太極拳의 原理에 關한 硏究

羅大觀,吳旼錫,宋泰元 대전대학교 한의학연구소 2001 혜화의학회지 Vol.10 No.1

Tae-Geuk-Guan(太極拳) Tae-Geuk(太極) is arranged Yum-Yang-O-Hang(陰陽五行) and created from Mu-geuk(無極) means great chaos. Jin-sik Tae-Geuk-Guan(陳式太極拳) has tenth essential theory. There are Li(理), Qi(氣), Samjul(三節), Sacho(四梢), Ojang(五臟), Samhap(三合), Yukjin(六進) Sinbup(身法) Bobup(甫法), Gangyou(剛柔). Li(理) is Rules of all things. Qi(氣) is body. Body is diveided into Samjul(三節), Sacho(四梢), Ojang(五臟) is inside body and make human'sbody and Qi(氣), Samhap(三合) is union of mind & intention, Qi & power, muscle & bone. Yukjin(六進) is movement of body. Sinbup(身法) has Chong(縱), Hoeng(橫), Ko(高), Jeo(低), Jin(進), Toe(退), Ban(反), Chuk(側). Bobup(步法) has Jin(進), Toe(退), Ban(反), Chuk(側). Yang-sik Tae-Geuk-Guan(揚式太極拳) has tenth essential theory. There are Songyo(송腰), Heolungjungkyung(虛靈頂경), Hamhungbalbae(含胸拔背), Chimgyungsuju(沈궁수주), Bunheosil(分虛實), Yongeuibulyonglyuk(用意不用力), sanghasangsu(上下相隋), Naeoesanghap(內外相合), Sangyunbudan(相連不斷), Dongchungguchung(動中求精)

금속이 도핑된 BiVO4 분말의 수열 합성 및 이의 열 변색 특성

우관주 ( Guan Zhu Wu ),손대희 ( Dae Hee Son ),진영읍 ( Young Eup Jin ),이근대 ( Gun Dae Lee ),박성수 ( Seong Soo Park ) 한국공업화학회 2015 공업화학 Vol.26 No.6

In this study, pure BiVO4 powder and metal-doped M-BiVO4 (M = Mg, Cu) powder, well known as thermochromic materials, were prepared from a mixed aqueous solution of bismuth nitrate (Bi(NO3)3) and ammonium vanadate (NH4VO3) in autoclave by hydrothermal method. The crystal structure, microstructure, and thermochromic property of samples were analyzed using FE-SEM, FT-IR, XRD, DSC, UV-Vis-NIR spectroscopy and colorimeter. When heating samples above phase transition temperature, the color of M-BiVO4 (M = Mg, Cu) sample was thermally changed more clearly than that of using only pure BiVO4 sample.

흉부 CT검사 시 검사부위를 벗어난 Topogram 부위에 Automatic Exposure Control 적용이 선량 및 화질에 미치는 영향

박관중(Guan Jung Park),김영옥(Young Ok Kim),여상근(Sang Geun Yeo),대창민(Chang Min Dae),민관홍(Kwan Hong Min) 대한전산화단층기술학회 2011 대한CT영상기술학회지 Vol.13 No.2

목적 임상에서 많이 시행하고 있는 흉부 computed tomography(이하 CT) 검사 시, 세 개의 각기 다른 CT장비 제조사의 automatic exposure control(이하 AEC) system을 인체 등가phantom에 적용하여, 검사부위를 벗어난 topogram을 검사하였다. 검사부위를 벗어난 topogram에서 AEC작동유무 및 CT dose index volume(이하 CTDI) 변화를 측정하고, 영상의 노이즈값의 비교를 통하여 선량 및 화질 변화를 알아보고자 하였다. 대상 및 방법 사용된 각 장비 회사별 CT 장비는 Brilliance 64 MDCT(Philips healthcare, 이하 P사), LightSpeed VCT XT 64 MIDCT(General Electric Medical System, 이하 G사), Somatom Definition Dual CT(Siemens Healthcare, 이하 S사)를 사용하였다. Rando phantom을 대상으로 하여 본원에서 흉부 검사 범위로 정하고 있는 성대에서 부신이 충분히 포함된 topogram을 정상군으로 정하고, 정상군과 비교하여 폐첨부에서 머리 방향쪽으로 2cm 검사부위를 벗어난 군을 A군, 4cm는 B군, 6cm는 C군, 8cm를 D군으로 대조군을 정하였다. 선량 평가를 위해 각 장비 제조회사에서 제공하는 CTDI값과 ionization chamber를 이용하여 CTDI값을 실측한 후, 정상군의 CTDI값을 기준으로 대조군의 CTDI 증감률을 산출하였다. 화질 평가는 AAPM phantom을 이용하여 정상군 및 대조군 실험 영상의 6시 방향 1/4지점에서 4×4cm의 크기의 region of interest(이하 ROI)를 설정하여 모든 slice의 평균오차의 값을 노이즈값으로 계산하여 평가하였다. 결과 정상적인 topogram과 검사부위를 벗어난 topogram의 AEC적용 결과는 P사의 경우는 ACS만 적용 시 노이즈값은 정상군은 12.9, A군은 약 12.7(p=0.0273, B군은 약 12.6(p=0.0195), C군은 약 12.2(p=0.002), D군은 약 12.l(p=0.002)로 측정되었으며, 대조군의 CTDI 증감률은 정상군과 비교하여 각 군에서 약 8.9%, 11.1%, 14.4%, 15.6% 증가하였다. ACS combined Z-DOM 적용 시에는 정상군 비교하여 CTDI 증감률은 각 군에서 약 3.0%, 4.0%, 4.0%, 5.0% 증가하지만, 노이즈값은 각 군에서 약 13.3, 약 13.2(p=0.0216), 13.1(p=0.0078), 12.9(p=0.0195), 12.9(p=0.0039)로 측정되었다. ACS combined D-DOM 적용 시에는 CTDI 증감률은 정상군 비교하여 각 군에서 약 0.9%, 1.8%, 1.8%, 2.7% 증가하였고, 노이즈값은 정상군은 약 12.7, 대조군은 약 12.6(p=0.0301), 12.5(p=0.0392), 12.5(p=0.0391), 12(p=0.002)로 통계학적으로 유의한 차이가 없었다. S사의 경우에는 노이즈값은 각 군에서 약 8.0, 7.9(p=0.0376), 7.6(p=0.0277), 7.5(p=0.002), 7.3(p=0.002)로 통계학적으로 유의한 차이가 없었다. CTDI 증감률은 정상군 비교하여 각 군에서 약 1.2%, 3.4%, 2.3%, 6.9% 증가하였다. G사의 경우는 Auto mA 적용 시, 정상군의 노이즈값은 약 45.0, A군은 약 44.1(p<0.0001), B군은 약 44.1(p<0.0001), C군은 약 44.1(p<0.0001), D군은 약 44.1(p<0.0001)으로 대조군에서는 모두 동일한 결과로 측정되었다. 정상군과 비교하여 대조군 모두 통계학적으로 유의한 차이가 없이, CTDI 증감률은 정상군과 비교하여 모든 대조군에서 동일하게 약 8.1% 증가를 보였다. 결론 검사부위를 벗어난 topogram을 얻은 후, topogram에 포함되지 않은 영역에 AEC를 적용하게 되면, 각 장비 회사마다 다소 차이는 있지만 영상의 질적 차이 없이 방사선 피폭선량이 최소 약 0.9%에서 최대 15.6% 증가하였다. 따라서 AEC를 적용 시 정확한 환자의 위치잡이가 선행되어야 topogram을 통해 정확한 정보를 얻을 수 있다. 그 정보를 바탕으로 AEC가 올바르게 동작하여 선량의 최적화를 달성할 수 있을 것으로 사료된다. I. Purpose The purpose of this study is to investigate the change of radiation dose and image quality in outside topogram of scan range applying automatic exposure control (AEC) through phantom study in chest CT. II. Meterial and Methods A Rando anthropomorphic chest phantom and AAPM phantom was scanned on a 64 multi detector CT using the AEC systems from three different manufacturers: General Electric Healthcare, Philips Medical Systems and Siemens Medical Solutions. A general scanning protocol was created for each examination where as many as possible of the scanning parameters were set equal. Divided into 5 groups according to include and not be scan range of topogram. Topogram, normally including scan range, is defined normal group. If not was control group, the group which was 2 an outside topogram of scan range toward head from lung apex was designated as A group, B group in 4 cm off, C group in 6 an off, and D group in 8 an off. CTDI was measured using ionization chamber and provided by CT modality. CTDI fluctuation ratios of control groups were calculated based on the values of CTDI in normal group. For the evaluation of image quality, mean error value was assessed by the image noise from AAPM phantom. III. Result As a result of application of AEC to normal and control groups, in case of P, when applying only ACS, noise of normal group was 12.9, 12.7(p=0.0273) in A group, 12.6(p=0.0195) in B group, 12.2(p=0.002) in C group, 12.1(p=0.002) in D group. CTDI fluctuation ratios of control group was increased by 8.9%i, 11.1%, 14.4%, 15.6% respectively in each group compared to normal group. When applying ACS combined Z-OOM, the CTDI fluctuation ratios of control groups was increased by 3.0%, 4.0%, 4.0%, 5.0% respectively, compared to normal group. However, noise was appeared to be 13.3, 13.2(p=0.0216), 13.1(p=0.0078), 12.9(p=0.0195), 12.9(p=0.0039). When applying ACS combined D-DOM, the CTDI fluctuation ratios was increased by 0.9%, 1.8%, 1.8%, 2.7% while noise value in normal group was 12.7, 12.6(p=0.0301), 12.5(p=0.0392, 12.5(p=0.0391), 12(p=0.002). No statistical significant difference was found. In case of S, noise appeared to be 8.0, 7.9(p=0.0376), 7.6(p=0.0277), 7.5(p=0.002), 7.3(p=0.002) respectively in each group leading to no statistical significant difference. CTDI fluctuation ratios, comparing to normal group, was increased by 1.2%, 3.4%, 2.3%, 6.9%. In case of G, when applying AutomA, the noise of normal group was measured to be 4.0, and 44.1(p<0.0001) in A~D control groups, Compared to normal group, there was no statistical significant difference in control groups, and also the fluctuation ratio (%) of CTDI showed the same ratio of 8.1% in all control groups. IV. Conclusions Radiation dose by different mmufacturer was increased by at minimum 0.9% up to at maximum 15.6%. And it was little difference of image quality found at all. Consequently, projection of topogram, normally included scan range, is very important applying AEC in CT examination.

Peroxisome Proliferator-Activated Receptor-Alpha Deficiency Protects Aged Mice from Insulin Resistance Induced by High-Fat Diet

Cha, Dae Ryong,Han, Jee Young,Su, Dong Ming,Zhang, Yahua,Fan, Xuefeng,Breyer, Matthew D.,Guan, Youfei S. Karger AG 2007 American journal of nephrology Vol.27 No.5

<P><I>Background/Aims:</I> Insulin resistance is a central feature of the metabolic syndrome and progressively increases with age, resulting in excessively high incidence of type II diabetes in the elderly population. Peroxisome proliferator-activated receptor-α (PPARα) is widely expressed in insulin target tissues, including those of the liver, kidney, and muscle, where it mediates expression of genes promoting fatty acid β-oxidation. The aim of this study was to evaluate the potential role of PPARα in insulin resistance in aging mice induced by a high-fat diet. <I>Methods:</I> We used male PPARα knockout (KO) mice and wild-type (WT) littermates that were 18 months old. Animals were fed with a high-fat diet (HFD) for 4 weeks, and metabolic parameters associated with insulin sensitivity were assessed. <I>Results:</I> Following HFD treatment, WT mice showed more severe insulin resistance than did mice lacking the PPARα gene, as assessed by both the glucose tolerance test (GTT) and insulin tolerance test (ITT). In addition, WT mice exhibited significantly higher HOMA-IR, plasma total cholesterol levels and urinary albumin-creatinine ratio but less liver weight than did PPARα KO mice. <I>Conclusion:</I> These data suggest that PPARα gene deficiency may protect aged mice from developing insulin resistance and albuminuria induced by a HFD.</P><P>Copyright © 2007 S. Karger AG, Basel</P>

A Simulation Study on Improving Throughput in a Crankshaft Line Considering Minimizing Investment Cost under Throughput Target

Wang, Guan,Lee, Dae Ryoung,Shin, Yang Woo,Moon, Dug Hee EJournal Publishing 2017 International journal of materials, mechanics and Vol.5 No.1

Articles : Life Science ; Preparation and in Vivo Evaluation of Piroxicam-Loaded Gelatin Microcapsule by Spray Drying Technique

( Ming Guan Piao ),( Chan Woo Yang ),( Dong Xun Li ),( Jong Oh Kim ),( Ki Young Jang ),( Bong Kyu Yoo ),( Jung Ae Kim ),( Jong Soo Woo ),( Won Seok Lyoo ),( Sung Soo Han ),( Yong Bok Lee ),( Dae Duk K 영남대학교 약품개발연구소 2008 영남대학교 약품개발연구소 연구업적집 Vol.18 No.-

Study on cultivation of novel species Haematocuccus pluvialis Y0519 in ICT-based container culture system

Yu Kyong LEE,Jae Guan KIM,Dae Geun KIM 한국생물공학회 2019 한국생물공학회 학술대회 Vol.2019 No.4

Alternative Isoforms of the mi Transcription Factor (MITF) Regulate the Expression of mMCP-6 in the Connective Tissue-Type Mast Cells Cultured with Stem Cell Factor

Sun-Hee Lee(이선희),Xiu-Ying Guan(관수영),Dae-Ki Kim(김대기) 한국생명과학회 2008 생명과학회지 Vol.18 No.10

mi transcription factor (MITF)는 비만세포의 분화를 조절하는 중요한 전사인자이다. 특히 MITF는 결합조직형 비만세포에서 일반적으로 발현하는 비만세포 특이적 세린 단백분해효소의 일종인 mMCP-6 유전자의 전사를 조절한다. 본 연구는 마우스 골수유래 배양비만세포에서 mMCP-6 유전자의 전사를 조절하는 MITF이형체를 규명하였다. MITF 이형체들의 발현은 RT-PCR로 확인하였다. IL-3존재 하에서 배양한 점막형 비만세포들은 MITF-A, -E, -H, -Mc 등이 발현하였다. 반면에 SCF존재 하에서 배양한 결합조직형 비만세포들은 MITF-A가 발현하였다. MITF이형체를 과발현시키면 NIH-3T3 세포에서 mMCP-6 promoter를 통한 luciferase 활성을 증가시키고, MC/9 비만세포주에서는 증가된 mMCP-6발현을 유도하였다. 더불어 비만세포에서의 mMCP-6 발현은 MITF-A 고갈로 인하여 유의적으로 억제되었다. MITF-A의 전사활성과 DNA결합은 MITF-E, -H, -Mc 등의 타 이형체들의 결과와 유사하였다. 따라서 본 연구의 결과들은 MITF-A가 마우스 결합조직형 비만세포에서 발현하여 mMCP-6 전사를 조절하는 중요한 이형체임을 제시한다. mi transcription factor (MITF) is important in regulating the differentiation of mast cells. In particular, MITF regulates the transcription of the mouse mast cell-specific serine protease (mMCP)-6 gene, which is generally expressed by the connective tissue-type of mast cells. In this study, we investigated alternative isoforms of MITF that regulate transcription of the mMCP-6 gene in bone marrow-derived cultured mast cells in mice. The expression of MITF isoforms was examined by RT-PCR. We observed that MITF-A, -E, -H and -Mc were expressed by mucosal-type mast cells cultured in the presence of IL-3, whereas the connective tissue-type mast cells cultured in the presence of stem cell factor (SCF) expressed MITF-A. Overexpression of MITF isoforms increased luciferase activity through the mMCP-6 promoter in NIH-3T3 cells and elevated the level of mMCP-6 expression in the MC/9 mast cell line. Moreover, mMCP-6 expression in mast cells was significantly inhibited by the depletion of MITF. The transcriptional activity and DNA binding of MITF-A was comparable to that of MITF isoforms, including MITF-E, -H, and -Mc. Our results therefore suggest that MITF-A may be an important isoform of MITF in regulating the transcription of mMCP-6 in mouse connective tissue mast cells.

연구논문(硏究論文)(재록(再錄)) : 생명과학 ; 생체이용율이 증가된 cyclosporine A 함유 히알우로닉 미립구의 개발

우종수 ( Jong Soo Woo ),박명관 ( Ming Guan Piao ),이동훈 ( Dong Xun Le ),유동성 ( Dong Sung Ryu ),최준영 ( Jun Young Choi ),김정애 ( Jung Ae Kim ),김정훈 ( Jeong Hoon Kim ),진성규 ( Sung Giu Jin ),김대덕 ( Dae Duk Kim ),류원석 ( W 영남대학교 약품개발연구소 2007 영남대학교 약품개발연구소 연구업적집 Vol.17 No.-

금속이 도핑된 BiVO₄ 분말의 수열 합성 및 이의 열 변색 특성

우관주,손대희,진영읍,이근대,박성수,Wu, Guan Zhu,Son, Dae Hee,Jin, Young Eup,Lee, Gun-Dae,Park, Seong Soo 한국공업화학회 2015 공업화학 Vol.26 No.6

본 연구에서는 열 변색 물질로 알려진 순수한 $BiVO_4$ 분말과 금속이 도핑된 $M-BiVO_4$ (M = Mg, Cu) 분말들을 bismuth nitrate ($Bi(NO_3)_3$)와 ammonium vanadate ($NH_4VO_3$)의 혼합 수용액으로부터 고압반응기에서 수열 합성법을 통하여 성공적으로 제조하였다. 시료들의 결정구조, 미세구조 및 열 변색 특성들은 FE-SEM, FT-IR, XRD, DSC, UV-Vis-NIR 분광기 및 colorimeter를 이용하여 분석하였다. 시료를 상전이 온도 이상으로 가열시키면, 순수한 $BiVO_4$ 시료에 비하여 $M-BiVO_4$ (M = Mg, Cu) 시료의 색상이 상대적으로 선명하게 열 변색하였다. In this study, pure $BiVO_4$ powder and metal-doped $M-BiVO_4$ (M = Mg, Cu) powder, well known as thermochromic materials, were prepared from a mixed aqueous solution of bismuth nitrate ($Bi(NO_3)_3$) and ammonium vanadate ($NH_4VO_3$) in autoclave by hydrothermal method. The crystal structure, microstructure, and thermochromic property of samples were analyzed using FE-SEM, FT-IR, XRD, DSC, UV-Vis-NIR spectroscopy and colorimeter. When heating samples above phase transition temperature, the color of $M-BiVO_4$ (M = Mg, Cu) sample was thermally changed more clearly than that of using only pure $BiVO_4$ sample.