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      • The influence of interfacial tensile strain on the charge transport characteristics of MoS2-based vertical heterojunction devices

        Huang, Fu,Cho, Byungjin,Chung, Hee-Suk,Son, Seung Bae,Kim, Jung Han,Bae, Tae-Sung,Yun, Hyung Joong,Sohn, Jung Inn,Oh, Kyu Hwan,Hahm, Myung Gwan,Park, Jung Hee,Hong, Woong-Ki The Royal Society of Chemistry 2016 Nanoscale Vol.8 No.40

        <P>We demonstrate the charge transport characteristics of MoS2-based vertical heterojunction devices through the formation of interfacial strain. Atomically thin MoS2 bilayers were directly synthesized on a p-type Si substrate by using chemical vapor deposition to introduce an interfacial tensile strain in the vertical heterojunction diode structure, which was confirmed by Raman, X-ray and ultraviolet photoelectron spectroscopy techniques. The electrical and optoelectronic properties of the heterojunction devices with the as-grown MoS2 (A-MoS2) on p-Si were compared with those of transferred MoS2 (T-MoS2)/p-Si devices. To clearly understand the charge transport characteristics induced by the interfacial tensile strain, the Fowler-Nordheim (FN) analysis of the electrical properties of the diode devices was conducted with the corresponding energy band diagrams. All of the fabricated MoS2-based vertical diodes exhibited clearly rectifying behaviors, but the photoresponse properties of the A-MoS2-based and T-MoS2-based heterojunctions exhibited distinct differences. Interestingly, we found that the tunneling barrier heights of the A-MoS2-based heterojunction devices were relatively higher than those of the T-MoS2-based devices and were almost the same before and after illumination due to the interfacial tensile strain, whereas those of the T-MoS2-based devices were lowered after illumination. Our study will help further understand the charge transport properties of 2D material-based heterojunction devices in the presence of interfacial strain, ultimately enabling the design of electronic and optoelectronic devices with novel functionalities.</P>

      • Understanding Users’ Continuance Intention in Cloud Computing Services : An Integrated Model

        BIN FU,Young-Soo Chung,Chul-HO Jung 한국경영정보학회 2014 한국경영정보학회 학술대회논문집 Vol.2014 No.1

        The Cloud Computing has become one of the hottest issues in the world of information technology (IT). However, the understanding of the determinants of user’s continuance intention in the context of cloud computing services is still limited. To fill the gap, this article attempts to demonstrate the factors that influence individuals’ continuance intention of cloud computing services. In this study, we adopted the Stimulus-Organism-Response (SOR) framework as research framework. And then, on the basis of the IS success model, UTAUT model and TTF, this research proposed an integrated model to investigate the factors that affect the cloud computing continuance intention. Furthermore, perceived functionality fit is regarded as a significant intervening variable and tested in the research..

      • IBM Zigbee Positioning Method for Smart Home Applications

        Ming-Hui Jin,Chung-Jung Fu,Chih-Hao Yu,Hung-Ren Lai,Ming-Whei Feng 보안공학연구지원센터 2008 International Journal of Smart Home Vol.2 No.2

        This paper presents a smart home system prototype which employs an indoor positioning system called the III Beacon Match (I3BM) positioning method to intelligently trigger the appropriately services for the home members. To overcome the ninja problem in the I3BM method, the signal filtering, adjustment and smooth procedures are proposed. The proposed system prototype employs the Zigbee module to implement the prototypes of the components for the I3BM positioning method, and the prototypes had passed the ZigBee Compliant Platform (ZCP) certification test. The proposed system prototype which intelligently controls the air condition and light system for smart home applications is also verifying in our demo room and in the smart house in National Taiwan University.

      • KCI등재

        Factors Influencing Breast Symptoms in Breastfeeding Women After Cesarean Section Delivery [Asian Nursing Research 5 (2011) 88e98] The authors regret for the incorrect author affiliation published in this article. The correct affiliation is as follows.

        Chia-Fen Hsien,Jung-Chung Fu,Cheng-Yu Long,Huey-Shyan Lin 한국간호과학회 2011 Asian Nursing Research Vol.5 No.3

        Purpose: The purpose of this study was to compare smoking prevalence and risk factors of smoking between Korean and Korean-Chinese middle school students. Methods: Data was collected from seventh and eighth grade students from 12 schools in Korea and 6schools in China. Descriptive statistics, Chi-square test, and t test were performed. Results: For data analysis 10,002 usable surveys were utilized. The smoking prevalence was higher in Korean-Chinese students than in Korean students. Risk factors, such as father smoking, friends smoking,gender, grade, academic achievement, alcohol use, and family income were associated with current smoking, and the differences in the two samples were significant. Korean-Chinese students were more likely than Korean students to have friends who smoked and a father who smoked. Smokers had a significantly higher rate of friends smoking, father smoking, and alcohol use. Korean-Chinese male students smoking prevalence was more than three times higher than Korean students. Korean students could sense a more anti-tobacco atmosphere in their environment. Korean-Chinese students were more likely than Korean students to perceive that it was easy to buy cigarettes and to smoke cigarettes in a public computer room. Conclusion: These results highlight the differences of smoking prevalence and risk factors between Korean-Chinese students and Korean students. The findings may help health educators and researchers to better understand adolescent smoking and risk factors cross culturally and aid in the development of more effective education programs, which could lead to preventing tobacco use among these populations.

      • SCISCIESCOPUS

        Docetaxel microemulsion for enhanced oral bioavailability: Preparation and <i>in vitro</i> and <i>in vivo</i> evaluation

        Yin, Yong-Mei,Cui, Fu-De,Mu, Chao-Feng,Choi, Min-Koo,Kim, Jung Sun,Chung, Suk-Jae,Shim, Chang-Koo,Kim, Dae-Duk Elsevier 2009 Journal of controlled release Vol.140 No.2

        <P><B>Abstract</B></P><P>A microemulsion system of docetaxel was prepared and evaluated for its solubilization capacity and oral bioavailability improvement. Based on a solubility study and pseudo ternary phase diagrams, microemulsions of about 30?nm in mean diameter were formulated with improved solubilization capacity towards the hydrophobic drug, docetaxel. The o/w microemulsion formulation (M-3) composed of Capryol 90 (oil), Cremophor EL (surfactant) and Transcutol (co-surfactant) enhanced the solubility of docetaxel up to 30?mg/mL, which maintained solubilization capacity for 24?h even after it was diluted 20 times with normal saline. The three formulations did not show significant difference in the <I>in vitro</I> lipid digestion study. Both the ultrafiltration and dialysis studies revealed that the release of 80% of docetaxel was released from the microemulsions within 12?h <I>in vitro</I>. Compared to the commercial product Taxotere<SUP>®</SUP> (0.025?µg/cm<SUP>2</SUP>), the apical to basolateral transport of docetaxel across the Caco-2 cell monolayer from the M-3 formulation (Capryol 90/Cremophor EL/Transcutol=29.4:24.9:12.4, w/w) was significantly improved (0.624?µg/cm<SUP>2</SUP>, <I>p</I><0.01). Moreover, the oral bioavailability of the M-3 formulation in rats (34.42%) rose dramatically compared to that of the orally administered Taxotere<SUP>®</SUP> (6.63%). This increase in bioavailability was probably due to the combined effect of the enhancement in solubility, the inhibition of P-gp efflux system and the increase in permeability. These results encourage further development of docetaxel microemulsions as an oral drug delivery system.</P> <P><B>Graphical abstract</B></P><P>Increased oral bioavailability of docetaxel in the microemulsions was observed by the combined effects of enhanced solubility, P-gp inhibition and permeability enhancing effects.</P><ce:figure></ce:figure>

      • SCIESCOPUS

        Preparation, characterization and in vitro intestinal absorption of a dry emulsion formulation containing atorvastatin calcium.

        Yin, Yong-Mei,Cui, Fu-De,Kim, Jung Sun,Choi, Min-Koo,Choi, Byung Chul,Chung, Suk-Jae,Shim, Chang-Koo,Kim, Dae-Duk Academic Press ; Taylor Francis 2009 DRUG DELIVERY Vol.16 No.1

        <P>A redispersible dry emulsion (DE) formulation of atorvastatin calcium (AC) was developed to enhance the in vitro dissolution of AC, thereby increasing its gastrointestinal absorption. The spray-drying technology was used where Plurol Oleique CC 497 was chosen as the oil phase. Effects of carriers, surfactants, and homogenizers on the characteristics of DE containing AC were systematically investigated. The final formulation consisted of dextrin and Poloxamer 188 as carrier and surfactant, respectively, and was homogenized by a high pressure homogenizer before spray drying. The in vitro release of AC from the optimized DE was significantly higher than that of pure AC powder (76% vs. 30% at 24 hr). The in vitro intestinal absorption of AC from the DE formulation was 0.77 microg/cm(2) at 2 hr, which was a 2.33-fold increase compared to the pure unformulated AC powder. These results suggest that the oral dry emulsion formulation could improve the intestinal absorption of AC.</P>

      • KCI등재

        Factors Influencing Breast Symptoms in Breastfeeding Women After Cesarean Section Delivery

        Chia-Fen Hsien,Jung-Chung Fu,Cheng-Yu Long,Huey-Shyan Lin 한국간호과학회 2011 Asian Nursing Research Vol.5 No.2

        Purpose The purposes of this study were to explore postpartum stress and breast symptoms in postpartum breastfeeding of parturient mothers as well as to identify the factors influencing the breast symptoms in breastfeeding women after cesarean section delivery. Methods A cross-sectional survey was conducted. A total of 162 breastfeeding women after cesarean section delivery were recruited from five hospitals in Taiwan. Structured questionnaires were used to collect data. Results The five highest postpartum stress comes from the flabby flesh of maternal belly, the baby getting sick suddenly, interrupted sleep, insufficient breast milk, and discomfort due to breast engorgement. The most two common breast symptoms in breastfeeding encountered by subjects in this study were breast engorgement and breast hardening, whereas the least common one was nipple bloody discharge. Cesarean section women with early suckling on the operating table had more breast symptoms in postpartum breastfeeding; and the higher the postpartum stress of them, the more the breast symptoms. Conclusions Breastfeeding in a comfortable condition is a key factor of precipitating breast milk secretion,so early suckling on the operating table may result in discomfort and stress of the woman and interfere with the secretion or production of breast milk. Additionally, it is a crucial factor of the success in breastfeeding that the nursing personnel can provide women help in maintaining breast milk production and secretion, taking care of a baby, and reminding women’s families (especially their husbands) of giving their assistance, encouragement and praises to relieve women’s postpartum stress.

      • KCI등재

        Comprehensive profiles and diagnostic value of menopausal-specific gut microbiota in premenopausal breast cancer

        Hou Ming-Feng,Ou-Yang Fu,Li Chung-Liang,Chen Fang-Ming,Chuang Chieh-Han,Kan Jung-Yu,Wu Cheng-Che,Shih Shen-Liang,Shiau Jun-Ping,Kao Li-Chun,Kao Chieh-Ni,Lee Yi-Chen,Moi Sin-Hua,Yeh Yao-Tsung,Cheng Chi 생화학분자생물학회 2021 Experimental and molecular medicine Vol.53 No.-

        In Western countries, breast cancer tends to occur in older postmenopausal women. However, in Asian countries, the proportion of younger premenopausal breast cancer patients is increasing. Increasing evidence suggests that the gut microbiota plays a critical role in breast cancer. However, studies on the gut microbiota in the context of breast cancer have mainly focused on postmenopausal breast cancer. Little is known about the gut microbiota in the context of premenopausal breast cancer. This study aimed to comprehensively explore the gut microbial profiles, diagnostic value, and functional pathways in premenopausal breast cancer patients. Here, we analyzed 267 breast cancer patients with different menopausal statuses and age-matched female controls. The α-diversity was significantly reduced in premenopausal breast cancer patients, and the β-diversity differed significantly between breast cancer patients and controls. By performing multiple analyses and classification, 14 microbial markers were identified in the different menopausal statuses of breast cancer. Bacteroides fragilis was specifically found in young women of premenopausal statuses and Klebsiella pneumoniae in older women of postmenopausal statuses. In addition, menopausal-specific microbial markers could exhibit excellent discriminatory ability in distinguishing breast cancer patients from controls. Finally, the functional pathways differed between breast cancer patients and controls. Our findings provide the first evidence that the gut microbiota in premenopausal breast cancer patients differs from that in postmenopausal breast cancer patients and shed light on menopausal-specific microbial markers for diagnosis and investigation, ultimately providing a noninvasive approach for breast cancer detection and a novel strategy for preventing premenopausal breast cancer.

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