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Yoo, J,Lee, S,Jung, Y,Lee, J,Youm, D,Ha, H,Kim, H,Ko, R-K,Oh, S Institute of Physics 2008 Journal of physics. Conference series Vol.97 No.1
<P>We measured the field profiles, <I>H</I>(<I>x,H</I><SUB>a</SUB>) s, near the surface of coated conductors (CCs) by using the scanning Hall probe method. The samples were SmBCO-CC tape fabricated by co-evaporation method and YBCO-CC tape fabricated by PLD method. The applied fields, <I>H</I><SUB>a</SUB>s, were decreased from <I>H</I><SUB>peak</SUB>to -<I>H</I><SUB>peak</SUB> stepwise. From the values of <I>H</I>(<I>x,H</I><SUB>a</SUB>), we calculated the current profiles, <I>J</I>(<I>x,H</I><SUB>a</SUB>) s, by the inversion method. From the values of <I>J</I>(<I>x,H</I><SUB>a</SUB>) and the corresponding flux densities, we calculated the hysteretic energy losses per cycle, <I>Q</I><SUB>M</SUB>s, for various <I>H</I><SUB>peak</SUB>s. From the values of <I>Q</I><SUB>M</SUB>, we calculated the characteristic functions, <I>g</I>s, by using the relation, <I>g</I>= π<I>Q</I><SUB>M</SUB>/μ<SUB>0</SUB><I>I</I><SUP>2</SUP><SUB>c</SUB>. Here, <I>I</I><SUB>c</SUB> is the critical current. For the range of <I>H</I><SUB>peak</SUB>/<I>H</I><SUB>c</SUB>≤ 3, the <I>g</I>-values of SmBCO CC tape were larger than those of YBCO CC tape. However, for the range of <I>H</I><SUB>peak</SUB>/<I>H</I><SUB>c</SUB> ≥ 3, the <I>g</I>-values of SmBCO CC tape were smaller than those of YBCO CC tape. When <I>H</I><SUB>peak</SUB>/<I>H</I><SUB>c</SUB> = 3, both sample show almost same value of <I>g.</I>However we found qualitatively different <I>J–B</I> hysteretic curves for both samples. We also compared our <I>g</I>-values with other <I>g</I>-values, which were directly measured by energy loss experiments. Our <I>g</I>-values of YBCO CC tapes were basically similar to the Brandt's theoretical values of <I>g</I> in the most range of <I>I</I><SUB>peak</SUB> in our measurements.</P>
Integrin αvβ3-mediated transcriptional regulation of TIMP-1 in a human ovarian cancer cell line
Kim, D.S.,Jeon, O.H.,Lee, H.D.,Yoo, K.H.,Kim, D.S. Academic Press 2008 Biochemical and biophysical research communication Vol.377 No.2
We have previously reported that a disintegrin inhibits solid tumor growth and metastasis in mouse model [I.C. Kang, Y.D. Lee, D.S. Kim, A novel disintegrin salmosin inhibits tumor angiogenesis, Cancer Res. 59 (1999) 3754-3760; S.I. Kim, K.S. Kim, H.S. Kim, D.S. Kim, Y. Jang, K.H. Chung, Y.S. Park, Inhibitory effect of the salmosin gene transferred by cationic liposomes on the progression of B16BL6 tumors, Cancer Res. 63 (2003) 6458-462]. In this study, we have investigated the modulatory effect of a disintegrin, saxatilin, on the balance between MMP-9 and tissue inhibitor of metalloproteinase-1 (TIMP-1) in human ovarian cancer cell line MDAH 2774. Functional mechanism of the disintegrin-mediated transcriptional regulation of MMP-9 and TIMP-1 was examined in the ovarian cancer cell line. Saxatilin strongly induced TIMP-1 expression in dose- and time-dependent manners, while the disintegrin suppressed MMP-9 expression. Further analyses clearly indicated that interaction of the disintegrin and integrin αvβ3 results in the TIMP-1 promoter activation via c-fos to suppress TNF-α-induced cancer cell invasion. These results demonstrate that integrin αvβ3-mediated transcriptional regulation of MMP-9 and TIMP-1 is critical for suppressing the ovarian cancer cell invasion.
Chae, H.S.,Singh, N.K.,Ahn, C.N.,Yoo, Y.M.,Jeong, S.G.,Ham, J.S.,Kim, D.W. Asian Australasian Association of Animal Productio 2006 Animal Bioscience Vol.19 No.11
The objective of this research was to provide the characterization and method for producing anti-E. coli O157:H7 antibodies in egg-laying hens and to determine if the antibody can restrain the proliferation of E. coli O157:H7 in-vitro. Selected antigenic fractions (whole cell, outer membrane protein and lipopolysaccharide (LPS)) from E. coli O157:H7 were injected to hens in order to produce anti-E. coli O157:H7 antibodies. The immune response and the egg yolk antibodies of laying hens against the whole cell, outer membrane protein and LPS antigens were monitored by ELISA. The level of antibodies against whole cell antigen monitored through ELISA sharply increased after the initial immunization, and it was found to be maximum on day 49 however, the level was maintained up to day 70. Antibodies (5 mg/ml) directed against the whole cell inhibited E. coli proliferation 10-13 times more than outer membrane protein or LPS. The antibody response against the whole cell antigens appeared to have higher activity in restraining the proliferation of E. coli O157:H7 than antibody against outer membrane protein or LPS. Results reflected that increasing the IgY's in the egg yolk could prevent greater economic losses due to human and animal health from pathogenic bacteria i.e. E. coli O157:H7.
Effect of the Length of Feed Withdrawal on Weight Loss, Yield and Meat Color of Broiler
Kim, D.H.,Yoo, Y.M.,Kim, S.H.,Jang, B.G.,Park, B.Y.,Cho, S.H.,Seong, P.N.,Hah, K.H.,Lee, J.M.,Kim, Y.K.,Hwang, I.H. Asian Australasian Association of Animal Productio 2007 Animal Bioscience Vol.20 No.1
The current study was conducted to determine the optimum length of feed withdrawal for pre-harvest broilers. A total of three hundred broilers were sampled from an industrial population, and 30 chicks for each weight group (e.g., 1.5 and 2.5 kg) were randomly assigned to feed withdrawal treatments for 0, 3, 6, 9 and 12 h. Weight loss, yield, muscle pH, objective meat color and weights of gastro intestinal contents, crop, gizzard, provenriculus, small intestine, caecum, and rectum were determined. Live weight loss was significantly (p<0.05) increased as length of feed withdrawal extended. A significant (p<0.05) carcass yield for both 1.5 and 2.5 kg groups coincided after 9 and 6 h feed withdrawal, respectively. Net weights of intestinal contents for crop and gizzard were significantly (p<0.05) reduced by 6 h, and the reduction for proventriculus and small intestine occurred from 3 h. A noticeable effect of feed withdrawal on pH for breast muscle at 3 h postmortem occurred only when chicks were fasted for 3 h of which pH (6.05) was significantly (p<0.05) higher than that for other groups including the control (5.74). There was a linear tendency of higher lightness (Hunter L* value) numerically for chicks fasted for longer periods. The highest coefficient of determinations of regression models to estimate weight loss as a function of fasting period and body weights were achieved, when the models included both linear and quadratic terms for fasting period, and linear term for both 1.5 ($R^2=0.76$) and 2.5 kg ($R^2=0.78$) body weight groups. Given the practical aspect, approximately 1.5 kg of body weight is dominant, weight loss could be predicted by the following function; live weight $loss=26.6-0.28{\times}(fasting period)^2+12.34{\times}pasting\;period-0.012{\times}body\;weight$, $R^2=0.76$. Current data implied that the optimum fasting time for pre-slaughter chicks varied depending on slaughter weight; 6 and 9-h fasting were recommendable for 2.5 and 1.5 kg chicks, with little effect on objective meat color.
Nam, S.M.,Choi, J.H.,Yoo, D.Y.,Kim, W.,Jung, H.Y.,Kim, J.W.,Kang, S.Y.,Park, J.,Kim, D.W.,Kim, W.J.,Yoon, Y.S.,Hwang, I.K. Pergamon Press ; Elsevier Science Ltd 2013 Experimental Gerontology Vol.48 No.11
Valeriana officinalis is used in herbal medicine of many cultures as mild sedatives and tranquilizers. In this study, we investigated the effects of extract from valerian root extracts and its major component, valerenic acid on memory function, cell proliferation, neuroblast differentiation, serum corticosterone, and lipid peroxidation in adult and aged mice. For the aging model, d-galactose (100mg/kg) was administered subcutaneously to 6-week-old male mice for 10weeks. At 13weeks of age, valerian root extracts (100mg/kg) or valerenic acid (340μg/kg) was administered orally to control and d-galactose-treated mice for 3weeks. The dosage of valerenic acid (340μg/kg), which is the active ingredient of valerian root extract, was determined by the content of valerenic acid in valerian root extract (3.401+/-0.066mg/g) measured by HPLC. The administration of valerian root extract and valerenic acid significantly improved the preferential exploration of new objects in novel object recognition test and the escape latency, swimming speeds, platform crossings, and spatial preference for the target quadrant in Morris water maze test compared to the d-galactose-treated mice. Cell proliferation and neuroblast differentiation were significantly decreased, while serum corticosterone level and lipid peroxidation in hippocampus were significantly increased in the d-galactose-treated group compared to that in the control group. The administration of valerian root extract significantly ameliorated these changes in the dentate gyrus of both control and d-galactose-treated groups. In addition, valerenic acid also mitigated the d-galactose-induced reduction of these changes. These results indicate that valerian root extract and valerenic acid enhance cognitive function, promote cell proliferation and neuroblast differentiation, and reduce serum corticosterone and lipid peroxidation in aged mice.
Yoo, H.Y.,Yan, S.,Ra, J.W.,Jeon, D.,Goh, B.,Kim, T.Y.,Mackeyev, Y.,Ahn, Y.Y.,Kim, H.J.,Wilson, L.J.,Alvarez, P.J.J.,Lee, Y.,Song, W.,Hong, S.W.,Kim, J.,Lee, J. Elsevier 2016 Applied catalysis. B, Environmental Vol.199 No.-
<P>This study demonstrates that tin porphyrin (SnP) loading on a silica substrate (SnP/silica) markedly accelerates the degradation of Microcystins (MCs) under visible light irradiation, despite a reduction of photosensitized singlet oxygen (O-1(2)) production. A comparative study using Rose Bengal, SnP, and C-60 aminofullerene suggested that the MC-RR decay rate was directly proportional to the photosensitizing activity for triplet state-induced oxidation, while it exhibited poor correlation to singlet oxygenation efficiency. This implies that electron transfer from MC to the triplet state of SnP (facilitated by favorable MC sorption on silica) contributes to the photosensitized MC oxidation. Experiments to examine sensitizers for the one-electron oxidation of 2,2'-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) showed the superiority of SnP/silica for photo-initiated electron transfer as a possible MC oxidation route. This was corroborated by the negligible effects of reagents that quench or facilitate singlet oxygenation (e.g., azide ion, D2O) on the MC-RR degradation rate. Despite MC-RR removal below detection levels, residual toxicity (indicated by a significant decrease in protein phosphatase inhibition activity) was observed. Tandem mass spectrometric analysis suggests that this residual toxicity may be ascribed to byproducts resulting from addition of a single oxygen atom to the Adda moiety. (C) 2016 Elsevier B.V. All rights reserved.</P>
Yoo, S.,Jang, D.,Joh, H. I.,Lee, S. Royal Society of Chemistry 2017 Journal of Materials Chemistry A Vol.5 No.2
<P>A high performance Fe3O4/Fe/Fe3C@PCNF heterogeneous Fenton catalyst was synthesized for aqueous H2O2 decomposition and was utilized to remove methylene blue in water. Surprisingly, Fe3O4/Fe/Fe3C@PCNF showed an extremely fast decomposition rate; this rate ranked as the highest value reported to date. Furthermore, it showed efficient removal of methylene blue in water which was tested at different H2O2 concentrations and solution temperatures. Based on detailed characterization, several unique features of this catalyst were presumed to be responsible for its remarkable catalytic activity for H2O2 decomposition as follows: (1) the presence of Fe-0 and delocalized pi-electrons of graphitic layers promotes the reduction of Fe3+ to Fe2+; (2) the catalyst particles were partially covered with a few defective graphitic layers, and H2O2 decomposition could occur through these defects; (3) the defective graphitic layers partially covered the catalyst particle to force the decomposition reaction to occur only in the vicinity of carbon and Fe3O4. Finally, this presumption was proved through experiments by changing the activation time of Fe3O4/Fe/Fe3C@PCNF. After H2O2 decomposition was completed, Fe3O4/Fe/Fe3C@PCNF could be efficiently separated by an external magnetic field because of its ferromagnetic behavior. Fe3O4/Fe/Fe3C@PCNF showed high removal activity of aqueous methylene blue tested under various conditions.</P>
LiF - BeF2 용융염상에서 금속과 금속 산화물의 불화 용해반응
유재형,황두성,정원명,우문식,이규일,박진호,박소진 한국공업화학회 1999 응용화학 Vol.3 No.1
A conversion technology of long-lived radioactive nuclides is to separate the elements involved in spent fuel and convert them into physical and chemical type suited to fuel for transmutation. This study has been investigated the experiments tar fluorination-dissolution of Zr , UO₂, and CeO₂. These compounds are components involved in spent fuel and especially, Zr is the cladding material of fuel. The fraction of fluorination-dissolution was increased linearly with time. Zr and UO₂ were converted respectively 24.2,5.2% after 3hours. CeO₂ was converted into fluoride only 0,19%. This is considered to be due to the solubility of H₂ in the LiF-BeF₂ molten salt. Because hydrogen is used to reduce CeO₂ to CeF₃ but the solubility of H₂ is very low in the molten salt.