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- 저자 : Cuicui Xu (검색결과 5 건)
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Xu, Chunlan,Sun, Rui,Qiao, Xiangjin,Xu, Cuicui,Shang, Xiaoya,Niu, Weining,Chao, Yu The Korean Society of Pharmacology 2014 The Korean Journal of Physiology & Pharmacology Vol.18 No.4
The study was conducted to investigate the role of vitamin E in the high altitude hypoxia-induced damage to the intestinal barrier in rats. Sprague-Dawley rats were divided into control (Control), high altitude hypoxia (HH), and high altitude hypoxia + vitamin E (250 mg/kg $BW^*d$) (HV) groups. After the third day, the HH and HV groups were placed in a hypobaric chamber at a stimulated elevation of 7000 m for 5 days. The rats in the HV group were given vitamin E by gavage daily for 8 days. The other rats were given equal volume saline. The results showed that high altitude hypoxia caused the enlargement of heart, liver, lung and kidney, and intestinal villi damage. Supplementation with vitamin E significantly alleviated hypoxia-caused damage to the main organs including intestine, increased the serum superoxide dismutase (SOD) (p< 0.05), diamino oxidase (DAO) (p< 0.01) levels, and decreased the serum levels of interleukin-2 (IL-2) (p< 0.01), interleukin-4 (IL-4) (p<0.001), interferon-gamma ($IFN-{\gamma}$) (p<0.01) and malondialdehyde (MDA) (p<0.001), and decreased the serum erythropoietin (EPO) activity (p<0.05). Administration of vitamin E significantly increased the S-IgA (p<0.001) in ileum and significantly improved the expression levels of occludin and $I{\kappa}B{\alpha}$, and decreased the expression levels of hypoxia-inducible factor 1 alpha and 2 alpha ($HIF-1{\alpha}$ and $HIF-2{\alpha}$), Toll-like receptors (TLR4), P-$I{\kappa}B{\alpha}$ and nuclear factor-${\kappa}B$ p65(NF-${\kappa}B$ P65) in ileum compared to the HH group. This study suggested that vitamin E protectis from intestinal injury caused by high altitude hypoxia environment. These effects may be related to the HIF and TLR4/NF-${\kappa}B$ signaling pathway.
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Fu, Cuicui,Jin, Sila,Oh, Joohee,Xu, Shuping,Jung, Young Mee The Royal Society of Chemistry 2017 The Analyst Vol.142 No.16
<P>A facile surface-enhanced Raman scattering (SERS) sensor based on a silver-ion-mediated amplification effect was designed for the determination of glucose concentration. In this approach, 4-aminothiophenol (4-ATP) molecules assembled on the surface of a gold wafer (Au wafer@4-ATP) act not only as Raman tags but also as linkage agents. Silver nanoparticles marked with cysteamine (AgNP@cys) were used as the SERS enhancement components because they could be bound to the Au wafer@4-ATP in the presence of silver ions through the formation of N → Ag<SUP>+</SUP> ← N coordination compounds. Here, the Ag<SUP>+</SUP> ions were obtained by using glucose oxidase to catalyze the oxidation of glucose, producing hydrogen peroxide (H2O2) to etch the AgNPs. Therefore, we recorded the SERS intensity of 4-ATP to determine the concentration of glucose in a phosphate buffer as low as 0.1 mM and further achieved a lowest detection of 0.5 mM glucose in human serum. These results show that the proposed approach has strong potential for practical applications.</P>
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Application of black box model for height prediction of the fractured zone in coal mining
Zhang, Shichuan,Li, Yangyang,Xu, Cuicui Techno-Press 2017 Geomechanics & engineering Vol.13 No.6
The black box model is a relatively new option for nonlinear dynamic system identification. It can be used for prediction problems just based on analyzing the input and output data without considering the changes of the internal structure. In this paper, a black box model was presented to solve unconstrained overlying strata movement problems in coal mine production. Based on the black box theory, the overlying strata regional system was viewed as a "black box", and the black box model on overburden strata movement was established. Then, the rock mechanical properties and the mining thickness and mined-out section area were selected as the subject and object respectively, and the influences of coal mining on the overburden regional system were discussed. Finally, a corrected method for height prediction of the fractured zone was obtained. According to actual mine geological conditions, the measured geological data were introduced into the black box model of overlying strata movement for height calculation, and the fractured zone height was determined as 40.36 m, which was comparable to the actual height value (43.91 m) of the fractured zone detected by Double-block Leak Hunting in Drill. By comparing the calculation result and actual surface subsidence value, it can be concluded that the proposed model is adaptable for height prediction of the fractured zone.
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Gang Zhou,Cunmin Wang,Qi Wang,Yixin Xu,Zhanyi Xing,Baoyong Zhang,Cuicui Xu 한국공업화학회 2022 Journal of Industrial and Engineering Chemistry Vol.108 No.-
In the process of coal seam water injection, the components of different fracturing fluids have differenteffects on coal. To analyze the effect of water injection fracturing fluid on the physical and chemical propertiesof coal, we studied the relationship between guar-based fracturing fluid and cationic clean fracturingfluid (C-VES). Microscopic experiments show that guar-based fracturing fluid has a certain viscosityeffect on coal, while C-VES can adsorb and capture the primary coal dust in coal. FTIR analysis shows thatC-VES has a great change on the content of coal functional groups, and guar-based fracturing fluid haslittle effect on coal. Industrial analysis shows that C-VES can better reduce the ash content of coal andhas a certain impact on the thermal efficiency of coal than guar based fracturing fluid. Combustion characteristicexperiment shows that guar-based fracturing fluid does not affect the combustion effect of coal,and C-VES can expand the exothermic temperature range of coal but has little effect on the main combustionof coal. Molecular dynamics simulation results show that C-VES has the best wetting effect oncoal. This research provides theoretical guidance for dust prevention and improving the use and conversionefficiency of coal.
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