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Fujita, Keizo,Kanda, Mitsuro,Ito, Seiji,Mochizuki, Yoshinari,Teramoto, Hitoshi,Ishigure, Kiyoshi,Murai, Toshifumi,Asada, Takahiro,Ishiyama, Akiharu,Matsushita, Hidenobu,Tanaka, Chie,Kobayashi, Daisuke The Korean Gastric Cancer Association 2020 Journal of gastric cancer Vol. No.
Purpose: Patients with pathological stage T1N+ or T2-3N0 gastric cancer may experience disease recurrence following curative gastrectomy. However, the current Japanese Gastric Cancer Treatment Guidelines do not recommend postoperative adjuvant chemotherapy for such patients. This study aimed to identify the prognostic factors for patients with pT1N+ or pT2-3N0 gastric cancer using a multi-institutional dataset. Materials and Methods: We retrospectively analyzed the data obtained from 401 patients with pT1N+ or pT2-3N0 gastric cancer who underwent curative gastrectomy at 9 institutions between 2010 and 2014. Results: Of the 401 patients assessed, 24 (6.0%) experienced postoperative disease recurrence. Multivariate analysis revealed that age ≥70 years (hazard ratio [HR], 2.62; 95% confidence interval [CI], 1.09-7.23; P=0.030) and lymphatic and/or venous invasion (lymphovascular invasion (LVI): HR, 7.88; 95% CI, 1.66-140.9; P=0.005) were independent prognostic factors for poor recurrence-free survival. There was no significant association between LVI and the site of initial recurrence. Conclusions: LVI is an indicator of poor prognosis in patients with pT1N+ or pT2-3N0 gastric cancer.
Keizo Fujita,Mitsuro Kanda,Seiji Ito,Yoshinari Mochizuki,Hitoshi Teramoto,Kiyoshi Ishigure,Toshifumi Murai,Takahiro Asada,Akiharu Ishiyama,Hidenobu Matsushita,Chie Tanaka,Daisuke Kobayashi,Michitaka F 대한위암학회 2020 Journal of gastric cancer Vol. No.
Purpose: Patients with pathological stage T1N+ or T2–3N0 gastric cancer may experience disease recurrence following curative gastrectomy. However, the current Japanese Gastric Cancer Treatment Guidelines do not recommend postoperative adjuvant chemotherapy for such patients. This study aimed to identify the prognostic factors for patients with pT1N+ or pT2–3N0 gastric cancer using a multi-institutional dataset. Materials and Methods: We retrospectively analyzed the data obtained from 401 patients with pT1N+ or pT2–3N0 gastric cancer who underwent curative gastrectomy at 9 institutions between 2010 and 2014. Results: Of the 401 patients assessed, 24 (6.0%) experienced postoperative disease recurrence. Multivariate analysis revealed that age ≥70 years (hazard ratio [HR], 2.62; 95% confidence interval [CI], 1.09–7.23; P=0.030) and lymphatic and/or venous invasion (lymphovascular invasion (LVI): HR, 7.88; 95% CI, 1.66–140.9; P=0.005) were independent prognostic factors for poor recurrence-free survival. There was no significant association between LVI and the site of initial recurrence. Conclusions: LVI is an indicator of poor prognosis in patients with pT1N+ or pT2–3N0 gastric cancer.
Firmicutes in Gut Microbiota Correlate with Blood Testosterone Levels in Elderly Men
Matsushita Makoto,Fujita Kazutoshi,Motooka Daisuke,Hatano Koji,Hata Junya,Nishimoto Mitsuhisa,Banno Eri,Takezawa Kentaro,Fukuhara Shinichiro,Kiuchi Hiroshi,Pan Yue,Takao Toshifumi,Tsujimura Akira,Yach 대한남성과학회 2022 The World Journal of Men's Health Vol.40 No.3
Purpose: In males, testosterone levels have been implicated in various diseases. Recently, the influence of gut microbialderived compounds on host metabolism has become evident, and it has been suggested that some gut bacteria may be involved in testosterone metabolism. In the present study, we examined the relationship between testosterone levels and gut microbiota in elderly Japanese men. Materials and Methods: We collected samples from Japanese male subjects suspected of having prostate cancer and underwent prostate biopsies and excluded patients with positive biopsies to avoid the effect of prostate cancer on the gut microbiota. In total, 54 Japanese males with negative biopsy results were included in our study. The gut microbiota was analyzed by 16S rRNA gene sequencing of bacterial DNA extracted from rectal swabs. Gut microbiota compositions were compared between the two groups according to the level of serum testosterone (above or below 3.5 ng /mL). Results: The median age of the cohort was 71 years, and the quartile range was 67 to 73 years. We observed no significant difference in alpha or beta diversity, but some bacteria belonging to the phylum Firmicutes (Clostridiales, Turicibacter, and Gemella) were increased in the high testosterone group. Serum testosterone levels positively correlated with the relative amount of Firmicutes (rS=0.3323, p=0.0141), and the amount of Firmicutes affected serum testosterone levels independent of host factors (age, body mass index, triglyceride, and total cholesterol; β=0.770, p=0.0396). Conclusions: Some intestinal bacteria belonging to the phylum Firmicutes were associated with testosterone levels in elderly males. Therefore, the gut microbiota could affect testosterone metabolism in elderly males.
Organic thin-film diodes with internal charge separation zone
Masaya Terai,Daisuke Kumaki,Takeshi Yasuda,Katsuhiko Fujita,Tetsuo Tsutsui 한국물리학회 2005 Current Applied Physics Vol.5 No.4
We demonstrate the fabrication of new organic thin-lm diodes with an internal bipolar charge separation (ICS) zone. Wefabricated an organic double-layer diode with the structure of indium-tin oxide (ITO)/tris(8-quinolinolato)aluminum(III) (Alq3)/N,N0-bis(3-methylphenyl)-1,10-biphenyl-4,40-diamine (TPD)/Al. The stacking order of Alq3 and TPD of this diode is reversedcompared with conventional organic double-layer LEDs. In the ITO/Alq3/TPD/Al device, only a small current ows in both caseswhen the ITO electrode is biased positive or negative, because the device has large charge injection barriers and transport resistance.When the combined zone composed of Mg-doped Alq3 and vanadium oxide layers was inserted between the Alq3/TPD interface,large current ow was observed at the positive bias on ITO electrode. The diode behaved quite similar with the conventional organicLED, ITO/TPD/Alq3/Al. The large increase of forward current can never be ascribed to the decrease of injection barriers nor chargetransport resistance, because no change of device conguration was added except for the addition of the zone at the Alq3/TPDinterface. This large forward current ow was ascribed to the internal bipolar charge separation within the added zone..