querying and more difficult in updating due to its structure characteristics. We all know that the original intention of data cube is to speed up the query performance, so we propose two novel clustering methods for query optimization: the recursion clustering method which clusters the nodes in a recursive manner to speed up point queries and the hierarchical clustering method which clusters the nodes of the same dimension to speed up range queries. To facilitate the implementation, we design a partition strategy and a logical clustering mechanism. Experimental results show our methods can effectively improve the query performance on data cubes, and the recursion clustering method is suitable for both point queries and range queries.
Semantic Enablement in IoT Service Layers—Standard Progress and Challenges
Gilani, Komal,Kim, Jaho,Song, JaeSeung,Seed, Dale,Wang, Chonggang IEEE 2018 IEEE internet computing Vol.22 No.4
<P>We believe that applying semantic technologies to IoT service layer platforms can improve data accessibility, data discoverability, and the ability to extract knowledge about the data. Therefore, this article shows how semantic technologies can be leveraged by IoT service layer platforms.</P>
Liu Ran,Han Xuehua,Gao Jing,Luo Min,Guo Dale,Wang Guangzhi 한국균학회 2023 Mycobiology Vol.51 No.3
Penicillium oxalicum strain can be isolated from the Bletilla striata (Thunb.) Reichb. f. tubers. Its solid-state fermentation products are concentrated by percolation extraction. Separation and purification have been conducted to the ethyl acetate extracts by preparative HPLC. Based on the use of spectrometry, we have determined 17 known compounds, 12,13-dihydroxy- fumitremorgin C (1), pseurotin A (2), tyrosol (3), cyclo-(L-Pro-L-Val) (4), cis-4-hydroxy-8- O-methylmellein (5), uracil (6), cyclo-(L-Pro-L-Ala) (7), 1,2,3,4-tetrahydro-4-hydroxy-4-quinolin carboxylic acid (8), cyclo-(Gly-L-Pro) (9), 2’-deoxyuridine (10), 1-(b-D-ribofuranosyl)thymine (11), cyclo-(L-Val-Gly) (12), 2’-deoxythymidine (13), cyclo-(Gly-D-Phe) (14), cyclo-L-(4-hydroxyprolinyl)- D-leucine (15), cyclo-(L)-4-hydroxy-Pro-(L)-Phe (16), uridine (17). Here, we report compounds 1–3, 5, 7–8, 11–12, 14–17 are first found and isolated from this endophyte.
Kumar, Narender,Harashima, Hirofumi,Kalve, Shweta,Bramsiepe, Jonathan,Wang, Kai,Sizani, Bulelani L.,Bertrand, Laura L.,Johnson, Matthew C.,Faulk, Christopher,Dale, Renee,Simmons, L. Alice,Churchman, M American Society of Plant Biologists 2015 The Plant cell Vol.27 No.11
<P>Although they play roles in many different developmental processes, the biochemical function of SMR-type CDK inhibitors is conserved among land plants.</P><P>The best-characterized members of the plant-specific SIAMESE-RELATED (SMR) family of cyclin-dependent kinase inhibitors regulate the transition from the mitotic cell cycle to endoreplication, also known as endoreduplication, an altered version of the cell cycle in which DNA is replicated without cell division. Some other family members are implicated in cell cycle responses to biotic and abiotic stresses. However, the functions of most SMRs remain unknown, and the specific cyclin-dependent kinase complexes inhibited by SMRs are unclear. Here, we demonstrate that a diverse group of SMRs, including an SMR from the bryophyte <I>Physcomitrella patens</I>, can complement an <I>Arabidopsis thaliana siamese</I> (<I>sim</I>) mutant and that both Arabidopsis SIM and <I>P. patens</I> SMR can inhibit CDK activity in vitro. Furthermore, we show that Arabidopsis SIM can bind to and inhibit both CDKA;1 and CDKB1;1. Finally, we show that <I>SMR2</I> acts to restrict cell proliferation during leaf growth in Arabidopsis and that <I>SIM</I>, <I>SMR1/LGO</I>, and <I>SMR2</I> play overlapping roles in controlling the transition from cell division to endoreplication during leaf development. These results indicate that differences in SMR function in plant growth and development are primarily due to differences in transcriptional and posttranscriptional regulation, rather than to differences in fundamental biochemical function.</P>
Song, Gyun Jee,Leslie, Kristen L,Barrick, Stacey,Mamonova, Tatyana,Fitzpatrick, Jeremy M,Drombosky, Kenneth W,Peyser, Noah,Wang, Bin,Pellegrini, Maria,Bauer, Philip M,Friedman, Peter A,Mierke, Dale F American Society for Biochemistry and Molecular Bi 2015 The Journal of biological chemistry Vol.290 No.5
<P>The regulation of the cell cycle by the ubiquitin-proteasome system is dependent on the activity of E3 ligases. Skp2 (S-phase kinase associated protein-2) is the substrate recognition subunit of the E3 ligase that ubiquitylates the cell cycle inhibitors p21(cip1) and p27(kip1) thus promoting cell cycle progression. Increased expression of Skp2 is frequently observed in diseases characterized by excessive cell proliferation, such as cancer and neointima hyperplasia. The stability and cellular localization of Skp2 are regulated by Akt, but the molecular mechanisms underlying these effects remain only partly understood. The scaffolding protein Ezrin-Binding Phosphoprotein of 50 kDa (EBP50) contains two PDZ domains and plays a critical role in the development of neointimal hyperplasia. Here we report that EBP50 directly binds Skp2 via its first PDZ domain. Moreover, EBP50 is phosphorylated by Akt on Thr-156 within the second PDZ domain, an event that allosterically promotes binding to Skp2. The interaction with EBP50 causes cytoplasmic localization of Skp2, increases Skp2 stability and promotes proliferation of primary vascular smooth muscle cells. Collectively, these studies define a novel regulatory mechanism contributing to aberrant cell growth and highlight the importance of scaffolding function of EBP50 in Akt-dependent cell proliferation.</P>
Receptor activator of nuclear factor-κB ligand is a novel inducer of myocardial inflammation.
Ock, Sangmi,Ahn, Jihyun,Lee, Seok Hong,Park, Hongryeol,Son, Jang Won,Oh, Jae Gyun,Yang, Dong Kwon,Lee, Wang Soo,Kim, Ho-Shik,Rho, Jaerang,Oh, Goo Taeg,Abel, Evan Dale,Park, Woo Jin,Min, Jeong-Ki,Kim, British Medical Association 2012 Cardiovascular research Vol.94 No.1
<P>Although increased levels of myocardial receptor activator of nuclear factor (NF)-κB ligand (RANKL) have been reported in heart failure, the role of this pathway in mediating activation of inflammatory pathways during myocardial remodelling is less well understood. This study sought to determine the role of myocardial RANKL in regulating cytokine expression.</P>
ULTRA-NARROW NEGATIVE FLARE FRONT OBSERVED IN HELIUM-10830 Å USING THE 1.6 m NEW SOLAR TELESCOPE
Xu, Yan,Cao, Wenda,Ding, Mingde,Kleint, Lucia,Su, Jiangtao,Liu, Chang,Ji, Haisheng,Chae, Jongchul,Jing, Ju,Cho, Kyuhyoun,Cho, Kyungsuk,Gary, Dale,Wang, Haimin American Astronomical Society 2016 The Astrophysical journal Vol.819 No.2
<P>Solar flares are sudden flashes of brightness on the Sun and are often associated with coronal mass ejections and solar energetic particles that have adverse effects on the near-Earth environment. By definition, flares are usually referred to as bright features resulting from excess emission. Using the newly commissioned 1.6. m New Solar Telescope at Big Bear Solar Observatory, we show a striking 'negative' flare with a narrow but unambiguous 'dark' moving front observed in He I 10830 angstrom, which is as narrow as 340 km and is associated with distinct spectral characteristics in Ha and Mg II lines. Theoretically, such negative contrast in He I 10830 angstrom can be produced under special circumstances by nonthermal electron collisions or photoionization followed by recombination. Our discovery, made possible due to unprecedented spatial resolution, confirms the presence of the required plasma conditions and provides unique information in understanding the energy release and radiative transfer in astronomical objects.</P>