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Preventive Effect of Natural Pigments Against Ultraviolet B-induced Cell Death in HaCat Cells
Jae Chung Lim,Chun Sik Bae,Soo Young Jeong,Hee-Ock Boo,Seong-Jin Hwang,Seul-Ki Lim,Min-Jung Park,Jong-Chun Kim,Seong-Soo Kang,Ho-Jae Han,Soo-Hyun Park 대한의생명과학회 2011 Biomedical Science Letters Vol.17 No.1
Skin is a physical barrier against diverse injury and damages. Exposure to ultraviolet (UV) radiation causes detrimental skin injuries such as inflammation and cell death. The value of natural pigments could be applied to many usages including cosmetics. This study was conducted to examine the protective effect of natural pigments extracted from mulberry, balsam pear, purple-colored sweet potato, pehmannia root, gardenia fruit, and black rice against UV-induced cell death in HaCaT cells, human keratinocyte cell lines. In the present study, the exposure of 50 mJ/㎠ UV-B for 24 hr induced cell death in HaCaT cells, which was prevented by the pretreatment of extracts of mulberry, balsam pear, purple-colored sweet potato, rehmannia root, gardenia fruit, and black rice. In addition, the exposure of 50 mJ/㎠ UV-B for 24 hr also increased lipid peroxide (LPO) formation, compared to control in HaCaT cells, which was prevented by the pretreatment of extracts of mulberry, balsam pear, purple-colored sweet potato, rehmannia root, gardenia fruit, and black rice. In conclusion, the extracts of mulberry, balsam pear, purple-colored sweet potato, rehmannia root, gardenia fruit, and black rice prevented the UV-B-induced cell apoptosis via the inhibition of oxidative stress in HaCaT cells.
Lim, Dahee,Kim, Wooki,Lee, Mi-Gi,Heo, Ho Jin,Chun, Ock K.,Kim, Dae-Ok 한국식품과학회 2012 Food Science and Biotechnology Vol.21 No.6
This study evaluated total phenolics, total flavonoids, and antioxidant capacity of randomly selected regular and decaffeinated coffees commercially available in Korea and their protective effects in human hepatic epithelial HepG2 cell line against oxidative stress. All coffees tested exhibited potent antioxidant capacity in chemical systems and, consequently, significant protection of cells from oxidative stress in vitro in a dose-dependent manner. In particular, $H_2O_2$-induced apoptosis as evaluated by annexin V staining and flow cytometry was prevented by coffee extracts, resulting in the enhanced cell viability. Of interest, the content of total phenolics and flavonoids in coffees demonstrated a positive correlation with antioxidant capacity, indicating that the antioxidant capacity of coffees may be attributed to those phytochemicals. In accordance with previous studies, caffeoylquinic acid (CQA) and its derivatives including 3-CQA, 4-CQA, 5-CQA, 3,4-diCQA, 3,5-diCQA, and 4,5-diCQA were identified as phenolic phytochemicals by a reversed-phase HPLC, with 5-CQA being a major component. Taken together, the present study demonstrated protective effects of regular and decaffeinated coffees on cells in vitro against overwhelming oxidative stress due to richness in phenolics, especially CQA and its derivatives. Coffees, regular or decaffeinated, may serve as a good source of health-beneficial phytochemicals in diet.
인삼 복합물의 뼈골격 성장과 IGF-1 생성 촉진 효과
Young Ock Kim,Ji Yeon Lee,Kyung Hun Park,Je Hun Choi,Ji Hea Yoon,Yu Su Shin,Heung Bin Lim,Chun Geon Park 한국약용작물학회 2016 한국약용작물학술대회 발표집 Vol.2016 No.10
Background : Insulin-like growth factor 1 (IGF-1) appears to enhance the differentiation of osteoblasts and to activate the mineralization of bone. Hence, the aim of this study was to investigate the effects of ginseng complex on the remodeling of rats tibia. Methods and Results : Ginseng complex significantly increased serum IGF-1 by 58% and 34.5% than the control, respectively. Treatment with α-amylase when manufacturing these extracts remarkably increased the concentration of IGF-1 by 63% and 36% above the control, respectively. This ways that this ginseng complex, especially α-amylase treated extracts, contained a higher level of IGF-1 secretion in the ginseng complex groups. In addition, increases of 8% in femuf length were found after 12 weeks of oral administration with ginseng complex (300mg/kg). Conclusion : These results mean that ginseng complex have beneficial effects on bone effects on bone growth via IGF-1.
L-α-lecithin으로 재구성된 Bacteriorhodopsin Vesicle에서 Methylene Blue의 Metachromasy
李弘,裵懸玉,林春玉,李厚卨 圓光大學校 基礎自然科學硏究所 1991 基礎科學硏究誌 Vol.10 No.2
Absorption properties of methylene blue(MB) in L-α-lecithin vesicle, bacteriorhodopsin and incorporated bacteriorhodopsin (InBR) vesicle system at 20∼60℃ has been studied by absorption spectroscopy. The equilibrium of MB between monomer and dimer in lecithin vesicles has been existed at low concentration of MB, but oligomer has been formed in vesicle at high concentration of MB. In most cases, the MB cluster was redistributed to monomer in the high concentration of lecithin vesicles. Adding BR to constant concentration of MB decreased the absorption ratio(a/P) of MB, and MB was formed oligomeric aggregate. Absorption ratio(α/β) of MB was increased during phase transition of InBR vesicles, but independent of phase transition of lecithin vesicles. It suggested that aggregate of MB on the surfaces of InBR vesicles were redistributed to monomer under the influence of lipid phase transition.