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( Myung Jin Lee ),( Kye Hyung Kim ),( Jong Youn Yi ),( Su Jin Choi ),( Chung Jong Kim ),( Nak Hyun Kim ),( Kyoung Ho Song ),( Pyoeng Gyun Choi ),( Ji Hwan Bang ),( Wan Beom Park ),( Eu Suk Kim ),( San 대한내과학회 2014 대한내과학회 추계학술대회 Vol.2014 No.1
In Vitro Antiviral Activity of Ribavirin Against Severe Fever with Thrombocytopenia Syndrome Virus Myung Jin LEE1, Kye-Hyung KIM1, Jongyoun YI2, SuJin CHOI1, Chung-Jong KIM1, Nak- Hyun KIM1, Kyoung-Ho SONG1, Pyoeng Gyun CHOI1, Ji-Hwan BANG1, Wan Beom PARK1, Eu Suk KIM1, Sang-Won PARK1, Hong Bin KIM1, Nam Joong KIM1, Myoung- Don OH1 Seoul National University College of Medicine, Korea1, Pusan National University School of Medicine, Korea2 Background: Severe fever with thrombocytopenia syndrome (SFTS) is an emerging infectious disease caused by a novel Bunyavirus, severe fever with thrombocytopenia syndrome virus (SFTSV). No effective antiviral therapy is proven yet, but clinical use of ribavirin (RBV) has been tried. We investigated the antiviral effect of RBV against SFTSV in vitro. Methods: To test for cytotoxicity of RBV, Vero cells were treated with different concentrations of RBV (3.90 to 500 μg/mL, two-fold dilution) and analyzed by cell viability MTS assay 48h post-infection. To determine antiviral activity of RBV against SFTSV, Vero cells were infected with SFTSV strain Gangwon/Korea/2012 at 100 TCID50 (50% tissue culture infective dose) per well in a 96-well plate, and RBV was added at the concentrations showing no or minimal cytotoxicity. Viral RNAs were extracted from the culture supernatants and quantifi ed using one-step real-time reverse transcription- PCR to amplify the partial large segment of SFTSV. Statistical analysis was done by one-way ANOVA with Tukey`s post hoc test. Results: Cytotoxicity due to RBV was not observed at RBV concentration =31.3 μg/ mL. Viral RNAs at 24h post-RBV treatment were reduced with increasing RBV concentrations (1-32 μg/mL), compared with those of mock-treated cells (P <0.01, Figure). Half maximal inhibitory concentration (IC50) of RBV was 3.69 μg/mL at 24h post-RBV treatment. Conclusions: Our study shows that RBV has antiviral effect against SFTSV in a dose-dependent manner. Further studies are required to evaluate the effi cacy of RBV in SFTS.
Java/qmail을 활용한 인터넷 메시지 시스템 설계 및 구현
이호성,이충세,조완섭 충북대학교 컴퓨터정보통신 연구소 2001 컴퓨터정보통신연구 Vol.9 No.1
90년대 중반부터 국내에 인터넷 붐이 일어나고 사용이 보편화되면서 전자메일은 개인간의 메시지를 가능하게 해주는 기반기술 중 하나로 자리잡고 있다. 기존의 POP(Post Office Protocol) 프로토콜을 이용하던 전자메일 시스템은 별도의 환경설정 없이 지역, 언어, 시간에 제약이 없는 웹기반의 메시지 시스템으로 발전하고 있다. 현재 웹기반 메시지 시스템에 사용되어지는 MTA(Mail Transfer Agent)로는 sendmail이 사실상의 표준으로 받아 들여지고 있다. 그러나 sendmail은 단일 모듈로 작성되었으며, 사이즈가 매우 크고, 보안상의 문제점도 지적되고 있다. 이에 본 논문에서는 sendmail의 문제점을 효율적으로 해결할 수 있는 qmail의 활용방법을 제시하고, 웹과 qmail을 연계할 수 있도록 자바를 통한 웹기반 인터넷 메시지 시스템을 설계 및 구현한다. The rapid growth of the internet and World-Wide Web(WWW) has allowed more people access to global computer network and network applications. Internet Service Provider profit by offering many kinds of Internet services such as electronic mail, WWW, FTP, and others. Electronic mail service is one of the most popular and essential services in Internet. so, it called "killer application". Mail server is a computer system that sends and receives electronic message for a number of users in a certain management domain. Mail servers are connected to networks and should reliably process incoming and outgoing mail messages. Sending and receiving tasks are actually processed by a special software called mail transfer agent in the mail server(e.g., sendmail or qmail). In this paper, we present the design and implementation of Internet message system. The system integrates two different technologies - the qmail an Java servlet. Our system combines advantages from both technologies so users may remotely manage their mail system easily and effectively.
이충휘,원종혁,옥준영 한국전문물리치료학회 2000 한국전문물리치료학회지 Vol.7 No.1
As in house care is develops and becomes part of the health care delivery system in Korea, it is necessary to quantify the viewpoints of in-patients and outpatients. The purposes of this study are to analyze the utilization of house visits by physical therapist and to investigate the viewpoint of in- and out-patients who had rehabilitation treatment at 3 general hospitals in Wonju, Korea. Two hundred and fifty-eight questionnaires were analyzed and the major findings are as follows: 1. Sixty-five point seven percentage of respondents showed their willingness to utilize house visits by physical therapist if an in house physical therapy program were established. 2. The questionnaire used a Likert-type scale to ask the respondents their viewpoints on in house physical therapy services. Most respondents showed a positive attitude, answering 'I agree'. The findings show that house visits by physical therapists should be introduced as an integral system for the delivery of health care in Korea.
최대 등척성 수축시 표면근전도에서 근 수축 개시점 결정을 위한 기법들의 신뢰도
정이정,조상현,이정훈,이상헌 한국전문물리치료학회 2003 한국전문물리치료학회지 Vol.10 No.1
The purpose of this study was to compare the relative accuracy of a range of computer-based analysis with respect to EMG onset determined visually by an experienced examiner. Ten healthy students (6 male, 4 female) were recruited and three times randomly selected trials of isometric contraction of wrist flexion and extension were evaluated using four technique. These methods were compared which varied in terms of EMG processing, threshold value and the number of samples for which the mean must exceed the defined threshold, and beyond 7% of maximum amplitude. To identify determination of onset time, ICCs(Intraclass Correlation Coefficients) was used and inter-rater and intra-rater reliability ranged good in visually derived onset values. The results of this study present that in wrist flexion and extension, the reliability of the inter and intra-examiner muscle contraction onset times through visual analysis showed beyond .971 with ICCs. The reliability of the muscle contraction onset time decision through visual reading, tested with computer analysis, showed a relationship of all the selected analysis methods with ICCs .859 and .871. The objective computer-based analysis comparing with visual reading at the same time is the effective and qualitative data analysis method, considering the specificity of each study method.
추건이,신충식 한국스포츠리서치 2004 한국 스포츠 리서치 Vol.15 No.6
The purpose of this study was to investigate the relationship service quality and service loyalty in commercial Sport Facilities. Subjects were 341 customer who have perticipated in commercial sport centers which are used the convenience sampling. This study were questionnaire developed by combing and modifying those that service quality by Park Dong-Kyun(2002), Kim Dae-Kwon(1994). For data analysis the frequency analysis, reliability analysis, multiple regression analysis were performed with SPSSWIN 9.0 The results are as follow. Among the factors of service qualities in the sports facilities, system factor, person factor, physical factor showed influence on service loyalty.
박중신,김태영,이훈 대한건축학회 2004 대한건축학회논문집 Vol.20 No.11
This paper aims to clarify the residential quarter organization and housing spatial form of Japanese migrant fishing village during the colonial period of Korea in Tongyoung and Janseungpo. Road system of the village was constituted from roads running parallel with coastline and small alleys stretching perpendicularly to them providing trapezoid shape of land. Residential quarter Organization of the village was considered of square forms, trapezoid forms, and non-fixed forms. The transformation of the dwellings usually occurs through plan extension and expansion of shop space. The rooms appear to be modified by giving them independent entry, a modification probably adapted to Korean lifestyle.