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RISS 인기검색어
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- 저자 : Sizani, Bulelani L. (검색결과 1 건)
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Kumar, Narender,Harashima, Hirofumi,Kalve, Shweta,Bramsiepe, Jonathan,Wang, Kai,Sizani, Bulelani L.,Bertrand, Laura L.,Johnson, Matthew C.,Faulk, Christopher,Dale, Renee,Simmons, L. Alice,Churchman, M American Society of Plant Biologists 2015 The Plant cell Vol.27 No.11
<P>Although they play roles in many different developmental processes, the biochemical function of SMR-type CDK inhibitors is conserved among land plants.</P><P>The best-characterized members of the plant-specific SIAMESE-RELATED (SMR) family of cyclin-dependent kinase inhibitors regulate the transition from the mitotic cell cycle to endoreplication, also known as endoreduplication, an altered version of the cell cycle in which DNA is replicated without cell division. Some other family members are implicated in cell cycle responses to biotic and abiotic stresses. However, the functions of most SMRs remain unknown, and the specific cyclin-dependent kinase complexes inhibited by SMRs are unclear. Here, we demonstrate that a diverse group of SMRs, including an SMR from the bryophyte <I>Physcomitrella patens</I>, can complement an <I>Arabidopsis thaliana siamese</I> (<I>sim</I>) mutant and that both Arabidopsis SIM and <I>P. patens</I> SMR can inhibit CDK activity in vitro. Furthermore, we show that Arabidopsis SIM can bind to and inhibit both CDKA;1 and CDKB1;1. Finally, we show that <I>SMR2</I> acts to restrict cell proliferation during leaf growth in Arabidopsis and that <I>SIM</I>, <I>SMR1/LGO</I>, and <I>SMR2</I> play overlapping roles in controlling the transition from cell division to endoreplication during leaf development. These results indicate that differences in SMR function in plant growth and development are primarily due to differences in transcriptional and posttranscriptional regulation, rather than to differences in fundamental biochemical function.</P>
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