장애인 복지를 위한 시설처우 고찰

김중대 대구효성카돌릭대학교사회과학연구소 1992 사회과학연구 Vol.1 No.-

蜃氣樓효과를 이용한 熱壙散率 측정에 관한 硏究

金大植,尹和重 충남대학교 1985 忠南科學硏究誌 Vol.12 No.2

The experimental techniques and theory for the mirage effect, or optical probe beam detection of thermal waves in opaque solids have been described in the literature. Recentry, it has also been demonstrated that this technique can be applied to measurements of thermal diffusivities of solids. In particular, measurements of the transverse optical probe beam deflection angle in mirage effect thermal wave detection can provide a direct and accurate determination of the thermal diffusivity constant. In this paper we present the results of such measurements carried out in the laboratories on a number of pure materials, including single crystals of various elements, silicon carbide and silicon nitride ceramics, compound semiconductors and metal alloys.

Usefulness of Diagnostic Biomarkers in Heart Failure

Dai-Joong Kim(김대중),Chang-Eun Park(박창은) 한국엔터테인먼트산업학회 2013 한국엔터테인먼트산업학회논문지 Vol.7 No.3

순환형 생체 진단마커는 심부전을 동반한 위험군 환자에서 진단이 점점 더 중요하다. 높은 감도의 트로포닌 분석은 진단에 있어서 정확하고 심근 경색의 신속한 탐지를 개선해야 한다. 심근경색의 초기에 감별되는 심근 손상의 지표는 제한적이고 심장 기능을 유지하기 위해 항 혈전 치료에 매우 중요하게 영향을 미친다. 트로포닌은 급성 관상 동맥 증후군에서 진단적, 예후적 의미를 모두 갖는다. 관상동맥 증후군이 아닌 증상에서 증가된 트로포 닌 수치에 근본적인 원인과 직접적인 관리의 대안이 비혈전성 기전에 대한 평가를 즉시한다. 이에 심근 경색 환자의 평가에 트로포닌의 역할과, 급성관상동맥증후군으로 추정되는 비 외상성 흉부통증 환자에서 도착 즉시, 트로포닌과 copeptin의 측정을 통해 심근 경색의 존재를 신속하고 안전하게 추정할 수 있다 이는 두 번째로 활용되는 바이오마커이다. 이동 구급차의 경우, 검사실보다 현장에서 사용했을때 . 바이오마커의 분석 결과를 제공하여 타당도, 실용도, 임상적 유용성이 유의성 있게 높이 평가되고 있다. 심부전의 마커는 심혈관질환과 관련된 다양한 생체지표로 활용할 수 있으며, 심부전 마커는 심혈관 질환의 위험 지표와 생체의 평가에 추가 할 수 있는 항목으로 가능성이 있다. 분석 및 임상 검증을 통해 심부전을 명확히 진단하고 지속적으로 임상 및 실험적 문제를 해결하기 위해 필요하다. 이러한 문제는 다양한 바이오마커의 사용을 통해 뿐만 아니라, 급성 관상 동맥질환의 지표로서 사용에 연관된다. Circulating biomarkers have become increasingly important in diagnosing and risk-stratifying patients with heart failure (HF). There is increasing interest in utilizing novel markers of cardiovascular disease risk and consequently, there is a need to assess the value of their use. High-sensitivity troponin assays are improving the diagnostic accuracy and rapid detection of myocardial infarction. The early identification of MI is vital for the institution of anti-thrombotic therapy to limit myocardial damage and preserve cardiac function. Troponin has both diagnostic and prognostic significance in the setting of acute coronary syndrome (ACS). Increased troponin levels in the absence of ACS should prompt an evaluation for an alternative, non-thrombotic mechanism of troponin elevation and direct management at the underlying cause. This describes the role of troponin in the evaluation of patients with suspected myocardial infarction. Also, In emergency department (ED), for nontraumatic chest pain (NTCP) is suggestive of acute coronary syndrome (ACS). The determination of copeptin on arrival to the ED in patients with NTCP suggestive of ACS, When used in the field than the laboratory. Analysis of biomarkers by providing the validity, utility, clinical usefulness is significantly appreciated. There is potential that a marker of heart failure can add to the value of existing indicators and biomarkers of cardiovascular disease risk. Additional analytical and clinical validations are needed to fully elucidate cardiac failure and resolve ongoing clinical and laboratory issues. While these issues are directed to the use of various biomarker in primary care, were relevant to the use of biomarker in acute coronary syndromes.

Seismic Qualification on the Large High Voltage Circuit Breaker

Young-Joong Kim(김영중),Chul-Hyun Kim(김철현),Dai-Woong Jun(전대웅) 한국소음진동공학회 2010 한국소음진동공학회 학술대회논문집 Vol.2010 No.4

장애인 복지를 위한 시설처우 고찰

김중대(Joong Dai Kim) 대구가톨릭대학교 사회과학연구소 1992 사회과학연구 Vol.1 No.-

경기일부지역의 적혈구 항체선별검사의 실태조사

김대중 ( Dai Joong Kim ),성현호 ( Hyun Ho Sung ),박창은 ( Chang Eun Park ) 대한임상검사과학회 2016 대한임상검사과학회지(KJCLS) Vol.48 No.1

Red blood cell (RBC) alloimmunization results from genetic disparity of RBC antigens between donor and recipients. The discrepancy of RBC antibody screening test occurs when the results of red cell tests do not agree with those of the serum test. In order to select the proper blood units for transfusion, clarification of the cause of discrepancies is essential. The RBC antibody screening test is an easy, quick, and reliable method for detection of clinically significant antibodies. Antibody screening and identification is recommended prior to transfusion to determine whether there is blood group incompatibility. We reported that phenotyping for E, D, M, E+c, and C+e antibody screening test should be extended. Therefore, these results indicate that anti-D and anti-E alloantibodies were major risk factors for haemolytic disease of the newborn or delayed haemolytic transfusion reactions in this study population. We suggested that its antibody screening be adapted to blood safety interventions. Targeted screening of selected recipients at risk offers less value than universal antibody screening, and more research is needed to determine the real incidence of this national condition.

농식품 표준 통합 정보화를 위한 플랫폼 관리 시스템 구축

장대자(Jang Dai-Ja),김희진(Kim Hee-Jin),송유정(Song Yu-Jung),김기연(Kim Kee-Yeun),연대중(Yeon Dae-Joong),김유(Kim Yu) 한국콘텐츠학회 2014 한국콘텐츠학회 종합학술대회 논문집 Vol.2014 No.11

Ultraviolet B (UVB) Induces Down-regulation of Parkin Gene Expression

Sung Hoon Kim,Yeo Wool Kang,Juyeon Lee,Hyun-Kyung Kim,Byung Chul Jung,Bohee Kim,Dai Joong Kim,Yoon Suk Kim 대한의생명과학회 2016 Biomedical Science Letters Vol.22 No.1

Ultraviolet (UV) irradiation induces cellular damage. A variety of cellular responses for repairing cellular damage including DNA damage occur after UV irradiation. During the repair processes, expression and activation of various molecules are regulated depending on the types of cellular damage. Parkin is an E3 ligase and act as a tumor suppressor. Recently, it has been reported that Parkin is involved in the DNA repair process. In the current study, we investigated whether UVB irradiation influences expression of Parkin. Parkin expression transiently decreased after UVB irradiation both at the mRNA and protein levels, but returned to normal levels thereafter. Taken together with cell viability data, Parkin expression is down-regulated during UVB-induced suppression of cell growth and is increased again in accordance with recovery of UVB-induced cell growth inhibition. However, Parkin overexpression or knockdown did not influence UVB-induced cell growth inhibition and recovery. We propose that Parkin could be a useful molecular marker for evaluating conditions of cells after UVB irradiation.

한국 폐경여성에서 골밀도와 Osteoprotegerin 유전자 A163G, T950C 다형성 연구

권동진 ( Dong Jin Kwon ),유영옥 ( Young Oak You ),김대훈 ( Dai Hoon Kim ),김재훈 ( Jae Hoon Kim ),박동춘 ( Dong Choon Park ),이희중 ( Hee Joong Lee ),김은중 ( Eun Jung Kim ),김진홍 ( Jin Hong Kim ) 대한폐경학회 2003 대한폐경학회지 Vol.9 No.3

골밀도가 감소하는 질환인 골다공증의 발생에는 여러 가지 다양한 요인들이 관여하는 것으로 지금까지 알려져 왔다. 특히 폐경기 여성에서 골다공증의 발생에는 파골세포에 의한골흡수가 증가하여 발생하는데 Osteoprotegerin(OPG) 유전자가 중요한 역할을 한다. 이에 저자들은 가톨릭대학교 의과대학 성빈센트병원 산부인과 폐경기 크리닉을 방문한 229명의 자연 폐경여성을 대상으로 요추, 대퇴골경부, Ward 삼각주, 되퇴돌기의 골밀도를 측정하여 정상군, 골감소증군과 골다공증군으로 분류하고 골다공증 발생에 있어서 중요한 역할을 하는 것으로 알려지 OPG 유전자의 A^(163)G, T^(950)C 다형성을 PCR-RELP 방법을 이용하여 관찰하고, 이러한 유전자형의 다형성이 골밀도와 어떤 연관성이 있는가를 알아보고자 본 연구를 시도 하였다. 저자들의 연구결과에서 대상 폐경기 여성의 A^(163)G, T^(950)C 유전자형 분포 양상은 AA 54.6%, AG 37.1%, GG 8.3%; TT 17.5%, TC 44.1%, CC 38.4%를 보였고, 전체 폐경여성에서 A^(163)G은 요추 부위에서 골밀도와 유의한 상관 관계를 보였다. A163G 유전자형의 다형성은 요추 부위에서는 정상군과 골다공증군, 대퇴골경부와 Ward 삼각주에서는 정상군에서 골밀도와 유의한 상관 관계를 보였다. T^(950)C 유전자형의 다형성은 大퇴골경부에서는 정상군과 골감소증군, Ward 삼각주에서 정상군에서만 골밀도와 유의한 상관 관계를 보였다. 이상의 결과로 한국인 폐경여성에서 OPG 유전자의 다형성은 골밀도 변화에 중요한 역할을 하는 것을 알 수 있었다. Objective: To examine the relationship between Osteoprotegerin gene polymorphisms, and bone mineral density(BMD). Methods: Restriction fragment length polymorphisms at the Osteoprotegerin A163G(promoter), T950C(promoter) gene site, and BMD at the lumbar spine and proximal femur were analyzed in 229 postmenopausal Korean women (81 normal, I I I osteopenic and 37 osteoporotic patients). BMDs were measured by DEXA. Results: The distribution of A163G and T950V polymorphisms in all postmenopausal women was as follows: AA 54.6%, AG 37.1%, GG 8.3%;TT 17.5%, TC 44.1%, CC 38.4%, respectively. After adjusting for potential confounding factors such as age, BMI and menopause duration, A163G polymorphism was significantly associated with BMD at the lumbar spine in all postmenopausal women. A163G polymorphism was significantly associated with BMD at the lumbar spine in normal and osteoporotic patients, and BMD at the femur neck and ward`s triangle in normal patients. T950C polymophism was significantly associated with BMD at the femur neck in normal and osteopenic patients, and BMD at the ward`s triangle in normal patients. Conclusion: These findings suggest that osteoprotegerin gene polymorphisms may be an important contributor to the variation of BMD among postmenopausal Korean women.

Effect of 4 - Nitroquinoline - 1 - oxide and 3 - Aminobenzamide on DNA Replication in Mammalian Cells

김춘광,박상대,이창중,윤희용 한국유전학회 1984 Genes & Genomics Vol.6 No.3

The effect of 4NQO on semiconservative DNA replication was investigated in CHO-K1 and XP2OS cells using alkaline sucrose gradient sedimentation analysis. 4NQO caused a dosedependent inhibition of DNA replication. In CHO-K1 cells, the inhibition of replicon initiation was primarily caused at low doses and blockage of chain growth was also observed at higher doses. However, in excision defective XP2OS cells, the main effect was the inhibition of chain elongation at all doses employed. These perturbations were lasted for long time and thereafter gradually recovered. Our observation indicates that excision repair may play a role in DNA replication. 3-AB did not affect the DNA replication by itself, but it alleviated the inhibitory effect of 4NQO.